Protective mechanism of curcumin against Vibrio vulnificus infection.

Na, Hee Sam,Cha, Mi Hye,Oh, Dool-Ri,Cho, Cheong-Weon,Rhee, Joon Haeng,Kim, Young Ran Elsevier Science Publishers, B.V. on behalf of the 2011 FEMS immunology and medical microbiology Vol.63 No.3

<P>Curcumin, a natural polyphenolic flavonoid extracted from the rhizome of Curcuma longa L., has many beneficial biological activities. However, there are relatively few reports of the effects of curcumin on pathogen infections. This study examined the effect of curcumin on a Vibrio vulnificus infection. The cytotoxicity of V. vulnificus to HeLa cells was significantly inhibited by curcumin (at 10 or 30?μM). To further examine the inhibitory mechanism of curcumin against V. vulnificus-mediated cytotoxicity, the level of bacterial growth, bacterial motility, cell adhesion, RTX toxin expression and host cell reactions were evaluated. Curcumin inhibited V. vulnificus growth in HI broth. Curcumin inhibited both bacterial adhesion and RTX toxin binding to the host cells, which can be considered the major protective mechanisms for the decrease in V. vulnificus cytotoxicity. Curcumin also inhibited host cell rounding and actin aggregation, which are the early features of cell death caused by V. vulnificus. In addition, curcumin decreased the V. vulnificus-induced NF-κB translocation in HeLa cells. Finally, curcumin protected mice from V. vulnificus-induced septicemia. In conclusion, curcumin may be an alternative antimicrobial agent against fatal bacterial infections.</P>

Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD

Kang Na Ri,Ahn Yo Han,박유진,Lee Keum Hwa,Baek Hee Sun,Kim Seong Heon,Cho Heeyeon,Cho Min Hyun,Shin Jae Il,Lee Joo Hoon,Cheong Hae Il,Kang Hee Gyung,Park Young Seo,Ha Il-Soo,Moon Duk-Soo,Han Kyoung Hee 대한의학회 2021 Journal of Korean medical science Vol.36 No.20

Background: Chronic kidney disease (CKD) has a negative impact on growth and development in children and is a risk factor for neurocognitive impairment; however, there is limited research on the cognitive function of children and adolescents with CKD. This study therefore aimed to investigate the mean intelligence and risk factors for low intelligence in children and adolescents with CKD. Methods: Eighty-one patients with CKD under 18 years old were included in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Participants completed either the Wechsler Intelligence Scale for Children (6–16 years), or Wechsler Adult Intelligence Scale (> 16 years). Results: The mean full-scale intelligence quotient (IQ) was 91 ± 19; 24.7% of participants scored a full-scale IQ below 80. Participants with a short stature (height Z scores < −1.88), failure to thrive (weight Z scores < −1.65), more severe CKD stage (≥ IIIb), longer duration of CKD (≥ 5 years), and those who were Medicare or Medicaid beneficiaries, had significantly lower mean full-scale IQs. Conclusion: On linear regression analysis, the association between the full-scale IQ, and longer duration of CKD and growth failure, remained significant after controlling for demographic and clinical variables. It is therefore necessary to investigate cognitive impairment in pediatric patients with CKD who exhibit growth failure or for a longer postmorbid period. It is believed that early interventions, such as kidney transplantation, will have a positive effect on IQ in children with CKD, as the disease negatively affects IQ due to poor glomerular filtration rate over time.

자료 : 영양사의 직무능력 향상을 위한 계속교육의 참여동기 분석

손정민 ( Cheong Min Sohn ),조영연 ( Young Yun Cho ),배미용 ( Mi Yong Bea ),도은경 ( Eun Kyoung Do ),나우리 ( Woo Ri Na ),김미성 ( Mi Sung Kim ) 대한영양사협회 2013 대한영양사협회 학술지 Vol.19 No.4

본 연구는 영양사 직무능력 향상을 위한 계속교육의 참여동기를 분석하여 향후 영양사의 계속교육 프로그램 개발을 위한 기초자료로 사용하기 위해 실시되었다. 영양사 622명을 대상으로 조사된 설문 분석 결과는 다음과 같다. 1. 본 연구에 참여한 영양사는 연령별, 최종학력별, 근무처별, 영양사 업무 근무경력별로 분류하여 조사하였다. 조사에 참여한 영양사의 연령대는 40대가 262명(42.1%)으로 가장 많았으며, 최종학력은 4년제 대학졸업이 322명(51.8%)으로 가장 많은 것으로 나타났다. 근무처는 학교 영양사가 251명(40.4%)으로 가장 많은 것으로 나타났으며, 근무 경력은 7∼10년 228명(36.7%)이 가장 많은 것으로 나타났다. 2. 전문영양사 계속교육 참여동기에 대한 타당성 및 신뢰도 검증을 위해 요인분석을 실시한 결과 총 4개의 요인이 도출되었다. 이는 각각 ‘전문역량 유지 및 개발’, ‘상호교류 및 전문가의 책임’, ‘직업의 안정성, 개인의 이익’, ‘고객에 대한 서비스’라 명명하였고, 이 중 ‘전문역량 유지 및 개발’의 설명분산이 29.343%로 가장 큰 것으로 나타났다. 참여요인의 Cronbach’s α값은 각각 0.967, 0.927, 0.878, 0.937로 분석되었다. 3. 본 설문에 참여한 영양사의 일반적 특성에 따른 계속교육 참여동기에 대한 분석결과 연령이 낮을 수록, 학력이 낮을수록, 유치원, 어린이집, 기타 근무자일 경우, 6년 이하의 경우에서 ‘직업의 안정성, 개인의 이익’에 대한 참여동기가 높은 것으로 분석되었다. 이상 결과를 종합하여 볼 때 영양사 계속교육 촉진 및 프로그램 개발을 위해 본 연구에서 분석된 연령, 학력, 근무처 및 경력 등을 고려하여 전문성을 증진시킬 수 있는 프로그램을 개발해야 할 것이며, 특히 연령이 적고, 경력이 길지 않은 영양사의 참여동기가 높은 것으로 보아 이들을 위해 전문성을 가진 프로그램 개발이 우선적으로 이루어져야 할 것으로 사료된다. This study analyzed the reasons for continuing education among dietitians. An internet-based survey of 622 dieticians was conducted from August 31, 2012 to September 12, 2012. Based on data from the Participation Reasons Scale (PRS) questionnaire, factor analysis was conducted by principle component analysis for the extraction of major factors. Subsequent reliability analysis was performed by assessing Cronbach`s α. The ANOVA-test was performed to compare the participation reason scores for each factors according to general characteristics. Statistical analysis was performed using SPSS ver.17.0, and P<0.05 was considered significant. Factor analysis for the participation reasons revealed four types of factors. These factors were “maintenance and development of professional competencies”, “interaction and responsibility of professionals”, “job stability and personal profits” and “services for customers” respectively. Among the participation reasons, “maintenance and development of professional competencies” was the first reason with a 29.34% variance. In addition, the participation reasons for continuing education differed according to age (P<0.05), the highest level of education (P<0.05), workplace (P<0.01), and work experience in dietetic area (P<0.001). In conclusion, continuing education programs for dietitians should focus on effectively developing and promoting professionalism.

대사증후군 남성에서의 혈중 Osteoprotegerin의 아디포넥틴과의 상관성과 비만도에 따른 차이

나우리(Woo Ri Na),손정민(Cheong Min Sohn) 대한지역사회영양학회 2011 대한지역사회영양학회지 Vol.16 No.6

Osteoprotegerin (OPG) plays a core role in bone reformation by antagonizing the effect of receptor activator of nuclear factor κ-B ligand (RANKL), and mediates vascular calcification in cardiovascular disease patients. Thus, we aimed to examine the relationship between serum OPG levels and cardiovascular factors and inflammatory markers in metabolic syndrome patients (MS). This cross-sectional study included 96 men who visited the diet clinic between May and July 2011. Patients were classified into 2 groups based on NCEP-ATP guidelines: normal and with MS (n = 50 and 46, respectively). Physical measurements, biochemical assay were measured. Serum OPG and IL-6, diponectin and hs-CRP were assessed. MS were aged 50.02 ± 10.85 years, and normal patients 52.07 ± 9.56 years, with no significant differences. Significant differences were not observed in BMI between the 2 groups. Moreover, significant differences were not observed in serum OPG, however, the serum OPG level (4.41 ± 1.86 pmol/L) differed significantly between an overweight MS (BMI > 25) and normal patients. OPG was correlated to age (r = 0.410, p = 0.000), HDL-cholesterol (r = 0.209, p = 0.015), and log adiponectin (r = 0.175, p = 0.042). Multiple regression analyses using the enter method showed that age (β = 0.412, p = 0.000) and BMI (β = 0.265, p = 0.000) considerably affected OPG. In conclusion, out study showed that serum OPG levels are correlated with cardiovascular risk factors, such as BMI, HDL-cholesterol and adiponectin in MS and adiponectin, suggesting that serum OPG has potential as a cardiovascular disease indicator and predictor. (Korean J Community Nutr 16(6) : 762~770, 2011)

OB-15 : Clinical characteristics of pregnancies complicated by congenital myotonic dystrophy

( Cheon Ga Yee ),( Na Ri Shin ),( Suk Joo Choi ),( Soo Young Oh ),( Cheong Rae Roh ),( Jong Hwa Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: The objective of this study was to investigate the clinical characteristics of pregnancies complicated by congenital myotonic dystrophy diagnosed in our institution. 방법: We retrospectively reviewed cases with congenital myotonic dystrophy of mothers and newborns admitted NICU and diagnosed after birth between July 2004 and May 2014 (6 inborn and 5 outborn babies). Clinical features including maternal history of infertility and prenatal ultrasonographic findings were reviewed from medical record available. The results from myotonic dystrophy protein kinase (DMPK) gene mutation test with the number of CTG repeat expansion from mothers and neonates were also assessed. 결과: All mothers were not aware of their own myotonic dystrophy traits before their pregnancies. History of infertility followed by assisted reproductive technology accounted for 57.1% (4/7). Median maternal age was 32 years old (range, 29-40). Median gestational age at delivery and neonatal birth weight were 35+6 week (range, 29+1-38+5) and 2850gm (range, 1380-3600) respectively. Most distinctive prenatal ultrasonographic finding was severe polyhydramnios (66.7%, 4/6) with median AFI of 43 (range, 37-66). In 37.5% (3/8) cases, decreased fetal movement was evident in prenatal ultrasound exam. Median hospital stay in NICU was 37 day (range, 5-397) and there was one infant death, which was complicated with hydrops. One-minute Apgar score <4 was 44.4% (4 /9) and five-minute Apgar score <7 was 66.7% (6/9). Median number of CTG repeat of mothers and neonates were 400 (range, 166-1000) and 1300 (range, 700-2700), respectively. 결론: Our data suggests that severe polyhydramnios with decreased fetal movement in pregnant women especially with a history of infertility requires a differential diagnosis of congenital myotonic dystrophy.

노인영양지수를 활용한 영양교육 프로그램의 효과평가 : 익산 지역 노인복지시설 이용자를 대상으로

이민형(Min hyung Lee),나우리(Woo ri Na),주완희(Wan hui Ju),손정민(Cheong min Sohn) 한국생활과학회 2018 한국생활과학회 학술대회 Vol.2018 No.11

Estimation of vitamin K intake in Koreans and determination of the primary vitamin K-containing food sources based on the fifth Korean National Health and Nutrition Examination Survey (2010-2011)

Eun-Soo Kim,Mi-Sung Kim,Woo-Ri Na,Cheong-Min Sohn 한국영양학회 2013 Nutrition Research and Practice Vol.7 No.6

There is little information on dietary vitamin K intake and nutritional status of daily requirements of vitamin K in Korea. The objective of this study was to investigate the vitamin K intake and major food sources of Vitamin K in Koreans. The survey data from the 2010-2011 Korean National Health and Nutrition Examination Survey of 7,792 subjects (aged 19-64 years) were examined. Total vitamin K intake was calculated from 24-hour dietary recall using a vitamin K food database, Computer Aided Nutritional analysis Program and the United States Department of Agriculture database. The geometric mean of vitamin K was estimated as 322.40 ± 6.33 ug/day for men and 271.20 ± 4.92 ug/day for women. Daily vitamin K intake increased significantly with age (p for trend < 0.001). The main food source of vitamin K was vegetables (72.84%), including cabbage kimchi (19.26%), spinach (17.38%), sesame leaves (7.11%), radish leaves (6.65%), spring onions (6.28%), and laver (4.82%), followed by seaweed, seasonings, and fat and oils. We observed that the vitamin K intake of Koreans was relatively higher than that reported by other studies in Western countries and differed depending on age.

Structural Base of Tricetin Sequential O-Methylation

Bong Gyu Kim,Byeong Suk Hong,Na Ri Cheong,You Hoon Cheong,Joong Hoon Ahn 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.5

Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study

Choi, Seong Hye,Kim, SangYun,Han, Seol-Heui,Na, Duk L.,Kim, Doh-Kwan,Cheong, Hae-Kwan,Lee, Jae-Hong,Kim, Seong Yoon,Hong, Chang Hyung,Moon, So Young,Kwon, Jay C.,Kim, Jung Eun,Jeong, Jee H.,Na, Hae Ri Springer-Verlag 2012 NEUROLOGICAL SCIENCES Vol.33 No.4

OB-06 : Gestational age at delivery and neonatal outcome in uncomplicated twin pregnancies: what is the optimal age for delivery according to chorionicity?

( Hye Jung Lee ),( Soo Hyun Kim ),( Mina Kim ),( Ji Hee Sung ),( Ji Yeon You ),( Jin Yi Kuk ),( Na Ri Shin ),( Soo Young Oh,),( Cheong Rae Roh ),( Jong Hwa Kim ),( Suk Joo Choi ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: To investigate the neonatal outcome according to gestational age at delivery in uncomplicated twin pregnancies and to determine the optimal timing for delivery in monochorionic and dichorionic twin pregnancies. 방법: This is a retrospective cohort study of women with twin pregnancies delivered beyond 35 weeks of gestation at Samsung Medical Center from 1994 to 2013. Pregnancies complicated by one-or-more fetal death before 35 weeks` gestation, fetal chromosomal or non-chromosomal major anomalies, preeclampsia, diabetes, preterm labor, preterm rupture of membrane, abruption placenta, and placenta previa were excluded. The primary outcome was a composite morbidity defined as having one-or-more of stillbirth, admission to neonatal intensive care unit (NICU), use of ventilator, respiratory distress syndrome and neonatal mortality. The outcome was analyzed according to gestational age at delivery and chorionicity. 결과: A total of 593 twin pregnancies were included (monochorionic=141, dichorionic=452). Preterm delivery <37 weeks` gestation was performed in 41.5% (246/593), but its rate decreased over the 19 years of study period (from 63.2% in 1995-1999 to 9.8% in 2010-2013). Monochorionic twins were more commonly delivered <37 weeks` gestation (50.4% vs. 38.7%, p=0.014) compared to dichorionic twins, and they had a higher risk of NICU admission, perinatal mortality and composite morbidity. The nadir of neonatal composite morbidity in monochorionic twins was observed at 37 weeks` gestation (35.3% in 35 week, 14.0% in 36 weeks, 5.7% in 37 week, 12.5% in 38 weeks, 8.3% in ≥39 week) and the nadir of neonatal composite morbidity in dichorionic twins was observed at beyond 38 weeks` gestation (31.7% in 35 week, 7.2% in 36 weeks, 3.3% in 37 week, 1.7% in 38 weeks, 0% in ≥39 week). 결론: Our data indicates that the optimal gestational age for delivery was 37 weeks in uncomplicated monochorionic pregnancies and beyond 38 weeks in dichorionic twin pregnancies.