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Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
Okada, Y.,Suzuki, A.,Ikari, K.,Terao, C.,Kochi, Y.,Ohmura, K.,Higasa, K.,Akiyama, M.,Ashikawa, K.,Kanai, M.,Hirata, J.,Suita, N.,Teo, Y.Y.,Xu, H.,Bae, S.C.,Takahashi, A.,Momozawa, Y.,Matsuda, K.,Momoh University of Chicago Press [etc.] 2016 American journal of human genetics Vol.99 No.2
<P>Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation study including east Asian and European populations (n=7,097 and 23,149, respectively). Our study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene, on anti-citrullinated protein autoantibody (ACPA)-positive RA risk (p=1.4 x 10(-) 9), which demonstrated a cis-expression quantitative trait loci (cis-eQTL) effect on HLA-DOA expression. Trans-ethnic comparison revealed different linkage disequilibrium (LD) patterns in HLA-DOA and HLA-DRB1, explaining the observed HLA-DOA variant risk heterogeneity among ethnicities, which was most evident in the Japanese population. Although previous HLA fine-mapping studies have identified amino acid polymorphisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionally identifies the dosage contribution of a non-classical HLA gene to disease etiology. Our study contributes to the understanding of HLA immunology in human diseases and suggests the value of incorporating additional ancestry in MHC fine-mapping.</P>
hajime Arimoto,F. Sano,G. Motojima,H. Yamazaki,H. Nakamura,H. Yabutani,H. Kitagawa,H. Okada,J. Arakawa,K. Kondo,K. Ohashi,K. Nagasaki,M. Yamada,M. Uno,M. Kikutake,M. Kaneko,N. Watanabe,N. Nishino,N. S 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
The measurement of D, CII and CIII line spectral profiles and the CD band spectrum from the vicinity of a test limiter surface is performed in Heliotron J test limiter experiments. With deep insertion of the limiter, there is a localized intense region of the D, CII and CIII line intensity in the limiter surface, and the CD band spectrum is observed at this region. It is considered that the deuterium ion flux and heat load concentrate at this region and enhance carbon impurity generation.r_che
The Weak Decay Widths of Λ Hypernuclei
H. Bhang,S. Ajimura,K. Aoki,A. Banu,T. Fukuda,O. Hashimoto,J. I. Hwang,S. Kameoka,B. H. Kang,E. Kim,김정호,T. Maruta,Y. Miura,Y. Miyake,T. Nagae,M. Nakamura,S. N. Nakamura,H. Noumi,S. Okada,Y. Okayasu,H. 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We have measured both the mesonic and nonmesonic weak decay widths of ^(12)_ΛC. For the mesonic decay, we have improved the accuracy of Γ_π^0 so that it reduced the error of Γ_(nm) from ≥10% to ≤5%. For the nonmesonic decay, we have solved the long standing Γ_n/Γ_p puzzle by measuring the ratio 0.51 ± 0.14 in the exclusive measurement. At the same time we have measured the width of the 3-body nonmesonic decay Γ_(2N) = 0.27 ± 0.13 for the first time. Combining the accurate Γ_n/Γ_p ratio and the first measured value Γ_(2N), we have finally obtained the Γ_n and Γ_p themselves taking account of the 3-body process. We have measured all the weak decay widths of _(12)_ΛC so that it provides the first complete set of widths for the investigation of ΔS = 1 baryon-baryon weak interaction.
Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12
CLEAR investigators,Kurreeman, Fina A.S.,Stahl, Eli A.,Okada, Y.,Liao, K.,Diogo, D.,Raychaudhuri, S.,Freudenberg, J.,Kochi, Y.,Patsopoulos, Nikolaos A.,Gupta, N.,Sandor, C.,Bang, S.Y.,Lee, H.S.,Padyuk University of Chicago Press [etc.] 2012 American journal of human genetics Vol.90 No.3
We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show that we can effectively discover RA risk alleles. Thirteen putatively associated SNPs that had not yet exceeded genome-wide significance (p < 5 x 10<SUP>-8</SUP>) in our previous RA genome-wide association study (GWAS) were analyzed in independent sample sets consisting of 4,366 cases and 17,765 controls of European, African American, and East Asian ancestry. Additionally, we conducted an overall association test across all 65,833 samples (a GWAS meta-analysis plus the replication samples). Of the 13 SNPs investigated, four were significantly below the study-wide Bonferroni corrected p value threshold (p < 0.0038) in the replication samples. Two SNPs (rs3890745 at the 1p36 locus [p = 2.3 x 10<SUP>-12</SUP>] and rs2872507 at the 17q12 locus [p = 1.7 x 10<SUP>-9</SUP>]) surpassed genome-wide significance in all 16,659 RA cases and 49,174 controls combined. We used available GWAS data to fine map these two loci in Europeans and East Asians, and we found that the same allele conferred risk in both ethnic groups. A series of bioinformatic analyses identified TNFRSF14-MMEL1 at the 1p36 locus and IKZF3-ORMDL3-GSDMB at the 17q12 locus as the genes most likely associated with RA. These findings demonstrate empirically that a multiethnic approach is an effective strategy for discovering RA risk loci, and they suggest that combining GWASs across ethnic groups represents an efficient strategy for gaining statistical power.
THE PROPERTIES OF DUST EMISSION IN THE GALACTIC CENTER REGION REVEALED BY FIS-FTS OBSERVATIONS
Yasuda, A.,Kaneda, H.,Takahashi, A.,Nakagawa, T.,Kawada, M.,Okada, Y.,Takahashi, H.,Murakami, N. The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
We present the results of far-infrared spectral mapping of the Galactic center region with FIS-FTS, which covered the two massive star-forming clusters, Arches and Quintuplet. We find that two dust components with temperatures of about 20 K and 50 K are required to fit the overall continuum spectra. The warm dust emission is spatially correlated with the [OIII] $88{\mu}m$ emission and both are likely to be associated with the two clusters, while the cool dust emission is more widely distributed without any clear spatial correlation with the clusters. We find differences in the properties of the ISM around the two clusters, suggesting that the star-forming activity of the Arches cluster is at an earlier stage than that of the Quintuplet cluster.