http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Freudenberg, J. (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Freudenberg, Jan,Lee, Hye-Soon,Han, Bok-Ghee,Shin, Hyoung Do,Kang, Young Mo,Sung, Yoon-Kyoung,Shim, Seung-Cheol,Choi, Chan-Bum,Lee, Annette T,Gregersen, Peter K,Bae, Sang-Cheol J.B. Lippincott Co 2011 Vol.63 No.4
<P>To perform a genome-wide association study (GWAS) in Koreans in order to identify susceptibility loci for rheumatoid arthritis (RA).</P>
-
프로이덴베르거, 실자 고려대학교 철학연구소 2004 철학연구 Vol.0 No.27
이 논문에서는 문화들에 있어서 상호문화적인 것으로부터 초문화적 관점들로 이동하는 데 있어 단지 문화라는 개념뿐만 아니라, 의미의 개념도 변화되어야 한다는 것을 보여주고자 한다. 우선 상호문화성과 초문화성의 개념들을 간략히 살펴볼 것이다. 그리고 상호 문화적 환경으로부터 의미 이론을 구성하려는 콰인의 ‘gavagai’라는 실험적 사유를 검토할 것이다. 이를 통해 초문화적 의미개념을 파악하기 위해서는 더 많은 것이 요구되며, 이것은 퍼스와 그의 기호론을 통해 찾아질 수 있을 것이다. 따라서 초문화적 관점에서 의미들은 고정될 수 없고, 의미 전개가 항상 의사소통적 과정 속에서 존재하는 개념을 선호해야 한다는 것을 주장하고자 한다. I want to present the thesis that in a shift from an intercultural to a transcultural perspective on cultures not only the concept of culture but also the concept of meaning must undergo a change. To argue for this, I will first briefly sketch the ideas of interculturality and transculturality. In a next step I will shortly review Quine's thought experiment of the 'gavagai' to construct a theory of meaning from an intercultural setting. In conclusion, I want to argue, for a transcultural concept of meaning more is needed. And this 'more' we might very well find in looking back to Peirce and his process-oriented semiotics. I hold that in such a transcultural perspective, meanings can't and should not be fixed, and therefore a conception, where the developing of meaning is always in a communicative process is to be preferred.
-
Yahya Alwatari,Devon C. Freudenberger,Jad Khoraki,Lena Bless,Riley Payne,Walker A. Julliard,Rachit D. Shah,Carlos A. Puig 대한심장혈관흉부외과학회 2024 Journal of Chest Surgery (J Chest Surg) Vol.57 No.2
Background: Data on perioperative outcomes of emergent versus elective resection in esophageal cancer patients requiring esophagectomy are lacking. We investigated whether emergent resection was associated with increased risks of morbidity and mortality. Methods: Data on patients with esophageal malignancy who underwent esophagectomy from 2005 to 2020 were retrospectively analyzed from the American College of Surgeons National Surgical Quality Improvement Program database. Thirty-day complication and mortality rates were compared between emergent esophagectomy (EE) and non-emergent esophagectomy. Logistic regression assessed factors associated with complications and mortality. Results: Of 10,067 patients with malignancy who underwent esophagectomy, 181 (1.8%) had EE, 64% had preoperative systemic inflammatory response syndrome, sepsis, or septic shock, and 44% had bleeding requiring transfusion. The EE group had higher American Society of Anesthesiologists (ASA) class and functional dependency. More transhiatal esophagectomies and diversions were performed in the EE group. After EE, the rates of 30-day mortality (6.1% vs. 2.8%), overall complications (65.2% vs. 44.2%), bleeding, pneumonia, prolonged intubation, and positive margin (17.7% vs. 7.4%) were higher, while that of anastomotic leak was similar. On adjusted logistic regression, older age, lower albumin, higher ASA class, and fragility were associated with increased complications and mortality. McKeown esophagectomy and esophageal diversion were associated with a higher risk of postoperative complications. EE was associated with 30-day postoperative complications (odds ratio, 2.39; 95% confidence interval, 1.66–3.43; p<0.0001). Conclusion: EE was associated with a more than 2-fold increase in complications compared to elective procedures, but no independent increase in short-term mortality. These findings may help guide data-driven critical decision-making for surgery in select cases of complicated esophageal malignancy.
-
Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12
CLEAR investigators,Kurreeman, Fina A.S.,Stahl, Eli A.,Okada, Y.,Liao, K.,Diogo, D.,Raychaudhuri, S.,Freudenberg, J.,Kochi, Y.,Patsopoulos, Nikolaos A.,Gupta, N.,Sandor, C.,Bang, S.Y.,Lee, H.S.,Padyuk University of Chicago Press [etc.] 2012 American journal of human genetics Vol.90 No.3
We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show that we can effectively discover RA risk alleles. Thirteen putatively associated SNPs that had not yet exceeded genome-wide significance (p < 5 x 10<SUP>-8</SUP>) in our previous RA genome-wide association study (GWAS) were analyzed in independent sample sets consisting of 4,366 cases and 17,765 controls of European, African American, and East Asian ancestry. Additionally, we conducted an overall association test across all 65,833 samples (a GWAS meta-analysis plus the replication samples). Of the 13 SNPs investigated, four were significantly below the study-wide Bonferroni corrected p value threshold (p < 0.0038) in the replication samples. Two SNPs (rs3890745 at the 1p36 locus [p = 2.3 x 10<SUP>-12</SUP>] and rs2872507 at the 17q12 locus [p = 1.7 x 10<SUP>-9</SUP>]) surpassed genome-wide significance in all 16,659 RA cases and 49,174 controls combined. We used available GWAS data to fine map these two loci in Europeans and East Asians, and we found that the same allele conferred risk in both ethnic groups. A series of bioinformatic analyses identified TNFRSF14-MMEL1 at the 1p36 locus and IKZF3-ORMDL3-GSDMB at the 17q12 locus as the genes most likely associated with RA. These findings demonstrate empirically that a multiethnic approach is an effective strategy for discovering RA risk loci, and they suggest that combining GWASs across ethnic groups represents an efficient strategy for gaining statistical power.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
