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이윤경,이재명,김원일 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.15 No.2
신소재인 탄소섬유강화 플라스틱(CFRP)을 피삭재로 선삭가공을 통하여 섬유각의 변화에 따른 절삭저항에 관하여 관찰하였다. 절삭저항은 섬유각 절삭깊이가 클수록 증가하고, 섬유각 15˚ 90˚ 는 절삭속도 40m/min 이상에서 절삭저항이 작아지나, 섬유각 45˚ 60˚ 에서는 절삭속도 40m/min 이상에서 절삭저항이 급격히 증가함을 알 수 있었다. 이송분력이 주분력 배분력보다 거의 2배 가까이 큰것은 섬유의 각도가 클수록 섬유의 방향이 이송방향에 미치는 영향이 크기 때문이라고 생각 된다. CFRP의 최적가공조건은 섬유각 15˚절삭속도 60m min임을 알 수 있다. Carbon Fiber Reinforced Plastic(CFRP), one of the new materials, was investigated about cutting resistance according to the change of fiber angle through in turning Cutting resistance, increases as the fiber angle increases. At the fiber angle of 15˚and 90˚ cutting resistance decreases for the cutting speed more than 40m/min. At the fiber angle of 45˚ and 60˚ cutting resistance increases for the cutting speed less than 40m' min becomes nearly two times the principal force the direction of fiber largely influence upon feed direction. Optimum cutting condition of CFRP can be found to the fiber angle 15˚and cutting speed of 60m/min.
119 구급대원의 노인학대 인식, 신고 및 교육 경험에 관한 연구
채명정,윤종근,김보영,Chae, Myeong-Jeong,Yun, Jong-Geun,Kim, Bo-Young 한국응급구조학회 2017 한국응급구조학회지 Vol.21 No.2
Purpose: The study investigated the perception, report, and education of elder abuse in 119 emergency medical technicians (EMTs) in Korea. Methods: A self-reported questionnaire was distributed to 110 EMTs in K city, and 100 answers were collected from June 1 to 10, 2015. The study instrument was perception regarding elder abuse and education inventory developed by Kim and Kim. Data were analyzed using SPSS/WIN 18.0 version. Results: The elder abuse perception score was 3.81 on a Likert 4-point scale. Physical abuse was the most common type, followed by verbal, financial, negligence, and emotional abuse. Most EMTs recognized that is important for the prevention of elder abuse, but most of them had no experience in reporting abuse. A majority of the EMTs had attended an elder abuse program and recognized the importsnce of such program. Conclusion: This study suggests the necessity of more targeted education of elder abuse prevention combined with family counseling methods and practical approach toward awareness of elder abuse.
Network analysis of drug-related problems in hospitalized patients with hematologic malignancies
Kim, Myeong Gyu,Jeong, Chae Reen,Kim, Hyun Jee,Kim, Jae Hyun,Song, Yun-Kyoung,Kim, Kyung Im,Ji, Eunhee,Yoon, Sung-Soo,Koh, Youngil,Cho, Yoon-Sook,Kim, In-Wha,Oh, Jung Mi Springer-Verlag 2018 SUPPORTIVE CARE IN CANCER Vol.26 No.8
Immunohistochemical detection of LOM strain viral antigens in suckling piglets in Jeju
Jae-Beum Kim(Jae-Beum Kim),Won-Gyu Cho(Won-Gyu Cho),Yun-Ho Kim(Yun-Ho Kim),Hyoung-Nam Jo(Hyoung-Nam Jo),Jae-Sung Heo(Jae-Sung Heo),Myeong-Won Suh(Myeong-Won Suh),Hyoung-Seok Yang(Hyoung-Seok Yang),Wan 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
Kim, Youngmi,Park, Deokbum,Kim, Hyuna,Choi, Munseon,Lee, Hansoo,Lee, Yun Sil,Choe, Jongseon,Kim, Young Myeong,Jeoung, Dooil American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.51
<P>Cancer/testis antigen <U>ca</U>ncer-associated <U>ge</U>ne (CAGE) is known to be involved in various cellular processes, such as proliferation, cell motility, and anti-cancer drug resistance. However, the mechanism of the expression regulation of CAGE remains unknown. Target scan analysis predicted the binding of microRNA-200b (miR-200b) to CAGE promoter sequences. The expression of CAGE showed an inverse relationship with miR-200b in various cancer cell lines. miR-200b was shown to bind to the 3′-UTR of CAGE and to regulate the expression of CAGE at the transcriptional level. miR-200b also enhanced the sensitivities to microtubule-targeting drugs <I>in vitro</I>. miR-200b and CAGE showed opposite regulations on invasion potential and responses to microtubule-targeting drugs. Xenograft experiments showed that miR-200b had negative effects on the tumorigenic and metastatic potential of cancer cells. The effect of miR-200b on metastatic potential involved the expression regulation of CAGE by miR-200b. miR-200b decreased the tumorigenic potential of a cancer cell line resistant to microtubule-targeting drugs in a manner associated with the down-regulation of CAGE. ChIP assays showed the direct regulation of miR-200b by CAGE. CAGE enhanced the invasion potential of a cancer cell line stably expressing miR-200b. miR-200b exerted a negative regulation on tumor-induced angiogenesis. The down-regulation of CAGE led to the decreased expression of plasminogen activator inhibitor-1, a TGFβ-responsive protein involved in angiogenesis, and VEGF. CAGE mediated tumor-induced angiogenesis and was necessary for VEGF-promoted angiogenesis. Human recombinant CAGE protein displayed angiogenic potential. Thus, miR-200b and CAGE form a feedback regulatory loop and regulate the response to microtubule-targeting drugs, as well as the invasion, tumorigenic potential, and angiogenic potential.</P>
Celastrol binds to ERK and inhibits FcεRI signaling to exert an anti-allergic effect
Kim, Youngmi,Kim, Kyungjong,Lee, Hansoo,Han, Sanghwa,Lee, Yun-Sil,Choe, Jongseon,Kim, Young-Myeong,Hahn, Jang-Hee,Ro, Jai Youl,Jeoung, Dooil Elsevier 2009 european journal of pharmacology Vol.612 No.1
<P><B>Abstract</B></P><P>The role of celastrol, a triterpene extracted from the Chinese “Thunder of God Vine,” in allergic inflammation was investigated. Celastrol decreased the secretion of β-hexosaminidase, decreased the release of histamine, decreased the expression of Th2 cytokines and decreased calcium influx and cell adhesion in antigen-stimulated RBL2H3 cells. Exposure to celastrol decreased the phosphorylation of extracellular regulated kinase (ERK) and the ERK kinase activity was decreased in RBL2H3 cells. A molecular dynamics simulation showed binding of celastrol to a large pocket in ERK2, which serves as the ATP-binding site. Exposure to celastrol inhibited the interaction between immunoglobulin Fc epsilon receptor I (FcεRIγ) and ERK and inhibited interaction between FcεRIγ and protein kinase C δ (PKCδ). Antigen stimulation induced an interaction between Rac1 and ERK as well as an interaction between Rac1 and PKCδ. Inhibition of ERK decreased Rac1 activity and inhibition of Rac1 decreased ERK activity in antigen-stimulated RBL2H3 cells. Celastrol regulated the expression of epithelial–mesenchymal transition (EMT)-related proteins through inhibition of PKCα, PKCδ, and Rac1 in antigen-stimulated RBL2H3 cells. Exposure to celatrol inhibited PKCδ activity in antigen-stimulated RBL2H3 cells. Celastrol exerted a negative effect on FcεRIβ signaling by inhibiting the interaction between heat shock protein 90 (hsp90) and proteins, such as, FcεRIβ, Akt and PKCα. Celastrol exerted a negative effect on <I>in vivo</I> atopic dermatitis induced by 2, 4-dinitrofluorobenzene (DNFB), which requires ERK. Celastrol also showed an inhibitory effect on skin inflammation induced by phorbol myristate acetate (PMA) in Balb/c mice. In summary, celastrol binds to ERK and inhibits FcεRI signaling to exert an anti-inflammatory effect.</P>
Kim, Youngmi,Eom, Sangkyung,Kim, Kyungjong,Lee, Yun-Sil,Choe, Jongseon,Hahn, Jang Hee,Lee, Hansoo,Kim, Young-Myeong,Ha, Kwon Soo,Ro, Jai Youl,Jeoung, Dooil Elsevier 2010 Molecular immunology Vol.47 No.5
<P><B>Abstract</B></P><P>Transglutaminase II (TGase II) is a protein cross-linking enzyme with diverse biological functions. Here we report the role of TGase II in allergic inflammation. Antigen stimulation induced expression and activity of TGase II by activation of NF-κB in rat basophilic leukemia (RBL2H3) cells. This induction of TGase II was dependent on FcϵRI and EGFR. Interaction between TGase II and rac1 was induced following antigen stimulation. TGase II was responsible for the increased production of reactive oxygen species, expression of prostaglandin E2 synthase (PGE2 synthase) and was responsible for increased secretion of prostaglandin E2. ChIP assay showed that TGase II, through interaction with NF-κB, was responsible for the induction of histone deacetylase-3 (HDAC3) and snail by direct binding to promoter sequences. HDAC3 and snail induced by TGase II, exerted transcriptional repression on E-cadherin. Snail exerted negative effect on expression of MMP-2, and secretion of Th2 cytokines. Inhibition of matrix metalloproteinase-2 (MMP-2) inhibited secretion of Th2 cytokines. <I>In vivo</I> induction of TGase II was observed in Balb/c mouse model of IgE antibody-induced passive cutaneous anaphylaxis. Chemical inhibition of TGase II exerted negative effect on IgE-dependent passive cutaneous anaphylaxis. Chemical inhibition of TGase II by cystamine exerted negative effect on Balb/c mouse model of phorbol myristate acetate (PMA)-induced atopic dermatitis. These results suggest novel role of TGase II in allergic inflammation and TGase II can be developed as target for the development of allergy therapeutics.</P>