Improved β-glucan Yield Using an Aureobasidium pullulans M-2 Mutant Strain in a 200-L Pilot Scale Fermentor Targeting Industrial Mass Production

Naoyuki Moriya,Yukiko Moriya,Hideo Nomura,Kisato Kusano,Yukoh Asada,Hirofumi Uchiyama,Enoch Y. Park,Mitsuyasu Okabe 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.6

β-(1→3)-D-glucans with β-(1→6)-glycosidiclinked branches are known to be immune activation agentsand are incorporated in anti-cancer drugs and healthpromotingsupplements. β-Glucan concentration was 9.2 g/Lin a 200-L pilot scale fermentor using mutant strainAureobasidium pullulans M-2 from an imperfect fungalstrain belonging to A. pullulans M-1. The culture broth ofA. pullulans M-2 had a faint yellow color, whereas that ofthe wild-type had an intense dark green color caused by theaccumulation of melanin-like pigments. β-Glucan producedby A. pullulans M-2 was identified as a polysaccharide ofD-glucose monomers linked by β-(1→3, 1→6)-glycosidicbonds through GC/MS and NMR analysis. When aconventional medium was used in the culture of A. pullulansM-2 in a 3-L jar fermentor, β-glucan concentration was1.4-fold that produced by the wild-type. However, when amedium optimized by statistical experimental design wasused with dissolved oxygen at 10%, the β-glucan concentrationwas 9.9 g/L with a yield of 0.52 (g β-glucan/g consumedsucrose), 2.9-fold that of the wild-type. This level ofproductivity was reproduced when the fermentation wasscaled up 200-L. The industrial production of high β-glucan without melanin-like pigments is highly expected,as a health-promoting supplement or functional food.

Type IIP supernova light curves affected by the acceleration of red supergiant winds

Moriya, Takashi J,Fö,rster, Francisco,Yoon, Sung-Chul,Grä,fener, Gö,tz,Blinnikov, Sergei I Oxford University Press 2018 Monthly notices of the Royal Astronomical Society Vol.476 No.2

<P>We introduce the first synthetic light-curve model set of Type IIP supernovae exploded within circumstellar media in which the acceleration of the red supergiant winds is taken into account. Because wind acceleration makes the wind velocities near the progenitors low, the density of the immediate vicinity of the red supergiant supernova progenitors can be higher than that extrapolated by using a constant terminal wind velocity. Therefore, even if the mass-loss rate of the progenitor is relatively low, it can have a dense circumstellar medium at the immediate stellar vicinity and the early light curves of Type IIP supernovae are significantly affected by it. We adopt a simple beta velocity law to formulate the wind acceleration. We provide bolometric and multicolour light curves of Type IIP supernovae exploding within such accelerated winds from the combinations of three progenitors, 12-16 M-circle dot; five beta, 1-5; seven mass-loss rates, 10(-5)-10(-2)M(circle dot) yr(-1); and four explosion energies, (0.5-2) x 10(51) erg. All the light-curve models are available at https://goo.gl/o5phYb. When the circumstellar density is sufficiently high, our models do not show a classical shock breakout as a consequence of the interaction with the dense and optically thick circumstellar media. Instead, they show a delayed 'wind breakout', substantially affecting early light curves of Type IIP supernovae. We find that the mass-loss rates of the progenitors need to be 10(-3)-10(-2)M(circle dot) yr(-1) to explain typical rise times of 5-10 d in Type IIP supernovae assuming a dense circumstellar radius of 10(15) cm.</P>

韓国の初級日本語教育と待遇表現

守屋美佐子(Moriya, Misako) 국제언어문학회 2016 國際言語文學 Vol.- No.35

Education of the Japanese expression of formalities is theeducation with regard to all language behavior including polite expressions, polite behavior, habits, and greetings as well as the way of using honorifics for smooth and natural human communications. Korean Language and Japanese Language are very similar in sentence structure, so Korean students acquire Japanese language more quickly than other foreigners. However the interference of the mother tongue produces misunderstandings easily, especially in formalities and honorifics. In this paper I indicate the problems with the education of the expression of politeness focusing on the usage of honorifics in the beginner"s course Japanese textbook. Then I also bring up the incompetence of the students who completed a beginner’s course on the basis of a questionnaire survey analysis conducted toward the students who have passed the Japanese Proficiency Test N1 and N2 level. Teaching Japanese expressions of politeness should not be made a priority after the intermediate level, but should be done at the first stage of the beginning level. And for that, development of teaching materials of the teaching methods should be required.

Grammaticalization and Semantic Typology: Time-relationship Adverbs in Japanese, Korean, English and German

( Tetsuharu Moriya ),( Kaoru Horie ) 한국언어정보학회 2002 국제 워크샵 Vol.2002 No.-

This paper discusses constraints on grammaticalization, a primarily diachronic process through which lexical elements take on grammatical functions. In particular, it will argue that two constraints on this process, namely Persistence and Layering, explain the different distributional patterns of time-relationship adverbs in Japanese, Korean, English and German. Furthermore, it will suggest that the distributional difference between Japanese and Korean time-relationship adverbs is not an isolated phenomenon but is a reflection of the overall semantic typological differences between the two languages in the sense of Hawkins (1986).

Bi-monthly hepatic arterial infusion chemotherapy as a novel strategy for advanced hepatocellular carcinoma in decompensated cirrhotic patients

Kei Moriya,Tadashi Namisaki,Shinya Sato,Masanori Furukawa,Akitoshi Douhara,Hideto Kawaratani,Kosuke Kaji,Naotaka Shimozato,Yasuhiko Sawada,Soichiro Saikawa,Hiroaki Takaya,Koh Kitagawa,Takemi Akahane,A 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.4

Background/Aims: We previously reported the comparable efficacy of bi-monthly hepatic arterial infusion chemotherapy (B-HAIC) to that of sorafenib chemotherapy for the treatment of advanced hepatocellular carcinoma (aHCC) in patients with compensated cirrhosis. In this study, we demonstrate the efficacy of B-HAIC in patients with decompensated cirrhosis. Methods: Forty-five patients with aHCC refractory to transcatheter arterial chemo-embolization (TACE) were treated with B-HAIC and were divided into two groups according to hepatic functional reserve (Child-Pugh grade). Overall survival period, treatment response, and adverse events in each group were analyzed. Results: Efficacy and disease control rates in the Child-Pugh B group (n=24; 21% and 71%, respectively) were not significantly impaired compared the Child-Pugh A group (n=21; 38% and 67%, respectively). Median survival time and survival rate at 12 months in the Child-Pugh B group were 422 days and 58.3%, respectively, whereas those in the Child- Pugh A group were 567 days and 70.8%, respectively. Importantly, the hepatic functional reserve of patients did not worsen in either group during the treatment period. Furthermore, the occurrence rate of adverse events leading to discontinuation of anti-tumor treatment was not significantly increased in the Child-Pugh B group. Conclusions: Given the preservation of hepatic functional reserve afforded by B-HAIC chemotherapy in patients with decompensated cirrhosis, B-HAIC might be an acceptable alternative strategy for aHCC patients who do not respond to TACE.

韓国の大学におけるビジネス日本語教育を考える

守屋美佐子(Moriya, Misako) 국제언어문학회 2017 國際言語文學 Vol.- No.38

The 21st century begins, and with rapid globalization, the important issue is to acquire "highly skilled overseas personnel" in Japanese companies in order to strengthen international economic power. To solve the problem of the decrease of the employment rate of university graduates and the increase of unemployed young men in the general public, Japanese Education for Business is necessary for the purpose of finding employment into a Japanese-affiliated company. The human resource which Japanese companies demand is one that understands Japanese business culture as well as one with a high Japanese language ability, and a talented person who has communicative competence in various fields. In Korean universities, institutional effort will be required to educate cooperative students with high Japanese language ability, good understanding and management of different cultures, and productive teamwork. In conclusion, much effort will be required to convey effective Japanese education in the corporate world.

韓国の日本語教育における漢字教育

守屋美佐子(Moriya, Misako) 國際言語文學會 2014 國際言語文學 Vol.- No.30

多文化社会における定住外国人に対する言語教育

守屋美佐子(Moriya, Misako) 국제언어문학회 2015 國際言語文學 Vol.- No.32

Japan’s immigration from abroad has been steadily increasing since the 1980s. In addition, Korea, with a rapid economic growth from the late 1980s, has seen an increase of immigration, particularly from South Asia and Central Asia, which has supplied the labor force. In recent years, due to the avoidance of 3D work, low birthrate, and the aging population, this trend is growing more in both countries. The increase of marriage immigrants from foreign countries to the farming and fishing areas has also advanced the transition of these countries to a multi-cultural society. Under these circumstances, the learning of the language becomes a core problem for foreign residents if they seek to adapt to society and live without inconvenience. In this paper, I consider the system and the method of language education for foreign residents in Korea and Japan, and clarify the issues in language education for foreign residents by comparing Korean education and Japanese education.

A Balance between Caustic Soda and Chlorine

Haruo Moriya 한국상품학회 1990 商品學硏究 Vol.- No.7

大學生の機械飜譯の利用と日本語敎育

모리야미사꼬 ( Moriya Misako ) 경남대학교 산업경영연구소 2019 지역산업연구 Vol.42 No.1

最近ではNaver、Googleなど主要ポ一タルサイトはことごとく機械飜譯サ一ビスを提供しているが、その性能の向上とともに正確さも增してきている。韓國人日本語學習者の機械飜譯の利用も增えており、敎育者はこの進步にどのように對應すべきかが重要な課題だと思われる。現在、慶南大學校日語敎育科の80%以上の學生が讀解や作文などの日本語學習にNaver、Google等の無料飜譯サ一ビスを利用しており、ほとんどの學生が利用經驗を持っている。近年、機械飜譯の性能が著しく向上したことは過去のデ一タと比較しても明らかである。自動飜譯で誤譯が生まれやすい部分は過去も現在も同樣、單語の共起關係レベルであり、これは日本語學習者の作文の誤用と同樣である。今後、日本語作文や讀解の指導において、機械飜譯の利用を無視することはできず、むしろ積極的な利用方法を探り、機械飜譯の利用を通した授業實踐の結果を明らかにし、指導法の定着に努める必要がある。 Recently, major portal internet services such as Naver, Google provide machine translation, and not only its performance but also accuracy upgraded. It is important issue that how a teacher corresponds with such progress as the usage of Korean for Japanese machine translation increases. Most students of Japanese department in Kyungnam university use machine translation provided by Naver and Google for composition and reading. The performance of machine translation significantly upgraded compared to past one. The mistranslation has existed not only past but also present. So, from now on, teachers do not ignore machine translation for Japanese composition and reading, they need to find how to use this machine translation in a class.