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Investigating the effect of strength on the LCPC abrasivity of igneous rocks
Kahraman, Sair,Fener, Mustafa,Kasling, Heiko,Thuro, Kurosch Techno-Press 2018 Geomechanics & engineering Vol.15 No.2
The abrasivity of rocks results in tool wear in rock excavation or drilling projects. It can affect significantly the cost and schedule of the projects performed in abrasive rock massess. For this reason, the understanding of the mechanism of rock abrasivity is very important for excavation projects. This study investigates the effect of strength on the LCPC abrasivity coefficient (LAC) for igneous rocks. The LCPT test, the uniaxial compressive strength (UCS) and the Brazilian tensile strength (BTS) tests were carried out on the igneous rock samples. The abrasive mineral content (AMC) was also determined for each rock type. First, the LAC was correlated to the AMC and a very good correlation was found between the two parameters. Then, the multiple regression analysis was carried out by including the AMC, UCS and BTS to the analysis in order to infer the effect of the strength on the LAC. It was seen that the correlation coefficients of multiple regression models were greater than that of the relation between the LAC and the AMC. It is concluded that the AMC is the dominant parameter determining the abrasivity of rock. On the other hand, the rock strength has also significant effect on rock abrasivity.
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Type IIP supernova light curves affected by the acceleration of red supergiant winds
Moriya, Takashi J,Fö,rster, Francisco,Yoon, Sung-Chul,Grä,fener, Gö,tz,Blinnikov, Sergei I Oxford University Press 2018 Monthly notices of the Royal Astronomical Society Vol.476 No.2
<P>We introduce the first synthetic light-curve model set of Type IIP supernovae exploded within circumstellar media in which the acceleration of the red supergiant winds is taken into account. Because wind acceleration makes the wind velocities near the progenitors low, the density of the immediate vicinity of the red supergiant supernova progenitors can be higher than that extrapolated by using a constant terminal wind velocity. Therefore, even if the mass-loss rate of the progenitor is relatively low, it can have a dense circumstellar medium at the immediate stellar vicinity and the early light curves of Type IIP supernovae are significantly affected by it. We adopt a simple beta velocity law to formulate the wind acceleration. We provide bolometric and multicolour light curves of Type IIP supernovae exploding within such accelerated winds from the combinations of three progenitors, 12-16 M-circle dot; five beta, 1-5; seven mass-loss rates, 10(-5)-10(-2)M(circle dot) yr(-1); and four explosion energies, (0.5-2) x 10(51) erg. All the light-curve models are available at https://goo.gl/o5phYb. When the circumstellar density is sufficiently high, our models do not show a classical shock breakout as a consequence of the interaction with the dense and optically thick circumstellar media. Instead, they show a delayed 'wind breakout', substantially affecting early light curves of Type IIP supernovae. We find that the mass-loss rates of the progenitors need to be 10(-3)-10(-2)M(circle dot) yr(-1) to explain typical rise times of 5-10 d in Type IIP supernovae assuming a dense circumstellar radius of 10(15) cm.</P>
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Guo, Hong-Yan,Xing, Yue,Sun, Yu-Qiao,Liu, Can,Xu, Qian,Shang, Fan-Fan,Zhang, Run-Hui,Jin, Xue-Jun,Chen, Fener,Lee, Jung Joon,Kang, Dongzhou,Shen, Qing-Kun,Quan, Zhe-Shan The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6
Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC<sub>50</sub> < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC<sub>50</sub> > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.
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