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Effect of Mn and C on Age Hardening of Fe–Mn–Al–C Lightweight Steels
Sung‑Won Park,Jun Young Park,Kyong Mox Cho,Jae Hoon Jang,Seong‑Jun Park,Joonoh Moon,Tae‑Ho Lee,Jong‑Ho Shin 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3
The effects of Mn and C content on the age hardening of Fe–Mn–Al–C lightweight steels, which have austenitic or duplex(austenite and ferrite) microstructures, were investigated. An increase in Mn content induced a delay of the age hardeningthat is caused by the formation of intra-granular κ-carbides. In order to interpret the effect of Mn content, first-principlescalculations were conducted using the supercells of Fe24Al8C8,Fe24Al8C7,Fe24(Al7Mn)C8, and Fe24(Al7Mn)C7. The calculationsshowed that an increase in Mn content could be the source of the delay of the intra-granular κ-carbide formation bysuppressing C atom’ occupation of the vacancy at the body-centered site of L12. An increase in C content accelerated theformation of intra-granular κ-carbides, which induced the intense age hardening, and coarse inter-granular κ-carbides, whichresulted in significant decrease in impact absorbed energy due to inter-granular fracture.
Flexible metal-insulator-metal (MIM) devices for plastic film AM-LCD
Sung-Jei Hong,Chan-Jae Lee,Jeong-In Han,Won-Keun Kim,Dae-Gyu Moon,Min-Gi Kwak,Sung-Kyu Park,Yong-Hoon Kim 한국물리학회 2002 Current Applied Physics Vol.2 No.3
We developed new flexible metal–insulator–metal (MIM) devices subject to plastic film substrate. The structure of the MIM device is that a Ta2O5 insulator is covered with two flexible Al electrodes on both sides. The flexible structure of the MIM device was successfully fabricated applyingour own etch-free process. 2002 Elsevier Science B.V. All rights reserved.
( Sung Woo Moon ),( Sang Hoon Lee ),( Ho Il Yoon ),( Moo Suk Park ),( Young Sam Kim ),( Joon Jang ),( Jae Ho Lee ),( Choon Taek Lee ),( Jin Haeng Jung ),( Hyo Sup Shim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: In non-small cell lung cancer (NSCLC) patients, concomitant idiopathic pulmonary fibrosis (IPF) or emphysema is related to poor survival independently. Combined pulmonary fibrosis and emphysema (CPFE) is a condition with features of both pulmonary fibrosis and emphysema. Here, we evaluated the effect of CPFE and IPF alone on the outcomes of NSCLC patients. Patients and Methods: We retrospectively evaluated 283 patients with CPFE or IPF who were diagnosed with NSCLC between November 2003 and February 2018 at two tertiary care hospitals in South Korea. Patients were classified into the CPFE and IPF groups according to chest computed tomography findings. Results: One-hundred-and-seven patients (37.8%; mean age: 70.1 years; men 97.2%) had CPFE. Compared with IPF patients, CPFE patients had higher smoking history; lower DLco (78.0% vs 64.8%, p< 0.001), lower forced expiratory volume in 1 second. Of all patients with NSCLC, 71.7% died during the follow-up period; 71.6% died in the CPFE group and 72.0% in the IPF group. Multivariate logistic regression analysis showed that CPFE (odds ratio [OR]: 2.26, 95% confidence interval [CI]: 1.09-4.69; P = 0.029) was significantly correlated with acute exacerbations (AEs). In a Cox proportional hazards analysis, stage >III NSCLC, higher Eastern Cooperative Oncology Group performance status, and higher gender-age-physiology index score was related to higher mortality. However, CPFE was not related to a higher mortality rate in univariate (hazard ratio [HR]: 1.04; 95% CI: 0.78-1.38, P = 0.799) or multivariate analysis (HR: 0.92; 95% CI: 0.68-1.26, P = 0.610). Conclusions: AE risk was higher in patients with CPFE and NSCLC, but all-cause mortality was not higher in patients with CPFE and NSCLC than in those with IPF and NSCLC. Physicians should be aware of the exaggerated risk of AE in patients with concomitant CPFE and NSCLC.
( Sung Min Park ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Pruritus is common in psoriasis, but the pathogenesis of pruritus in psoriasis remains unclear. Moreover, reliable information on the characteristics of pruritus according to psoriasis clinical phenotypes is lacking. Objectives: To investigate the clinical characteristics of pruritus according to clinical phenotypes of psoriasis and to determine its association with inflammatory mediators related to pruritus.Methods: Clinical data on pruritus were collected by questionnaire including Leuvin itch scale. Quantitative measurement of serum neuropeptides and cytokines including substance P (SP), histamine, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), calcitonin gene related peptide (CGRP) and interleukin-31 (IL-31) were analyzed. Results: Eighty-four patients with psoriasis (56 men, 28 women; mean age, 48.1 years) were divided into two groups according to clinical phenotype: chronic stable and eruptive inflammatory. There was no significant difference of pruritus intensity, psoriasis area severity index, and serum level of SP, histamine, VIP, NPY, CGRP, IL-31 between two groups. Serum SP level was significantly higher in patients with pruritus compared with patients without pruritus and normal controls. Conclusion: Substance P may play a role in pruritus of psoriasis as a systemic factor. However, characteristics of pruritus, serum neuropeptides related to pruritus did not differ according to clinical phenotype of psoriasis.
( Sung Min Park ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Dermatologic diseases are generally managed on outpatient clinic and most of them show very low mortality. However, some severe dermatologic diseases are life- threatening. Objectives: To investigate the dermatological diseases leading to death and related factors. Methods: A retrospective study was conducted by reviewing medical records of patients who died in the dermatology ward, Pusan National University Hospital from 1998 to 2014. Patients`` demographics, their dermatologic diseases, immediate causes of death, comorbidities, and factors related death were investigated. Results: The total number of inpatients on dermatology during the study period was 3,142. Fourteen patients (6 males, and 8 females) expired while in hospital. The median age was 63.8 years (ranged 18 to 86), and the maximum number of death occurred in the age group more than 70 years old. Drug reaction was the most common underlying dermatologic disease, followed by bullous disease, generalized pustular psoriasis, dermatomyositis. Sepsis due to infection was the most common immediate cause of death. All patients had at least one comorbidities including hypertension, diabetes mellitus, kidney disease, and angina. Conclusion: Old age, comorbidities and septicemia were important factors which contributed to the mortality. Theintensive care is required during hospitalization in patients with severe dermatologic disease accompanying above risk factors.
Fabrication of Indium Tin Oxide (ITO) Thin Film with Pre-treated Sol Coating
Sung-Jei Hong,Chan-Jae Lee,Dae-Gyu Moon,한정인,Seung-Suk Choi,Yong-Hoon Kim 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.3
A new pre-treated sol-coating method to fabricate an indium tin oxide (ITO) thin lm is introduced in this paper. The pre-treatment sol-coating method is to form a seed layer on the substrate before spin coating of ITO sol. The pre-treatment was carried out at room temperature in order not to damage the substrate during the pre-treatment. It is eective to enhance the formation of the ITO sol lm on the substrate, owing to the seed layer. The seed layer consists of ultrane grains, which are observed at the pre-treated substrate. For the optimal pre-treatment condition, we used pre-treatment times of 24, 48, 72, and 96 hours to observe the eect on the characteristics of ITO sol lm. As a result, the lowest resistance could be achieved with a pre-treatment time of 72 hours. The optical transmittance of the ITO sol lm with the pre-treatment time of 72 hours exceeded 80 % at a wavelength of 400 nm. So, an ITO sol lm with good electrical and optical properties could be fabricated by using the pretreatment sol coating. A new pre-treated sol-coating method to fabricate an indium tin oxide (ITO) thin lm is introduced in this paper. The pre-treatment sol-coating method is to form a seed layer on the substrate before spin coating of ITO sol. The pre-treatment was carried out at room temperature in order not to damage the substrate during the pre-treatment. It is eective to enhance the formation of the ITO sol lm on the substrate, owing to the seed layer. The seed layer consists of ultrane grains, which are observed at the pre-treated substrate. For the optimal pre-treatment condition, we used pre-treatment times of 24, 48, 72, and 96 hours to observe the eect on the characteristics of ITO sol lm. As a result, the lowest resistance could be achieved with a pre-treatment time of 72 hours. The optical transmittance of the ITO sol lm with the pre-treatment time of 72 hours exceeded 80 % at a wavelength of 400 nm. So, an ITO sol lm with good electrical and optical properties could be fabricated by using the pretreatment sol coating.
Sang-Hoon Kim,Shin Hwang,Gi-Won Song,Dong-Hwan Jung,Deok-Bog Moon,Jae Do Yang,Hee Chul Yu 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.1
Backgrounds/Aims: Mechanisms for the development of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients remain unclear. The aim of the present study was to identify genes and pathways involved in the development of HBV-associated HCC. Methods: The GSE121248 gene dataset, which included 70 HCCs and 37 adjacent liver tissues, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in HCCs and adjacent liver tissues were identified. Gene ontology and Kyoto Encyclopedia of Genes and Genome pathway enrichment analyses were then performed. Results: Of 134 DEGs identified, 34 were up-regulated and 100 were down-regulated in HCCs. The 34 up-regulated DEGs were mainly involved in nuclear division, organelle fission, spindle and midbody formation, histone kinase activity, and p53 signaling pathway, whereas the 100 down-regulated DEGs were involved in steroid and hormone metabolism, collagen-coated extracellular matrix, oxidoreductase activity, and activity on paired donors, including incorporation or reduction of molecular oxygen, monooxygenase activity, and retinol metabolism. Analyses of protein-protein interaction networks with a high degree of connectivity identified significant modules containing 14 hub genes, including ANLN, ASPM, BUB1B, CCNB1, CDK1, CDKN3, ECT2, HMMR, NEK2, PBK, PRC1, RACGAP1, RRM2, and TOP2A, which were mainly associated with nuclear division, organelle fission, spindle formation, protein serine/threonine kinase activity, p53 signaling pathway, and cell cycle. Conclusions: This study identified key genes and carcinogenic pathways that play essential roles in the development of HBV-associated HCC. This may provide important information for the development of diagnostic and therapeutic targets for HCC.