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Long working hours and cardiovascular disease: a meta-analysis of epidemiologic studies.
Kang, Mo-Yeol,Park, Hyunseung,Seo, Jeong-Cheol,Kim, Donghoon,Lim, Youn-Hee,Lim, Sinye,Cho, Soo-Hun,Hong, Yun-Chul Lippincott Williams & Wilkins 2012 Journal of Occupational and Environmental Medicine Vol.54 No.5
<P>To conduct a meta-analysis from published studies to evaluate the relationship between long working hours and the risk of cardiovascular disease (CVD).</P>
( Kang Mo Gu ),( Jong Wook Shin ),( Joo Young Lee ),( Jin Se Kim ),( Ju Young Jang ),( Jae Woo Jung ),( Jae Chol Choi ),( Jae Yeol Kim ),( In Won Park ),( Byung Whui Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Histologic type of lung cancer has important roles for determining treatment strategies and patients` prognosis. Immunohistochemistry may be used to verify neuroendocrine differentiation within tumor. Advanced non-small cell lung cancer with neuroendocrine differentiation is rare form of non-small cell lung cancer. In this report, we presents a case of advanced non-small cell lung cancer with neuroendocrine differentiation. Case: 64-year-old man was admitted to the hospital because of dyspepsia and weight loss (56kg->45.6kg) for one year. Physical examination showed non-specifi c fi ndings. In laboratory fi nding, tumor marker was elevated (CEA 7.05U/ml, PIVKA II 501 mAUg/ ml). The fi ndings on abdominal imaging(Enhanced abdomen & pelvic CT and abdominal ultrasonography) showed multiple variable sized peripheral enhanced, hypervascular liver masses suggesting metastatic liver malignancy. Esophagogastroduodenoscopy and colonoscopy showed no abnormal lesion in stomach, duodenum and colon. For fi nding primary origin, enhance chest CT was done and 46mm mass lesion was detected in left upper lung and mediastinal lymph node metastasis were also detected. PET-CT showed higher fi uorodeoxyglucose(FDG) uptake in left upper lung mass, liver masses and moderate uptake in left hilar lymph node, right ileum, right femur, left femur head. For pathologic confi rm, CT-guided lung biopsy was done, poorly differentiated adenocarcinoma with neuroendocrine differentiation with a few positive for thyroid transcription factor-1(TTF-1), positive for CD56, negative for p63 was confi rmed. Clinical staging was Stage IV(T2aN2M1b). The patient received palliative chemotherapy with gemcitabine with carboplatin(fi rst line) and gefi tinib with nimotuzumab(second line).r
( Kang Mo Gu ),( Jong Wook Shin ),( Joo Young Lee ),( Jin Se Kim ),( Ju Young Jang ),( Jae Woo Jung ),( Jae Chol Choi ),( Jae Yeol Kim ),( In Won Park ),( Byung Whui Choi ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Introduction: Histologic type of lung cancer has important roles for determining treatment strategies and patients’ prognosis. Immunohistochemistry may be used to verify neuroendocrine differentiation within tumor. Advanced non-small cell lung cancer with neuroendocrine differentiation is rare form of non-small cell lung cancer. In this report, we presents a case of advanced non-small cell lung cancer with neuroendocrine differentiation. Case: 64-year-old man was admitted to the hospital because of dyspepsia and weight loss (56kg->45.6kg) for one year. Physical examination showed non-specific findings. In laboratory finding, tumor marker was elevated (CEA 7.05U/ml, PIVKA II 501 mAUg/ml). The findings on abdominal imaging(Enhanced abdomen & pelvic CT and abdominal ultrasonography) showed multiple variable sized peripheral enhanced, hypervascular liver masses suggesting metastatic liver malignancy. Esophagogastroduodenoscopy and colonoscopy showed no abnormal lesion in stomach, duodenum and colon. For finding primary origin, enhance chest CT was done and 46mm mass lesion was detected in left upper lung and mediastinal lymph node metastasis were also detected. PET-CT showed higher fluorodeoxyglucose(FDG) uptake in left upper lung mass, liver masses and moderate uptake in left hilar lymph node, right ileum, right femur, left femur head. For pathologic confirm, CT-guided lung biopsy was done, poorly differentiated adenocarcinoma with neuroendocrine differentiation with a few positive for thyroid transcription factor-1(TTF-1), positive for CD56, negative for p63 was confirmed. Clinical staging was Stage IV(T2aN2M1b). The patient received palliative chemotherapy with gemcitabine with carboplatin(first line) and gefitinib with nimotuzumab(second line).
S-336 A Case report : Secondary hypertrophic osteoarthropathy with early stage lung cancer
( Kang Mo Gu ),( Joo Young Lee ),( Jae Chol Choi ),( Jong Wook Shin ),( Jae Yeol Kim ),( In Won Park ),( Byoung Whui Choi ),( Jae Woo Jung ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Introduction:?Hypertrophic osteoarthropathy (HOA) occurs 5-10% patients with advanced lung cancer. Typical HOA characterized by clubbing of digits, periosteal new-bone formation and synovial effusion. In early stage of lung cancer, severe joint pain may be the presenting symptom of HOA and may precede clubbing of digits. We report a rare case of HOA combined with early stage of lung cancer.?Case:?A 52-year-old man with severe both knee joint pain and edema presented with a 4-month history. In physical examination, ballotment of patella and severe tenderness of knee joints were detected. Bone scan showed bilateral symmetrically increased cortical uptake along femurs and tibias suggested HOA. Laboratory findings were negative for rheumatoid factor and anti-CCP antibody, but the antinuclear antibody titer was 1:80. Joint fluid analysis showed nonspecific arthritis pattern. He suffered from chronic cough at the time knee pain started. For evaluate causes of chronic cough and HOA, chest PA and chest CT scan were done. About 4.5cm sized spiculated mass lesion in the right upper lobe was detected. Percutaneous needle biopsy confirmed adenocarcinoma. The patient received right upper lobectomy by video-assisted thoracoscopic surgery. Pathologic stage was non-small cell lung cancer stage IB (T2aN0M0). One month later, his pain was subsided without medication and bone scan showed decreased cortical uptake of involved bones.
Increased risk of gastric cancer in workers with occupational dust exposure
( Mo-yeol Kang ),( Jiyoun Jung ),( Jung-wan Koo ),( Inah Kim ),( Hyoung-ryoul Kim ),( Jun-pyo Myong ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0
Background/Aims: Workers who are exposed to dust in the workplace tend to show a higher incidence of gastric cancer. Nevertheless, scientific evidence to support an association between dust exposure and the risk of gastric cancer is inadequate. This study aimed to investigate whether or not occupational dust exposure influences the risk of gastric cancer. Methods: We collected the electronic data from the Pneumoconiosis Health Examination (PHE) program, provided by the Ministry of Employment and Labor and the Korea Workers’ Compensation and Welfare Service from 2002 to 2017. The PHE database was linked to the National Health Insurances databases. The age-standardized incidence ratio (SIR) and 95% confidence intervals (CIs) of the risk of gastric cancers were evaluated in workers with occupational dust exposure, and the results were compared to those in the general population. Results: From 2004 to 2015, 1,543 cases of gastric cancer were observed in the male participants, as compared with 1,174 of expected cases, which yielded an SIR of 1.314 (95% CI, 1.249 to 1.380). Under dust exposure, the risk of gastric cancer was increased 23.9% in the male participants (95% CI, 19.9 to 27.5), and the degree of impairment of lung function was inversely related to the risk of gastric cancer. Conclusions: Workers with occupational dust exposure were at higher risk of developing gastric cancer than the general population. Thus, future efforts for the prevention of gastric cancer are necessary for dust exposed workers.