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강모열(Mo-Yeol Kang),조수헌(Soo-Hun Cho),임연희(Youn-Hee Leem),김진희(Jin-Hee Kim),배상혁(Sang-Hyuk Bae),홍윤철(Yun-Chul Hong) 대한직업환경의학회 2011 대한직업환경의학회지 Vol.23 No.3
Objectives: We conducted this study to investigate the relationship between the blood concentration of cadmium and cognitive function in elderly Koreans. Methods: This research is a part of the Korean Elderly Environmental Panel Study (KEEPS). A total of 403 subjects were enrolled and analyzed from August 2008 through August 2010. Demographic information and medical histories were obtained using a questionnaire. Blood concentration of cadmium and Mini-Mental State Examination (MMSE) with Functional Activities Questionnaire (FAQ) were evaluated for each subject. Results: The mean age of subjects was 70.67 (SD 5.18, n=403) and 72% were female. The mean blood cadmium level was 1.22 μg/dl (SD 0.56), mean MMSE score was 25.12 out of 30 and mean FAQ score was 2.03 out of 30. Using linear regression analysis to estimate the relationship between blood cadmium concentration and MMSE and FAQ, we observed a significant association between log transformed values of blood cadmium levels and MMSE (p<0.002) or FAQ (p=0.005) scores. After adjusting for age, sex, level of education, alcohol consumption and smoking habits, the relationship between blood cadmium concentration and MMSE and FAQ scores ramained statistically significant (p=0.033 and 0.029, respectively). Conclusions: These results suggest that blood cadmium concentration is strongly associated with cognitive function and functional activity in the elderly.
서울 일부 지역 고령자들에서 휘발성유기화합물과 포름알데히드가 심박동변이에 미치는 영향
서정철(Jeong-Cheol Seo),강모열(Mo-Yeol Kang),조수헌(Soo-Hun Cho),임연희(Youn-Hee Lim),김진희(Jin-Hee Kim),손종렬(Jong-Ryeul Sohn),홍윤철(Yun-Chul Hong) 대한직업환경의학회 2011 대한직업환경의학회지 Vol.23 No.3
Objectives: The purpose of the present study was to investigate the effects of volatile organic compounds, and formaldehyde on heart rate variability among elderly people who are vulnerable to ambient pollution. Methods: From May to August of 2009, 57 subjects older than 60 years were recruited in this study. Indoor air pollutants (volatile organic compounds and formaldehyde) were measured by a personal passive sampler. Heart rate variability (HRV) was measured in the sitting position for five minutes and assessed by time-domain and frequency-domain. Results: Multiple linear regression analysis showed significantly less low-frequency (LF) and high-frequency (HF) associated with elevated benzene levels. Exposure to toluene was associated with decreases in the Standard deviation of the NN intervals (SDNN) and LF. SDNN and LF were negatively associated with the increment of ethylbenzene levels. Conclusions: An adverse effect on cardiovascular function caused by volatile organic compounds was observed among the elderly people of Seoul even though indoor air pollutant levels were lower than the yearly average guideline for indoor air quality in Korea.