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Mira Choo,JungA Hwang,SangWon Jeon,SoYoung Oh,Hokyoung Yoon,HeonJeong Lee,YongKu Kim 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.4
Objective-We aimed to investigate possible associations between three norepinephrine transporter gene (SLC6A2) single nucleotide polymorphisms (T182C, A3081T, and G1287A) and schizophrenia. Also, we investigated the relationships of those polymorphisms with clinical severity and characteristics of schizophrenia. Methods-Participants were 220 schizophrenia patients in the acute phase and 167 healthy controls. The genotype, allele frequency, and haplotype of each group were analyzed for T182C, A3081T, and G1287A polymorphisms. Of the 220 schizophrenia patients, 163 patients were evaluated with the Positive and Negative Syndrome Scale (PANSS) and the Korean version of the Calgary depression scale for schizophrenia (K-CDSS) at baseline. Results-We found no significant differences between the schizophrenia patient group and the control group in genotype distribution or allele frequency of the three tested polymorphisms. Likewise, we could not find any significant differences in genotype or allele frequency by analyzing according to gender. In the haplotype study, no significant association emerged between specific haplotype combinations and schizophrenia. We also found no association between clinical scales (PANSS and K-CDSS) and the studied polymorphisms. Conclusion-Our results suggest that the investigated polymorphisms of the NET gene are not associated with susceptibility to schizophrenia or its clinical features in a Korean population. However, this study remains significant because it is the first haplotype study to investigate associations between NET gene (SLC6A2) single nucleotide polymorphisms and schizophrenia in a Korean population. Future research with a larger sample size and more genetic markers is needed to replicate our results.
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Mira Kim,Jiyoung Jeon,Jongouk Baek,Jaeyul Choi,Eun Ju Park,Jiyeon Song,Hyojeong Bang,Kwee-Hyun Suh,Young Hoon Kim,Jongmin Kim,Doran Kim,민경훈,Kwang-Ok Lee 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Smart Multiple-Tap System Based on WiFi for reduction of Standby-Power
Jeon, Jeong-woo,Yi, Mira 한국컴퓨터정보학회 2017 韓國컴퓨터情報學會論文誌 Vol.22 No.6
In this paper, we proposed a smart multiple-tap system which a remote user with smartphone can control multiple-taps in order to reduce standby-power consumption more conveniently when plugged-in electric appliances are turned-off. Recently, several researches of smart multiple-tap using IoT technology has reported. However, in these researches, an additional device like as a server computer is necessary, or multiple-taps could be only remotely controlled by smartphone and not directly controlled by on/off switch. The proposed smart multiple-tap system does not need any additional device only if it has a WiFi router, and it can be used for user as well as remote control using smartphone application and physically direct control using contact switches like existing multiple-taps. Our approach is to develop a smart multiple-tap device capable of WiFi communication can each serve as a server or a client, and can be operated by the hybrid switch combining the on/off contact switch and the relay switch. We implemented the prototype of the proposed system composed of the smart multiple-tap device and the smartphone application, and the test of the prototype validates the proposed system.
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Kim, Mira,Jeon, Jiyoung,Baek, Jongouk,Choi, Jaeyul,Park, Eun Ju,Song, Jiyeon,Bang, Hyojeong,Suh, Kwee Hyun,Kim, Young Hoon,Kim, Jongmin,Kim, Doran,Min, Kyung Hoon,Lee, Kwang-Ok Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Jeong, Mira,Piao, Zheng-Hao,Kim, Mi Sun,Lee, Suk Hyung,Yun, Sohyun,Sun, Hu-Nan,Yoon, Suk Ran,Chung, Jin Woong,Kim, Tae-Don,Jeon, Jun Ho,Lee, Jiwon,Kim, Hyun-Nam,Choi, Je-Yong,Choi, Inpyo Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.4
<P>Hematopoietic stem cells (HSCs) are maintained in a quiescent state in bone marrow (BM) niches by intrinsic and extrinsic signals. The mechanisms regulating the quiescence and mobilization of HSCs, however, remain unclear. In this study, we report that the expression of thioredoxin-interacting protein (TXNIP) is decreased during HSC activation. In Txnip(-/-) mice, the long-term reconstituting HSC population is decreased and exhausted, and its capacity to repopulate is rapidly lost. These effects are associated with hyperactive Wnt signaling, an active cell cycle, and reduced p21 expression under conditions of stress. TXNIP deficiency reduced the CXCL12- and osteopontin-mediated interaction between HSCs and the bone marrow, and impaired homing and retention in the osteoblastic niche, resulting in mobilized HSCs. Therefore, we propose that TXNIP is essential for maintaining HSC quiescence and the interaction between HSCs and the BM niche.</P>
병원의 서비스 회복이 공정성 지각과 행동의도에 미치는 영향
전진우 ( Jinwoo Jeon ),백미라 ( Mira Baek ),정기택 ( Keetaig Jung ),이훈영 ( Hoonyoung Lee ) 경희대학교 경영연구원 2015 의료경영학연구 Vol.9 No.3
This research analyzed correspondence effort what the hospital cope with, relation of fairness sensation, fairness and customer satisfaction which is perceived by service recovery, perceived value, hospital image and influencing relationship of future behavior intention to recover service failure. In result of the research, refund and discount among the hospital correspondence effort have a most effect on distribution fairness. This means customers show most positive response about typical output of service recovery strategy. Also, we can know importance of policy, process, tools to support customer`s complain and hospital swift response. Apologize and explanation influences to mutual relation fairness perception positively. Here is intriguing result. procedural justice in contrary with distributive justice and interactional justice doesn```t have a positive affect to perceived value. In other words, typical reward and heartfelt apologize and explanation has positive affect to perceived value, perceived value of policy, process, tools used by decision maker doesn``t have positive affect to customer`s perceived value. On the other hand, customer`s perceived value and satisfaction about perceived justice through service recovery has a positive affect to hospital image, this hospital image has positive affect to future behavior intention. There were multiple researches that can be used for all sorts of things. But, the research for hospital was insufficient. What is important is that we draw an objective research conclusion considering that hospital is one of the service company. Also, in case of medical service failure, it can be used for reference about service recovery method that customers want, and it can be helpful to improvement of medical service quality.
Nirmala, R.,Jeon, Kyung Soo,Navamathavan, R.,Park, Mira,Kim, Hak Yong,Park, Soo-Jin 한국섬유공학회 2014 FIBERS AND POLYMERS Vol.15 No.5
In this study, we describe the preparation and characterization of electrospun Nylon66 composite nanofibers incorporated with carbon nanotubes (CNT) fillers and silver nanoparticles. We have incorporated the composites in to Nylon66 nanofibers to enhance the characteristics of the resultant composite nanofibers. The resultant composite nanofibers were characterized by using field-emission scanning electron microscopy, energy dispersive X-ray analysis, high-resolution transmission electron microscopy, X-ray diffraction, and current-voltage (I-V) measurement analysis. The morphology of the composite nanofibers exhibited densely arranged mesh-like ultrafine nanofibers which were strongly bound in between the main fibers. From I-V characteristics, it was observed that the incorporation of CNT fillers and Ag nanoparticles in to electrospun Nylon66 composite nanofibers can be significantly enhanced the electrical properties.
간호 · 보건계열 대학생의 자아존중감, 외모만족도가 취업스트레스에 미치는 영향
전현숙(Hyensook Jeon),이미라(Mira Lee) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.12
본 연구는 간호학과와 보건계열학과 졸업예정자 515명을 대상으로 대학생의 자아존중감, 외모만족도, 취업스트레스 정도를 알아보고, 취업스트레스에 미치는 영향요인을 알아보기 위한 서술적 조사연구이다. 자료수집은 2016년 5월 2일부터 13일까지 진행하였으며 수집된 자료는 SPSS 19.0 프로그램을 이용하여 빈도와 백분율, 평균과 표준편차, t-test, ANOVA, Scheffe’s 검증, Pearson"s Correlation Coefficient, 다중회귀분석을 통하여 분석하였다. 연구결과는 다음과 같다. 대상자의 일반적 특성 중 경제 수준은 자아존중감, 외모만족도, 취업스트레스 모두에 유의한 영향을 미쳤으나, 학과 선택 동기와 학과선택 결정을 학생 스스로 했는지의 여부는 모든 변수에 영향을 미치지 않았다. 자아존중감과 외모만족도간에는 순상관관계가 있었으며, 취업스트레스는 자아존중감과 외모만족도와 역상관관계가 있었다. 취업스트레스에 가장 큰 영향을 미치는 요인은 자아존중감이었고 그 외 요인은 취업처, 전공만족도, 전공계열로 24.4%의 설명력을 보였다. 따라서, 간호 · 보건계열 학생에게 전공계열과 취업처를 고려한 맞춤형 프로그램을 제공함으로써 자아존중감과 전공만족도를 높이고 취업스트레스를 줄여야 할 것으로 사료된다. The aim of this study was to describe the self-esteem, appearance satisfaction, and job-seeking stress and to investigate the effects of self-esteem and appearance satisfaction on job-seeking stress in nursing and healthcare related students. A total of 515 third and fourth year graduate students were included in this study. The data were collected between May 2 and May 13 of 2016 and analyzed using t-test, ANOVA, Scheffe"s test, Pearson"s Correlation Coefficient, and multiple regression with SPSS 19.0. The economic state had an influence on self-esteem, appearance satisfaction, and job-seeking stress; however, the motive of application and decision of the department of selection did not have any influence. A positive correlation was found between self-esteem and appearance satisfaction. Moreover, job-seeking stress was negatively correlated with both self-esteem and appearance satisfaction. The strongest predictor of job-seeking stress was self-esteem. Self-esteem, employment-area, satisfaction with major, and college majors accounted for 24.4% of job-seeking stress based on multiple regression analysis. These findings indicate that it is necessary to develop a program that would increase self-esteem and satisfaction with major and decrease job-seeking stress according to college majors and employment-area in nursing and health care related students.