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Quang, Tran Hong,Ngan, Nguyen Thi Thanh,Minh, Chau Van,Kiem, Phan Van,Nhiem, Nguyen Xuan,Tai, Bui Huu,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Song, Seok-Bean,Kim, Young-Ho Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited $TNF{\alpha}$-induced NF-${\kappa}B$ transcriptional activity in HepG2 cells in a dose-dependent manner, with $IC_{50}$ values ranging from 6.2 to 9.1 ${\mu}M$. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with $EC_{50}$ values ranging from 4.1-$12.7{\mu}M$. Compounds 4 and 5 exhibited $PPAR{\alpha}$, $PPAR{\gamma}$, and $PPAR{\beta}({\delta})$ transactivational activities in a dose-dependent manner, with $EC_{50}$ values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 ${\mu}M$, respectively.
α-Glucosidase Inhibitors from the Roots of Sophora flavescens
Quang, Tran Hong,Ngan, Nguyen Thi Thanh,Minh, Chau Van,Kiem, Phan Van,Tai, Bui Huu,Thao, Nguyen Phuong,Kwon, Se-Uk,Lee, Young-Mi,Kang, Hee-Kyoung,Kim, Young-Ho Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.5
Anti-inflammatory Triterpenoid Saponins from the Stem Bark of <i>Kalopanax pictus</i>
Quang, Tran H.,Ngan, Nguyen T. T.,Minh, Chau V.,Kiem, Phan V.,Nhiem, Nguyen X.,Tai, Bui H.,Thao, Nguyen P.,Tung, Nguyen H.,Song, Seok B.,Kim, Young H. American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.9
<P>Five new compounds, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (<B>1</B>), 4,23,29-trihydroxy-3,4-<I>seco</I>-olean-12-en-3-oate-28-oic acid (<B>2</B>), 3β,6β,23-trihydroxyolean-12-en-28-oic acid 28-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranoside (<B>3</B>), 3-<I>O</I>-[2,3-di<I>-O</I>-acetyl-α-<SMALL>l</SMALL>-arabinopyranosyl]hederagenin 28-<I>O</I>-α-<SMALL>l</SMALL>-rhamnopyranosyl-(1→4)-β-<SMALL>d</SMALL>-glucopyranosyl-(1→6)-β-<SMALL>d</SMALL>-glucopyranoside (<B>4</B>), and 3-<I>O</I>-[3,4-di-<I>O</I>-acetyl-α-<SMALL>l</SMALL>-arabinopyranosyl]hederagenin 28-<I>O</I>-α-<SMALL>l</SMALL>-rhamnopyranosyl-(1→4)-β-<SMALL>d</SMALL>-glucopyranosyl-(1→6)-β-<SMALL>d</SMALL>-glucopyranoside (<B>5</B>), as well as 10 known compounds (<B>6</B>–<B>15</B>), were isolated from the stem bark of <I>Kalopanax pictus</I>. Compounds <B>1</B>–<B>5</B> and <B>7</B>–<B>14</B> inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC<SUB>50</SUB> values ranging from 0.6<B></B>to 16.4 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed on the basis of decreases in COX-2 and iNOS gene expression in HepG2 cells. The structure–activity relationship of the compounds with respect to anti-inflammatory activity is also discussed.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-9/np200382s/production/images/medium/np-2011-00382s_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200382s'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200382s'>ACS Electronic Supporting Info</A></P>
TRANHONG QUANG,Nguyen Thi Thanh Ngan,Chau Van Minh,Phan Van Kiem,Nguyen Xuan Nhiem,BUIHUU TAI,Nguyen Phuong Thao,Doobyeong Chae,Vivek Bhakta Mathema,고영상,이제현,양서영,김영호 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
Kalopanax pictus (Araliaceae) is a deciduous treedistributed in Korea, Japan, and China. The stem bark ofK. pictus has been functionally used as a traditional crude drugfor the treatment of various inflammatory diseases. In thepresent study, we describe the inhibitory effects of oleananetypetriterpenes and saponins isolated from the stem bark ofK. pictus on production of pro-inflammatory cytokines inLPS-stimulated bone marrow-derived dendritic cells. Of thecompounds tested, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3b,6b,23-trihydroxyolean-12-en-28-oicacid 28-O-b-D-glucopyranoside (3), nipponogenin E (6),3b,6b,23-trihydroxyolean-12-en-28-oic acid (7), and caulophyllogenin(19) significantly inhibited the production ofIL-12 p40 and IL-6 with IC50 values ranging from 3.3 to 9.1 lM. Compounds 2, 3, 7, and 19 significantly suppressedthe secretion ofTNF-a with IC50 ranging from8.8 to 20.0 lM. These data provide scientific support for the use of K. pictusstem bark and its triterpene and saponin components in theinhibition of pro-inflammatory cytokine secretion, includingIL-12 p40, IL-6, and TNF-a, and for prevention and treatmentof inflammatory diseases.
Tran Hong Quang,Seok Bean Song,Bui Thi Thuy Luyen,Nguyen Phuong Thao,BUIHUU TAI,Nguyen Xuan Nhiem,Phan Van Kiem,Chau Van Minh,Nguyen Thi Thanh Ngan,김영호 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 6.2 to 9.1 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with EC50 values ranging from 4.1-12.7 μM. Compounds 4 and 5 exhibited PPARα, PPARγ, and PPARβ(δ) transactivational activities in a dose-dependent manner, with EC50 values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 μM, respectively.
Phan Van Kiem,김영호,Chau Van Minh,Nguyen Xuan Nhiem,Nguyen Xuan Cuong,BUIHUU TAI,TRANHONG QUANG,Hoang Le Tuan Anh,Pham Hai Yen,Ninh Khac Ban,김승현,Mingjie Xin,차지윤,이영미 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12
Bioassay-guided fractionation based on the anti-inflammatory activity of a methanol extract of Ficus microcarpa leaves led to the isolation of seven galactolipids: 2(S)-3-O-octadeca-9Z,12Z,15Ztrienoylglyceryl-O-β-D-galactopyranoside (1), (2S)-2,3-O-dioctadeca-9Z,12Z,15Z-trienoylglyceryl-O-β-D-galactopyranoside (2), (2S)-2,3-O-dioctadeca-9Z,12Z-dienoylglyceryl-O-β-D-galactopyranoside (3), (2S)-3-O-octadeca-9Z,12Z,15Z-trienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (4), (2S)-2,3-O-dioctadeca-9Z,12Z,15Z-trienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (5), gingerglycolipid B (6), and (2S)-2,3-O-dioctadeca-9Z,12Z-dienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (7). Their chemical structures were elucidated by mass, 1D-, and 2D-NMR spectroscopic methods as well as chemical methods. The antiinflammatory effect of these compounds on TNF-α induced IL-8 secretion in the HT-29 cell line was evaluated. All above galactolipids showed significant inhibition ranging 40% at a concentration of 50 μM. The results suggest that galactolipids from the leaves of F. microcarpa may be used as potent anti-inflammatory agents.
Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
Kiem, Phan Van,Quang, Tran Hong,Huong, Tran Thu,Nhung, Le Thi Hong,Cuong, Nguyen Xuan,Minh, Chau Van,Choi, Eun-Mi,Kim, Young-Ho 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-$\beta$-glucopyranoside (5), (-)-lyoniresinol (6), and $\alpha$-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 ($30\;{\mu}M$) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
Chemical Components from the Vietnamese Soft Coral Lobophytum sp.
Tung, Nguyen Huu,Minh, Chau Van,Kiem, Phan Van,Huong, Hoang Thanh,Nam, Nguyen Hoai,Cuong, Nguyen Xuan,Quang, Tran Hong,Nhiem, Nguyen Xuan,Hyun, Jae-Hee,Kang, Hee-Kyoung,Kim, Young-Ho 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with $IC_{50}$ values of 8.2 and $5.6\;{\mu}M$ for 1; 5.1 and $1.8\;{\mu}M$ for 2, respectively.