종강덕(從康德)적 실천철학론 왕양명(王陽明)적 「지행합일」(知行合一)설(說)

이명휘 한국중국학회 1994 中國學報 Vol.34 No.1

Wang Yangming’s Doctrine of the “Unity of Knowing and Acting” in the Light of Kant’s Practical Philosophy

Ming-huei Lee 성균관대학교 유교문화연구소 2023 儒敎文化硏究(中文版) Vol.- No.39

Wang Yangming’s doctrine of the “unity of knowing and acting” (zhi xing heyi 知行合一) can be traced back to Mencius’s theory of “original knowing” (liangzhi 良知). Similarly, Kant discussed the relationship of theory to practice on three different levels (morality, the law of the state, and international law) in his article, “On the Common Saying: This May Be True in Theory, But It Does Not Apply in Practice.” Kant proposed the unity of theory and practice on the level of morality. So, this article uses Kant’s related concepts of theory and practice to interpret Wang’s doctrine of the “unity of knowing and acting” with the aim of clarifying some misinterpretations of it. Thereby, I argue that, although Wang Yangming put forward the doctrine of “the unity of knowing and acting” at a different time than his doctrines of “heart-mind is principle” (xin ji li 心即理) and “the extension of original knowing” (zhi liangzhi 致良知), these three doctrines are logically interconnected.

鄭霞谷對四端七情的詮釋

李明輝(Lee Ming-huei) 한국양명학회 2006 陽明學 Vol.0 No.17

四端七情 논변이 조선 유학사상에서 중요한 논쟁 대상이지만, 王陽明 자신은 이 문제에 대해 특별히 언급한 적이 없다. 조선의 양명학자 정하곡은 王陽明의 ‘心卽理說’과 理氣觀을 받아들여 지신의 ‘生理說’을 제시했다. 그는 生理說을 가지고 王陽明의 良知說올 해석했을 뿐 아니라, 良知ㆍ惻隱은 先後가 없다는 뜻을 밝혀냈다. 이러한 사상의 배경 아래서 그는「四端七情」說을 썼다. 「四端七情」說은 陽明 사상의 논리적 파생으로 볼 수 있다. 정하곡은 退溪처럼 理의 活動性을 긍정했고, 四端과 七情의 이질성올 주장했다. 그러나 퇴계와 다른 점은 四端과 七情이 서로 전환할 수 있는 가능성을 강조한 점이다. 退溪 사상이 朱子에 치우쳐 있음과 동시에 陽明의 경향을 띠고 있지만, 陽明의 기본 입장과는 어느 정도 거리가 있음을 보여준다.

Impaired Na+/K+-ATPase Function in Patients with Interstitial Cystitis/Painful Bladder Syndrome

Jane-Dar Lee,Wen-Kai Yang,Ming-Huei Lee 대한의학회 2016 Journal of Korean medical science Vol.31 No.2

Na+/K+-ATPase (NKA) is abundantly expressed in the basolateral membrane of epithelial cells, which is necessary for tight junction formation. The tight junction is an urothelial barrier between urine and the underlying bladder. Impairment of tight junctions allows migration of urinary solutes in patients with interstitial cystitis/painful bladder syndrome (IC/PBS). We evaluated NKA expression and activity in bladder samples from patients with IC/PBS. The study group consisted of 85 patients with IC/PBS, and the control group consisted of 20 volunteers. Bladder biopsies were taken from both groups. We determined the expression and distribution of NKA using NKA activity assays, immunoblotting, immunohistochemical staining, and immunofluorescent staining. The protein levels and activity of NKA in the study group were significantly lower than the control group (1.08 ± 0.06 vs. 2.39 ± 0.29 and 0.60 ± 0.04 vs. 1.81 ± 0.18 μmol ADP/mg protein/hr, respectively; P < 0.05). Additionally, immunofluorescent staining for detection of CK7, a marker of the bladder urothelium, predominantly colocalized with NKA in patients in the study group. Our results demonstrated the expression and activity of NKA were decreased in bladder biopsies of patients with IC/PBS. These findings suggest that NKA function is impaired in the bladders from patients with IC/PBS.

VEGF and FGF2 improve revascularization, survival, and oocyte quality of cryopreserved, subcutaneously transplanted mouse ovarian tissues

( Cheng-en Hsieh ),( Yuh-ming Hwu ),( Sheng-hsiang Li ),( Chung-hao Lu ),( Ming-huei Lin ),( Robert Kuo-kuang Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

Objective: To investigate the effect of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) on revascularization, survival, and oocyte quality of cryopreserved, subcutaneously transplanted mouse ovarian tissue. Methods: Outbred ICR mice (n = 112) were used as the animal model. Vitrified mouse ovarian tissues were treated without (control group) or with VEGF and FGF2 before autologous subcutaneous transplantation. After transplantation for 2 or 3 weeks, grafts’ survival, angiogenesis, and oocyte quality were examined. Results: VEGF and FGF2 promoted revascularization and significantly increased the survival rate of subcutaneously transplanted cryopreserved ovarian tissues compared with the untreated grafted control. The two growth factors did not show long-term effects on the ovarian grafts. In contrast to the untreated ovarian grafts, active folliculogenesis was revealed as the number of various follicles was significantly higher or had an increased trend in the VEGF and FGF2-treated ones. Though the fertilization rate had no differences between VEGF/FGF2 and control group; however, the oocyte quality was much better in the VEGF/FGF2-treated grafts as demonstrated by the higher ratio of blastocyst development. Conclusions: Introducing of angiogenic factors such as VEGF and FGF2 may be a promising strategy to improve revascularization, survival, and oocyte quality of cryopreserved, subcutaneously transplanted mouse ovarian tissue.

Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver

Kao Ying-Hsien,Lin Yu-Chun,Lee Po-Huang,Lin Chia-Wei,Chen Po-Han,Tai Tzong-Shyuan,Chang Yo-Chen,Chou Ming-Huei,Chang Chih-Yang,Sun Cheuk-Kwan 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5

Background: This study investigated whether xenotransplantation of human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) reduces thioacetamide (TAA)-induced mouse liver fibrosis and the underlying molecular mechanism. Methods: Recipient NOD/SCID mice were injected intraperitoneally with TAA twice weekly for 6 weeks before initial administration of WJ-MSCs. Expression of regenerative and pro-fibrogenic markers in mouse fibrotic livers were monitored post cytotherapy. A hepatic stallate cell line HSC-T6 and isolated WJ-MSCs were used for in vitro adhesion, migration and mechanistic studies. Results: WJ-MSCs were isolated from human umbilical cords by an explant method and characterized by flow cytometry. A single infusion of WJ-MSCs to TAA-treated mice significantly reduced collagen deposition and ameliorated liver fibrosis after 2-week therapy. In addition to enhanced expression of hepatic regenerative factor, hepatocyte growth factor, and PCNA proliferative marker, WJ-MSC therapy significantly blunted pro-fibrogenic signals, including Smad2, RhoA, ERK. Intriguingly, reduction of plasma fibronectin (pFN) in fibrotic livers was noted in MSC-treated mice. In vitro studies further demonstrated that suspending MSCs triggered pFN degradation, soluble pFN conversely retarded adhesion of suspending MSCs onto type I collagen-coated surface, whereas pFN coating enhanced WJ-MSC migration across mimicked wound bed. Moreover, pretreatment with soluble pFN and conditioned medium from MSCs with pFN strikingly attenuated the response of HSC-T6 cells to TGF-β1-stimulation in Smad2 phosphorylation and RhoA upregulation. Conclusion: These findings suggest that cytotherapy using WJ-MSCs may modulate hepatic pFN deposition for a better regenerative niche in the fibrotic livers and may constitute a useful anti-fibrogenic intervention in chronic liver diseases.

Proton Pump Inhibitor-unresponsive Laryngeal Symptoms Are Associated With Psychological Comorbidities and Sleep Disturbance: A Manometry and Impedance-pH Monitoring Study

Wen-Hsuan Tseng,Wei-Chung Hsu,Tsung-Lin Yang,Tzu-Yu Hsiao,Jia-Feng Wu,Hui-Chuan Lee,Hsiu-Po Wang,Ming-Shiang Wu,Ming-Shiang Wu,Ping-Huei Tseng 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.3

Background/AimsLaryngeal symptoms are largely treated with empiric proton pump inhibitor (PPI) therapy if no apparent pathology shown on ear, nose, and throat evaluation and reflux-related etiologies are suspected. However, treatment response remains unsatisfactory. This study aimed to investigate the clinical and physiological characteristics of patients with PPI-refractory laryngeal symptoms. MethodsPatients with persistent laryngeal symptoms despite PPI treatment for ≥ 8 weeks were recruited. A multidisciplinary evaluation comprising validated questionnaires for laryngeal symptoms (reflux symptom index [RSI]), gastroesophageal reflux disease symptoms, psychological comorbidity (5-item brief symptom rating scale [BSRS-5]) and sleep disturbance (Pittsburgh sleep quality index [PSQI]), esophagogastroduodenoscopy, ambulatory impedance-pH monitoring, and high-resolution impedance manometry were performed. Healthy asymptomatic individuals were also recruited for comparison of psychological morbidity and sleep disturbances. ResultsNinety-seven adult patients and 48 healthy volunteers were analyzed. The patients had markedly higher prevalence of psychological distress (52.6% vs 2.1%, P < 0.001) and sleep disturbance (82.5% vs 37.5%, P < 0.001) than the healthy volunteers. There were significant correlations between RSI and BSRS-5 scores, and between RSI and PSQI scores (r = 0.26, P = 0.010, and r = 0.29, P = 0.004, respectively). Fifty-eight patients had concurrent gastroesophageal reflux disease symptoms. They had more prominent sleep disturbances (89.7% vs 71.8%, P < 0.001) than those with laryngeal symptoms alone but similar reflux profiles and esophageal motility. ConclusionsPPI-refractory laryngeal symptoms are mostly associated with psychological comorbidities and sleep disturbances. Recognition of these psychosocial comorbidities may help optimize management in these patients.