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CODA-ML: context-specific biological knowledge representation for systemic physiology analysis
Kwon, Mijin,Yim, Soorin,Kim, Gwangmin,Lee, Saehwan,Jeong, Chungsun,Lee, Doheon BioMed Central 2019 BMC bioinformatics Vol.20 No.10
<P><B>Background</B></P><P>Computational analysis of complex diseases involving multiple organs requires the integration of multiple different models into a unified model. Different models are often constructed in heterogeneous formats. Thus, the integration of the models requires a standard language format that can effectively represent essential biological information. However, the previously introduced formats have limitations that prevent from adequately representing essential biological information, particularly specifications of bio-molecules and biological contexts.</P><P><B>Results</B></P><P>We defined an XML-based markup language called context-oriented directed association markup language (CODA-ML), which better represents essential biological information. The CODA-ML has two major strengths in designating molecular specifications and biological contexts. It can cover heterogeneous entity types involved in biological events (e.g. gene/protein, compound, cellular function, disease). Molecular types of entities can have molecular specifications which include detailed information of a molecule from isoforms to modifications, enabling high-resolution representation of molecules. In addition, it can distinguish biological events that vary depending on different biological contexts such as cell types or disease conditions. Especially representation of inter-cellular events as well as intra-cellular events is available. These two major strengths can resolve contradictory associations when different models are integrated into one unified model, which improves the accuracy of the model.</P><P><B>Conclusions</B></P><P>With the CODA-ML, diverse models such as signaling pathways, metabolic pathways, and gene regulatory pathways can be represented in a unified language format. Heterogeneous entity types can be covered by the CODA-ML, thus it enables detailed description for the mechanisms of diseases or drugs from multiple perspectives (e.g., molecule, function or disease). The CODA-ML is expected to help integrate different models into one systemic model in an efficient and effective. The unified model can be used to perform computational analysis not only for cancer but also for other complex diseases involving multiple organs beyond a single cell.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12859-019-2812-7) contains supplementary material, which is available to authorized users.</P>
라이프로깅에 대한 고찰 및 향후 마케팅 연구에 대한 제언
권미진 ( Kwon Mijin ),서정화 ( Seo Jeonghwa ),박혜연 ( Park Hyeyeon ),한영지 ( Han Youngjee ),김학균 ( Kim Hakkyun ) 한국소비자학회 2024 소비자학연구 Vol.35 No.1
라이프로깅(lifelogging)은 개인의 일상을 기록해 나가는 모든 활동을 의미한다. 오늘날 스마트 환경과 웨어러블 기기의 발달로 소비자는 라이프로깅을 통해 자신의 경험과 정보를 끊김 없이 기록하고 정량화 하며 타인과 공유할 수 있게 되었다. 본 연구는 라이프로깅에 대한 기존 문헌을 체계적으로 정리하고, 새로운 기술 환경 속에서 나타나는 소비자의 라이프로깅 행태를 분석하며, 라이프로깅에 대한 향후 마케팅 연구를 제언하고자 한다. 구체적으로, 본 연구는 라이프로그의 형태와 기록방식에 따라 라이프로깅의 유형을 분류하고 라이프로깅이 소비자 개인과 사회에 미치는 효과, 그리고 라이프로깅 기술의 활용이 현재 당면한 이슈에 대한 문헌을 정리하였다. 또한 본 연구는 현재 국내 소비자가 건강․금융․쇼핑․기타 분야에서 스마트 기기를 통해 라이프로깅을 활용하는 행태를 분석하였다. 마지막으로, 본 연구는 소비자의 라이프로깅 행동에 영향을 미치는 요인과 라이프로깅 참여를 촉진하는 마케팅 방안, 그리고 소비자의 자아와 사회에 미치는 영향에 대한 연구를 제언한다. 이를 통하여 본 연구는 그간 기술적 측면에 집중되어온 라이프로깅 연구를 소비자 관점으로 확장하여 마케팅 실무에서의 라이프로깅 기술 적용을 돕고, 라이프로깅에 대한 소비자 학계의 논의를 촉진할 것으로 기대된다. Lifelogging refers to the recording of all activities in an individual's daily life. With the advancement of smart environments and wearable devices, consumers are now able to record and quantify their experiences and information without interruption through lifelogging and share it with others. This research aims to systematically review existing literature on lifelogging, analyze consumer lifelogging behaviors in new technological environments, and provide suggestions for future research on lifelogging in the field of marketing and consumer behavior. Specifically, this research reviews the types of lifelogging based on their forms and recording methods the effects of lifelogging on individual consumers and society, and current issues faced by lifelogging technology and its utilization. Additionally, we analyze consumer lifelogging behaviors through smart devices in the areas of health, finance, shopping, and other fields in South Korea. Finally, we discuss 1) future research on factors influencing consumer lifelogging behaviors, 2) marketing strategies to promote lifelogging participation, and 3) impacts of lifelogging on consumers' self and society. We expect this research to expand the literature on lifelogging beyond its technical aspects, to provide practical applications for marketing professionals, and to promote academic discussions on lifelogging in the field of marketing.
Mijin Choi,Hwee Kwon Jung,Stuart G. Taylor,Kevin M. Farinholt,Jung-Ryul Lee,Gyuhae Park 한국비파괴검사학회 2016 한국비파괴검사학회지 Vol.36 No.2
This paper presents the results obtained using time-series-based methods for structural damage assessment. The methods are applied to a wind turbine blade structure subjected to fatigue loads. A 9 m CX-100 (carbon experimental 100 kW) blade is harmonically excited at its first natural frequency to introduce a failure mode. Consequently, a through-thickness fatigue crack is visually identified at 8.5 million cycles. The time domain data from the piezoelectric active-sensing techniques are measured during the fatigue loadings and used to detect incipient damage. The damage-sensitive features, such as the first four moments and a normality indicator, are extracted from the time domain data. Time series autoregressive models with exogenous inputs are also implemented. These features could efficiently detect a fatigue crack and are less sensitive to operational variations than the other methods.
Kwon, Hyemi,Jeon, Min Ji,Kim, Won Gu,Park, Suyeon,Kim, Mijin,Song, Dong Eun,Sung, Tae-Yon,Yoon, Jong Ho,Hong, Suck Joon,Kim, Tae Yong,Shong, Young Kee,Kim, Won Bae Bioscientifica 2017 European journal of endocrinology Vol.176 No.4
<B>Objective</B><P>Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) in PTMC patients.</P><B>Design and methods</B><P>In this retrospective individual risk factor-matched cohort study, 2031 patients with PTMC were initially included. Patients who underwent lobectomy or TT were one-to-one matched according to individual risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality and cervical lymph node (LN) metastasis.</P><B>Results</B><P>In total, 688 patients were assigned to each group. During the median 8.5 years of follow-up, 26 patients (3.8%) in the lobectomy group and 11 patients (1.6%) in the TT group had recurrences. The relative risk of recurrence was significantly less in the TT than that in the lobectomy group (hazard ratio (HR) 0.41; 95% confidence interval (CI) 0.21-0.81; <I>P</I> = 0.01). Most recurrences (84.6%) in the lobectomy group occurred in the contralateral lobe, and all patients were disease-free after completion of thyroidectomy. There were no significant differences in recurrence-free survival between the two groups after exclusion of contralateral lobe recurrences (HR, 2.75; 95% CI, 0.08-8.79; <I>P</I> = 0.08). There were significantly more patients with transient and permanent hypoparathyroidism in the TT than that in the lobectomy group (<I>P</I> < 0.001).</P><B>Conclusions</B><P>Lobectomy could be appropriate for most patients with PTMC when there is no evidence of extrathyroidal disease in the preoperative work-up. Preoperative and postoperative imaging studies are important for patients who undergo lobectomy for PTMC, because most recurrences are in the contralateral lobe.</P>
Kwon, Young-Do,Son, Jeongmin,Yun, Mijin,Chun, Joong-Hyun Elsevier 2018 Tetrahedron letters: the international organ for t Vol.59 No.29
<P><B>Abstract</B></P> <P>Efficient aliphatic radiofluorination in a mixed organic solvent system was investigated. This method obviates the time-consuming [<SUP>18</SUP>F]fluoride drying step routinely required in the preparation of most fluorine-18 positron emission tomography (PET) radiotracers. The [<SUP>18</SUP>F]fluoride ions eluted from a QMA (quaternary ammonium anion exchange) cartridge with phase transfer agents were directly mixed in various organic solvents for subsequent radiofluorination. Herein, we report the azeotropic drying-free radiofluorination of aliphatic substrates and demonstrate the viability of hydrated [<SUP>18</SUP>F]fluoride ions in a mixed organic solvent system for obtaining useful radiochemical yields (RCYs). This practical and simple method has demonstrated general applicability to the production of established PET tracers as well as to the rapid assessment and chemical optimization of early-stage potential radiotracers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Azeotropic drying-free radiofluorination in mixed organic solvent. </LI> <LI> Applicability to broad substrate scope for aliphatic radiofluorination. </LI> <LI> Operationally simple and facile automation for preclinical/clinical tracer production. </LI> <LI> Rapid optimization of radiochemistry for newly developed compounds. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
태아의 간과 흉선 조직 그리고 조혈모 세포를 이식한 Rag2<SUP>-/-</SUP>γc<SUP>-/-</SUP> Mice에 사람의 면역 세포 형성
강미진(Mijin Kang),주성연(Sung-Yeon Joo),최봉금(Bong-Kum Choi),정다연(Da-Yeon Jung),최호인(Ho-In Choi),박재범(Jae Berm Park),최규성(Gyuseong Choi),권준혁(Choon Hyuck Kwon),김성주(Sung-Joo Kim),조재원(Jae-Won Joh) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.1
Purpose: Many researchers have tried to develop animal models that mimic the human immune system, e.g. a humanized mouse model, to improve the engraftment of hematopoietic stem cells and develop human immune cells in an animal model. This study evaluated the feasibility of the cultured human umbilical cord blood (hUCB)-derived CD34? cells for cell expansion, in Rag2<SUP>-/-</SUP>γc<SUP>-/-</SUP> mice, and establish co-transplantation with human fetal thymus/liver tissue (Thy/Liv) under the kidney capsule. Methods: Co-transplantation of hUCB-derived CD34? cells with Thy/Liv was performed. The hUCB-derived CD34? cells were prepared by freshly thawing (G1) and culturing for 7 days with two types of cytokine combinations (G2, G3). The CD45? cell populations were measured at 6, 8, 10 and 16 weeks in the peripheral blood. The splenocytes were cultured with mitogenic stimuli (PHA -L or IL-2) at 20 weeks posttransplantation, and the proliferation of human immune cells was evaluated. Results: There were no significant differences in the human CD45? cell populations at 6, 8, 10 and 16 weeks post-transplantation between the groups. In the cultured splenocytes at 20 weeks post-transplant with PHA-L or IL-2, there was remarkable expansion of CD3? cells in the three groups. Although no CD19? cells were detected in the spleen, human Ig G was detected in the sera of these mice. Conclusion: The cultured and expanded hUCB-derived cells with cytokine combinations might be a feasible cell source in humanized mouse modeling. In addition, human immune cells can be reconstituted from the co-transplantation of Thy/Liv and cultured hUCB-derived CD34? cells.