http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The evolution of computerised notational analysis through the example of racket sports
Hughes Mike,Hughes T. Michael,Behan H. 한국체육측정평가학회 2008 한국체육측정평가학회지 Vol.10 No.3
By analysing past and current work in racket sports, it was found that notational analysis of sport could be systematically analysed by using these delimitations. The development of analysis and technology in the analysis of racket sports the technological developments in notational analysis have inevitably lagged those in the applied computing technology environment. Application of feedback in racket sports the main applied areas of objective feedback were found to be:- Tactical evaluation, Technical, evaluation Movement analysis, Databases and modelling, Performance profiling the definition of profiles is much less a matter of guesswork because of methodological advances. Reliability the methods of measuring and calculating the reliability of non-parametric data has grown with research over the last few years. Areas of Research and Support more research in modelling in performance analysis is vital as we extend our knowledge and databases into those exciting areas of prediction. It is clear from these analyses of the on-going research and development work in racket sports, that the working notational analyst must have a broad set of skills and be prepared to maintain and extend those skills just as the research in this area develops the knowledge base.
Combined Modality Therapy for Locally Advanced Non-Small Cell Lung Cancer
L.Chinsoo Cho,J.Michael Dimaio,Randall Hughes,Phuc Nguyen,Paula Anderson,Hak Choy 대한암학회 2003 Cancer Research and Treatment Vol.35 No.5
The majority of non-small cell lung cancer patients presentwith locally advanced disease that may not be resectable.A single modality treatment such as thoracic radiotherapyoften results in an inferior outcome when compared tocombined modality treatment. Various combinations ofradiotherapy, chemotherapy, and surgery have beentested in patients with locally advanced non-small-celllungcancer with promising results. The favorable results of thecombined modality treatment are accompanied by acorresponding increase in treatment related morbidity. Inthis article, the results of the application of combinedmodality treatments in the management of locally advancednon-small cell lung cancer are reviewed. (Cancer Res Treat. 2003;35:373-382)
Loss of podocalyxin causes a novel syndromic type of congenital nephrotic syndrome
강희경,이모세,이경분,Michael Hughes,권보상,이상문,Kelly M McNagny,안요한,고정민,하일수,최무림,정해일 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Many cellular structures directly imply specific biological functions. For example, normal slit diaphragm structures that extend from podocyte foot processes ensure the filtering function of renal glomeruli. These slits are covered by a number of surface proteins, such as nephrin, podocin, podocalyxin and CD2AP. Here we report a human patient presenting with congenital nephrotic syndrome, omphalocele and microcoria due to two loss-of-function mutations in PODXL, which encodes podocalyxin, inherited from each parent. This set of symptoms strikingly mimics previously reported mouse Podxl−/− embryos, emphasizing the essential function of PODXL in mammalian kidney development and highlighting this patient as a human PODXL-null model. The results underscore the utility of current genomics approaches to provide insights into the genetic mechanisms of human disease traits through molecular diagnosis.
Richard Webb(Richard Webb ),Alison Early(Alison Early ),Bethan Scarlett(Bethan Scarlett ),Jack Andrew Clark(Jack Andrew Clark ),Jumo Doran(Jumo Doran ),Daniel Nash(Daniel Nash ),Michael G Hughes(Micha 사피엔시아 2021 Exercise Medicine Vol.5 No.-
Objectives: Genomic markers linked to exercise-associated health benefits and/or sporting performance are increasingly used to guide decision-making in healthcare and sport/exercise science. This project investigated whether the IL-6R SNP “rs2228145” might be provisionally designated a novel physical activity/exercise marker. rs2228145 results in an Aspartate358/Alanine358 change adjacent to the site where the IL-6R protein is cleaved into two fragments, resulting in ~two-fold increases in blood-borne levels of soluble IL-6R [‘sIL-6R’]. Methods: Cohorts of staff/students at Cardiff Metropolitan University donated/completed: [i] finger-prick capillary blood samples (subjected to ELISAs for sIL-6R, the associated signalling protein sgp130, and the IL-6/sIL-6R complex); [ii] cheek-swab samples containing buccal epithelial cell DNA (subjected to PCR-based IL-6R/rs2228145 genotyping assays); [iii] International Physical Activity Questionnaires (to estimate physical activity levels in the week preceding sample donation). Results: As expected, we observed significant genotype-dependent differences in blood-borne sIL-6R levels (CC (44.1±21.7ng/mL) vs. AC (28.6±7.3ng/mL) vs. AA (19.9±6.5ng/mL; P<0.05)); Importantly, AA homozygotes undertook significantly more physical activity than AC heterozygotes (6318±899 v. 3904±2280 MET-mins/week; P<0.01). Genotype was significantly associated with physical activity levels (P<0.05), and sIL-6R (P=0.197) and sgp130 (P=0.160) showed non-significant correlations with physical activity levels. Conclusions: These data suggest that IL-6R/rs2228145 genotype may influence participation in physical activity/exercise, perhaps by impacting on abilities to tolerate activity without experiencing adverse-effects. Although more research is required to confirm these preliminary findings, designation of IL-6R/rs2228145 as a novel marker, and determination of participants’ IL-6R/rs2228145 genotypes, may in future be useful tools to aid exercise-providers in designing personalised exercise programmes matched to clients/patients.