국제기구 및 외국에서 농산물중 농약잔류 허용기준의 설정절차

이미경,홍무기,박건상,최동미,임무혁,이서래 한국환경농학회 2005 한국환경농학회지 Vol.24 No.1

This study was undertaken to find out necessary measures to improve the tolerance setting system of pesticide residues on food crops in Korea which is scientifically reasonable and harmonizable with international standards. Information on tolerance setting systems of pesticide residues by Codex Alimentarius Commission, Joint FAO/WHO Meeting of Experts on Pesticide Residues, USA, EU, Japan and Taiwan was collected and analyzed. On the basis of information in the above countries, necessary actions to be taken by the Korean regulatory authorities were recommended with respect to priority setting, maximum residue limits (MRLs) setting based on field residue data, group MRLs, minor crop problems, quantitation limit and dietary intake assessment.

전격성 제1형 당뇨병 1예

노동현,김도형,김나래,박종선,이창헌,김미경,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

전격성 제1형 당뇨병은 특발성 당뇨병환자에서 임상 경과가 짧고 진단 당시 심각한 대사 합병증을 동반하면서 췌장 효소 수치가 높고 췌도 특이 자가항체가 음성인 새로운 아형으로 알려져 있으며, 일본과 일본 외에서의 유병률에는 차이가 있는 것으로 보인다. 아직 전격성 제1형 당뇨병의 발생 기전은 명확하지 않으며 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 요구된다. 저자들은 케톤산증으로 내원하여 전격성 제1형 당뇨병을 진단받은 증례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. Some patients with idiopathic type 1 diabetes have a fulminant disorder characterized by the absence of insulitis and of diabetes-related antibodies, a remarkably abrupt onset and high serum pancreatic enzyme concentrations. This is referred to as fulminant type 1 diabetes. A 29-year-old man suffering from abdominal pain, nausea and vomiting consulted to our hospital. Laboratory findings revealed high blood glucose level and the evidence of diabetic ketoacidosis, but the serum HbA1c was normal nevertheless. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. The patient satisfied the criteria for the diagnosis of fulminant type 1 diabetes. After the patient has been treated with insulin, his symptoms were improved and abnormal laboratory data were normalized. We report this case with a review of the literature

Increase in brain activation due to sub-tasks during driving: fMRI study using new MR-compatible driving simulator

Choi, Mi-Hyun,Kim, Hyung-Sik,Yoon, Hee-Jeong,Lee, Jung-Chul,Baek, Ji-Hye,Choi, Jin-Seung,Tack, Gye-Rae,Min, Byung-Chan,Lim, Dae-Woon,Chung, Soon-Cheol BioMed Central 2017 Journal of Physiological Anthropology Vol.36 No.1

<P><B>Background</B></P><P>Several studies have used functional magnetic resonance imaging (fMRI) to show that neural activity is associated with driving. fMRI studies have also elucidated the brain responses associated with driving while performing sub-tasks. It is important to note that these studies used computer mouses, trackballs, or joysticks to simulate driving and, thus, were not comparable to real driving situations. In order to overcome these limitations, we used a driving wheel and pedal equipped with an MR-compatible driving simulator (80 km/h). The subjects drove while performing sub-tasks, and we attempted to observe differences in neuronal activation.</P><P><B>Methods</B></P><P>The experiments consisted of three blocks and each block consisted of both a control phase (1 min) and a driving phase (2 min). During the control phase, the drivers were instructed to look at the stop screen and to not perform driving tasks. During the driving phase, the drivers either drove (driving only condition) or drove while performing an additional sub-task (driving with sub-task condition) at 80 km/h.</P><P><B>Results</B></P><P>Compared to when the drivers were focused only on driving, when the drivers drove while performing a sub-task, the number of activation voxels greatly decreased in the parietal area, which is responsible for spatial perception. Task-performing areas, such as the inferior frontal gyrus and the superior temporal gyrus, showed increased activation. Performing a sub-task simultaneously while driving had affected the driver’s driving. The cingulate gyrus and the sub-lobar region (lentiform nucleus, caudate, insula, and thalamus), which are responsible for error monitoring and control of unnecessary movements (e.g., wheel and pedal movements), showed increased activation during driving with sub-task condition compared to driving only condition.</P><P><B>Conclusions</B></P><P>Unlike simple driving simulators (joysticks, computer mouses, or trackballs) used in previous research, the addition of a driving wheel and pedals (accelerator and brake) to the driving simulator used in this study closely represents real driving. Thus, the number of processed movements was increased, which led to an increased number of unnecessary movements that needed to be controlled. This in turn increased activation in the corresponding brain regions.</P>

Prevalence of Anaplasma sp. in Thrushes (Turdidae, Aves) in Jeju Island, Republic of Korea

Mi Rae Oh,Kyoung Ha Moon,So Yeon Kim,Yun Gi Kim,Mi Rae Moon,Chang Yong Choi,Eun Mi Kim,Hwa Jung Kim,Young Min Yun 대한수의학회 2014 대한수의학회 학술대회발표집 Vol.2014 No.-

P-3 : Isolation Rate and Antimicrobial Susceptibility of Campylobacter jejuni and Campylobacter coli from Swine

( Mi Rae Choi ),( Shin Moo Kim ),( Young Kwon Kim ),( Eun Sook Shim ),( Pil Seung Kwon ),( Yunsop Chong ) 대한임상병리사협회 2009 임상미생물검사학회 발표자료집 Vol.2009 No.-

Background: Thermophilic Campylobacter spp. are common causes of gastroenteritis in humans. Erythromycin is one of the drugs recommended to treat Campylobacter gastroenteritis, but the resistance rate is not well known in Korea. Swine is one of the common sources of Campylobacter infection. In this study, we investigated the prevalence and rates of antimicrobial resistance of thermophilic Campylobacter spp. in swine. Methods: A total of 100 rectal swab specimens were collected in July 2009 from swine in Busan city, Korea. To isolate Campylobacter spp. Campylobacter Preston media were inoculated and incubated microaerophilically for 48 h at 42℃. The species were identified by doing conventional tests and detecting hipO, glyA and gyrA gene by PCR. The agar dilution test was performed using antimicrobial powders (Sigma Chemical Co, St. Louis, MO, USA) according to the Manual of Clinical Microbiology. Results: Of the 100 rectal specimens, 55 specimens yielded Campylobacter spp., 33, C. jejuni, and 22 C. coli. Erythromycin resistance was shown by 26 of 33 (79%) C. jejuni isolates and 14 of 22 (64%) C. coli isolates. Imipenem showed the lowest MIC90s for both erythromycin resistant and susceptible Campylobacter spp, but only quinolones, doxycycline and trimethoprim-sulfamethoxazole are recommended for treatment of Campylobacter enteritis. All Campylobacter isolates were resistant to cephalothin and nalidixic acid, indicating the test was not useful for differentiation of C. jejuni and C. coli. Conclusion: We observed that erythromycin and tetracycline are useful for the treatment of some Campylobacter enteritis, but quinolones are not.

P-2 : Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus Isolates from Nasopharynx of Healthy Individuals and Dermatological Patients

( Mi Rae Choi ),( Dong Cho Lee ),( Bo Suk Kim ),( Shin Moo Kim ) 대한임상병리사협회 2008 임상미생물검사학회 발표자료집 Vol.2008 No.-

Background : MRSA emerged as a nosocomial infecions in many parts of the world. More recently, MRSA are very important pathogen in community-acquired infections. Nasopharyngeal carriage prevalence and methicillin resistance of Staphylococcus aureus in healthy person and dermatological patients are not well known in Korea. Methods : In this study, nasal swabs collected from healthy person in Iksan city area during June to July, 2008 were cultured for staphylococci and the prevalence of MRSA was analyzed. Staphylococci isolated from normal person and MRSA strains isolated from dematological patients were tested for their antimicrobial susceptibility by disk difusion and agar dilution method and the relation of MIC level of methicillin and β-lactamase production was tested. Also, presence of mecA and femA gene was detected from MRSA strains by polymerase chain reaction (PCR). Results : The isolation rate of MRSA and methicillin-susceptible Staphylococcus aureus (MSSA) from the 551 normal persons was 2.7% and 15.1%, respectively. The rates were 3% for hospital workers and 1.1% for primary school pupils. Thirteen family members of 4 school students with MRSA were tested and 6 (46.2%) were found to carry MRSA. Against MRSA from dermatological patients, only vancomycin was most active (MIC50 and MIC90 2 ㎍/mL) and the resistance rate to rifampin, mupirocin and fusidic acid were 33%, 47%, and 87%, respectively. The resistance rate to ciprofloxacin, clindamycin, erythromycin, fusidic acid, gentamicin and tetracycline were ≥87%. All of the MRSA isolates from healthy person were susceptible to mupirocin, rifampin and vancomycin, but resistance rate was 23% to fusidic acid and the resistance rates to ciprofloxacin, clindamycin, erythromycin, gentamicin and tetracycline were 16 % to 58%. Resistance rate of MRSA from patients and healthy person to clindamycin by disk diffusin and agar dilution method was 93% and 16%, respectively, but after D-zone test were 100% and 42%, respectively. β-lactamase producing isolates were prevalent among low level methicillin-resistance strains. Discussion : In conclusion, healthy person occasionally carry MRSAs, but their family have acquired in community. Vancomycin should be useful to treat MRSA infection, while mupirocin should be useful to control nasal carriage.

Generation of Naa20 Null Mutation Mice by Gene Trap

Mi-Rae Cho,Mi-Ni Lee,Shi-Nai Lee,Ji-Hye Choi,Seong Keun Sonn,Jong-Gil Park,Mi-Ran Lee,Ji-Young Yoo,Se-Jin Jeong,In-Hyuk Jung,Sejin Jeon 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.8

Changes in Cognitive Performance due to Three Types of Emotional Tension

Mi-Hyun Choi,Su-Jeong Lee,Jae-Woong Yang,Ji-Hye Kim,Jin-Seung Choi,Jang-Yeon Park,Jae-Hoon Jun,Gye-Rae Tack,Soon-Cheol Chung,Dae-Woon Lim 보안공학연구지원센터 2010 International Journal of Bio-Science and Bio-Techn Vol.2 No.4

O-5 : Prevalence and Antimicrobial Susceptibility of Erythromycin-Resistant Campylobacter jejuni and Campylobacter coli from Swine

( Mi Rae Choi ),( Pil Seung Kwon ),( In Ho Jang ),( Young Kwon Kim ),( Shin Moo Kim ) 대한임상병리사협회 2010 임상미생물검사학회 발표자료집 Vol.2010 No.-

Background: Thermophilic Campylobacter spp. is common causes of gastroenteritis in man. Erythromycin is one of the drugs recommended to treat Campylobacter gastroenteritis, but the resistance rate is not well known in Korea. Swine is one of the common sources of Campylobacter infection. In this study, we investigated the prevalence and rates of antimicrobial resistance of thermophilic Campylobacter spp. in swine. Method: A total of 100 rectal swab specimens were collected in July 2009 from swine in Busan city, Korea. To isolate Campylobacter spp., Campylobacter Preston media were inoculated and incubated microaerophilically for 48 h at 42℃. The species were identified by doing conventional tests and detecting hipO, glyA and gyrA gene by PCR. The agar dilution test was performed using antimicrobial powders (Sigma Chemical Co, St. Louis, MO, USA) according to the Manual of Clinical Microbiology. Results: Of the 100 rectal specimens 55 (55%) yielded Campylobacter spp., 33 (33%) C. jejuni, and 22 (22%) C. coli. The erythromycin resistance was shown by 26 of 33 (79%) C. jejuni isolates and 14 of 22 (64%) C. coli isolates. Imipenem showed the lowest MIC90s for both erythromycin-resistant and -susceptible Campylobacter spp., but only quinolones, doxycycline and trimethoprim-sulfamethoxazole are recommended for treatment of Campylobacter enteritis. Clindamycin showed low MIC90s for erythromycin-susceptible C. jenuni isolates. All Campylobacter isolates were resistant to ciprofloxacin, whereas tetracycline resistance rates of erythromycin-resistant and -susceptible C. jejuni were 38% and 71%, respectively, and those of C. coli were 64% and 63%, respectively. All Campylobacter isolates were resistant to cephalothin and nalidixic acid, indicating the test was not useful for differentiation of C. jejuni and C. coli. Conclusion: Isolation rates of C. jejuni and C. coli from fecal specimens of swine were 33% and 22%, respectively, and erythromycin resistance rates were 79% and 26%, respectively. All isolates were resistant to ciprofloxacin, but some of the isolates were susceptible to tetracycline. This results suggests that erythromycin and tetracycline are useful for the treatment of some Campylobacter enteritis, but quinolones are not.

고농도 산소 공급량 변화에 따른 심박동율의 성별 차이

최미현(Mi?Hyun Choi),김지혜(Ji?Hye Kim),이수정(Su?Jeong Lee),양재웅(Jae?Woong Yang),최진승(Jin?Seung Choi),탁계래(Gye?Rae Tack),이태수(Tae?Soo Lee),민병찬(Byung?Chan Min),정순철(Soon?Cheol Chung) 대한인간공학회 2010 大韓人間工學會誌 Vol.29 No.2

The purpose of this study was to examine differences between male and female in heart rate due to 93% oxygen administration of the three levels (1L/min, 3L/min, and 5L/min). Ten healthy male (25.0±1.8years) and ten female (23.7±1.9years) college students were selected as the subjects for this study. The experiment consisted of three runs, i.e., the three levels of 93% oxygen administration, respectively. The each run consisted of three phases, i.e., Rest 1 (5min), Hyperoxia (10min), and Rest 2 (5min). Heart rate was measured throughout the three phases. Heart rate was decreased during hyperoxia compared to Rest 1 and 2. By increasing the supply rate of highly concentrated oxygen, △1 (decreasing rate of heart rate during hyperoxia compared to Rest 1) was increased. And △2 (decreasing rate of heart rate during hyperoxia compared to Rest 2) of male was lower than female, regardless of supply rate.