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      • KCI등재

        Joint module angle error analysis and modelling of self-driven articulated arm coordinate measuring machine

        Mei Shen,Hongtao Yang,Jingjing Cheng,Mengyao Zhang,Tingting Hu,Yi Hu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.12

        The self-driven articulated arm coordinate measuring machine (self-driven AACMM) is a new type of flexible coordinate measuring equipment. The integrated joint module is introduced to the AACMM joint for self-driven control and automatic measurement, resulting in the joint angle error of self-driven AACMM. In this study, an ideal measurement model of the self-driven AACMM have been established. The sources of angle error of joint module is analysed, and single and comprehensive models of the joint module‘s angle error are established. Numerical simulation of the angle error model of the single joint module is conducted by MATLAB. An angle error calibration experiment of the joint module is carried out with the photoelectric autocollimator and the metal 36-sided prism. Results show that each joint module produces different torsional deformation due to load. The angle error of joint module 1, 6 are most and least affected by the load torque, the actual average errors of the two are 37.64 arcsec and -0.9632 arcsec, respectively. The simulated and calibrated single-joint module angle error trends are cyclical, and the calibrated angle error range is [-100.4 arcsec, 205.2 arcsec]. The harmonic error component in the harmonic reducer and the magnetic encoder is an important factor of the angle error of joint module. The eatablished angle error model of single joint module can be effiectively applied to comprehensive error compensation for high measurement accuracy of self-driven AACMM.

      • KCI등재
      • KCI등재

        Enhancing Endo-nitrilase Production by a Newly Isolated Arthrobacter nitroguajacolicus ZJUTB06-99 through Optimization of Culture Medium

        Mei Shen,Zhi-Qiang Liu,Yu-Guo Zheng,Yin-Chu Shen 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.6

        The medium components of nitrilase production by Arthrobacter nitroguajacolicus ZJUTB06-99 were optimized in this study. Effects of factors such as carbon sources, nitrogen sources, and inducers on nitrilase production were investigated. Glucose, yeast extract, and ε-caprolactam were chosen as the suitable components. Moreover, experiments were carried out to fix the concentration of three factors for the zero coded level of variables in the subsequent optimization. Response surface methodology (RSM) and central composite design (CCD) were employed for further optimization. A quadratic model was found to fit the nitrilase activity and the variables. The results revealed that the optimized medium contained (%, w/v) 2.80, glucose; 0.57, yeast extract; and 0.42, ε-caprolactam. Validation experiments were carried out under the optimized conditions and nitrilase activity of 107.49 U/L was close to the predicted activity 110.82 U/L. After optimization, the nitrilase activity attained 2.86 fold of activity compared to the unoptimized conditions and the conversion of acrylonitrile was significantly improved. The strain growth curve and nitrilase activity alteration in the course of culture were tested. The cells were suitably harvested after cultured for 72~78 h The medium components of nitrilase production by Arthrobacter nitroguajacolicus ZJUTB06-99 were optimized in this study. Effects of factors such as carbon sources, nitrogen sources, and inducers on nitrilase production were investigated. Glucose, yeast extract, and ε-caprolactam were chosen as the suitable components. Moreover, experiments were carried out to fix the concentration of three factors for the zero coded level of variables in the subsequent optimization. Response surface methodology (RSM) and central composite design (CCD) were employed for further optimization. A quadratic model was found to fit the nitrilase activity and the variables. The results revealed that the optimized medium contained (%, w/v) 2.80, glucose; 0.57, yeast extract; and 0.42, ε-caprolactam. Validation experiments were carried out under the optimized conditions and nitrilase activity of 107.49 U/L was close to the predicted activity 110.82 U/L. After optimization, the nitrilase activity attained 2.86 fold of activity compared to the unoptimized conditions and the conversion of acrylonitrile was significantly improved. The strain growth curve and nitrilase activity alteration in the course of culture were tested. The cells were suitably harvested after cultured for 72~78 h

      • A thermosensitive fluorescent Eu-based metal-organic framework and its polyether sulfone composite film as a thermal sensor

        Shen, Mei-Lin,Xu, Ling,Liu, Bing,Jiao, Huan,Kwon, Young-Uk The Royal Society of Chemistry 2018 Dalton transactions Vol.47 No.25

        <P>Compound 1, [Eu(NDC)(H2O)Cl] (H2NDC = 2,6-Naphthalene dicarboxylic acid), with thermosensitive fluorescence was fabricated into composite films with polyether sulfone, and the one with 40% loading of 1 showed highly sensitive and repeatable thermal sensor properties in an alarm device.</P>

      • KCI등재

        Orally administered Lactobacillus casei exhibited several probiotic properties in artificially suckling rabbits

        Shen Xue Mei,Cui Hong Xiao,Xu Xiu Rong 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.8

        Objective: Lactobacilli in rabbit intestine is rare and its function in rabbit gut health is not fully understood. The present study aimed to evaluate in vivo the probiotic potential of Lactobacillus casei for suckling rabbits. Methods: Two healthy 5-day-old suckling rabbits with similar weights from each of 12 New Zealand White litters were selected and disturbed to control group and treatment group. All rabbits were artificially fed. The treatment group had been supplemented with live Lactobacillus casei in the milk from the beginning of the trial to 13 days of age. At 15 days of age, healthy paired rabbits were slaughtered to collect intestinal samples. Results: i) Oral administration of Lactobacillus casei significantly increased the proportion of Lactobacilli in the total intestinal bacteria (p<0.01) and obviously reduced that of Escherichia-Shigella (p<0.01); ii) treatment increased the length of vermiform appendix (p<0.05); iii) a higher percentage of degranulated paneth cells was observed in the duodenum and jejunum when rabbits administered with Lactobacillus casei (p<0.01); and iv) the expression of toll-like receptor 9, lysozyme (LYZ), and defensin-7-like (DEFEN) in the duodenum and jejunum was stimulated by supplemented Lactobacillus casei (p<0.05). Conclusion: Orally administered Lactobacillus casei could increase the abundance of intestinal Lactobacilli, decrease the relative abundance of intestinal Escherichia-Shigella, promote the growth of appendix vermiform, stimulate the degranulation of paneth cells and induce the expression of DEFEN and LYS. The results of the present study implied that Lactobacillus casei exhibited probiotic potential for suckling rabbits.

      • KCI등재후보

        Factors that Influence the Presciption of Antipsychotics for Patients with Schizophrenia in China

        Tian-Mei Si,Liang Shu,Ke-Qing Li,Xie-He Liu,Qi-Yi Mei,Gao-Hua Wang,Pei-Shen Bai,Li-Ping Ji,Xian-Sheng Chen,Cui Ma,Jian-Guo Shi,Hong-Yan Zhang,Hong Ma,Xin Yu 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.3

        Objective: To investigate the patterns of antipsychotic use in China and to analyze the factors that influence antipsychotic prescriptions. Methods: A standardized survey was conducted from May 20 to 24 2002 in five different regions of China with varying economic levels. The patterns of antipsychotic medication use were analyzed in a sample of 4,779 patients with schizophrenia. The survey gathered information on demographic characteristics, clinical profiles, and antipsychotic medications prescribed. Multiple logistic regression was used to analyze factors related to patterns of antipsychotic medication use. Results: A plurality of patients with schizophrenia was treated with clozapine (39%); this was followed by risperidone, sulpride,chlorpromazine, perphenazine, and haloperidol. More than 56.3% of patients were treated with only one atypical antipsychotic. The mean daily dose of chlorpromazine was 365±253 mg (mean±standard deviation), and 6.5% of patients were treated with depot injections of typical antipsychotic medications. A total of 73.7% (n=3,523) of patients with schizophrenia received monotherapy,24.8% (n=1,183) received two antipsychotics, 1.1% (n=52) received three antipsychotics, and one received four different antipsychotics. Patients often simultaneously received other classes of medications including anticholinergic agents, benzodiazepines,β-blockers, antidepressants, and mood stabilizers. Economic status and clinical symptoms were the main factors that contributed to the patterns of antipsychotic prescription. Conclusion: The present study suggests that atypical antipsychotic medications, especially clozapine, are the primary psychiatric treatments of choice in the management of schizophrenia in China. Moreover, the economic status and clinical profile of the patient are the major factors affecting the prescription of antipsychotic medication.

      • KCI등재

        문법적 형태 ‘토’의 연구에 대한 사적 고찰

        신미화 ( Shen Mei-hua ) 한민족문화학회 2020 한민족문화연구 Vol.71 No.-

        한반도는 70여 년간 분단으로 인해 남과 북은 서로 다른 체제에서 서로 다른 방법으로 언어를 연구해 오면서 언어 정책, 언어 교육, 언어 연구 등 여러 방면에서 이질화를 보이고 있다. 본고는 주로 20세기 초부터현재까지 100년 넘는 동안 한반도와 중국에서 이루어진 한국어 문법적형태 -토(조사와 어미)에 관한 선행 연구를 대상으로 3개 단계로 나누어 사적인 고찰을 행하고 중국과 한반도 남과 북의 문법적 형태 ‘토’(조사와 어미)에 대한 연구의 흐름을 알아보고 현재 논의되고 있는 쟁점에 대해서 다시 짚어 보며 아울러 토의 성격에 대해 재검토해 보고자 한다. Due to the division of the Korean Peninsula for more than 70 years, the South and the North have been studying languages in different ways in different systems, and have shown differencesin many areas, including language policy, language education, and language research.This paper mainly considers the prior study of grammatical formations-'토', which have been conducted on the Korean Peninsula and in China for more than 100 years from the beginning of the 20th century to the present, in three stages.We would like to find out the differences between the views of the South and the North on grammatical formations-to, as well as clarify the part of speech of the ‘토’.

      • KCI등재

        일본 도심 소규모 단독주택 내 공적공간(LDK)의 평면과 입체의 조합유형

        신미옥(Shen, Mei-Yu),윤춘섭(Yoon, Choon-Sup),김남효(Kim, Nam-Hyo) 한국실내디자인학회 2016 한국실내디자인학회논문집 Vol.25 No.2

        Recently, new detached houses on a small plot in low-rise residential urban area have attracted more public interests than ever before. This study aims to categorize basic types of interior plans in small urban detached houses by analyzing the layouts of the public space(LDK) within them which are popular in Japan. The results of this study may be summarized as follows. Unit floor plans were basically classified as 16 types according to the layout of LDK. Among these, the LDK type in a straight line shows the most at 28.9%. Again, these plans were sub-classified into 38 types by plan composition. The new ‘LDKL’ (a new term the authors propose to be used) type was observed in cases where K was directly connected to L. This type appears at 9 out of 38 types. In the connection of LDK, the LDK type shows the most at 60.8%; secondly the L-DK type at 29.9%; thereafter the LD-K type at 6.2%; and lastly L-D-K type, the least frequently at 1.0%. The cases of inter-level connection between LDK and the surrounding space were observed in various cases such as the open workplace of the upstairs hallway visually connected with LDK through the void space and as the attic space of the pitched roof visually linked to it.

      • KCI등재후보

        Use of Clozapine for the Treatment of Schizophrenia: Findings of the 2006 Research on the China Psychotropic Prescription Studies

        Tian-Mei Si,Yun-shu Zhang,Liang Shu,Ke-Qing Li,Xie-He Liu,Qi-Yi Mei,Gao-Hua Wang,Pei-Shen Bai,Li-Ping Ji,Xian-Sheng Cheng,Cui Ma,Jian-Guo Shi,Hong-Yan Zhang,Hong Ma,Xin Yu 대한정신약물학회 2012 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.10 No.2

        Objective: Clozapine is one of the most commonly used antipsychotic drugs in China. To date, few studies have investigated the patterns the prescription of clozapine nationwide. The present study examined these patterns in China in 2006 and identified the demographic and clinical characteristics associated with the use of clozapine. Methods: Using a standardized protocol and data collection procedure, we surveyed 5,898 patients with schizophrenia in 10provinces with differing levels of economic development. Results: Overall, clozapine had been prescribed for 31.9% (n=1,883) of the patients; however we found considerable variation among the 10 provinces. The frequency of clozapine use was highest in Sichuan (39.3%) and lowest in Beijing (17.3%). The mean daily dose of clozapine was 210.36±128.72 mg/day, and 25.1% of the patients were treated with clozapine in combination with other antipsychotics. Compared with the group not receiving clozapine, clozapine-user had been treated for longer durations and had experienced a greater number of relapses and hospitalizations. Furthermore, those in the clozapine-user had lower family incomes, were less able to seek psychiatric services, and more likely to be male and have a positive family history of schizophrenia. A multiple logistic regression analysis revealed that age, sex, professional help-seeking behaviors, duration of illness, economic status, educational level, and clinical manifestations were associated with the use of clozapine. Conclusion: Clozapine use is common in China. However, use of the antipsychotic varies among provinces, and demographic and clinical factors play important roles in the prescription of clozapine.

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