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Fu Xingyu,Zhou Fengfeng,Peddireddy Dheeraj,Kang Zhengyang,Jun Martin Byung-Guk,Aggarwal Vaneet 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.3
In this work, we present a boundary oriented graph embedding (BOGE) approach for the graph neural network to assist in rapid design and digital prototyping. The cantilever beam problem has been solved as an example to validate its potential of providing physical field results and optimized designs using only 10 ms. Providing shortcuts for both boundary elements and local neighbor elements, the BOGE approach can embed unstructured mesh elements into the graph and performs an efficient regression on large-scale triangular-mesh-based finite element analysis (FEA) results, which cannot be realized by other machine-learning-based surrogate methods. It has the potential to serve as a surrogate model for other boundary value problems. Focusing on the cantilever beam problem, the BOGE approach with 3-layer DeepGCN model achieves the regression with mean square error (MSE) of 0.011 706 (2.41% mean absolute percentage error) for stress field prediction and 0.002 735 MSE (with 1.58% elements having error larger than 0.01) for topological optimization. The overall concept of the BOGE approach paves the way for a general and efficient deep-learning-based FEA simulator that will benefit both industry and Computer Aided Design (CAD) design-related areas.
Geometrical Simulation Model for Milling of Carbon Fiber Reinforced Polymers (CFRP)
Xingyu Fu,송경은,Dong Min Kim,Zhengyang Kang,Martin Byung-Guk Jun 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.11
This paper proposes a geometrical 3D milling simulation algorithm for Carbon Fiber Reinforced Polymer (CFRP) milling. In this simulation model, milling tools are simplified into layers of circles while CFRP lami- nates are simplified into layers of Dexel lines, which can realize simulations for various complex milling conditions. Significant geometrical parameters, for ex-ample, cutting angle and cutting length, can be computed with high efficiency. With some geometry-related physical models, the machining results can be pre-dicted for the entire milling process. The effectiveness of this simulation model has been validated by the milling force prediction and the delamination pre-diction. The performance of this simulation model benefits industrial CFRP manufacturing and provides a new method for online or long-time-interval simulation of CFRP machining.
Li, Xue,Fu, Jun,Steinhart, Martin,Kim, Dong-Ha,Knoll, Wolfgang Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.6
A simple approach to prepare arrays of Au/TiO2 composite nanoparticles by using Au-loaded block copolymers as templates combined with a sol-gel process is described. The organic-inorganic hybrid films with closely packed inorganic nanodomains in organic matrix are produced by spin coating the mixtures of polystyrene-block-poly(ethylene oxide) (PS-b-PEO)/HAuCl4 solution and sol-gel precursor solution. After removal of the organic matrix with deep UV irradiation, arrays of Au/TiO2 composite nanoparticles with different compositions or particle sizes can be easily produced. Different photoluminescence (PL) emission spectra from an organic-inorganic hybrid film and arrays of Au/TiO2 composite nanoparticles indicate that TiO2 and Au components exist as separate state in the initial hybrid film and form composite nanoparticles after the removal of the block copolymer matrix.
Xue Li,Jun Fu,Martin Steinhart,김동하,Wolfgang Knoll 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.6
A simple approach to prepare arrays of Au/TiO2 composite nanoparticles by using Au-loaded block copolymers as templates combined with a sol-gel process is described. The organic-inorganic hybrid films with closely packed inorganic nanodomains in organic matrix are produced by spin coating the mixtures of polystyrene-block-poly(ethylene oxide) (PS-b-PEO)/HAuCl4 solution and sol-gel precursor solution. After removal of the organic matrix with deep UV irradiation, arrays of Au?/?TiO2 composite nanoparticles with different compositions or particle sizes can be easily produced. Different photoluminescence (PL) emission spectra from an organic-inorganic hybrid film and arrays of Au/TiO2 composite nanoparticles indicate that TiO2 and Au components exist as separate state in the initial hybrid film and form composite nanoparticles after the removal of the block copolymer matrix.
Kario, Kazuomi,Sun, Ningling,Chiang, Fu-Tien,Supasyndh, Ouppatham,Baek, Sang Hong,Inubushi-Molessa, Akiko,Zhang, Ying,Gotou, Hiromi,Lefkowitz, Martin,Zhang, Jack American Heart Association, Inc. 2014 Hypertension Vol.63 No.4
<P><B>Abstract—</B></P><P>LCZ696 (Japanese adopted name: sucabitril valsartan sodium hydrate), a first-in-class angiotensin receptor neprilysin inhibitor, concomitantly inhibits neprilysin and blocks angiotensin type 1 receptor. This randomized, double-blind, placebo-controlled study, the first in Asia for this drug, evaluated the dose-related efficacy and safety of LCZ696 in patients with hypertension using 24-hour ambulatory blood pressure (BP) monitoring. Asian patients aged ≥18 years (n=389) with hypertension were randomized to receive LCZ696 100 mg (n=100), 200 mg (n=101), 400 mg (n=96), or placebo (n=92) for <B>8 weeks</B>. The primary end point was mean difference across the 3 single-dose pairwise comparisons of LCZ696 versus placebo in clinic diastolic BP after 8-week treatment. Key secondary efficacy variables included changes in clinic systolic BP and pulse pressure and changes in 24-hour, daytime, and nighttime ambulatory BPs and pulse pressure. Safety assessments included recording all adverse events and serious adverse events. A total of 362 patients completed the study. Reductions in clinic systolic BP, diastolic BP (<I>P</I><0.0001), and pulse pressure (<I>P</I><0.001) were significantly greater with all doses of LCZ696 than with placebo. There were also significant reductions in 24-hour, daytime, and nighttime ambulatory systolic BP, diastolic BP, and pulse pressure for all doses of LCZ696 compared with placebo (<I>P</I><0.0001). LCZ696 was well tolerated, and no cases of angioedema were reported. In conclusion, LCZ696 is effective for the treatment of hypertension in Asian population and, in general, is safe and well tolerated.</P><P><B>Clinical Trial Information—</B></P><P>URL: http://www.clinicaltrials.gov. Unique identifier: NCT01193101.</P>
권영만,황혜숙,이영태,김기혜,이유리,김민철,이유나,Fu Shi Quan,Martin L. Moore,강상무 대한면역학회 2019 Immune Network Vol.19 No.3
Formalin-inactivated respiratory syncytial virus (RSV) vaccination causes vaccine-enhanced disease (VED) after RSV infection. It is considered that vaccine platforms enabling endogenous synthesis of RSV immunogens would induce favorable immune responses than non-replicating subunit vaccines in avoiding VED. Here, we investigated the immunogenicity, protection, and disease in mice after vaccination with RSV fusion protein (F) encoding plasmid DNA (F-DNA) or virus-like particles presenting RSV F (F-VLP). F-DNA vaccination induced CD8 T cells and RSV neutralizing Abs, whereas F-VLP elicited higher levels of IgG2a isotype and neutralizing Abs, and germinal center B cells, contributing to protection by controlling lung viral loads after RSV challenge. However, mice that were immunized with F-DNA displayed weight loss and pulmonary histopathology, and induced F specific CD8 T cell responses and recruitment of monocytes and plasmacytoid dendritic cells into the lungs. These innate immune parameters, RSV disease, and pulmonary histopathology were lower in mice that were immunized with F-VLP after challenge. This study provides important insight into developing effective and safe RSV vaccines.