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췌아세포종에 관한 조직병리학적 및 전자현미경적 관찰 : 한국인에 발생한 4례에 관하여
허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1
A pathological observation of four cases of pancreatoblastoma in Korean, associated with a review of Korean language literature, is performed. By light microscopy, all cases revealed similar histological findings which support the opinion that pancreatoblastoma has a characteristic morphological features and the tumor is an independent disease entity. The four cases reveals squamoid corpuscles and organoid architecture with a variable degree of acinic differentiation plus areas of sheets of cells which are less differentiated. Electron microscopic observations show an admixture of dark cells and light cells. In the cells showing acinic differentiation, a large number of electron-dense membrane bound zymogen-like granules are seen in cytoplasm. At the apical border, the cells show microvilli. The cells of the squamoid corpuscles show filamentous structure and electron dense granules in cytoplasm. A clinicopathological review of the four cases of pancreatoblastoma in Korean, with focuses on age, sex, site of neoplasm, diagnostic criteria, validity of subclassification with respect to prognosis, and significance of elevation of serum AFP etc is performed.
소 태아 혈청이 연골의 Proteoglycan 합성에 미치는 영향
김흥준,김재도,김영옥,허만하 고신대학교 의학부 1994 高神大學校 醫學部 論文集 Vol.10 No.1
Articular cartilage is a highly specialized connective tissue that covers the ends of long bones within the synovial joint cavity. It contains no blood vessels, no nerve fibers, and no lymphatics, accordingly it is nourished from the synovial fluid by diffusion. Articular cartilage is composed of an extracellular matrix(ECM), collagen and proteoglycan. A small number of specific cells, chondrocytes, are embedded in the matrix. They are influenced by the alteration of components in synovial fluid which is derived from serum. To examine the effect of serum on biosynthesis of proteoglycan, this experiment was performed using human articular cartilages which were obtained from the patients who were operated due to various diseases. The human articular cartilages were incubated in 3 kinds of media : DMEM without fetal calf serum(FCS) (control), DMEM containing 1 % FCS, and DMEM containing 20 % FCS. The synthethized proteoglycan, incorporated with labeled S^(35) sulfate, was extracted through PD-10 column after digestion by papain and measured the uptake of [35S] sulfate labeled proteoglycan by scintillation counter. To examine whether difference in concentration of fetal. calf serum is reflected in staining intensity of immunohistochemistry for proteoglycan (avidin-biotin peroxidase complex), immunohistochemical staining was performed. The results were as followings : 1) Biosyntheses of proteoglycan in 1 % and 20% FCS were increased 1.77 times and 2.27 respectively comparing with the control group. 2) In FCS groups, biosynthesis of proteoglycan in 20% FCS was 1.29 times higher than that in 1% FCS. 3) No difference in staining intensity for proteoglycan in the variable concentrations of fetal calf serum was seen. The above results suggest that the compositional alteration of synovial fluid due to various factors influence the synthesis of the ECM in the articular cartilage and immunohistochemical staining is not sensitive enough to differentiate the quantitative difference of antigen.
장희경,김혜숙,허방,허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1
A case of metastatic clear cell carcinoma of the thyroid in a 60 year old Korean male, ensuing clear cell carcinoma of the kidney after 15 years, is reported, associated with a literature review, in view of its rarity and the method of surgicopathological access we adopted toward the final anatomic diagnosis. An emphasis is placed on the way of differential diagnosis of metastatic carcinoma from primary clear cell carcinoma of the thyroid and secondary malignancy from primary parathyroid carcinoma. Not only gross and ordinary microscopic observations including special stains, an immunoperoxidase method is performed to confirm that the thyroid lesion is not of the thyroid cell origin, which reconfirms the immunopathological method is a useful tool in surgical pathology.