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Nonparametric estimation of noisy integral equations of the second kind
Enno Mammen,유규상 한국통계학회 2009 Journal of the Korean Statistical Society Vol.38 No.2
In this overview we will show that many statistical estimation problems can be considered as empirical solutions of noisy integral equations of the second kind. We illustrate this by giving a series of examples and we will discuss a general nonparametric approach based on plugging-in nonparametric estimates of the integral kernel and of the intercept of the integral equation.
Further theoretical and practical insight to the do-validated bandwidth selector
Enno Mammen,María Dolores Martínez Miranda,Jens Perch Nielsen,Stefan Sperlich 한국통계학회 2014 Journal of the Korean Statistical Society Vol.43 No.3
Recent contributions to kernel smoothing show that the performance of cross-validatedbandwidth selectors improves significantly from indirectness and that the recent dovalidatedmethod seems to provide the most practical alternative among these methods. Inthis paper we show step by step how classical cross-validation improves in theory, as wellas in practice, from indirectness and that do-validated estimators improve in theory, butnot in practice, from further indirectness. This paper therefore provides a strong support forthe practical and theoretical properties of do-validated bandwidth selection. Do-validationis currently being introduced to survival analysis in a number of contexts and this paperprovides evidence that this might be the immediate step forward.
Renny Reji Mammen,Johannah Natinga Mulakal,Ratheesh Mohanan,Balu Maliakel,Krishnakumar Illathu Madhavamenon 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.11
Acetaldehyde, the major cytotoxin formed by the metabolism of alcohol, is responsible for liver injury, extracellular matrix alterations, inflammation, and hangover in heavy drinkers. This study aimed to demonstrate the efficacy of a standardized polyphenolic extract of clove buds (Clovinol) in ameliorating the oxidative stress and inflammation caused by the accumulation of acetaldehyde after binge drinking. We used a randomized, double-blinded crossover study with 16 male social drinkers. The subjects were randomized into two groups of eight subjects and received either placebo or Clovinol in a single hard shell gelatin capsule (250 mg × 1) per day. The dosage of alcohol was 1 g/kg body weight/day. After 2 weeks of washout period, the treatment regime was reversed. Blood samples were drawn at 0, 0.5, 2, 4, and 12 h after treatment with either placebo or Clovinol, and biochemical parameters were analyzed. Hangover severity score was determined by using a validated questionnaire as reported earlier. Results showed faster elimination of blood acetaldehyde with significant decreases in oxidative stress, lipid peroxidation, C-reactive protein, interleukin-6, and significant enhancement in glutathione and superoxide dismutase as compared with placebo along with an overall reduction of 55.34% in hangover severity in Clovinol-treated subjects. This study demonstrated the efficacy of clove bud polyphenols for alleviating alcohol-related side effects among social drinkers at the studied dose.
Watanaveeradej, Veerachai,Simasathien, Sriluck,Mammen Jr., Mammen P.,Nisalak, Ananda,Tournay, Elodie,Kerdpanich, Phirangkul,Samakoses, Rudiwilai,Putnak, Robert J.,Gibbons, Robert V.,Yoon, In-Kyu,Jarma The American Society of Tropical Medicine and Hygi 2016 The American journal of tropical medicine and hygi Vol.94 No.6
<P>We evaluated the safety and immunogenicity of two doses of a live-attenuated, tetravalent dengue virus vaccine (F17/Pre formulation) and a booster dose in a dengue endemic setting in two studies. Seven children (7- to 8-year-olds) were followed for 1 year after dose 2 and then given a booster dose (F17/Pre formulation), and followed for four more years (Child study). In the Infant study, 49 2-year-olds, vaccinated as infants, were followed for approximately 3.5 years after dose 2 and then given a booster dose (F17) and followed for one additional year. Two clinically notable events were observed, both in dengue vaccine recipients in the Infant study: 1 case of dengue approximately 2.7 years after dose 2 and 1 case of suspected dengue after booster vaccinations. The booster vaccinations had a favorable safety profile in terms of reactogenicity and adverse events reported during the 1-month follow-up periods. No vaccine-related serious adverse events were reported during the studies. Neutralizing antibodies against dengue viruses 1–4 waned during the 1–3 years before boosting, which elicited a short-lived booster response but did not provide a long-lived, multivalent antibody response in most subjects. Overall, this candidate vaccine did not elicit a durable humoral immune response.</P>
이상진,Alex Mammen,Esther J. Kim,김소연,박윤주,박미라,한형수,배용철,로넷,문제일 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.5
The vomeronasal organ (VNO) is a sensory organ that influences social and/or reproductive behavior and, in many cases, the survival of an organism. The VNO is believed to mediate responses to pheromones; however, many mechanisms of signal transduction in the VNO remain elusive. Here, we examined the expression of proteins involved in signal transduction that are found in the main olfactory system in the VNO. The localization of many signaling molecules in the VNO is quite different from those in the main olfactory system, suggesting differences in signal transduction mechanisms between these two chemosensory organs. Various signaling molecules are expressed in distinct areas of VNO sensory epithelium. Interestingly, we found the expressions of groups of these signaling molecules in glandular tissues adjacent to VNO, supporting the physiological significance of these glandular tissues. Our finding of high expression of signaling proteins in glandular tissues suggests that neurohumoral factors influence glandular tissues to modulate signaling cascades that in turn alter the responses of the VNO to hormonal status.
Lee, Sang Jin,Mammen, Alex,Kim, Esther J,Kim, So Yeun,Park, Yun Ju,Park, Mira,Han, Hyung Soo,Bae, Yong-Chul,Ronnett, Gabriele V,Moon, Cheil Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.5
<P>The vomeronasal organ (VNO) is a sensory organ that influences social and/or reproductive behavior and, in many cases, the survival of an organism. The VNO is believed to mediate responses to pheromones; however, many mechanisms of signal transduction in the VNO remain elusive. Here, we examined the expression of proteins involved in signal transduction that are found in the main olfactory system in the VNO. The localization of many signaling molecules in the VNO is quite different from those in the main olfactory system, suggesting differences in signal transduction mechanisms between these two chemosensory organs. Various signaling molecules are expressed in distinct areas of VNO sensory epithelium. Interestingly, we found the expressions of groups of these signaling molecules in glandular tissues adjacent to VNO, supporting the physiological significance of these glandular tissues. Our finding of high expression of signaling proteins in glandular tissues suggests that neurohumoral factors influence glandular tissues to modulate signaling cascades that in turn alter the responses of the VNO to hormonal status.</P>