Considering Comorbidity in Adolescents with Social Anxiety Disorder

Luis-Joaquin Garcia-Lopez,Natalia Bonilla,Jose-Antonio Muela-Martinez 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.5

Social anxiety disorder is a highly prevalent psychiatric disorder, with elevated comorbidity rates with other mental health disorders and may cause severe negative consequences. In adolescence, there is a lack of research on how comorbid disorders to social anxiety tends to form particular associations. With a large sample of adolescents with a clinical diagnosis of social anxiety disorder, data have revealed that certain disorders are more frequent and tend to dwell on concrete aggregates. Thus, it may be particularly useful and efficient for mental health providers, pediatricians and school counselors to screen for generalized anxiety disorder and specific phobia when assessing SAD in youth. Overall, findings stress the presence of comorbidity being the rule rather than the exception in adolescents with social anxiety disorder, and the need for further examination of its impact on assessment and differential diagnosis on this psychiatric disorder.

Transvaginal/transrectal ultrasound for assessing myometrial invasion in endometrial cancer: a comparison of six different approaches

Juan Luis Alcazar,Laura Pineda,Txanton Martinez-Astorquiza Corral,Rodrigo Orozco,Jesús Utrilla-Layna,Leire Juez,Matías Jurado 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.3

Objective: To compare the diagnostic performance of six different approaches for assessing myometrial infiltration using ultrasound in women with carcinoma of the corpus uteri. Methods: Myometrial infiltration was assessed by two-dimensional (2D) transvaginal or transrectal ultrasound in 169 consecutive women with well (G1) or moderately (G2) differentiated endometrioid type endometrial carcinoma. In 74 of these women three-dimensional (3D) ultrasound was also performed. Six different techniques for myometrial infiltration assessment were evaluated. The impression of examiner and Karlsson’s criteria were assessed prospectively. Endometrial thickness, tumor/ uterine 3D volume ratio, tumor distance to myometrial serosa (TDS), and van Holsbeke’s subjective model were assessed retrospectively. All subjects underwent surgical staging within 1 week after ultrasound evaluation. Definitive histopathological data regarding myometrial infiltration was used as gold standard. Sensitivity and specificity for all approaches were calculated and compared using McNemar test. Results: The impression of examiner and subjective model performed similarly (sensitivity 79.5% and 80.5%, respectively; specificity 89.6% and 90.3%, respectively). Both methods had significantly better sensitivity than Karlsson's criteria (sensitivity 31.8%, p<0.05) and endometrial thickness (sensitivity 47.7%, p<0.05), and better specificity than tumor/uterine volume ratio (specificity 28.3%, p<0.05) and TDS (specificity 41.5%, p<0.05). Conclusion: Subjective impression seems to be the best approach for assessing myometrial infiltration in G1 or G2 endometrioid type endometrial cancer by transvaginal or transrectal ultrasound. The use of mathematical models and other objective 2D and 3D measurement techniques do not improve diagnostic performance.

Quasi m-Cayley strongly regular graphs

Klavdija Kutnar,Luis Martinez,Aleksander Malnic,Dragan Marusic 대한수학회 2013 대한수학회지 Vol.50 No.6

We introduce a new class of graphs, called quasi m-Cayleygraphs, having good symmetry properties, in the sense that they admita group of automorphisms G that fixes a vertex of the graph and actssemiregularly on the other vertices. We determine when these graphs arestrongly regular, and this leads us to define a new algebro-combinatorialstructure, called quasi-partial difference family, or QPDF for short. Wegive several infinite families and sporadic examples of QPDFs. We alsostudy several properties of QPDFs and determine, under several condi-tions, the form of the parameters of QPDFs when the group G is cyclic.

Volumetric lipoinjection of the fronto-orbital and temporal complex with adipose stem cells for the aesthetic restoration of sequelae of craniosynostosis

Castro-Govea, Yanko,Vela-Martinez, Amin,Trevino-Garcia, Luis Alberto Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.2

Background Non-syndromic craniosynostosis causes craniofacial asymmetry and may persist after cranioplasty. These postoperative asymmetries are primarily depressions. In some cases, patients may be subjected to pranks and harassment by their peers, affecting their psychosocial development. We propose lipoinjection enriched with adipose stem cells (ASCs) to treat the sequelae of craniosynostosis in the fronto-orbital and temporal complex in cranioplasty patients, with the goal of improving the appearance of the upper third of the face. Methods Twelve children (four boys and eight girls) between 4 and 8 years of age (mean age, 6 years) in the postoperative period after treatment for plagiocephaly, brachycephaly, and trigonocephaly were included, with a follow-up period of 1 to 18 months. Fat tissue was obtained from the lower abdomen, and ASCs were isolated using the Yoshimura technique. Lipoinjection was performed using several mini-approaches to ensure adequate distribution. Results Two different scales were used to evaluate the aesthetic outcomes. At 6 months, three plastic surgeons independent of the study classified the results using a Likert scale. The patients' parents categorized the results using a visual analog scale at 6, 9, and 18 months. R esults were favorable on both scales, as the patients' facial appearance improved and they reported increased happiness and self-esteem due to their remodeled facial appearance. Conclusions We suggest that lipoinjection enriched with ASCs is a good alternative for correcting asymmetry of the fronto-orbital and temporal contour in patients with sequelae of craniosynostosis. This treatment will help boost patients' self-esteem starting at an early age.

Antidiabetic and Renal Protective Properties of Berrycactus Fruit (Myrtillocactus geometrizans)

Rosalia Reynoso-Camacho,Paola Martinez-Samayoa,Minerva Ramos-Gomez,Horacio Guzma´n,Luis M. Salgado 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.5

Native plants are exceedingly valuable because they are sources of natural products with applications for the treatment of various diseases. Berrycactus fruit (Myrtillocactus geometrizans) has been consumed in Mexico since ancient times due to its sweetness. The hypoglycemic and antioxidant effects of this fruit were evaluated in streptozotocin-induced diabetic rats by replacing the drinking water with berrycactus juice (2 or 4 g/kg). After 4 weeks of treatment, the diabetic animals showed an improvement in their conditions, as reflected by diminished circulating glucose levels (up to 50%), diminished triglycerides (up to 67%), and diminished total cholesterol (up to 35%) compared with diabetic nontreated controls, and these effects were dose dependent. The dose of 4 g/kg produced the best results. The administration of the juice improved renal function and helped to restore normal levels of glutathione and glutathione S-transferase in the kidney. The expressions of two transcription factors that are relevant to normal functioning of the kidney changed due to the administration of the juice; compared to the diabetic nontreated controls, the level of nuclear factor kappa of B-cells diminished, and the total level of peroxisome proliferator-activated receptor gamma increased. The results of this study highlight the importance of the compounds that are present in berrycactus fruit as adjuvants in the treatment of diabetes and its renal complications.

Prognostic role of genetic biomarkers in clinical progression of prostate cancer

Maria Jesus Alvarez-Cubero,Luis Javier Martinez-Gonzalez,Maria Saiz,Pedro Carmona-Saez,Juan Carlos Alvarez,Manrique Pascual-Geler,Jose Antonio Lorente,Jose Manuel Cozar 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-

The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk patients. A cohort of 451 men (235 patients and 216 controls) was studied. We calculated means of regression analysis using clinical values (stage, prostate-specific antigen, Gleason score and progression) in patients and controls at the basal stage and after a follow-up of 72 months. Significantly different allele frequencies between patients and controls were observed for rs1904577 and rs918 (MSR1 gene) and for rs17552022 and rs5030739 (ELAC2). We found evidence of increased risk for PCa in rs486907 and rs2127565 in variants AA and CC, respectively. In addition, rs627928 (TT–GT), rs486907 (AG) and rs3747531 (CG–CC) were associated with low tumor aggressiveness. Some had a weak linkage, such as rs1904577 and rs2127565, rs4792311 and rs17552022, and rs1904577 and rs918. Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa. In the future, clinical use of these biomarkers, in combination with current ones, could potentially reduce the rate of unnecessary biopsies and specific treatments.

QUASI m-CAYLEY STRONGLY REGULAR GRAPHS

Kutnar, Klavdija,Malnic, Aleksander,Martinez, Luis,Marusic, Dragan Korean Mathematical Society 2013 대한수학회지 Vol.50 No.6

We introduce a new class of graphs, called quasi $m$-Cayley graphs, having good symmetry properties, in the sense that they admit a group of automorphisms G that fixes a vertex of the graph and acts semiregularly on the other vertices. We determine when these graphs are strongly regular, and this leads us to define a new algebro-combinatorial structure, called quasi-partial difference family, or QPDF for short. We give several infinite families and sporadic examples of QPDFs. We also study several properties of QPDFs and determine, under several conditions, the form of the parameters of QPDFs when the group G is cyclic.

HOXA9 is Underexpressed in Cervical Cancer Cells and its Restoration Decreases Proliferation, Migration and Expression of Epithelial-to-Mesenchymal Transition Genes

Alvarado-Ruiz, Liliana,Martinez-Silva, Maria Guadalupe,Torres-Reyes, Luis Alberto,Pina-Sanchez, Patricia,Ortiz-Lazareno, Pablo,Bravo-Cuellar, Alejandro,Aguilar-Lemarroy, Adriana,Jave-Suarez, Luis Feli Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

HOX transcription factors are evolutionarily conserved in many different species and are involved in important cellular processes such as morphogenesis, differentiation, and proliferation. They have also recently been implicated in carcinogenesis, but their precise role in cancer, especially in cervical cancer (CC), remains unclear. In this work, using microarray assays followed by the quantitative polymerase chain reaction (qPCR), we found that the expression of 25 HOX genes was downregulated in CC derived cell lines compared with non-tumorigenic keratinocytes. In particular, the expression of HOXA9 was observed as down-modulated in CC-derived cell lines. The expression of HOXA9 has not been previously reported in CC, or in normal keratinocytes of the cervix. We found that normal CC from women without cervical lesions express HOXA9; in contrast, CC cell lines and samples of biopsies from women with CC showed significantly diminished HOXA9 expression. Furthermore, we found that methylation at the first exon of HOXA9 could play an important role in modulating the expression of this gene. Exogenous restoration of HOXA9 expression in CC cell lines decreased cell proliferation and migration, and induced an epithelial-like phenotype. Interestingly, the silencing of human papilloma virus (HPV) E6 and E7 oncogenes induced expression of HOXA9. In conclusion, controlling HOXA9 expression appears to be a necessary step during CC development. Further studies are needed to delineate the role of HOXA9 during malignant progression and to afford more insights into the relationship between downmodulation of HOXA9 and viral HPV oncoprotein expression during cercical cancer development.

Surgical management with intentional replantation on a tooth with palato-radicular groove

Forero-Lopez, Jorge,Gamboa-Martinez, Luis,Pico-Porras, Laura,Nino-Barrera, Javier Laureano The Korean Academy of Conservative Dentistry 2015 Restorative Dentistry & Endodontics Vol.40 No.2

A palato-radicular groove (PRG) is a developmental anomaly primarily found in the maxillary lateral incisors. It is a potential communication path between the root canal and the periodontium that decreases the survival prognosis of the affected tooth, therefore compromising the stability of the dental structure in the oral cavity. The aim of this case report is to present an original technique where a PRG was treated by means of intracanal disinfection, PRG sealing with glass ionomer, replantation with intentional horizontal 180 degree rotation of the tooth, and an aesthetic veneer placed to provide adequate tooth morphology. The clinical and biological benefits of this novel technique are presented and discussed.

Volumetric lipoinjection of the fronto-orbital and temporal complex with adipose stem cells for the aesthetic restoration of sequelae of craniosynostosis

Yanko Castro-Govea,Amin Vela-Martinez,Luis Alberto Treviño-Garcia 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.2

Background Non-syndromic craniosynostosis causes craniofacial asymmetry and may persist after cranioplasty. These postoperative asymmetries are primarily depressions. In some cases, patients may be subjected to pranks and harassment by their peers, affecting their psychosocial development. We propose lipoinjection enriched with adipose stem cells (ASCs) to treat the sequelae of craniosynostosis in the fronto-orbital and temporal complex in cranioplasty patients, with the goal of improving the appearance of the upper third of the face. Methods Twelve children (four boys and eight girls) between 4 and 8 years of age (mean age, 6 years) in the postoperative period after treatment for plagiocephaly, brachycephaly, and trigonocephaly were included, with a follow-up period of 1 to 18 months. Fat tissue was obtained from the lower abdomen, and ASCs were isolated using the Yoshimura technique. Lipoinjection was performed using several mini-approaches to ensure adequate distribution. Results Two different scales were used to evaluate the aesthetic outcomes. At 6 months, three plastic surgeons independent of the study classified the results using a Likert scale. The patients’ parents categorized the results using a visual analog scale at 6, 9, and 18 months. R esults were favorable on both scales, as the patients’ facial appearance improved and they reported increased happiness and self-esteem due to their remodeled facial appearance. Conclusions We suggest that lipoinjection enriched with ASCs is a good alternative for correcting asymmetry of the fronto-orbital and temporal contour in patients with sequelae of craniosynostosis. This treatment will help boost patients’ self-esteem starting at an early age.