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( Jaime Aherrera ),( Lowe Chiong ),( Paul Reganit ),( Felix Punzalan ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Patients with documented acute coronary syndromes (ACS) exhibit a wide spectrum of early risk of death. An elevated neutrophil count predicts a worse outcome in ACS. In contrast, a low lymphocyte count is related to high risks of adverse outcomes. The neutrophil-lymphocyte ratio (NLR), therefore, integrates for two WBC subtypes with opposite actions in terms of vascular infl ammation. Objectives: Among patients diagnosed with ACS, we aim to determine if an elevated NLR taken within 24 hours of admission is associated with higher rates of adverse outcomes. Methods: A prospective cohort of adult patients admitted with a diagnosis of ACS was conducted. The participants were stratifi ed into two: low to intermediate NLR (NLR < 6.5) and high NLR (NLR > 6.50). Primary outcome was in-hospital mortality. Secondary outcomes include development or worsening of congestive heart failure (CHF) and the development of cardiogenic shock, re-infarction, renal failure, pneumonia, and arrhythmias. Results: 117 patients with a mean age of 60 +/- 13 were included. Diagnosis on admission was unstable angina (28%), NSTEMI (40%), and STEMI (37%). Analysis of data showed that the odds of in-hospital deaths among those with a high NLR is 5.71 times higher compared to those with low-intermediate NLR [OR 5.71 (1.53-21.23, p 0.009)]. Using linear regression, the NLR of patients who were non-survivors was computed at 9.91, while the NLR of those who survived was 5.47. A high NLR was also predictive of the development or worsening of CHF, shock, re-infarction, arrhythmias, and development of any adverse outcome. Conclusion: Among patients with ACS, an elevated NLR (>6.5) taken within 24 hours of presentation is a useful marker to predict in-hospital mortality, development or worsening or CHF, and development of shock, re-infarction, and arrhythmias.
Goodson III, William H.,Lowe, Leroy,Carpenter, David O.,Gilbertson, Michael,Manaf Ali, Abdul,Lopez de Cerain Salsamendi, Adela,Lasfar, Ahmed,Carnero, Amancio,Azqueta, Amaya,Amedei, Amedeo,Charles, Ame Oxford University Press 2015 Carcinogenesis Vol.36 No.suppl1
<P>Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.</P>
Lowe, Tristan,Azough, Feridoon,Freer, Robert The Korean Ceramic Society 2003 한국세라믹학회지 Vol.40 No.4
Ceramics of xCaTiO$_3$-(1-x)Li$_{0.5}$Nd$_{0.5}$TiO$_3$(xCT-(1-x)LNT) series have been prepared by the mixed oxide route. Powders were calcined at 110$0^{\circ}C$ ; cylindrical specimens were fired at temperatures in the range 1300-150$0^{\circ}C$. Sintered products were typically 90-95% dense. The microstructures were dominated by angular grains typically 1.3${\mu}{\textrm}{m}$ to 3.5 ${\mu}{\textrm}{m}$ in size. Twinning in the microstructures was analysed using Electron Back Scattered Diffraction (EBSD). Microwave dielectric properties of xCT-(1-x)LNT at 2.1 GHz ($\varepsilon$$_{r}$, Qxf, and $\tau$r) were 170,3800 GHz and 744 ppm/$^{\circ}C$ for pure CaTiO$_3$ and 80,2000 GHz and -240 ppm/$^{\circ}C$ for LNT. The $\tau$r decreases almost linearly from 744 for pure CaTiO$_3$ to -240 for pure LNT.LNT.T.
Leveraging Digital Learning Platforms for Competitive Advantage in Higher Education
Devesh Lowe,Bhavna Galhotra,Yukti Ahuja 한국디지털융합학회 2020 IJICTDC Vol.5 No.1
Higher education in India was not always confined to a learning process in four walls. Our ancient learning methodology included conversations, debates, life studies, and learning through observations. With the passage of time learning was confined to the study of written texts and prescribed syllabi. Though it has contributed remarkably in the last two centuries towards the establishment of new world order, its relevance is now often questioned due to the pace of technological changes and industries’ expectations from young graduates. In the last decade, there is an evident shift towards Digital Learning platforms as a mandatory part of the standard curriculum and as a source of obtaining extra knowledge with flexibility of choosing subjects and content for learning. Platforms like Coursera, EDX, NPTEL, STP, and Udemy are ready to efficiently fill the gap between standard university curriculum and industry requirement. In this paper, authors have identified and recognized the role of digital learning platforms as a mandatory part of higher education and have studied the impact on young learners. This paper presents an analysis based on the opinions of first-time users of such platforms. Through this study, authors have tried to identify the persisting shortcomings and effectiveness in the current scenario and have also recommended suitable measures to be integrated for the effective utilization of this resource.
Role of Chitosan Nanoparticles in Drug Delivery - A Review
( Baboucarr Lowe ),( Kwan-young Chang ),( Jae-ho Hwang ),( Jayachandran Venkatesan ),( Dong Gyu Kim ),( Se-kwon Kim ) 한국키틴키토산학회 2016 한국키틴키토산학회지 Vol.21 No.4
There have been extensive studies on naturally occurring polymers such as chitosan. Chitosan have been studied as primary carrier of several therapeutic drugs and other biomolecules. The use of chitosan in this area of biomedical research is favored by its biocompatible, biodegradable, hemostatic maintenance, anti-microbial, anticancerogenic, and anticholesteremic properties. The use of chitosan nanoparticles have favored encapsulation of therapeutic anti-tumor drugs producing control and sustained release profiles. In this review we examined the roles chitosan nanoparticles in controlled and sustain release mechanisms and how they are co-conjugated with other materials for enhanced target delivery of drug in cancer cells.
Baboucarr Lowe,남승윤 대한의용생체공학회 2016 Biomedical Engineering Letters (BMEL) Vol.6 No.4
Purpose To develop a robust ECM and enhance cellularmaterialinteraction, we developed a cysteine-based nanocompositecombined with chitosan, nanohydroxyapatite andgelatin (cysteine-CnHAG) to effectuate essential factors. Methods The scaffolds were fabricated under same conditionsusing a freeze-drying technique and characterized with ascanning electron microscopy to study its internal architectureincluding pore distribution. They were further interactedwith human bone marrow derived mesenchymal stem cells(hMSCs) to investigate its biocompatibility. In this, cell viabilityand cell adhesion was assessed using optical microscopy. Results From the results, the scaffolds display a non-toxiceffect with hMSCs and have a pore size range of between12-142 μm. The result of the optical microscopy showedadhesion of the cells on the scaffold matrix of both cysteine-CnHAG and CnHAG, which implies the microenvironmentof the scaffold is largely suitable for the MSC developmentConclusions In conclusion, we believe cysteine-CnHAG canbe a novel nanocomposite for potential applications in thefield of bone tissue engineering.