http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Baboucarr Lowe,남승윤 대한의용생체공학회 2016 Biomedical Engineering Letters (BMEL) Vol.6 No.4
Purpose To develop a robust ECM and enhance cellularmaterialinteraction, we developed a cysteine-based nanocompositecombined with chitosan, nanohydroxyapatite andgelatin (cysteine-CnHAG) to effectuate essential factors. Methods The scaffolds were fabricated under same conditionsusing a freeze-drying technique and characterized with ascanning electron microscopy to study its internal architectureincluding pore distribution. They were further interactedwith human bone marrow derived mesenchymal stem cells(hMSCs) to investigate its biocompatibility. In this, cell viabilityand cell adhesion was assessed using optical microscopy. Results From the results, the scaffolds display a non-toxiceffect with hMSCs and have a pore size range of between12-142 μm. The result of the optical microscopy showedadhesion of the cells on the scaffold matrix of both cysteine-CnHAG and CnHAG, which implies the microenvironmentof the scaffold is largely suitable for the MSC developmentConclusions In conclusion, we believe cysteine-CnHAG canbe a novel nanocomposite for potential applications in thefield of bone tissue engineering.
Role of Chitosan Nanoparticles in Drug Delivery - A Review
( Baboucarr Lowe ),( Kwan-young Chang ),( Jae-ho Hwang ),( Jayachandran Venkatesan ),( Dong Gyu Kim ),( Se-kwon Kim ) 한국키틴키토산학회 2016 한국키틴키토산학회지 Vol.21 No.4
There have been extensive studies on naturally occurring polymers such as chitosan. Chitosan have been studied as primary carrier of several therapeutic drugs and other biomolecules. The use of chitosan in this area of biomedical research is favored by its biocompatible, biodegradable, hemostatic maintenance, anti-microbial, anticancerogenic, and anticholesteremic properties. The use of chitosan nanoparticles have favored encapsulation of therapeutic anti-tumor drugs producing control and sustained release profiles. In this review we examined the roles chitosan nanoparticles in controlled and sustain release mechanisms and how they are co-conjugated with other materials for enhanced target delivery of drug in cancer cells.
Combination of Nano-Hydroxyapatite with Stem Cells for Bone Tissue Engineering
Venkatesan, Jayachandran,Lowe, Baboucarr,Anil, Sukumaran,Kim, Se-Kwon,Shim, Min Suk American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.9
<P>Tissue engineering seeks to exploit functional biomaterials and engineer them to serve as artificial templates that promote the regeneration of tissues and damaged organs. Engineered scaffold materials recapitulate the extracellular matrix and provide cells with information essential for tissue development. Nanotechnologies make use of the material at the nanoscale for targeted interactions at molecular levels and deliver biochemical cues for cell growth required for tissue formation. In bone tissue engineering, nano-hydroxyapatite (nHA), which is a calcium phosphate-based material, is extensively used as a bone defect substitute to mimic the natural bioceramic portion of bone. nHA can be functionalized in the form of composite scaffolds along with other polymers, ceramic, and growth factors to enable bone tissue regeneration. In addition, the material directs stem cell differentiation into specific lineages. This stem cell-based therapy is a prominent approach in organ development and tissue regeneration. Here, we examine nHA interactions with stem cells in the form of designed scaffolds and offer important considerations about the fundamental challenges and prospects for its application in bone tissue engineering.</P>