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Tang, Qi-Ling,Guo, Ji-Quan,Wang, Qi-You,Lin, Hai-Shu,Yang, Zhou-Ping,Peng, Tong,Pan, Xue-Diao,Liu, Bing,Wang, Su-Jun,Zang, Lin-Quan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.
Blind Super-Resolution Image Reconstruction Based on Weighted POCS
Ling Tang 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.5
In the paper a weighted Projection onto to convex sets (POCS) algorithm for image super-resolution reconstruction is proposed, which using POCS scheme to reconstruct image without knowing the degradation model and related parameters. In the proposed algorithm, adaptive block matching is utilized to estimate translational motion among various images firstly, and then APRX algorithm is adopted to estimate the point spread function (PSF) and the ideal high resolution image. Finally based on the traditional POCS algorithm, the paper introduced the prior information about low resolution image definition into POCS to calculate the residual and control the threshold by weighted parameter of image relative definition, and realized the dynamic threshold selection in the whole progress of reconstruction. Results of experiments show that the algorithm in the objective evaluation and visual effects achieves better reconstruction results, which confirm the validity and robustness of the proposed algorithm.
Predictive value of post-operative drain amylase levels for post-operative pancreatic fistula
Tang Ee Ling Serene,Shelat Vishalkumar G,Junnarkar Sameer Padmakumar,Huey Cheong Wei Terence,Low Jee Keem,Wang Bei,Woon Wei Liang Winston 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4
Backgrounds/Aims: Traditionally, surgically placed pancreatic drains are removed, at the discretion of the operating surgeon. Moving towards enhanced recovery after surgery (ERAS), we looked for predictors for early drain removal. The purpose of this paper was to establish which postoperative days’ (POD) drain amylase is most predictive against post-operative pancreatic fistula (POPF). Methods: We conducted a retrospective study of 196 patients who underwent pancreatic resection at our institute from January 2006 to October 2013. Drain amylase levels were routinely measured. The International Study Group of Pancreatic Fistula (ISGPF) definition of POPF, and clinical severity grading were used. Results: 5.1% (10 of 196) patients developed ISGPF Grades B and C POPF. Negative predictive value of developing significant POPF, if drain amylase values were low on PODs 1 and 3 was 98.7% (95% CI: 0.93-1.00). This translated to confidence in removing surgically placed pancreatic drains, at POD 1 and 3 when drain amylase values are low. Conclusions: Patients with low drain amylase values on POD 1 and 3, are unlikely to develop POPF and may have pancreatic drains removed earlier.
Ling Tang,Lihua Kang,Mingyuan Zhu,Guangqin Luo,Bin Dai 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2
By incorporating H3PW12O40 (HPW) heteropolyacid into mesoporous TUD-1 materials, a series of HPWTUD-1 catalysts were synthesized. Nitrogen adsorption–desorption isotherm, XRD and FTIR characterizations showed that these catalyst exhibited mesoporous structure, and HPW presented in the catalysts with Keggin structure. The catalytic performances of the HPW-TUD-1 catalysts were tested through the oxidative desulfurization (ODS) process of dibenzothiophene (DBT) model oil. The results showed that the obtained 20HPW-TUD-1 catalyst displayed excellent catalytic activity and recover ability for ODS. The desulfurization rate of DBT reached up to 98.1%, and almost no catalytic activity loss was observed after three recycles of the catalyst.
Xiao Tang,Kun Tong,Lishan Zhu,Guoqing Fu,Wei Chang,Ting Zhou,Zhibing Zhang,Ling Tong,Ling Zhang,Yuqin Shi,Ling Zhang,Yuqin Shi 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.4
Di-2-ethylhexyl phthalate (DEHP) which belongs to phthalatic-acid esters, is a kind of harmful, global environmental pollutants. It is a known endocrine disrupting chemical and male reproductive toxicant. However, the mechanism by which DEHP exposure result in male reproductive toxicity is still unclear. To elucidate the productive toxicity mechanism of DEHP, we attemptted to investigate oxidative stress, apoptotic effects, mRNA and protein expression of apoptosis-associated genes including FasL, caspase-3, and caspase-8 in GC-2spd (mouse spermatogenic cells). The results showed that, with the increase of DEHP concentration, cell apoptosis rate increased; the activities of relation index of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD) and glutatione peroxidase (GSH-PX) changed significantly; the mRNA and protein expression levels of FasL, caspase-3, -8, altered obviously. These results suggested that DEHP could induce apoptosis of GC-2spd cells through oxidative stress and FasL-dependent pathway.
( Zhi-ling Tang ),( Si-min Li ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.6
The main processes of a cognitive radio system include spectrum sensing, spectrum decision, spectrum sharing, and spectrum conversion. Experimental results show that these stages introduce a time delay that affects the spectrum sensing accuracy, reducing its efficiency. To reduce the time delay, the frequency spectrum prediction was proposed to alleviate the burden on the spectrum sensing. In this paper, the deep recurrent neural network (DRNN) was proposed to predict the spectrum of multiple time slots, since the existing methods only predict the spectrum of one time slot. The continuous state of a channel is divided into a many time slots, forming a time series of the channel state. Since there are more hidden layers in the DRNN than in the RNN, the DRNN has fading memory in its bottom layer as well as in the past input. In addition, the extended Kalman filter was used to train the DRNN, which overcomes the problem of slow convergence and the vanishing gradient of the gradient descent method. The spectrum prediction based on the DRNN was verified with a WiFi signal, and the error of the prediction was analyzed. The simulation results proved that the multiple slot spectrum prediction improved the spectrum efficiency and reduced the energy consumption of spectrum sensing.
Cervical Cancer Mortality Trends in China, 1991-2013, and Predictions for the Future
Du, Pei-Ling,Wu, Ku-Sheng,Fang, Jia-Ying,Zeng, Yang,Xu, Zhen-Xi,Tang, Wen-Rui,Xu, Xiao-Ling,Lin, Kun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: To analyze cervical cancer mortality trends in China from 1991-2013 and forecast the mortality distribution in future five years (2014-2018), and provide clues for prevention and treatment. Materials and Methods: Mortality data for cervical cancer in China from 1991 to 2013 were used to describe the epidemiological characteristics and distribution, including the trend of the standardized mortality rate, urban-rural differences, and age variation. Trend-surface analysis was used to analyze the geographical distribution of mortality. Curve estimation, time series, gray modeling, and joinpoint regression were performed to predict and forecast mortality trends. Results: In recent years, the mortality rate of cervical cancer has increased, and there is also a steady increase in the incidence from 2003 to 2013 in China. Mortality rates in rural areas are higher than in urban areas. The mortality dramatically increases in the 40+ yr age group, reaching a peak in the >85 yr age group. In addition, geographical analysis showed that the cervical cancer mortality increased from the southwest to west-central and from the southeast to northeast of the country. Conclusions: The incidence rate and the mortality rate are increasing from 1991 to 2013, and the predictions show this will continue in the future. Thus, implementation of prevention and management programs for cervical cancer are necessary in China, especially for rural areas, young women in urban areas, and high risk regions (the west-central).
Si-Qi Tang,Ling-Long Tang,Yan-Ping Mao,Wen-Fei Li,Lei Chen,Yuan Zhang,Ying Guo,Qing Liu,Ying Sun,Cheng Xu,Jun Ma 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2
Purpose The occurrence pattern of immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) in cancer treatment remains unclear. Materials and Methods Phase II-III clinical trials that evaluated ICI-based treatments in cancer and were published between January 2007 and December 2019 were retrieved from public electronic databases. The pooled median time to onset (PMT-O), resolution (PMT-R), and immune-modulation resolution (PMT-IMR) of irAEs were generated using the metamedian package of R software.Results Twenty-two eligible studies involving 23 clinical trials and 8,436 patients were included. The PMT-O of all-grade irAEs ranged from 2.2 to 14.8 weeks, with the longest in renal events. The PMT-O of grade ≥ 3 irAEs was significantly longer than that of all-grade irAEs induced by programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1) inhibitors (27.5 weeks vs. 8.4 weeks, p < 0.001) and treatment of nivolumab (NIV) plus ipilimumab (IPI) (7.9 weeks vs. 6.0 weeks, p < 0.001). The PMT-R of all-grade irAEs ranged from 0.1 to 54.3 weeks, with the shortest and longest in hypersensitivity/infusion reaction and endocrine events, respectively. The PMT-IMR of grade ≥ 3 irAEs was significantly shorter than that of all-grade irAEs caused by PD-1/PD-L1 blockade (6.9 weeks vs. 40.6 weeks, p=0.002) and NIV+IPI treatment (3.1 weeks vs. 5.9 weeks, p=0.031).Conclusion This study revealed the general and specific occurrence pattern of ICI-induced irAEs in pan-cancers, which was deemed to aid the comprehensive understanding, timely detection, and effective management of ICI-induced irAEs.
Isolation and Expression Analysis of a GDSL-like Lipase Gene from Brassica napus L.
Ling, Hua,Zhao, Jingya,Zuo, Kaijing,Qiu, Chengxiang,Yao, Hongyan,Qin, Jie,Sun, Xiaofen,Tang, Kexuan Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.3
As lipolytic enzymes, GDSL lipases play an important role in plant growth and development. In order to identify their functions and roles, the full-length cDNA of a GDSL lipase gene, designated BnLIP2, was isolated from Brassica napus L. BnLIP2 was 1,300 bp long, with 1,122 bp open reading frame (ORF) encoding 373 amino acid residues. Sequence analysis indicated that BnLIP2 belonged to GDSL family. Southern blot analysis indicated that BnLIP2 belonged to a small gene family in rapeseed genome. RT-PCR analysis revealed that BnLIP2 was a tissue-specific expressing gene during reproductive growth and strongly expressed during seed germination. BnLIP2 expression could not be detected until three days after germination, and it subsequently became stronger. The transcript of this gene was deficient in root of seedlings growing at different stages. When juvenile seedlings were treated by methyl jasmonate (MeJ), salicylic acid (SA) and naphthalene acetic acid (NAA), BnLIP2 expression could not be induced in root. Our study implicates that BnLIP2 probably plays an important role in rapeseed germination, morphogenesis, flowering, but independent of root growth and development.