Relationship between Subjective Body Perception and Self-Esteem in Senior Citizen Center Elders

Lina Lee,Jiyoung Kim,Ju Ah Park,Jong-Im Kim 한국간호과학회 2019 한국간호과학회 학술대회 Vol.2019 No.10

Information at the Wave of Your Hand

Lina Lee,Yousra Javed,Steven Danilowicz,Mary Lou Maher 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.12

Many universities are placing large screen displays in public locations to provide information about their academic programs and events. Typically, these displays are not interactive and the person viewing the information can only see a small subset as (s)he passes by. We present a gesture-based interactive system that can be used for any public information system when the information can be represented by entities and relations. In our demonstration system we have defined entities and relations among classes, professors, research topics, organizations, and events both within a department at a university. This Gesture Interactive Information System is a “Walk-Up-And-Use” interface that utilizes gesture recognition via Microsoft Kinect, and is designed so that multiple users may interact with the system. To provide clarity and visual hierarchy, information is displayed in clusters of circles with different sizes and color to differentiate between the various information types. This information can be arranged by type or discipline in order to provide users with multiple ways to explore the relationships between the various entities in the information system. Our user evaluation studies show that the system was able to attract the passers-by attention and engage them. The mean rating for system’s design consistency, content engagement, and ease of navigation was significantly higher than other usability aspects.

The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death.

Ren, Lina,Yang, Hee-Young,Choi, Hoon-In,Chung, Kyoung-Jin,Yang, Ung,Lee, Il-Kwon,Kim, Hyeoung-Joon,Lee, Dong-Seok,Park, Byung-Ju,Lee, Tae-Hoon Pergamon Press 2011 Oncology Research Vol.19 No.8

<P>(-)-Epigallocatechin 3-gallate (EGCG) is a potent antioxidant polyphenol in green tea that acts as an anticancer agent via both direct and indirect pathways. Although the relationship between EGCG's anticancer effects and its antioxidant activity is not fully understood, it is known that EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. In IM9 multiple myeloma cells, EGCG acted in a dose- and time-dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin V (PrdxV) were selectively and significantly reduced by EGCG. Moreover, the ROS scavenger NAC completely inhibited EGCG-induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a Prdx(VC48S) mutant, protected IM9 cells from EGCG-induced apoptosis. EGCG-induced reductions in cell viability and PrdxV levels were also observed in primary CD138+ multiple myeloma cells from patients. These results suggest that PrdxV is a key target via which EGCG mediates its anticancer effects.</P>

Role of Amino Acid Residues within the Disulfide Loop of Thanatin , a Potent Antibiotic Peptide

(Myung Kyu Lee),(Lina Cha),(Si Hyung Lee),(Kyung Soo Hahm) 생화학분자생물학회 2002 BMB Reports Vol.35 No.3

Thanatin, a 21-residue peptide, is an inducible insect peptide with a broad range of activity against bacteria and fungi. It has a C-terminal disulfide loop, like the frog skin secretion antimicrobial peptides of the brevinin family. In this study, we tried to find the effect of a number of amino acids between the disulfide bond. Thanatin showed stronger antibacterial activity to Gram negative bacteria than other mutants, except Th1; whereas, the mutant peptides with deletion had higher activity to Gram positive bacteria than thanatin. An increase in the number of amino acid(s) using the alanine residue decreased the antibacterial activity in all of the bacteria. Th1 with deletion of threonine at position 15 (Thr15) showed similar antibacterial activity against Gram-negative bacteria, but had higher activity against the Gram positive bacteria. In order to study the structure-function relationship, we measured liposome disruption by the peptides and CD spectra of the peptides. Th1 also showed the highest liposome leaking activity and α-helical propensity in the sodium dodecyl sulfate solution, compared with other peptides. Liposome disruption activity was closely correlated with the anti-Gram positive bacterial activity. All of the peptides showed no hemolytic activity. Th1 was considered to be useful as an antimicrobial peptide with broad spectrum without toxicity.

Necroptosis Is a Mechanism of Death in Mouse Induced Hepatocyte-Like Cells Reprogrammed from Mouse Embryonic Fibroblasts

Lee, Yun-Suk,Park, Kyung-Mee,Yu, Lina,Kwak, Ho-Hyun,Na, Hee-Jun,Kang, Kyung-Sun,Woo, Heung-Myong Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.7

Liver transplantation is recommended for patients with liver failure, but liver donors are limited. This necessitates the development of artificial livers, and hepatocytes are necessary to develop such artificial livers. Although induced hepatocyte-like cells are used in artificial livers, the characteristics of mouse induced hepatocyte-like cells (miHeps) reprogrammed with embryonic fibroblasts have not yet been clarified. Therefore, this study investigated the mechanisms underlying the survival, function, and death of miHeps. miHeps showed decreased cell viability, increased cytotoxicity, decreased hepatic function, and albumin and urea secretion at passage 14. Addition of necrostatin-1 (NEC-1) to miHeps inhibited necrosome formation and reactive oxygen species generation and increased cell survival. However, NEC-1 did not affect the hepatic function of miHeps. These results provide a basis for development of artificial livers using hepatocytes.

오호츠크해고기압의 출현일과 강도의 변동에 관한 연구 : 한반도에 영향을 미친 날을 중심으로

조리나(Lina Cho),이승호(Seungho Lee) 대한지리학회 2011 대한지리학회지 Vol.46 No.1

본 연구에서는 오호츠크해고기압이 한반도에 영향을 미치는 날과 강도의 변화를 규명하고자 하였다. 지상 일기도와 기상자료, 재분석자료 등을 분석하여 다음과 같은 결과를 얻었다. 4월의 주변 육지기온이 높은 해일수록 오호츠크해고기압의 첫 출현일이 일러지는 경향이다. 최근 오호츠크해고기압의 출현일수는 감소하였으며, 그 강도는 6월 해수면온도와 주변 육지기온의 차이가 클수록 강해지는 경향이다. 4 · 5월, 6월, 7월의 오호츠크해고기압 출현일수는 주변 육지기온이 상승할수록 증가하며, 해수면온도와 주변 육지기온의 차이가 커질수록 강도가 강해진다. 오호츠크해고기압의 첫 출현일이 일러짐에 따라 4월과 5월의 오호츠크해고기압 출현일수는 증가하고 강도는 약해질 수 있다. 그러나 6월에는 반대의 경향이 나타날 수 있다. This paper aims to investigate the frequency and intensity variations of Okhotsk high pressure system focused on the Korean Peninsula. Weather chart (00UTC), daily weather data and reanalysis data were used. The first occurrence date of Okhotsk high pressure system tends to be earlier in those years that surrounding land air temperature in April is high. The frequency of Okhotsk high has recently decreased, and its intensity tends to be stronger when the difference between sea surface temperature and surrounding land air temperature is big. The frequency of Okhotsk high in April, May, June and July increases when surrounding land air temperature is high, and its intensity grows when the difference between surrounding land air temperature and sea surface temperature is big. The frequency of Okhotsk high may increase and its intensity may increase when the first occurrence date comes earlier. In june, however, the reverse may apply.

SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner

Jia, Lina,Lee, Hun Seok,Wu, Chun Fu,Kundu, Juthika,Park, Sang Gyu,Kim, Ryong Nam,Wang, Li-Hui,Erkin, Ö,zgü,r Cem,Choi, Jong-Sun,Chae, Seoung Wan,Yang, Ho Bin,Choi, Yoon-La,Shin, Young Kee American Association for Cancer Research 2014 Molecular Cancer Research Vol.12 No.12

<P>SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin through the inhibition of GSK-3β. Here, SMAD4 modulated AURKA in a TGFβ-independent manner. Overexpression of SMAD4 significantly suppressed AURKA function, including colony formation, migration, and invasion of cell lines. In addition, SMAD4 bound to AURKA induced degradation of AURKA by the proteasome. A luciferase activity assay revealed that the transcriptional activity of the β-catenin/TCF complex was elevated by AURKA, but decreased by SMAD4 overexpression. Moreover, target gene analysis showed that SMAD4 abrogated the AURKA-mediated increase of β-catenin target genes. However, this inhibitory effect of SMAD4 was abolished by overexpression of AURKA or silencing of AURKA in SMAD4-overexpressed cells. Meanwhile, the SMAD4-mediated repression of AURKA and β-catenin was independent of TGFβ signaling because blockage of TGFβR1 or restoration of TGFβ signaling did not prevent suppression of AURKA and β-catenin signaling by SMAD4. These results indicate that the tumor-suppressive function of SMAD4 is mediated by downregulation of β-catenin transcriptional activity via AURKA degradation in a TGFβ-independent manner.</P><P><B>Implications:</B> SMAD4 interacts with AURKA and antagonizes its tumor-promoting potential, thus demonstrating a novel mechanism of tumor suppression. <I>Mol Cancer Res; 12(12); 1779–95. ©2014 AACR</I>.</P>

Carboxylic acid functionalized imidazolium-based ionic liquids: efficient catalysts for cycloaddition of CO2 and epoxides

Han, Lina,Choi, Soo-Jin,Park, Moon-Seok,Lee, Seon-Myong,Kim, Yu-Jin,Kim, Moon-Il,Liu, Binyuan,Park, Dae-Won Springer-Verlag 2012 Reaction kinetics, mechanisms and catalysis Vol.106 No.1

LoRa 기술 분석

이리나(Lina Yi),이가람(Garam Lee),김호원(Howon Kim) 한국통신학회 2017 한국통신학회 학술대회논문집 Vol.2017 No.6

Regulatory Factors in Shaping New Towns of Malaysia

이리나,주서령,Lee, Lina,Ju, Seo Ryeung The Korean Housing Association 2014 한국주거학회 논문집 Vol.25 No.4

The post-war period has witnessed the emergence of new towns in a number of countries in Southeast Asia. New town development started in Malaysia with Petaling Jaya as a satellite town in 1953 to accommodate the rapid growing population of Kuala Lumpur. New towns have been designed in accordance with the British town planning principles, based on the modern ideal city. Nonetheless, they have constituted a regional character as they have incorporated local factors such as local technologies as well as site and climatic conditions. In the shaping of the new towns in modern cities, regulatory aspects have played important roles. The regulations decide the basic framework for planning of new town, block plan and unit plan. The ultimate goal of this study is to understand the identity of the new town planning of Malaysia. As a first step, we reviewed the local regulations, standards, and design guidelines which are applicable to the new town planning from the national land use to local plans. As a result, we categorized the guidelines into four areas: urban space, site plan, street system, block plan and unit plan. We expect this study to provide the framework of the Malaysia's new town planning from the perspective of the local regulations.