Implication of hydrolysis on vanadium precipitation with acidic ammonium salt from high concentration of alkaline vanadium solution

Jiang Lin,He Wenyi,Du Guangchao,Zheng Hao,Peng Yi 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.10

Vanadium precipitation with acidic ammonium salt is widely applied in industrial practice of vanadium pentoxide production. However, the ammonia wastewater produced in the precipitation process and resultant environmental issues have been paid increasing attention. With the intention of reducing wastewater and extra cost, an enhancement in the vanadium content of basic qualified solution is the most directly effective method. Unfortunately, high vanadium concentration brings about a low precipitation rate and a high Na content in ammonium polyvanadate, as a result of hydrolysis existence in the precipitation process. The effect of hydrolytic vanadium reaction on acidic ammonium salt precipitation has rarely been reported. Therefore, the whole precipitation process, including the effect of pH value, reaction temperature and vanadium concentration on precipitation result were clarified by analyzing the thermodynamic form of vanadate radicals in this work. Simultaneously, a study on technological parameters was inquired based on the theoretical analysis. The phase composition and crystal morphology of precipitates were also inspected using XRD and SEM-EDS. The results show the negative reaction of vanadium hydrolysis cannot be eliminated in the process of vanadium precipitation with acidic ammonia salt. When vanadium content is higher than 35g/L, Na in APV is easy to exceed 0.6%. Na mainly precipitates in V2O5·H2O in the formation of amorphous body or chemical absorption. The results in this work provide a fundamental guide for the application of high concentration vanadium precipitation technology.

Galactosylated Chitosan-g-PEI/DNA Complexes-loaded Poly(organophosphazene) Hydrogel as a Hepatocyte Targeting Gene Delivery System

Jiang, Hu-Lin,Kim, You-Kyoung,Lee, Sun-Mi,Park, Mi-Ran,Kim, Eun-Mi,Jin, Yong-Mei,Arote, Rohidas,Jeong, Hwan-Jeong,Song, Soo-Chang,Cho, Myung-Haing,Cho, Chong-Su 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4

Hydrogels are widely used in drug delivery systems because they can control the release and thereby enhance the efficiency of locally delivered bioactive molecules such as therapeutic drugs, proteins, or genes. For gene delivery, localized release of plasmid DNA or polymer/DNA complexes can transfect cells and produce sustained protein production. We tested the galactosylated chitosan-graft-polyethylenimine (GC-g-PEI)/DNA complexes-loaded poly(organophosphazene) thermosensitive biodegradable hydrogel as a hepatocyte targeting gene delivery system. The poly(organophosphazene) hydrogel loaded with GC-g-PEI/DNA complexes showed low cytotoxicity and higher transfection efficiency than PEI/DNA complexes, as well as good hepatocyte specificity in vitro and in vivo. Our results indicate that poly(organophosphazene) hydrogels loaded with GC-g-PEI/DNA complexes may be a safe and efficient hepatocyte targeting gene delivery system.

A Voronoi path planning extracted from improved skeleton for dynamic environments

Lin Jiang,Jun Li,Yuxin Hu,Feng Pan,Jianyang Zhu,Bin Lei,Rui Lin 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4

Aiming at the problems that the robot being in the process of navigation cannot meet the requirements of real-time and accuracy at the same time, moreover is too close to obstacles and lacks the initiative to avoid obstacles, a Voronoi diagram algorithm for improved skeleton extraction suitable for dynamic environment is proposed. On the one hand, firstly the grid map is preprocessed by binarization, corrosion and expansion, so the reduced skeleton map suitable for navigation is obtained, then the reduced skeleton map is extracted for searching the global path, finally the improved cubic spline smoothing algorithm is used to optimize the global path each planned, thus overcoming the defects of bloated and tortuous in the path obtaining by original Voronoi diagram algorithm. On the other hand, the position information of all obstacles is obtained by a single scan lidar. Firstly, segmenting and linearly fitting all laser point clouds to remove the known obstacles in the map. Then to mark new possible dynamic obstacles with circles of appropriate size. Secondly detecting dynamic obstacles by the alteration of their center coordinates, moreover, solving their motion equations. Finally expanding the cost map along the speed direction of dynamic obstacles and combining DWA dynamic window method to realize dynamic obstacle avoidance. Compared with the original DWA algorithm, it can predict the motion state of dynamic obstacles in advance, which improves the safety of the robot in the dynamic environment. Moreover, the effectiveness of the algorithm is verified by many simulation experiments and real environment experiments.

Impact of Dissection after Drug-Coated Balloon Treatment of De Novo Coronary Lesions: Angiographic and Clinical Outcomes

Lin Hui,신은석,전은정,백영준,Scot Garg,김태현,손창배,최병주,Liu Kun,Song Lin Yuan,Wang Zhi,Jiang Hao,Shi Zhentao,Tang Qiang 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.12

Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with ahigh risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections andsubsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novocoronary lesions. Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) followingDCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vesselfailure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vesselthrombosis). Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differencesin LLL (90.8%) returning for angiography at 6 months (0.05±0.19 mm in non-dissection and 0.05±0.30 mm in dissection group, p=0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariateanalysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completelyhealed, and there was no newly developed dissection at 6-month angiography. Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associatedwith an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).

Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma

Lin Lin,Jinquan Cai,Zixiao Tan,Xiangqi Meng,Ruiyan Li,Yang Li,Chuanlu Jiang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2

Purpose Isocitrate dehydrogenase 1 (IDH1) mutations are the most common genetic abnormalities in low-grade gliomas and secondary glioblastomas. Glioma patients with these mutations had better clinical outcomes. However, the effect of IDH1 mutation on drug sensitivity is still under debate. Materials and MethodsIDH1-R132H mutant cells were established by lentivirus. IDH1-R132H protein expression was confirmed by western blot. The expression of ataxia telangiectasia mutated (ATM) signaling pathway and apoptosis-related proteins were detected by immunofluorescence and western blot. Temozolomide (TMZ) induced cell apoptosis was detected by flow cytometry. Tumor cell proliferation was detected by Cell Counting Kit-8. In vivo nude mice were used to confirm the in vitro roles of IDH1 mutation.ResultsWe established glioma cell lines that expressed IDH1-R132H mutation stably. We found that TMZ inhibited glioma cells proliferation more significantly in IDH1 mutant cells compared to wild type. The IC50 of TMZ in IDH1-R132H mutant group was less than half that of wild-type group (p < 0.01). TMZ significantly induced more DNA damage (quantification of γH2AX expression in IDH1 mutation vs. wild type, p < 0.05) and apoptosis (quantification of AnnexinV+propidium iodide–cells in IDH1 mutation versus wild type, p < 0.01) in IDH1 mutant gliomas compared to wild-type gliomas. The ATM-associated DNA repair signal was impaired in IDH1 mutant cells. Inhibiting the ATM/checkpoint kinase 2DNA repair pathway further sensitized IDH1 mutant glioma cells to chemotherapy. We found that IDH1 mutation significantly inhibited tumor growth in vivo (the tumor size was analyzed statistically, p < 0.05). Moreover, we confirmed that gliomas with IDH1 mutation were more sensitive to TMZ in vivo compared to wild type significantly and the results were consistent with the in vitro experiment. ConclusionThese results provide evidence that combination of TMZ and ATM inhibitor enhances the antitumor effect in IDH1 mutant gliomas.

Different fates of oocytes with DNA double-strand breaks in vitro and in vivo

Lin, Fei,Ma, Xue-Shan,Wang, Zhen-Bo,Wang, Zhong-Wei,Luo, Yi-Bo,Huang, Lin,Jiang, Zong-Zhe,Hu, Meng-Wen,Schatten, Heide,Sun, Qing-Yuan Taylor Francis 2014 Cell Cycle Vol.13 No.17

ANALYSIS OF SOME PROJECTION METHODS FOR THE INCOMPRESSIBLE FLUIDS WITH MICROSTRUCTURE

Jiang, Yao-Lin,Yang, Yun-Bo Korean Mathematical Society 2018 대한수학회지 Vol.55 No.2

In this article, some projection methods (or fractional-step methods) are proposed and analyzed for the micropolar Navier-Stokes equations (MNSE). These methods allow us to decouple the MNSE system into two sub-problems at each timestep, one is the linear and angular velocities system, the other is the pressure system. Both first-order and second-order projection methods are considered. For the classical first-order projection scheme, the stability and error estimates for the linear and angular velocities and the pressure are established rigorously. In addition, a modified first-order projection scheme which leads to some improved error estimates is also proposed and analyzed. We also present the second-order projection method which is unconditionally stable. Ample numerical experiments are performed to confirm the theoretical predictions and demonstrate the efficiency of the methods.

A Practical Stability Control Strategy for DC/DC Converters

Lin Jiang,Po Li 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3

This paper aims at designing an intelligent controller, based on control Lyapunov Function strategy integrated with fabricating discrete model of Buck and Boost converters and analyzing energy changes during the DC/DC progress to realize tracing reference current on Buck and Boost converters. In addition, practical stability phenomenon research and transient performance analysis has been proposed to give an insight to the influence of controller parameters in achieving an enhanced output performance and how the time of sample period affect the error of practical stability will be illustrated. The novelty of this controller in comparison to other schemes lies in the improved performance of practical stability.

Effects of Soy Isoflavone on Performance, Meat Quality and Antioxidative Property of Male Broilers Fed Oxidized Fish Oil

Jiang, S.Q.,Jiang, Z.Y.,Lin, Y.C.,Xi, P.B.,Ma, X.Y. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.8

This study was conducted to determine the effect of dietary soy isoflavone (ISF, 0 and 20 mg/kg) on performance, meat quality and antioxidative property in male broilers. Six replicates of 45 birds (42 d old) were used for each treatment. The birds were fed soybean meal-free diets containing 3% oxidized fish oil (acid value, 6.76 mg potassium hydroxide/g; and peroxide value, 6.18 meq/kg) for 3 wk. The results showed that average daily gain, feed intake, feed conversion and carcass traits were not affected by soy ISF. Compared with the control group, breast muscle color redness value and water holding capacity were increased (p<0.05) by ISF supplementation. The activity of plasma catalase was increased by supplementing with 20 mg ISF/kg diet. In breast muscle, Broilers fed 20 mg ISF/kg had decreased production of malondialdehyde and lactic acid. The ISF supplementation elevated total antioxidative capacity and activities of total superoxide dismutase and glutathione peroxidase. The results indicated that dietary ISF could increase redness and water holding capacity of meat, and antioxidative property of meat in male broilers fed oxidized fish oil diet.

Lightweight object detection network model suitable for indoor mobile robots

Lin Jiang,Wenkang Nie,Jianyang Zhu,Xumin Gao,Bin Lei 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2

This work proposes a lightweight object detection network model ShuffleNetSSD (S-SSD) to solve the problem of single shot multibox detector (SSD) network model where it cannot meet the real-time performance requirement in the task of object detection and recognition of indoor mobile robot. This model is suitable for indoor mobile robot by improving the SSD network model based on ShuffleNet network. The main idea of the improvement is that SSSD replaces VGG-16 network as the basic feature extraction network of SSD network model with ShuffleNet network. The proposed model is based on the design of deep separable convolution, point-by-point grouping convolution, and channel rearrangement. It retains the design idea of multiscale feature graph detection of SSD network model. This model ensures a slight decline in detection accuracy while greatly reduces the amount of computation generated by the network operation, thereby greatly improving the detection rate. A data set for the task of object detection and recognition of indoor mobile robot is made. The S-SSD lightweight network model is superior to the original SSD network model and tiny-YOLO lightweight network model in terms of detection accuracy and detection rate, and can simultaneously meet the requirement of detection accuracy and real-time performance in the task of indoor object detection and recognition of mobile robot. These findings are verified through the comparative experiments of object detection accuracy and detection rate and real-time object detection and recognition of mobile robot under the actual indoor scene.