Dermoscopy for the Diagnosis of Creeping Hair Caused by Ingrowing Hair: A Case Report

Lijuan Xu,Xinhai Liu,Wei Zhu,Lingling Zheng 대한피부과학회 2023 Annals of Dermatology Vol.35 No.-

Creeping hair is a rare condition characterized by creeping eruption with a black line at the advancing end, mimicking cutaneous larva migrans. The condition is also referred to as cuta- neous pili migrans, migrating hair, and embedded hair. A total of 52 cases have been reported since 1957 and most cases were published in English. Herein, we report a case in which creep- ing hair occurred in the iliac region and review the literature from 1957 to February 2021. A 35-year-old Chinese female presented with a black moving linear eruption that had migrated from the lower abdomen to the iliac region without causing any symptoms during a 3-year period. Cutaneous examination showed a 6.5-cm-long black linear lesion beneath the skin that was revealed to be a hair shaft. After removal of the hair, the eruption diminished and no re- currence occurred in 3 months of follow-up. The creeping hair that had migrated with its lower end forward was confirmed by observation under dematoscopy and light microscopy. A review of the literature revealed that creeping hair occurs most frequently in young and middle-aged patients and the reported cases are mainly from Asia. The top locations involve the foot. The causative hair includes head hair, beard, pubic hair, body hair, and one case of dog hair. A close- up examination and dermoscopic inspection are helpful for the diagnosis of creeping hair.

성별에 따른 심혈관질환자의 건강행위에 미치는 요인

수리주안(Lijuan Xu),유승미(Seungmi Ryu),궁화수(Hwasoo Goong) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.3

본 연구는 심혈관질환자의 건강행위를 개선할 수 있는 프로그램을 개발하기 위하여 성별차이를 중심으로 건강행위에 미치는 요인의 차이를 파악하기 위하여 수행된 연구로, 경기도와 충남 소재 2개 대학병원에 내원한 심혈관질환자 228명(남자 114명, 여자114명)을 대상으로 하였다. 자료수집을 위한 설문조사는 2013년 1월부터 2013년 2월까지 실시하였으며 수집된 자료는 SPSS 20.0으로 분석하였다. 연구결과 심혈관질환자 남성과 여성사이의 건강행위이행의 유의한 차이가 있었다. 여성이 건강행위 중 운동습관, 스트레스관리, 금연행위에서 남성보다 건강행위를 더 잘하는 것으로 나타났다. 남성과 여성사이의 건강행위의 예측인자는 남성은 연령, 자기효능감, 의료인 지지, 지각된 장애성, 지각된 민감성, 자율적 동기로 45 %를 차지하였고 여성은 연령, 자율적 동기, 자기효능감, 의료인지지로 51%를 차지하였다. 특히 가장 설명력이 높은 변수는 남성은 자기효능감, 여성은 자율적 동기이었다. 따라서 남성과 여성사이의 건강행위의 예측인자가 유의하게 차이가 있는 본 연구결과를 반영하여 심혈관질환자의 지속적인 건강행위이행을 위하여 간호중재 시 성별 특성에 따른 차별화된 방안이 고려되어야 될 것이다. Purpose: The purpose of the study was to investigate the difference of health behavior modification between male and female patients with cardiovascular disease; and to compare the predictors of health behavior between the male and female subjects. Methods: A comparative study design was used in the study. A total of 228 patients(male 114, female 114) with cardiovascular disease were recruited from outpatients clinics in 2 university hospitals in Korea. Data were analyzed using t-test, X², ANOVA, ANCOVA, Pearson correlation, and multiple regression with SPSS 20.0. Results: There was significant difference of health behavior between male and female patients with cardiovascular disease (F=9.45, p=0.002). The significant predictors of health behavior among male subjects were self-efficacy, perceived barriers, perceived susceptibility, medical support and autonomous motivation, accounting for 45%; the significant predictors of health behavior among female subjects were self-efficacy, medical support and autonomous motivation, accounting for 51%. Conclusions: It is suggested to take different health promotions strategies to maintain the performance of health behaviors among male and female patients with cardiovascular diseases.

One-Step Solvothermal Synthesis of Tetranitro-Cobalt Phthalocyanine/Reduced Graphene Oxide Composite

Lijuan Zhang,Hejun Li,QIANGANG FU,Zhanwei Xu,Kezhi Li,Jianfeng Wei 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.3

Tetranitro-cobalt phthalocyanine/reduced graphene oxide (TNCoPc/RGO) composite was prepared using ethylene glycol as reducing agent and precursor. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the composite. The electrochemical performance of the composite was examined by cyclic voltammetry and rotating disk electrode. The SEM observation and UV-Vis absorption spectrophotometer reveal that TNCoPc nanoparticles are closely contacted with RGO. The results show that the composite has a larger peak current and a higher current density than TNCoPc for oxygen reduction in an alkaline medium. This work offers a simple and environmental route for the synthesis of metal phthalocyanine (MPc)/RGO, which is adaptable to a wide range of applications in fuel cells.

Screening a Panel of Acid-producing Strains by Developing a High-throughput Method

Lijuan Zhu,Hui Zhang,Shiyuan Wang,Anqi Zhao,Lingbo Qu,Wenlong Xiong,Md. Asraful Alam,Wenlong Ma,Yongkun Lv,Jingliang Xu 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.5

Organic acids are natural cellular metabolites, which are widely used in food, pharmaceutical, and chemical industries. Among them, L-lactic acid is of special interest, because it is widely used in food and pharmaceutical industries and its monopolymer (poly (lactic acid)) is a green, renewable, biodegradable, and biocompatible alternative to the petroleum-based polymers. Currently, organic acids are predominantly produced by microbial fermentation. Their productions have been substantially improved by genetic modifications, metabolic engineering, and fermentation optimizations. However, the commonly used microbial producers still suffer from low acidic tolerance. Screening higher tolerant acid-producing microorganisms from the nature is relatively less explored. The traditional fermented foods are good resources for the screening of acid-producing and probiotic microorganisms. However, they are relatively less explored, especially those foods in developing countries. To speed up the acid-producing microorganism screening, we developed and validated a high-throughput method in this study. By using this method, we screened 1,296 colonies in 4 days and obtained a panel of acid-producing microorganisms. Among them, a Lacticaseibacillus rhamnosus showed the potential for organic acid production and probiotics applications.

大学生在线学习效果的多维度比较研究

Lijuan Huang,Xiaoyan Xu Institute of Management Research 2023 Journal of East Asia Management Vol.4 No.2

Online and offline mixed teaching mode has become an important way to promote the connotative development of higher education. Under the background that offline teaching has become mature, in order to further promote the development of online education, and promote the implementation of the mixed teaching mode, to mix and to provide basis for the construction of the mixed teaching mode, this study takes the online learning effect as the evaluation basis, adopts the online questionnaire survey to conduct statistical analysis of the online learning behavior of 2213 college students, and discusses the differentiation phenomenon of online learning groups from the micro, meso and macro perspectives. It is found that there are significant differences in the online learning effect of college students in terms of the type of learning platform, whether the school implements the online offline mixed teaching mode, education background, grade (bachelor's degree), and region. Colleges and universities should strengthen the promotion of online and offline mixed teaching mode; The online learning platform should improve the platform function and strengthen the functional differentiation design of learning resources for students. Education departments pay attention to the learning effect of online learners in different regions, and bridge the gap in regional education.

Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway

Du Lijuan,Xu Changyi,Tang Kun,Shi Jia,Tang Lu,Lisha Xiao,Lei Chengcheng,Liu Huicong,Liang Yuxia,Guo Yubiao 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.3

Purpose: Epithelial cystatin SN (CST1), a type 2 cysteine protease inhibitor, was significantly upregulated in asthma. In this study, we aimed to investigate the potential role and mechanism of CST1 in eosinophilic inflammation in asthma. Methods: Bioinformatics analysis on Gene Expression Omnibus datasets were used to explore the expression of CST1 in asthma. Sputum samples were collected from 76 asthmatics and 22 control subjects. CST1 mRNA and protein expression in the induced sputum were measured by real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and western blotting. The possible function of CST1 was explored in ovalbumin (OVA)-induced eosinophilic asthma. Transcriptome sequencing (RNA-seq) was used to predict the possible regulated mechanism of CST1 in bronchial epithelial cells. Overexpression or knockdown of CST1 was further used to verify potential mechanisms in bronchial epithelial cells. Results: CST1 expression was significantly increased in the epithelial cells and induced sputum of asthma. Increased CST1 was significantly associated with eosinophilic indicators and T helper cytokines. CST1 aggravated airway eosinophilic inflammation in the OVA-induced asthma model. In addition, overexpression of CST1 significantly enhanced the phosphorylation of AKT and the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2), while knockdown using anti-CST1 siRNA reversed the trend. Furthermore, AKT had a positive effect on SERPINB2 expression. Conclusions: Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.

Astragalus Polysaccharides Attenuate Ovalbumin-Induced Allergic Rhinitis in Rats by Inhibiting NLRP3 Inflammasome Activation and NOD2-Mediated NF-κB Activation

Jiangtao Xu,Qiong Zhang,Zhaoxin Li,Yuhang Gao,Zhiyu Pang,Yina Wu,Geng Li,Dongyong Lu,Lijuan Zhang,Detang Li 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1

Allergic rhinitis (AR) is an IgE-mediated chronic inflammatory disease of the allergic nasal mucosa. It has a significant effect on quality life; most patients with AR also suffer from sleep disorders, mood disorders, and deterioration in social relationships. As increasing numbers of medicinal plants show productive anti-inflammatory activity against inflammatory diseases, there is growing interest in natural medicinal plant ingredients. To this end, we selected Astragalus polysaccharides (APS) to evaluate its anti-inflammatory effect on ovalbumin-induced AR rats, and we further explored its impact on NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. We found that APS can alleviate the nasal symptom of AR rats and attenuate pathological alterations. APS also reduced the inflammatory cytokine levels. APS not only inhibited the NLRP3 inflammasome activation but also inhibited NF-κB activation by decreasing NOD2 expression and blocking the phosphorylation of NF-κB (p65). In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. These findings indicate that APS has the potential to be used as a therapeutic agent for AR.

The Secure IEEE 11073:20601 Protocol and Agent Structure for Protecting PHD

Xiaolong Xu,Zhonghe Gao,Lijuan Han 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.12

In this paper, we suggest improvements of security in IEEE 11073:20601 protocol and the structure of its agent for protecting user’s healthcare information safely. Current IEEE 11073:20601 standard does not provide any method to ensure security of data exchange, and it assumes that data exchange is secured by other means. The suggested improvements include mechanism to enhance security in exchanging and storing data in PHD. While providing those advantages, it also satisfies availability by effective encoding rules and data protecting algorithm.

Analysis of the Growth and Metabolites of a Pyruvate Dehydrogenase ComplexDeficient Klebsiella pneumoniae Mutant in a Glycerol-Based Medium

Danfeng Xu,Zongxiao Jia,Lijuan Zhang,Shuilin Fu,Heng Gong 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.5

To determine the role of pyruvate dehydrogenase complex (PDHC) in Klebsiella pneumoniae, the growth and metabolism of PDHC-deficient mutant in glycerol-based medium were analyzed and compared with those of other strains. Under aerobic conditions, the PDHC activity was fourfold higher than that of pyruvate formate lyase (PFL), and blocking of PDHC caused severe growth defect and pyruvate accumulation, indicating that the carbon flux through pyruvate to acetyl coenzyme A mainly depended on PDHC. Under anaerobic conditions, although the PDHC activity was only 50% of that of PFL, blocking of PDHC resulted in more growth defect than blocking of PFL. Subsequently, combined with the requirement of CO2 and intracellular redox status, it was presumed that the critical role of PDHC was to provide NADH for the anaerobic growth of K. pneumoniae. This presumption was confirmed in the PDHC-deficient mutant by further blocking one of the formate dehydrogenases, FdnGHI. Besides, based on our data, it can also be suggested that an improvement in the carbon flux in the PFL-deficient mutant could be an effective strategy to construct highyielding 1,3-propanediol-producing K. pneumoniae strain.

PI Tracking Control for Nonlinear Time-varying Delay Markov Jump Systems

Cong Liu,Lijuan Xu 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.2

This paper considers robust stochastic stability and PI tracking control problem for Markov jump systems with both input delay and an unknown nonlinear function. Based on the traditional PI control strategy, a new controller design scheme is proposed for nonlinear time-delay Markov jump systems which can realize multiple control objectives including robust stochastic stability and tracking performance. By using the Lyapunov stability theory and LMI algorithms, a sufficient condition for the solution to robust stochastic stability and tracking control problem is obtained. Then, the desired controller with PI structure is designed, which ensures the resulting closed-loop system is robust stochastically stable and the system state has favorable tracking performance. Finally, a numerical example is provided to illustrate the effectiveness of the proposed results.