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Li-chao Sun,Hong-bo Zhang,Cheng-Dong Gu,Shi-Dong Guo,Gang Li,Rui Lian,Yao Yao,Guo-qiang Zhang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Sepsis is a clinical syndrome with no effective protective or therapeutic treatments. Acacetin, a natural flavonoid compound, has anti-oxidative and anti-inflammatory effects which can potentially work to reduce sepsis. We investigated the potential protective effect of acacetin on sepsis-induced acute lung injury (ALI) ALI and dissect out the underlying mechanisms. Mice were divided into five groups: a sham group, a sepsis-induced ALI group, and three sepsis groups pre-treated with 20, 40, and 80 mg/kg body weight of acacetin. We found that acacetin significantly attenuated sepsis-induced ALI, in histological examinations and lung edema. Additionally, acacetin treatment decreased protein and inflammatory cytokine concentration and the number of infiltrated inflammatory cells in BALF compared with that in the non-treated sepsis mice. Pulmonary myeloperoxidase (MPO) activity was lower in the acacetin-pre-treated sepsis groups than in the sepsis group. The mechanism underlying the protective effect of acacetin on sepsis is related to the regulation of certain antioxidation genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), superoxide dismutases (SODs), and heme oxygenase 1 (HO-1).Taken together, our results indicate that acacetin pre-treatment inhibits sepsis-induced ALI through its anti-inflammatory and antioxidative activity, suggesting that acacetin may be a potential protective agent for sepsis-induced ALI.
Doping effect on the adsorption of Na atom onto graphenes
Li-Hua Yao,Wen-Qiang Cao,Mao-Sheng Cao 한국물리학회 2016 Current Applied Physics Vol.16 No.5
We investigate the adsorption of Na atoms on pristine graphene and four types of defect graphenes using the first-principles calculations. The adsorption energies, electronic structures, Na storage capacities and the average potentials of Na atoms on different graphenes are calculated. The adsorption energies of Na atoms on B-doped, vacancy and B-doped vacancy graphenes are 1.93 eV, 2.46 eV, and 2.08 eV, respectively, which are much lower than that of Na on the pristine graphene (0.71 eV) and Na on Ndoped graphene (0.27 eV). The orbital hybridizations in the B-doped, vacancy and B-doped vacancy graphenes can be observed from the partial density of states, while there is no obvious orbital hybridization in the N-doped graphene as well as the pristine graphene. The B-doped vacancy graphene has the best Na storage capacity, while B-doped and vacancy graphenes also possess better Na storage capacities than those of the pristine graphene and N-doped graphene. This work demonstrates that the graphene introducing both B dopant and vacancy is expected to be a potential material for storing Na.
Smad4 Expression in Hepatocellular Carcinoma Differs by Hepatitis Status
Yao, Lei,Li, Fu-Jun,Tang, Zhi-Qiang,Gao, Shuang,Wu, Qe-Quan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Aims: Primary hepatocellular carcinoma (HCC) is a common malignancy often related to hepatitis viral infection. Smad4 is known to mediate the TGF-${\beta}$ pathway to suppress tumorigenesis. However, the function of Smad4 in HCC is still controversial. In this study we compared levels of Smad4 in HCC tissues with or without hepatitis virus infection and adjacent normal-appearing liver. Methods: Samples from HCC patients were analyzed for Smad4 protein and mRNA expression by immunohistochemistry (IHC), RT-PCR and Western blotting. Results: We found that tumor tissues expressed less Smad4 mRNA and protein than the adjacent tissues. Most HCC tumor tissues were negative for Smad4 in IHC staining, while the majority of adjacent tissues were positively stained. Interestingly, protein levels were higher in HCC tissues with viral hepatitis than those without virus infection. Suppression of expression appeared closely related to HCC, so that Smad4 appears to function as a tumor suppressor gene (TSG). Conclusion: Patients with hepatitis viral infection, at higher risk for HCC, exhibited increased Smad4 protein expression suggesting hepatitis virus may modulate Smad4 expression, which is functionally distinct from its putative role as a TSG. Smad4 expression may thus be an applicable marker for diagnosis and/or a target to develop therapeutic agents for HCC.
Equivalent hysteresis model based SOC estimation with variable parameters considering temperature
He, Yao,Li, Qiang,Zheng, Xinxin,Liu, Xintian The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.3
Estimation of the state of charge (SOC) of a lithium-ion battery is one of the key technologies in battery management systems. The accuracy of SOC estimation mainly depends on the accuracy of the battery model. The traditional Thevenin model has limited application due to its fixed parameters. In addition, its accuracy is not high. This paper proposes a variable parameter equivalent hysteresis model based on the Thevenin model. The parameters of this model are regarded as variables that vary with temperature and SOC. They can be identified by hybrid pulse power characteristic (HPPC) experiments. In addition, the model also considers the hysteresis characteristics of the open circuit voltage (OCV) and uses a mathematical recursive equation to describe it. Experimental and simulation results show that the proposed model has a higher accuracy and a wider application than the Thevenin model. On the basis of this model, SOC estimation is carried out based on modified covariance extended Kalman filter (MVEKF) at different temperatures. The results show that the SOC estimation accuracy of the MVEKF method is significantly higher than that of an extended Kalman filter (EKF).
Xinyan Li,Mozhi Wang,Mengshen Wang,Xueting Yu,Jingyi Guo,Tie Sun,Litong Yao,Qiang Zhang,Yingying Xu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.4
Currently, neoadjuvant chemotherapy is a standard therapeutic strategy for breast cancer, as it can provide timely and individualized chemo-sensitivity information and is beneficial for custom-designing subsequent treatment strategies. To accurately select candidates for neoadjuvant chemotherapy, the association between various immunohistochemical biomarkers of primary disease and tumor response to neoadjuvant chemotherapy has been investigated, and results have shown that certain pathological indicators evaluated after neoadjuvant chemotherapy are associated with long-term prognosis. The Food and Drug Administration (FDA) has recommended that complete pathological response can be used as a surrogate endpoint for neoadjuvant chemotherapy, which is related to better prognosis. Considering that residual tumor persists in the majority of patients after neoadjuvant chemotherapy, the value of various pathological indicators of residual disease in predicting the long-term outcomes is being extensively investigated. This review summarizes and compares various predictive and prognostic indicators for patients who have received neoadjuvant chemotherapy, and analyzes their efficacy in different breast cancer subtypes.
Good performance of Sc (0001) surface adsorbing CO molecule
Hao Zhi-Qiang,Yang Jian-Long,Li Hui,Yao Jian-Gang 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.9
There is a big discrepancy in terms of calculating the surface energy of the HCP Sc (0001) surface for previous theoretical results. Herein, we used a relatively reasonable method to predict the calculated value (1.263 J/m2), which agrees well with the experimental outcome (1.275 J/m2). Based on this, the adsorption behaviors of CO at different sites, i.e., hollow (H1, H2, and H3), bridge (B1), and top sites (T1), were explored theoretically. The results suggest that hollow sites, particularly the H1 site exhibits a good performance in adsorbing CO molecule, and that the adsorption energy reaches nearly 3.5 eV, which corresponds to a significant elongation of the C–O distance (more than 24%). In addition, the CO adsorbed at the H1 site is seen to be located parallelly at the surface. An obvious substantive variation of the CO molecular orbit of H1 adsorption site is observed.
Yonggang Zhang,Li Ren,Hua-qiang Chu,Xue-fei Zhou,Tianming Yao,Ya-lei Zhang 한국미생물·생명공학회 2019 한국미생물·생명공학회지 Vol.47 No.4
Microalgae have been explored as potential host species for biofuel production. Environmental factors affect algal growth and cellular composition. The effects of several key environmental factors, such as temperature, light, and pH of the medium on the growth and biochemical composition of Scenedesmus obliquus were investigated in this study. The highest growth rate of microalgae was observed at an optimal temperature of 25℃, 150 μmol/(m2·s) light intensity, and pH 10.0. The biochemical composition analysis revealed that the carbohydrate content decreased at lower (20℃) or higher temperature (35℃), whereas the protein and lipid contents increase at these temperatures. The fluctuation of light intensity significantly affected the contents of protein, carbohydrate, and lipid. The protein levels varied greatly when the pH of the medium was below 7.0. The carbohydrate and lipid contents significantly increased at pH above 7.0.
Study of Robustness Approximate Time-Optimal System
Xu, Song Yuan,Yao, Li Qiang,Rong, Hong Bing,Xu, Shao Qing 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
Using the $quot;bang-bang$quot;control the system can obtain the optimal time. But there have the chatter and the bad robustness after considering the practical factors. If we use the chang structure principle, the chatter will be diminated and the system will get the strong robustness. This paper adopted this two kinds of the principles to design the satellite attitute control system and the satisfied results were received.