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초음파 근관기구를 이용한 근관충전법의 근관페쇄능에 관한 주사 전자현미경적 연구
최라영,이인숙 大韓齒科保存學會 1990 Restorative Dentistry & Endodontics Vol.15 No.2
AbstractThe purpose of this study was to evaluate the adaptation of root canal filling material to the dentinal wall of root canal and to compare the sealing ability of the root canal filling materials using ultrasonic endodontic instument with injection-molded thennoplasticized gutta-percha filling method and lateral condensation method.Fifty fresh human single root exiracted for orthodontic treatment, were randomly selected, and instrume- nted by step-back technique.And then, the teeth were divided into 5 groups according to each root canal filling methods. In the experimental group 1 and group 2, the root canals were filled with gutta perdia cases using ultrasonic instrument with and without sealer.In the experimental group 3 and 4, using jection - moldeed thennoplasticized gutta - percha method by obtui?canals were filled with and without sealer. In the control group, the canals were filled with sealer by lateral candensation. And then, 5 teeth of each group were immersed in black Indian ink, decalcified and cleared. The depth of dye penetration into the root canal were evaluated with stereoscope (Reichert Ltd., USA). Among the 5 teeth remaining in each group, the single longituding grooves were made on the labial and lingual root surfaces and then immersed in the liquid nitrogen to fracture the teeth spontaneously without any distortions of gutta-percha.Each specimens were examined with X-650 Scanning Electron Microscope(Hitachi ltd, Japan) to show the adaptation to the canal wall, void, homogenicity of filling material and location of .gutta-percha or sealer in the dentinal tubules of the root canal.The observations were as follows: 1. The experimental group 1 showed smaller mean dye penetration than control group, and showed the penetraton of sealer in the dentinal tubules of apical third of the root canal. 2. The experimental group 2 and group 4 showed the penetration of gutta - percha in the dentinal tubules of root canals. 3. The experimental group 1 and group 3 showed less mean dye penetration than the experimental group 2 and group 4. 4. The experimental group 1 and group 2 showed better adaptation of filling materials than control group.
La-Sim Bae(La-Sim Bae),Ryun-Seok Oh(Ryun-Seok Oh),Jun-Ho Choi(Jun-Ho Choi) 한국화재소방학회 2023 International Journal of Fire Science and Engineer Vol.37 No.1
At present, the standard for installing evacuation equipment that enables occupants to evacuate on their own is determined by the use of a building and its floor area. However, according to the “Installation Maintenance and Safety Control of Fire-Fighting Systems Act” and “Fire Safety Standards for evacuation equipment”, the installation standard for evacuation equipment mentions only the minimum number of equipment to be installed based on the floor area. Thus, this installation standard fails to reflect the corresponding number of occupants in a building and the effectiveness of the evacuation equipment. Thus, there is a high probability that most of the evacuation equipment installed based on the “one-size-fits-all” legal regulation will not guarantee the safety of occupants in case of a fire. To address this, the performance evaluation of the effectiveness of evacuation and the distribution ratio of equipment per occupant needs to be prioritized. Therefore, we conduct mock experiments on the descending lifeline and elevating evacuation equipment to analyze their efficiencies. Moreover, we propose a model for calculating the evacuation time for the descending lifeline and elevating evacuation equipment based on the experimental results. Furthermore, we conduct effectiveness evaluation by using the evacuation equipment. The results show that most people cannot be evacuated using the evacuation equipment. That is, evacuation equipment was determined to be insufficient for ensuring safety as per the current standard. Therefore, the installation of evacuation equipment according to its efficiency and capacity is considered necessary.
Development of orthotopic patient-derived tumor xenograft models in endometrial cancer
( Hyun-jin Choi ),( Eun Jin Heo ),( Young Jae Cho ),( Ji Eun Hong ),( Hye-kyung Jeon ),( Doo-yi Oh ),( Yoon-la Choi ),( Sangyong Song ),( Jung-joo Choi ),( Yoo-young Lee ),( Chel Hun Choi ),( Tae-joon 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To evaluate orthotopic xenografting of endometrial cancer(EM Ca) in mice for development of novel translational research platform in endometrial cancer. 방법: Fresh surgical specimens were taken from patients with EM Ca after surgery at Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea between December, 2011 to February, 2016. We successfully established PDXs by orthotopic and subrenal capsule implantation of patient’s EM Ca tissues into female BALB/C-nude mice. The subrenal capsule implatation method were that pieces of EM Ca specimens from patients were meticulosely grafted in the subrenal capsule. Mean while, estrogen preconditioning was done for orthotopic implatation by given a daily s.c injection of 0.1μg estradial for three days. After then, pieces of EM Ca specimens from patients were meticulosly grafted in the enlarged mice’s uterus. The H&E staining, short tandem repeat, array comparative genomic hybridization, human and mouse albumin test and cancer panel were conducted to verifythe histopathologic and genetic similarity between the PDXs and primary patient’s tissues. 결과: Orthotopic PDX engraftment rate were sucessful in 100% (3/3 cases). While, Successful rate of subrenal capsule implantation method was 55.6% (10/18 cases). In orthotopic PDXs, median duration of first generation of PDX develoment from implantation of patient’s tissues was 5.43month (range: 0.83-6.63 month). And, in subrenal capsule implantation PDXs, median duration of first generation was 5.05month (range : 4.17-9.33 month). Both methods were proved to preserve histopathologic and genetic silimarity between PDXs and the primary patient’s tissues. 결론: The PDXs for endometiral cancer with histopathologic and genetic stability can be efficiently developed by an orthotopic implantation method rather than a subrenal capsule implantation method. This method can a promising platform for conducting translational research and future precision medicine in endomerial cancer.
Choi, Jin Woo,Kim, Dae Gyu,Lee, Al-Eum,Kim, Hye Rim,Lee, Jin Young,Kwon, Nam Hoon,Shin, Young Kee,Hwang, Soon-Kyung,Chang, Seung-Hee,Cho, Myung-Haing,Choi, Yoon-La,Kim, Jhingook,Oh, Seung Hyun,Kim, Bo Public Library of Science 2011 PLoS genetics Vol.7 No.3
<P>Although ARS-interacting multifunctional protein 2 (AIMP2, also named as MSC p38) was first found as a component for a macromolecular tRNA synthetase complex, it was recently discovered to dissociate from the complex and work as a potent tumor suppressor. Upon DNA damage, AIMP2 promotes apoptosis through the protective interaction with p53. However, it was not demonstrated whether AIMP2 was indeed pathologically linked to human cancer. In this work, we found that a splicing variant of AIMP2 lacking exon 2 (AIMP2-DX2) is highly expressed by alternative splicing in human lung cancer cells and patient's tissues. AIMP2-DX2 compromised pro-apoptotic activity of normal AIMP2 through the competitive binding to p53. The cells with higher level of AIMP2-DX2 showed higher propensity to form anchorage-independent colonies and increased resistance to cell death. Mice constitutively expressing this variant showed increased susceptibility to carcinogen-induced lung tumorigenesis. The expression ratio of AIMP2-DX2 to normal AIMP2 was increased according to lung cancer stage and showed a positive correlation with the survival of patients. Thus, this work identified an oncogenic splicing variant of a tumor suppressor, AIMP2/p38, and suggests its potential for anti-cancer target.</P><P><B>Author Summary</B></P> <P>Lung cancer is one of the most common cancers and a leading cause of death resulting from cancer. Despite intensive investigation, effective therapeutic targets and reliable biomarkers are still limited. Here we found that a tumor suppressor, AIMP2 (MSC p38), produces a variant lacking a part of its structure in cancer tissues. We designated it AIMP2-DX2. This smaller version of AIMP2 compromises the normal tumor suppressive activity of AIMP2 and induces tumor formation. We also found that the expression of AIMP2-DX2 was increased according to cancer progression. In addition, the patients with higher expression of AIMP2-DX2 showed lower survival than those with lower levels of this variant. Suppression of AIMP2-DX2 slowed tumor growth, suggesting it as a new therapeutic target. In summary, this work newly identified a tumor-inducing factor, AIMP2-DX2, that can be used as a therapeutic target and biomarker associated with lung cancer.</P>
Choi, Su-La,Choi, Yun-Sil,Kim, Young-Kwan,Sung, Nack-Do,Kho, Chang-Won,Park, Byong-Chul,Kim, Eun-Mi,Lee, Jung-Hyung,Kim, Kyung-Mee,Kim, Min-Yung,Myung, Pyung-Keun 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
We employed human SK-MEL-28 cells as a model system to identify cellular proteins that accompany N-(4-methyl)phenyl-O-(4-methoxy)phenyl-thionocarbamate (MMTC)-induced apoptosis based on a proteomic approach. Cell viability tests revealed that SK-MEL-28 skin cancer cells underwent more cell death than normal HaCaT cells in a dose-dependent manner after treatment with MMTC. Two-dimensional electrophoresis in conjunction with matrix-assisted laser desorption/ionization-time of flight (MALDl- TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-κB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific eye/in D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. The migration suppressing effect of MMTC on SK-MEL-28 cell was tested. MMTC suppressed the metastasis of SK-MEL-8 cells. It was also identified that MMTC had little angiogenic effect because it did not suppress the proliferation of HUVEC cell line. These results suggest that MMTC is a novel chemotherapeutic and metastatic aoents aqainst the SK-MEL-28 human melanoma cell line.