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Possible Presence of an Interleukin-6-Like Molecule in the Immunized Bombyx mori L. (Lepidoptera)
Kim, Iksoo,Lee, Young-Shin,Lee, Joon-Ha,Kim, Sang-Hyun,Kang, Pil-Don,Lee, In-Hee,Kim, Jin-Won,Lee, Heui-Sam,Kang, Seok-Woo Korean Society of Sericultural Science 2003 International Journal of Industrial Entomology Vol.7 No.2
Cytokines represent an essential part of the innate immune response in mammals. Recently, several studies have reported the presence of cytokine-like activities and molecules in the invertebrates such as echinoderms, tunicates, mollusks and insects. In our serial study, we investigated presence of cytokines in the silkworm, Bombyx mori, infected with several immune inducers. Western blotting analysis using rabbit anti-human cytokines showed the presence of IL-6-like molecule in the hemolymph collected at 8 and 24 hrs after infection with peptidoglycan and oligodeoxynucleotide, and the molecular weight of the proteins was ∼45 kDa. We attempted to isolate the molecule by gel permeation HPLC, anion exchange chromatography, ultra centrifugation, and immuno-dot-blot assay, but until now the effort was not much successful yet. It, however, does not appear that the IL-6-like molecule in the silkworm larvae is a mere experimental artifact happened by Western blotting analysis. Instead, further experiment on this subject probably will provide us more fruitful result as detected in other invertebrates including insects.
Cytotoxicity of Triterpenes Isolated from <i>Aceriphyllum rossii</i>
Lee, IkSoo,Yoo, Jae Kuk,Na, MinKyun,Min, Byung Sun,Lee, JongPill,Yun, Bong Sik,Jin, WenYi,Kim, HongJin,Youn, UiJung,Chen, Quan Cheng,Song, Kyung Sik,Seong, Yeon Hee,Bae, KiHwan The Pharmaceutical Society of Japan 2007 Chemical & pharmaceutical bulletin Vol.55 No.9
<P>Bioassay-guided fractionation of a MeOH extract of the whole plant of <I>Aceriphyllum rossii</I> (Saxifragaceae) led to the isolation of two new triterpenes, 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3α-hydroxyolean-12-en-27-oic acid (4), β-peltoboykinolic acid (5), aceriphyllic acid A (6), oleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for <I>in vitro</I> cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1—6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC<SUB>50</SUB> values ranging from 12.2 to 28.7 μ<SMALL>M</SMALL> and from 12.1 to 25.8 μ<SMALL>M</SMALL>, respectively.</P>
Cytotoxicity of Ergosterol Derivatives from the Fruiting Bodies of Hygrophorus russula
IkSoo Lee,JinPyo Kim,나민균,정현주,민병선,배기환 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Bioassay-guided fractionation of the CHCl3-soluble fraction of a MeOH extract of the fruiting bodies of Hygrophorus russula led to the isolation of five ergosterol derivatives (1 - 5). The structures of these compounds were identified as ergosterol peroxide (1), ergosta-4,6,8(14),22-tetraen-3-one (2), ergosta-7,22-diene-3b,5a,6a-triol (3), ergosta-7,22-diene-3b,5a,6b,9a-tetraol (4), and 5a,6a-epoxy-ergosta-8(14),22-diene-3b,7a-diol (5) by comparing their physicochemical and spectral data with those in the literature. These compounds were evaluated for in vitro cytotoxicity against A549 and XF498 cancer cell lines. Most of the tested compounds, except for compound 3, exhibited moderate cytotoxicity against both A549 and XF498 cell lines with IC50 values ranging from 10.2 to 18.3 ?g/mL and from 11.4 to 24.6 ?g/mL, respectively.
Lee, IkSoo,Kim, Junghyun,Kim, Young Sook,Yoo, Nam Hee,Kim, Chan-Sik,Jo, Kyuhyung,Kim, Joo-Hwan,Bach, Tran The,Kim, Jin Sook American Society of Pharmacognosy ; American Chemi 2012 Journal of natural products Vol.75 No.7
<P>Six new cycloartane-type triterpenes (1-6), 24-methylenecycloartane-3관,6관,7관-triol (1), 24-methylenecycloartane-3관,6관,7관,16관-tetraol (2), 24-methylenecycloartane-3관,6관,16관-triol (3), 24-methylenecycloartane-3관,7관,16관-triol 3-O-관-d-xylopyranoside (4), 24-methylenecycloartane-3관,6관,16관-triol 3-O-관-d-xylopyranoside (5), and 24-methylenecycloartane-3관,6관,7관-triol 3-O-관-d-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartane-3관,6관,7관,16관-tetraol 3-O-관-d-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated.</P>