http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Terpenylated coumarins as SIRT1 activators isolated from Ailanthus altissima.
Dao, Trong-Tuan,Tran, Tien-Lam,Kim, Jayeon,Nguyen, Phi-Hung,Lee, Eun-Hee,Park, Junsoo,Jang, Ik-Soon,Oh, Won-Keun American Society of Pharmacognosy ; American Chemi 2012 Journal of natural products Vol.75 No.7
<P>Four new terpenylated coumarins (1-4) were isolated from the stem bark of Ailanthus altissima by bioactivity-guided fractionation using an in vitro SIRT1 deacetylation assay. Their structures were identified as (2'R,3'R)-7-(2',3'-dihydroxy-3',7'-dimethylocta-6'-enyloxy)-6,8-dimethoxycoumarin (1), 6,8-dimethoxy-7-(3',7'-dimethylocta-2',6'-dienyloxy)coumarin (2), (2'R,3'R,6'R)-7-(2',3'-dihydroxy-6',7'-epoxy-3',7'-dimethyloctaoxy)-6,8-dimethoxycoumarin (3), and (2'R,3'R,4'S,5'S)-6,8-dimethoxy-7-(3',7'-dimethyl-4',5'-epoxy-2'-hydroxyocta-6'-enyloxy)coumarin (4). Compounds 1-4 strongly enhanced SIRT1 activity in an in vitro SIRT1-NAD/NADH assay and an in vivo SIRT1-p53 luciferase assay. These compounds also increased the NAD-to-NADH ratio in HEK293 cells. The present results suggest that terpenylated coumarins from A. altissima have a direct stimulatory effect on SIRT1 deacetylation activity and may serve as lead molecules for the treatment of some age-related disorders.</P>
Salternamides A-D from a Halophilic Streptomyces sp. Actinobacterium.
Kim, Seong-Hwan,Shin, Yoonho,Lee, So-Hyoung,Oh, Ki-Bong,Lee, Sang Kook,Shin, Jongheon,Oh, Dong-Chan American Society of Pharmacognosy ; American Chemi 2015 Journal of natural products Vol.78 No.4
<P>Salternamides A-D (1-4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated from a halophilic Streptomyces strain isolated from a saltern on Shinui Island in the Republic of Korea. The planar structures of the salternamides, which are new members of the manumycin family, were elucidated by a combination of spectroscopic analyses. The absolute configurations of the salternamides were determined by chemical and spectroscopic methods, including the modified Mosher's method, J-based configuration analysis, and circular dichroism spectroscopy. Salternamide A (1), which is the first chlorinated compound in the manumycin family, exhibited potent cytotoxicity against a human colon cancer cell line (HCT116) and a gastric cancer cell line (SNU638) with submicromolar IC50 values. Salternamides A and D were also determined to be weak Na(+)/K(+) ATPase inhibitors.</P>
Nortriterpene glycosides of the sarasinoside class from the sponge Lipastrotethya sp.
Lee, Jung-Ho,Jeon, Ju-eun,Lee, Yeon-Ju,Lee, Hyi-Seung,Sim, Chung J,Oh, Ki-Bong,Shin, Jongheon American Society of Pharmacognosy ; American Chemi 2012 Journal of natural products Vol.75 No.7
<P>Five new nortriterpene glycosides, along with eight known compounds of the sarasinoside class, were isolated from the tropical sponge Lipastrotethya sp. collected from Chuuk, Micronesia. The structures of these new compounds, designated as sarasinosides N-R (9-13), were determined by combined spectroscopic and chemical methods. The aglycone portions of 10-13 were found to be unprecedented among nortriterpeneoids on the basis of extensive NMR analyses. Several of these compounds exhibited cytotoxicity against A549 and K562 cell lines as well as weak inhibitory activity against Na(+)/K(+)-ATPase.</P>
Lee, IkSoo,Kim, Junghyun,Kim, Young Sook,Yoo, Nam Hee,Kim, Chan-Sik,Jo, Kyuhyung,Kim, Joo-Hwan,Bach, Tran The,Kim, Jin Sook American Society of Pharmacognosy ; American Chemi 2012 Journal of natural products Vol.75 No.7
<P>Six new cycloartane-type triterpenes (1-6), 24-methylenecycloartane-3관,6관,7관-triol (1), 24-methylenecycloartane-3관,6관,7관,16관-tetraol (2), 24-methylenecycloartane-3관,6관,16관-triol (3), 24-methylenecycloartane-3관,7관,16관-triol 3-O-관-d-xylopyranoside (4), 24-methylenecycloartane-3관,6관,16관-triol 3-O-관-d-xylopyranoside (5), and 24-methylenecycloartane-3관,6관,7관-triol 3-O-관-d-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartane-3관,6관,7관,16관-tetraol 3-O-관-d-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated.</P>
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
Won, Tae Hyung,Song, Inn-Hye,Kim, Kuk-Hwa,Yang, Woo-Young,Lee, Sang Kook,Oh, Dong-Chan,Oh, Won-Keun,Oh, Ki-Bong,Shin, Jongheon American Society of Pharmacognosy ; American Chemi 2015 Journal of natural products Vol.78 No.4
<P>Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1-6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).</P>