http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice
Yang, J-Y,Lee, Y-S,Kim, Y,Lee, S-H,Ryu, S,Fukuda, S,Hase, K,Yang, C-S,Lim, H S,Kim, M-S,Kim, H-M,Ahn, S-H,Kwon, B-E,Ko, H-J,Kweon, M-N Society for Mucosal Immunology 2017 Mucosal immunology Vol.10 No.1
<P>In humans, the composition of gut commensal bacteria is closely correlated with obesity. The bacteria modulate metabolites and influence host immunity. In this study, we attempted to determine whether there is a direct correlation between specific commensal bacteria and host metabolism. As mice aged, we found significantly reduced body weight and fat mass in Atg7(Delta CD11c) mice when compared with Atg7(f/f) mice. When mice shared commensal bacteria by cohousing or feces transfer experiments, body weight and fat mass were similar in both mouse groups. By pyrosequencing analysis, Bacteroides acidifaciens (BA) was significantly increased in feces of Atg7(Delta CD11c) mice compared with those of control Atg7(f/f) mice. Wild-type C57BL/6 (B6) mice fed with BA were significantly more likely to gain less weight and fat mass than mice fed with PBS. Of note, the expression level of peroxisome proliferator-activated receptor alpha (PPARa) was consistently increased in the adipose tissues of Atg7(Delta CD11c) mice, B6 mice transferred with fecal microbiota of Atg7(Delta CD11c) mice, and BA-fed B6 mice. Furthermore, B6 mice fed with BA showed elevated insulin levels in serum, accompanied by increased serum glucagon-like peptide-1 and decreased intestinal dipeptidyl peptidase-4. These finding suggest that BA may have potential for treatment of metabolic diseases such as diabetes and obesity.</P>
포스터 전시 : 간 ; 간세포암에서 cDNA microarray에 의한 유전자 표현 profile
탁원영 ( W. Y. Tak ),조창민 ( C. M. Cho ),권영오 ( Y. O. Kweon ),김성국 ( S. K. Kim ),최용환 ( Y. H. Choi ),정준모 ( J. M. Chung ),정은정 ( E. J. Chung ),김문규 ( M. K. Kim ),김정철 ( J. C. Kim ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<서론> 간세포암은 전세계적으로 암으로 사망하는 주된 원인 중 하나로서 대부분이 B형 및 C형 간염 바이러스가 원인이 되어 발생한다. 암의 발생은 세포내에서 일어나는 일련의 분자들의 변화의 결과로 발생하는 것으로 알려져 있다. 이러한 변화가 수많은 유전자의 표현에 변화를 초래하며 비정상적인 세포의 성장에 다른 여러 가지 조직학적 및 임상적 형태로 나타난다고 알려져 있다. 따라서, 생물학적 진행과정에 관련된 유전자 표현의 변화가 생물학의 주요한 문제로 대
Kim, H M,Lee, B R,Lee, E S,Kwon, M H,Huh, J H,Kwon, B-E,Park, E-K,Chang, S-Y,Kweon, M-N,Kim, P-H,Ko, H-J,Chung, C H Nature Publishing Group 2018 International Journal of Obesity Vol.42 No.2
<P>Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are characterized by an increase in hepatic triglyceride content with infiltration of immune cells, which can cause steatohepatitis and hepatic insulin resistance. C-C chemokine receptor 7 (CCR7) is primarily expressed in immune cells, and CCR7 deficiency leads to the development of multi-organ autoimmunity, chronic renal disease and autoimmune diabetes. Here, we investigated the effect of CCR7 on hepatic steatosis in a mouse model and its underlying mechanism. Our results demonstrated that body and liver weights were higher in the CCR7<SUP>−/−</SUP> mice than in the wild-type (WT) mice when they were fed a high-fat diet. Further, glucose tolerance and insulin sensitivity were markedly diminished in CCR7<SUP>−/−</SUP> mice. The number of invariant natural killer T (iNKT) cells was reduced in the livers of the CCR7<SUP>−/−</SUP> mice. Moreover, liver inflammation was detected in obese CCR7<SUP>−/−</SUP> mice, which was ameliorated by the adoptive transfer of hepatic mononuclear cells from WT mice, but not through the transfer of hepatic mononuclear cells from CD1d<SUP>−/−</SUP> or interleukin-10-deficient (IL-10<SUP>−/−</SUP>) mice. Overall, these results suggest that CCR7<SUP>+</SUP> mononuclear cells in the liver could regulate obesity-induced hepatic steatosis via induction of IL-10-expressing iNKT cells.</P>
삽입물에 의한 관내 층류열전달 증진에 관한 실험적 연구
권영철,장근선,정지환 대한설비공학회 2000 설비공학 논문집 Vol.12 No.7
In order to understand the laminar flow heat transfer enhancement by the swirl flow, the effects of heat transfer in a circular pipe with a twisted tape insert were investigated experimentally. In the present study, the uniform heat flux condition was considered. The laminar heat transfer correlations were developed using the least-square-fit from the surface temperature distribution of an electrically-heated pipe and flow property data. Average Nusselt number correlations with the twisted tape insert were expressed as a function of swirl parameter, Reynolds number and Prandtl number. In the case of the twisted ratio y = 6.05, the mean Nusselt number increased approximately 500% and the friction factor increased approximately 300%, compared to the case of the empty pipe, respectively.
이재구,정인상,권정욱,안기창 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 1997 연구보고서 Vol.2 No.-
광분해 촉진에 의한 작물중 잔류농약의 인위적인 경감을 위하여 자연계에 천연적으로 존재하거나 또는 합성화합물중에서 감광작용을 가질 것으로 기대되는 40여종에 대하여 감광작용을 검정하여 6개의 화합물을 선발하고 사과와 오이에 사용되는 살균제중 iprodione, bitertanol, chlorothalonil, dichlofluanid 및 myclobutanil을 관행법에 따라 상기 작물에 살포한 후 감광제를 처리하여 얻은 결과를 요약하면 다음과 같다. ① 40여종의 자연계에 천연적으로 존재하는 화합물과 합성유기 및 무기화합물의 감광작용을 탐색하여 ketone계인 PS-1, 방향족 amine계인 PS-2, quinone계인 PS-3, 무기화합물인 PS-4, 유기산염인 PS-5, 광촉매제인 PS-6를 선발하였고, 모래를 이용한 예비실험을 통하여 각 농약에 대하여 3종의 감광제를 선발하였다. ② 상기 농약의 각 작물에 대한 회수율은 0.5ppm과 1.0ppm에서 모두 91%∼106%로 비교적 양호하였다. ③ 사과에 처리된 iprodione의 경우 방향족 ketone계 감광제인 PS-1을 처리하고 15일 경과 후 잔류량은 무처리의 74%로 감소하였고, 그 이외의 감광제는 큰 효과는 없었다. ④ 감광제 처리에 의한 사과중 chlorothalonil의 잔류량 경감효과는 방향족 ketone계 감광제인 PS-1과 방향족 amine계 감광제인 PS-2를 처리하고 1일 경과 후에 그 잔류량은 대조구의 각각 56%와 54%로 그 효과가 현저하였다. ⑤ 사과에 처리된 bitertanol의 경우 모든 처리구에서 그다지 큰 효과는 없었으나 무기화합물인 PS-4처리구에서 처리 1일 후에 그 잔류량은 대조구의 63%이었다. ⑥ 오이에 처리된 iprodione의 경우 방향족 ketone계 감광제인 PS-1을 처리하고 3일과 15일 경과 후 그 잔류량은 무처리의 각각 44%와 30%로 광분해 촉진 효과가 컸다. ⑦ 감광제 처리에 의한 오이중 myclobutanil의 잔류량 경감효과는 반도체 광촉매제인 PS-6을 처리하고 1일 경과 후에 그 잔류량은 대조구의 73%이었다. ⑧ 감광제 처리에 의한 오이중 dichlofluanid의 잔류량 경감효과는 방향족 ketone게 감광제인 PS-1을 처리하고 3일과 7일 경과 후 그 잔류량은 각각 무처리의 44%와 25%로 광분해 촉진효과가 컸다. ⑨ 위의 결과를 요약하면 작물과 농약에 관계없이 방향족 ketone계 감광제인 PS-1은 비교적 광범위하게 광분해 촉진효과를 나타내었고, 방향족 amine계 감광제인 PS-2, 무기화합물 PS-4 및 반도체 광촉매제인 PS-6은 농약에 따라 특이하게 그 효과를 나타내었다.
잡견에서 조영제 혈관외유출 예방을 위한 스트레인 게이지 기반의 EDA 시스템 성능 평가를 위한 실험적 연구
권대철,유병규,이종석,조문선,양성환,Kweon, D.C.,Yoo, B.G.,Lee, J.S.,Cho, M.S.,Yang, S.H. 대한의용생체공학회 2008 의공학회지 Vol.29 No.1
The major risk associated with the use of automated power injectors is the well known complication of contrast material extravasation at the injection site. Automated injection of computed tomography (CT) contrast media can produce the compartment syndrome. The purpose of this study was to assess the ability of this device during clinically important episodes of extravasation. The extravasation detection accessory (EDA) system was composed of a strain gage, an amplifier and a computer based system. A strain gage pliable adhesive patch was applied to the skin aver the intravenous catheter and the catheter was connected to the power injector with a cable to monitor the resolution data. If the programmed monitoring, which was developed with MS Visual C++, at the extravasation occurred, then the injection was interrupted the auto injector. CT was used to demonstrate the clinically important extravasation. This study was a prospective, observational study in which the EDA system was used to monitor the automated mechanical injection of contrast material in 7 dogs. There were two true-positive cases (range of extravasation volumes: $18{\sim}22ml$), twenty three true-negative cases, three false-positive cases and no false-negative cases. The EDA system had a sensitivity of 100% and a specificity of 88% for the detection of clinically important extravasation. The EDA system had good sensitivity for the detection of clinically important extravasation and the EDA system has the clinical potential for the early detection of extravasation of the contrast medium that is administered with power injectors. The EDA system is easy to use safe and accurate for the monitoring extravasation of the intravenous injections, and this system may prove especially useful in CT applications.
Ryu, J.H.,Yoo, J.Y.,Kim, M.J.,Hwang, S.G.,Ahn, K.C.,Ryu, J.C.,Choi, M.K.,Joo, J.H.,Kim, C.H.,Lee, S.N.,Lee, W.J.,Kim, J.,Shin, D.M.,Kweon, M.N.,Bae, Y.S.,Yoon, J.H. Mosby 2013 The Journal of allergy and clinical immunology Vol.131 No.2
Background: Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways. In contrast to this general concept, we hypothesized that innate immunity of the upper and lower airways is respectively distinctive, because the immunologic conditions of the nasal and lung mucosa as well as the functions of the immune cells within their epithelia are different. Objective: We wanted to identify distinctive mechanisms of innate immunity in the nose and lung mucosa, which are responsible for house dust mite (HDM)-induced AR and allergic asthma (AA), respectively. Methods: We constructed a mouse model of AR or AA induced by sensitization and consequent provocation with HDM extracts. Results: HDM-derived β-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than β-glucans/TLR2, was critical to HDM-induced AA. These differences were attributed to the specific role of β-glucans and LPS in inducing the surface expression of TLR2 and TLR4 and their translocation to lipid rafts in nasal and bronchial epithelial cells, respectively. We also showed that dual oxidase 2-generated reactive oxygen species mediate both β-glucan-induced TLR2 activation and LPS-induced TLR4 activation. Conclusions: We describe a novel finding of distinctive innate immunity of the nose and lungs, respectively, which trigger AR and AA, by showing the critical role of HDM-induced TLR activation via dual oxidase 2-mediated reactive oxygen species.
Interleukin-1 유전자 다형성이 helicobacter pylori 감염과 위암 발생에 미치는 연관성 -예비보고-
유창범 ( C. B. Ryu ),천갑진 ( G. J. Cheon ),장재영 ( J. Y. Jang ),권계원 ( K. W. Kweon ),김진오 ( J. O. Kim ),조주영 ( J. Y. Cho ),이준성 ( J. S. Lee ),진소영 ( S. Y. Jin ),이문성 ( M. S. Lee ),심찬섭 ( C. S. Shim ),김부성 ( B. S. Ki 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 위암에 있어서 H. pylori 감염은 위암발생과정의 다단계 중 중요한 초기 단계에 관여하는 것으로 알려져 있다. H. pylori 감염이 위암과 십이지장궤양을 유발되는 현상을 병동인자의 차이가 아닌 감염된 숙주의 유전적 소인의 차이로 설명하려는 시도가 되고 있다. Interleukin-1 유전자 다형성으로 인하여 강력한 위산분비 억제제인 Interleukin-1 β의 생성 촉진됨으로서 H. pylori 감염이 숙주의 반응에 중요한 역할을 한다