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이광은 ( Kwang Eun Lee ),김유미 ( Yoo Mee Kim ),강은석 ( Eun Seok Kang ),김혜진 ( Hae Jin Kim ),정혜원 ( Hae Won Chung ),이시훈 ( Sh Hoon Lee ),김형진 ( Hyeung Jin Kim ),김대중 ( Dae Jung Kim ),김수경 ( Soo Kyung Kim ),안철우 ( Ch 대한내과학회 2002 대한내과학회지 Vol.63 No.5
Background : It is well known that non-alcoholic fatty liver disease is associated with metabolic syndrome such as obesity, type II diabetes mellitus, dyslipidemia. Non-alcoholic fatty liver disease is frequently found in non-obese adults, but the meaning of it is unknown. So we studied the association of non-alcoholic fatty liver disease in non-obese adults and metabolic abnormalities. Methods : We examined 779 Korean adults above 30 years old (274 men, 505 women) participating in medical check-up in Health Promotion Center. Hepatitis B and C serologies were negative, and average weekly alcohol intake was .2 drinks. A standard interview, physical examination and biochemical study was conducted. An experienced operator carried out ultrasound liver studies. Results : 370 subjects had non-alcoholic fatty liver disease (47.3%). The frequency in men was higher than that in women (57.3 vs 42.2%, p<0.05). The frequency in non-obese (BMI<25 kg/m2, n=431) group was lower than that in obese (BMI.25 kg/m2, n=348) group (65.5 vs 32.3%, p<0.05). Compared with obese group, waist circumference, waist hip ratio, body fat, impaired fasting serum glucose, total cholesterol, HDL-cholesterol, total cholesterol to HDL-cholesterol ratio, fasting insulin, proinsulin, HOMA-IR and HOMA-beta were significantly different in non-obese, non-alcoholic fatty liver group. After multiple regression analysis, waist circumference was associated with non-alcoholic fatty liver disease in non-obese individuals. Odd ratios of insulin resistance in non-obese, non-alcoholic fatty liver group were 5.8 (CI: 3.1.10.9). Conclusion : The frequency of non-alcoholic fatty liver disease was very high in non-obese adults and well associated with central obesity and insulin resistance.(Korean J Med 63:488-495, 2002) Key Words : Non - alcoholic fatty liver disease, Body mass index, Metabolic syndrome, Central obesity
Seok Hyeri,Park Dae Won,Kim Kwang Nam,Kim Min Ja,Kim Sung-Han,Kim Jeong Yeon,Park Su Eun,Park Se Yoon,Eun Byung Wook,Lee Mi Suk,장현하,Jung Hyungul,Jeong Hye Won,Jo Soo-Nam,Chin Bum Sik,Choi Young Hwa,Ch 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3
During the 2019 domestic measles outbreak in Korea, measles occurred in healthcare workers with two doses of the measles, mumps and rubella vaccine, and the strict application of the Occupational Safety and Health Act required medical institutions to identify healthcare workers' immunity to measles and vaccinate the susceptible pockets. In response to the frontline medical institutions' request to review the measles recommendations and guidelines, the Korean Society of Infectious Diseases held a roundtable discussion on the causes of measles outbreak, timing of vaccinations, antibody tests, and booster vaccinations for healthcare workers, and financial support from the government and municipality as well as response strategies against the outbreak in healthcare settings. In Korea, the seroprevalence of measles is decreasing in the vaccine-induced immunity group during the maintenance of measles elimination over several years. The susceptible group against measles is in their 20s and 30s, and this may be because of waning immunity rather than non-response considering Korea's vaccine policy. The risk of measles nosocomial infection from community increases as these susceptible pockets actively engage in medical institutions. Thus, data on the immunity of low seroprevalence group in Korea are needed, further discussion is needed on the booster vaccination based on the data. Especially, antibody testing and vaccination in healthcare workers may be necessary to prevent the spread of measles in medical insutitutions, and further discussion is needed regarding specific testing methods, and the timing and frequency of test and vaccination.
고지방식이 유도 비만쥐에서 화분이 체중 감소 및 지질대사에 미치는 영향
여주홍(Joo-Hong Yeo),전정우(Jeong-Woo Chon),이광길(Kwang-Gill Lee),우순옥(Soon-Ok Woo),남성희(Sung-Hee Nam),권해용(HaeYong Kweon),한상미(Sang-Mi Han),조유영(You-Young Jo),이희삼(Heui-Sam Lee),이명렬(Myung-Ryul Lee),최용수(Yong-Soo Ch 한국양봉학회 2009 韓國養蜂學會誌 Vol.24 No.3
The intake of high caloric foods and change in lifestyles of industrialized countries has exponentially increased the prevalence of obesity. Pollen contains the richest known source of vitamins, minerals, proteins, and amino acids. Pollen has been traditionally used for the treatment of improve stamina, energy and promote health, and vitality. First, we investigated the anti-adipogenic effect by measuring lipid accumulation with Oil red O staining. The accumulation of triacylglycerol was decreased in 3T3-L1 cells treated with pollen as compared with untreated cells. Second, we investigated the anti-obesity effect of pollen in diet-induce obesity mice. C57BL/6J mice were artificiality induced by dietary manipulation with a high fat diet for 10weeks. After obesity in mice was achieved, pollen groups were administered with pollen at a dose of 100, 300㎎/㎏/day by oral gavages for another 10weeks. At the end of the experiment, the body weight of pollen groups were significantly reduced as compared with that of the high fat diet group by 15.2%, 7.5%, respectively. Serum levels of triglyceride and total cholesterol of pollen groups were significantly decreased compared with that of the high fat diet group while the serum levels of HDLcholesterol were significantly increased. Hepatic levels of triglyceride and total cholesterol in pollen groups were significantly decreased than those of high fat diet group. The results suggest that pollen can be used as potential therapeutic substance as part of prevention or treatment strategy of obesity.
Single Oral Dose Toxicity Test of Persicae Semen Aqueous Extracts in Mice
( Hun Bum Cho ),( Ji Ha Park ),( Bu Il Seo ),( Su Yeon Ch ),( Kyu Ryul Park ),( Seung Hoon Choi ),( Chang Kyun Han ),( Chang Hyun Song ),( Soo Jin Park ),( Sae Kwang Ku ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.3
Objectives : This study was to evaluate the single dose toxicity of Persicae Semen (PS) in ICR mice.Methods : Aqueous extracts of PS (Yield = 18.60%) were administered as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) guidelines (2009-116, 2009). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. Results : Amygdalin contents in PS aqueous extracts were detected as 32.50±5.96 μg/ml. We could not find any PS extracts treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations up to 2,000 mg/kg in both female and male mice, except for transient and slight loss of locomotion detected in female and male mice treated with 2,000 mg/kg. In addition, pharmacological immunomodulatory effects related findings were also demonstrated in 2,000mg/kg treated female and male mice as hypertrophy and hyperplasia of lymphoid cells in the submandibular lymph nodes. Conclusions : Based on the results of this experiment, the approximate lethal dose (ALD) of PS extracts after single oral treatment in female and male mice were considered above 2,000 mg/kg, respectively. It should be carefully used in clinics because the possibilities of respiratory or neurological disorders were observed when administered over 2,000 mg/kg of PS extract related to amygdalin.
Sim, Doo Sun,Jeong, Myung Ho,Kim, Hyo Soo,Gwon, Hyeon Cheol,Seung, Ki Bae,Rha, Seung Woon,Chae, Shung Chull,Kim, Chong Jin,Cha, Kwang Soo,Park, Jong Sun,Yoon, Jung Han,Chae, Jei Keon,Joo, Seung Jae,Ch Elsevier 2018 Journal of cardiology Vol.72 No.5
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Dual antiplatelet therapy (DAPT) is recommended in patients receiving drug-eluting stents (DES). However, bleeding risk should be weighed against ischemic risk. Utility of GRACE risk score and ACUITY-HORIZONS bleeding risk score was assessed in patients with acute myocardial infarction (MI) according to use of P2Y12 blocker.</P> <P><B>Methods</B></P> <P>From the Korea Acute Myocardial Infarction Registry-National Institute of Health database, 7791 patients with acute MI receiving DES were divided into ticagrelor (<I>n</I> =1554) and clopidogrel (<I>n</I> =6237) groups. Propensity-matched 12-month mortality and bleeding event rates were compared according to GRACE and ACUITY-HORIZONS scores. Patients who received thrombolysis, prasugrel or anticoagulants, or who discontinued or switched DAPT were excluded.</P> <P><B>Results</B></P> <P>In all patients, high-risk patients more often received clopidogrel. After propensity score matching (<I>n</I> =1553 in each group), 12-month mortality was not different, but TIMI major bleeding rate was higher with ticagrelor (2.8% vs. 1.4%, <I>p</I> =0.007). On subgroup analysis, 12-month mortality was lower with ticagrelor in patients with high (>140) compared to low-to-moderate risk GRACE score (5.1% vs. 7.9%, <I>p</I> =0.04). When combined with ACUITY-HORIZONS bleeding score, 12-month mortality was lower with ticagrelor in patients with high GRACE score but without very high (≥20) ACUITY-HORIZONS score (2.4% vs. 5.3%, <I>p</I> =0.03).</P> <P><B>Conclusions</B></P> <P>In patients with acute MI receiving DES, GRACE and ACUITY-HORIZONS scores may help guide DAPT. In patients with high GRACE score, a more potent P2Y12 blocker may be considered, particularly in the subset not at very high risk of bleeding.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Both ischemic and bleeding risks are correlated with mortality post-percutaneous coronary intervention. </LI> <LI> GRACE and ACUITY-HORIZONS scores may help guide dual antiplatelet therapy (DAPT) in patients with acute myocardial infarction (MI). </LI> <LI> The optimal DAPT regimen in Asian patients with acute MI needs to be determined. </LI> </UL> </P>
Pre-hospital delay and emergency medical services in acute myocardial infarction
( Seung Hun Lee ),( Hyun Kuk Kim ),( Myung Ho Jeong ),( Joo Myung Lee ),( Hyeon-Cheol Gwon ),( Shung Chull Chae ),( In-Whan Seong ),( Jong-Seon Park ),( Jei Keon Chae ),( Seung-Ho Hur ),( Kwang Soo Ch 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.1
Background/Aims: Minimising total ischemic time (TIT) is important for improving clinical outcomes in patients with ST-segment elevation myocardial infarction who have undergone percutaneous coronary intervention (PCI). TIT has not shown a significant improvement due to persistent pre-hospital delay. This study aimed to investigate the risk factors associated with pre-hospital delay. Methods: Individuals enrolled in the Korea Acute Myocardial Infarction Registry-National Institutes of Health between 2011 and 2015 were included in this study. The study population was analyzed according to the symptom-to-door time (STDT; within 60 or > 60 minutes), and according to the type of hospital visit (emergency medical services [EMS], non-PCI center, or PCI center). Results: A total of 4,874 patients were included in the analysis, of whom 28.4% arrived at the hospital within 60 minutes of symptom-onset. Old age (> 65 years), female gender, and renewed ischemia were independent predictors of delayed STDT. Utilising EMS was the only factor shown to reduce STDT within 60 minutes, even when cardiogenic shock was evident. The overall frequency of EMS utilisation was low (21.7%). Female gender was associated with not utilising EMS, whereas cardiogenic shock, previous myocardial infarction, familial history of ischemic heart disease, and off-hour visits were associated with utilising EMS. Conclusions: Factors associated with delayed STDT and not utilising EMS could be targets for preventive intervention to improve STDT and TIT.
Jung, Seok-Won,Kim, Hyeon-Joong,Lee, Byung-Hwan,Choi, Sun-Hye,Kim, Hyun-Sook,Choi, Yang-Kyu,Kim, Joon Yong,Kim, Eun-Soo,Hwang, Sung-Hee,Lim, Kwang Yong,Kim, Hyoung-Chun,Jang, Minhee,Park, Seong Kyu,Ch The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.3
Background: Anticancer agents induce a variety of adverse effects when administered to cancer patients. Busulfan is a known antileukemia agent. When administered for treatment of leukemia in young patients, busulfan could cause damage to the male reproductive system as one of its adverse effects, resulting in sterility. Methods: We investigated the effects of Korean Red Ginseng extract (KRGE) on busulfan-induced damage and/or dysfunction of the male reproductive system. Results: We found that administration of busulfan to mice: decreased testis weight; caused testicular histological damage; reduced the total number of sperm, sperm motility, serum testosterone concentration; and eventually, litter size. Preadministration of KRGE partially attenuated various busulfan-induced damages to the male reproductive system. These results indicate that KRGE has a protective effect against busulfan-induced damage to the male reproduction system. Conclusion: The present study shows a possibility that KRGE could be applied as a useful agent to prevent or protect the male reproductive system from the adverse side effects induced by administration of anticancer agents such as busulfan.