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      • 비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

        최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

        Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

      • SCISCIE

        Quantitative analysis of alternative transcripts of human PCDH11X/Y genes

        Ahn, Kung,Huh, Jae-Won,Kim, Dae-Soo,Ha, Hong-Seok,Kim, Yun-Ji,Lee, Ja-Rang,Kim, Heui-Soo Wiley Subscription Services, Inc., A Wiley Company 2010 American Journal of Medical Genetics Part B: Neuro Vol. No.

        <P>The Protocadherin 11X/Y (PCDH11X/Y) gene pair has been proposed as a carrier of the variation relating to cerebral asymmetry and psychosis on the ground that the Y gene was generated by duplication at 6 million years (close to the chimpanzee–human separation) and there is a case for an X/Y determinant of cerebral asymmetry. The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. Twelve alternative transcripts of PCDH11X/Y genes were presently identified by in silico analysis. To investigate the biological roles of alternative transcripts of PCDH11X/Y genes, the transcripts were analyzed by real-time reverse transcription-polymerase chain reaction amplification. A total of 31 normal tissues including 11 different regions of human brain were used to investigate a wide spectrum of expression profiles. Dominant expression patterns were identified in several tissues (Tx1-fetal liver; Tx3-adult brain; Tx4-adult brain and kidney; Tx5-bone marrow; Ty1-fetal brain; Ty2-adrenal gland). Tx4 transcripts showed specific expression patterns in olfactory tissues. The findings can guide functional investigation of neuropsychiatric disorders. © 2009 Wiley-Liss, Inc.</P>

      • KCI등재SCISCIE

        Structural and quantitative expression analyses of HERV gene family in human tissues

        Ahn, Kung,Kim, Heui-Soo Springer-Verlag 2009 Molecules and cells Vol.28 No.2

        <P>Human endogenous retroviruses (HERVs) have been implicated in the pathogenesis of several human diseases as multi-copy members in the human genome. Their gene expression profiling could provide us with important insights into the pathogenic relationship between HERVs and cancer. In this study, we have evaluated the genomic structure and quantitatively determined the expression patterns in the env gene of a variety of HERV family members located on six specific loci by the RetroTector 10 program, as well as real-time RT-PCR amplification. The env gene transcripts evidenced significant differences in the human tumor/normal adjacent tissues (colon, liver, uterus, lung and testis). As compared to the adjacent normal tissues, high levels of expression were noted in testis tumor tissues for HERV-K, in liver and lung tumor tissues for HERV-R, in liver, lung, and testis tumor tissues for HERV-H, and in colon and liver tumor tissues for HERV-P. These data warrant further studies with larger groups of patients to develop biomarkers for specific human cancers.</P>

      • KCI등재
      • 임상실습 교육을 위한 임상실습지도자제도(preceptorship)의 모형개발

        안양희,최상순,허혜경,임영미,신윤희,박소미,김대란,김기경,김기연 연세대학교 교육대학원 2002 연세교육과학 Vol.50 No.-

        The purpose of this study was to construct a modified preceptorship model that could be used to improve the quality of clinical practice for student nurses in the Department of Nursing, Wonju College of Medicine, Yonsei University. Through a literature review, three workshops, and analysis of the preceptorship performance of new nurses, three findings were identified. First, based on the literature review and workshops, a modified preceptorship proposal for clinical practice for student nurses in the hospital setting was developed. It contained standard criteria outlining qualifications and rewards for preceptors, training for preceptors, and regulations concerning reciprocal relations among preceptors, head nurses, clinical instructors, and students. Second, results of the analysis of the preceptorship performance of new nurses in the hospital found implications for improvement of self-esteem and self-confidence and, for burden in overloading. Third, based on the literature review, the modified preceptorship proposal, and the results of the analysis of the preceptorship performance of new nurses, a modified preceptorship model was constructed. The modified preceptorship model for clinical practice for student nurses in both hospital and community settings contained standard criteria outlining qualifications and rewards for preceptors, training and education fur preceptors, and regulations concerning reciprocal relations. The standard criteria for qualification as a preceptor should be at least a BSN, at least two years experience, and leadership ability. Rewards for preceptors could be job conditions. For the training and education of preceptors, the difference between hospital and community settings was the content and duration of training. The common training content for preceptors were objectives, orientation to curriculum and preceptorship, clinical practice guidelines, communication channels between health teams and preceptors, nursing process, nursing interventions, and evaluation. In conclusion, the findings suggest a need fur further study on preceptorship when used to improve the quality of clinical practice for student nurses in the both hospital and community settings. The ultimate goal of the research on preceptorship was not only to help student nurses to enhance their ability in clinical practice, but also to maintain the quality of clinical practice in the professional nurses in any clinical setting.

      • 地域住民參與에 의한 都市公園 管理方案에 관한 硏究 : 서울市 5個 都市公園을 對象으로

        安建鏞,金成珍 서울대학교 농과대학 농업개발연구소 1992 서울대농학연구지 Vol.17 No.1

        서울市는 都市公園의 面種이 不足하여, 새로운 公園用地의 確報조 매우 어려운 實情이다. 따라서 서울市 都市公園行政은 현재 施設化 되어 利用되고 있는 公園을 合理的으로 運營하고 管理하여 利用者의 레크레이션 經驗의 質을 높여줄 수 있는 管理方案의 講究가 시급한 과제라고 생각된다. 그러나 현재 서울市는 公園面積의 增加에 반해 管理體制의 整備가 遲延되어 公園의 管理가 形式的이고 消極的으로 進行되고 있다. 管理體制의 改善을 위해서는 公園管理者 및 地域住民, 利用者의 管理에 대한 認識의 轉換과 住民의 參與가 필수적인 요소로서 파악되고 있다. 本 硏究는 서울시의 都市公園을 直接 管理하고 있는 公園管理者 22人과 標出에 의해 선정된 5個 都市公園의 誘置圈內에 居住한는 住民 232人을 對象으로 서울市의 都市公園 管理實態를 把握하고, 管理에 대한 住民意識과 參與意識을 分析항여 管理의 效率化와 利用의 生活化를 도모 할 수 있는 方案으로서 評價되는 地域住民에 의한 都市公園 管理方案을 提案하는데 目的을 두었으며, 結果는 다음과 같다. (1) 서울市의 都市公園管理는 一般 行政의 一環으로 취급되고 있으며, 管理의 目標와 重點的인 管理業務가 公園施設의 維持管理에 초점이 맞추어지고 있기 때문에 利用者의 管理需要에 能動的으로 대처하고 있지 못하다. 都市公園管理에 대해 地域住民이 不滿足하는 事項은 維持管理에 관한 事項이 大部分을 차지하고 있다. 그리고 管理人力과 豫算이 매우 부족하며 利用者의 意識水準이 낮고, 破壞行爲가 빈번하게 발생하고 있어 管理上에 많은 問題가 累積되고 있는 實情이므로 都市公園이 그 機能을 제대로 수행하지 못하는 원인이 되고 있다. (2) 住民과 公園管理者 모두 동일하게 都市公園管理의 責任은 住民과 公園利用者에게 있는 것으로 認識하고 있으며, 公園管理에 대해 建議나 參與한 經驗은 公園管理行政의 硬直性과 造成爲主의 公園政策으로 말미암아 저조한 것으로 分析되었다. 地域住民이 都市公園管理에 參與하고자 하는 參與意志는 높게 분석되었으며, 여자보다 남자가, 연령이 증가할 수록, 利用頻度가 높을수록 참여의지는 높은 것으로 분석되었다. 建議經驗과 參與經驗이 있는 住民의 參與意志가 더욱 높은 것으로 나타났는데, 都市公園管理에대한 地域住民의 관심을 높일 수 있도록 綠化行事 等을 開催하는 것이 필요하다. 그리고 建議經驗과 參與經驗이 확대될수록 參與意志는 높아질 것으로 기대되므로 住民이 쉽게 管理에 대해 建議할 수 있고 參與할 수 있도록 그 통로를 확대하는 것이 필요하다. 또한, 公園管理廳의 硬直性을 脫皮하고, 公園管理에 대한 認識이 '管理 즉 統制'에서 '管理 즉 奉仕'로 轉換하는 것이 필요하다. (3) 地域住民의 參與方法에 있어서 老人會, 早期會 等 기존의 住民團體에 委託管理하는 方法보다 새로운 公園管理團體를 結成하는 方法이 더욱 선호되고 있다. 住民의 參與方法에 대해서 公園과 公園類型間 獨立的인 것으로 검증되었으며, 參與意志가 높을수록 새로운 公園管理團體를 結成하는 方法을 選好하고 있다. 따라서 住民參與制를 보다 積極的으로 施行하기 위하여 새로운 公園管理團體를 結成하는 方法이 필요하다고 생각된다. 住民이 遂行할수 있는 管理業務로는 公園의 淸掃, 禁止行爲와 危險行爲의 注意, 어린이의 놀이지도, 公園管理에 대한 提案 等으로서 비교적 專門的 知識이 필요하지 않는 業務가 적합한 것으로 分析되었으며, 병충해 방제, 공원재산의 관리, 관리계획의 作成 等 專門的 技術을 要하는 業務는 技術講習을 한 後나 住民에 의한 管理가 成 한 以後에 實施하는 것이 바람직하다. 住民이 公園을 管理할 경우 필요한 財源은 서울市가 負擔하고, 管理團體를 통해 住民이 共同으로 補助하는 方案이 바람직한 것으로 分析되었고, 그 外에 희망하는 住民이나 地域內 企業의 寄附를 받는 方案의 講究가 必要한 것으로 생각된다. The purpose of this study is to suggest the method for the neighborhood to manage urban parks, with surveying the real state of urban parks management of Seoul and analysing the awareness and the preference for the community participation of the sampled managers and residents. The results are summarized as follows: 1. The urban parks management in Seoul is dealt with as a part of the general administration and is concenetrated to maintain park's facilities, and to restrain users' various behabiors. As a result, it follows that user' needs for management fail to be completely satisfied. And the accumulated problems such as vandalisms, manpower problems, budgetary deficits prevent urban parks from playing their innate roles. 2. The residents perceived urban parks management depends upon themselves, but have seldom memorialised the Government, participated in managements of the neighboring park. But the majority of them wish voluntarily to take part in the urban parks management. It seems to be needed to arouse the residents to interest in management by holding events such as A Tree-Planting Campaign, to encourage them to propose and participate in management with ease by opening the administrative processes, because the interested, the experienced is willing to take part in all the more. 3. The neighborhood prefer to organize anew the corps for the management of the neighboring park rather than commit to the existed local groups such as the senior citizen association and so forth. The appropriate works for the residents are proven to be the task uncalled for professional skills such as cleaning, cautioning prohibited and dangerous behabiors, coaching children's play, and providing informations of management and maintenance etc., and it seems that the fund should be burdened to Seoul city and is subsidized by the neighborhood cooperatively.

      • CCl₄를 投與한 家兎에 있어 人蔘抽出物이 脂質代謝에 미치는 影響

        安在鏞,成樂應,南宮垠,權寧韶 中央醫學社 1968 中央醫學 Vol.14 No.5

        The serum lipid contents, i.e. total cholesterol, phospholipids and triglycerides were determining at various time intervals after allowing inhalation of carbon tetrachloride to control rabbits and those administered Ginseng for 8 weeks. At the same time, comparison was made between the control and Ginseng-fed animals in regard to the liver lipids determined. 1) The elevation of serum total cholesterol and triglyceride contents were less marked in Ginseng-fed than in the control. 2) Although no marked change was observed in serum phospholipid contents in the control at Ginseng-fed, a slight increase was noted in the latter. 3) The lipids in the liver tissue were generally elevated in both control and Ginseng fed, the elevation being less marked in the Ginseng-fed animals.

      • KCI등재후보

        강원도 원주지역 초·중·고등학생의 식습관 및 섭식행동에 관한 단면연구

        허혜경,박소미,김기연,김춘배,안정숙,송희영,김기경 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

        Purpose : The purpose of this study was to investigate the dietary habits of students in order to identify risk groups according to their Body Mass Index (BMI), and to compare the eating behavior of students in the normal range (19<I≤24) and those in risk groups (BMI≤19, 24<I≤27, BMI>). Method : 1176 elementary school students, 850 middle school students and 672 high school City, were the participants The instrument for this study was a structured questionnaire that included demographic data as well as dietary habits, and the eating behavior instrument developed by Stunkard &essick(1985) and revised by Kim &im (1997). Result : 1) As students moved up in grade level their dietary habits became more irregular and the degree that students chewed food was reduced 2) As students moved up in grade level, a greater number of the students did not eat breakfast. The reasons given were that there were not enough time before classes started(40.4%) and a lack of appetite in the morning(10.6%) in high school students. 3) As for supper, from 67.8 to 81.9% of subjects reported having regular supper. However the rest of the subjects did not eat supper because of anorexia and fear of weight gain. 4) The results identified risk groups according to their BMI showed that for elementary school students, 55.9% were in the low weight group, 5.5% in the overweight group, and 0.9% in the obese group. For middle and high school students, 40.6% and 35.5% respectively were in the low weight group, 7.4% and 6.3% in the overweight group, and 4.1% and 2.5% the obese group. 5) Comparisons of the eating behavior of students in the normal weight group with that of those in the three risk groups showed that there were significant differences in 'hunger' and 'cognitive restraint of eating' in elementary school students, and significant differences in 'cognitive restraint of eating' in middle and high school students. Conclusion : The results of this study show that management of diet in school health sholud be addressed from both the aspect of lack of nutrition and that of excess nutrition. In other words, good diet is as important for students in the low weight group as it is f3r those in the overweight and obese groups. The estatblishment of good dietary habits and eating behavior in students, by nurses and dieticians should be done by providing repeated diet education and involvement in diet counseling.

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