면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

Toward Fine-grained Data-level Access Control Model for Multi-tenant Applications

Kun Ma,Weijuan Zhang,Zijie Tang 보안공학연구지원센터(IJGDC) 2014 International Journal of Grid and Distributed Comp Vol.7 No.2

AtMe : An Online Multi-tenant Social Networking Service in Campus

Kun Ma,Zijie Tang,Zhe Yang,Shuwei Yao 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.5

Recently, more and more undergraduates have turned Internet to find support and take part in society in campus. However, current SNS systems are not oriented to a specific campus. In this paper, we design an online multi-tenant social networking service in campus, including At Helper and At Society. At Helper aims at improving the success ratio of the help process with a multi-tenant architecture, and At Society provides social services using popular instant messaging mobile application. Both modules change the traditional operation and maintenance to rent services. Besides, the key innovative design, such as multi-tenancy and access-aware data cache, are discussed in detail.

Observer-based Non-fragile Mixed Passivity and H∞ Feedback Control for Fuzzy Stochastic Jump System Subject to Quantized Measurements

Kun Ma,Guangming Zhuang,Jianwei Xia,Guoliang Chen,Huasheng Zhang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.9

This paper considers the topic of the observer-based non-fragile mixed passivity and H∞ state feedback control for time-varying delay and norm-bounded parameter uncertainties fuzzy stochastic Markovian jump system subject to quantized measurements. The aim of this paper is to provide a suitable observer-based non-fragile state feedback controller to enhance stochastic stabilization of the closed-loop system and satisfy mixed passivity and H∞ performance. By constructing mode-dependent Lyapunov-Krasovskii functional, novel conditions are achieved in virtue of linear matrix inequalities. Two examples including truck-trailer model are given to illustrate the effectiveness of the developed method.

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.

현행 부정청탁금지법(소위‘김영란법’)의 핵심 문제점과 개정 방안

마정근(Ma, Jong-Kun) 한양법학회 2016 漢陽法學 Vol.27 No.4

Due to the execution of “The Improper Solicitation and Graft Act” are quite a few changes that are occurring in the economic life of the people and the market. These changes will have a negative also be positive. It is worrisome that a burning candle is ridiculous results bedbugs japeuryeoda incest can be caused. We are sure to remember “Don’t as throw the baby out with the bathwater.” Especially when the economy is in the economic downturn in the wrong factors or pay a price to return it and can only be restored to the previous level. The nation is now shrinking factor in a market suffering from long-term recession will be avoided as much as possible. Negative effects of the market downturn and the act can be a positive social effect transparency in public office. Education institutions targeting the belonging configuration in order to avoid confusion over the enforcement of the current act, as well as illegal solicitation is being conducted also a variety of education for the public. However, including the media, which is found to be a serious misunderstanding of the act, even above the interests authoritative interpretation organization, the Anti-Corruption and Civil Rights Commission. Meanwhile. Many ordinary citizens not engaged in public service know they are not good at hitting is not subject to the applicable act. And for those who think themselves the subjects of applicable act, unlike the contents of this Act it shall also contracted a life too. On the other hand, there is a authoritative interpretation agency and the judiciary do not show a difference of opinion conflict or less in part related to the interpretation and application of act standards initiative characters are confused whether to comply with certain criteria and weighting. This paper is the first ‘subject of application’ and ‘duties related requirement’ that the essential requirements of the many controversial points of The Improper Solicitation and Graft Act, and second, ‘gifts, etc.’ and follows centered on the concepts such as ‘social normal usages’ It proposed to derive the same key improvements. First, the Prohibition of Acceptance of Financial or other Advantages are unified by then incorporated into the Criminal Code. Second, and except for the media and private schools involved in applied subjects. Third, all of the provisions that can be punished in the duties unrelated official should be deleted. Fourth, get rid of the Restriction of Acceptance of Honoraria for Outside Lectures or Relevant Activities. Otherwise, the current act and regulations as it shall be the “as the public official or relevant person’s the abuse behavior, they accept the reward money related to his or her duties or requested due to de facto influence arising from his or her position or responsibilities in the outside lecture or relevant activity” only applies to, and the upper limit of reward of the outside lecture or relevant activity should be eliminated entirely. Sixth, it should also be punished in violation of the act of a foreign country. Seventh, the requirement for the prohibition of illegal appeal should be defined as a request for illegal or unfair economic gain from the beginning.

레저스포츠 참여자의 희망, 성취목표성향, 열정의 관계

마세근(Se Kun Ma),김석일(Seok Il Kim) 한국사회체육학회 2011 한국사회체육학회지 Vol.0 No.46

This purpose of the study was to investigate the relationship of hope on goal orientation and passion in leisure sport participants. The subjects were 320 leisure sport participants who responded to the questionnaires, these were hope, goal orientation and passion. The results of this study were as followings. first, pathway thinking of hope had a positive effect on task goal orientation and ego goal orientation. Also, agency thinking had a positive effect on ego goal orientation. Second, task goal orientation of achievement goal orientation had a positive effect on harmonious passion and obsessive passion. And ego goal orientation had a positive effect on harmonious passion and obsessive passion. These results were discussed based on previous literature and theory.

Characteristics of Odor in the Major Facilities of a Fishery Industrial Complex

Seong-Gyu Seo,Zhong-Kun Ma,Jun-Min Jeon 한국냄새환경학회 2009 실내환경 및 냄새 학회지 Vol.8 No.2

The objectives of this study were to analyze the characteristics of odor in the major facilities of a fishery industrial complex using the air dilution olfactory method and the instrumental analysis method. The results indicate that although the limit of dilution to threshold (D/T) ratio in the major facilities is not regulated by the Odor Emission Standard, the mean (D/T) ratio over than 3,000 which is higher than the limit in the outlet of industrial area 3 times was found at three sampling sites. In the case of the concentration of the malodorous compounds, ammonia concentration is higher than any other odor compounds. The methyl mercaptan, n-Butyric acid and hydrogen sulfide as the main pollutants are confirmed by the odor quotient (OQ). In our study, it is showed a moderately good correlation between the (D/T) ratio and the sum of OQ. By this result, we can estimate the odor characteristics and evaluate the potential impact of each odor compound. In addition, we consider that it will affect the people"s normal life and even cause for complaint around the boundary area by the diffusion of odor.

Catalytic Combustion of Propionaldehyde over Alumina-Supported Manganese Oxides

Yi Liu,Zhong-Kun Ma,Seong-Gyu Seo 한국냄새환경학회 2011 실내환경 및 냄새 학회지 Vol.10 No.1

In this study, the catalytic combustion of propionaldehyde, which is an Offensive Odorant Substance assigned by the Korean Ministry of Environment (KMOE), over alumina-supported manganese oxide (Mn/Al2 O3) catalysts was investigated. The combustion reaction was carried out in a fixed-bed reactor at the temperature range of 200 ∼340 ℃. Mn/Al2O3 catalysts with Mn loadings ranging from 3.9 to 18.3 wt.% were prepared by impregnation method. The physicochemical characteristics of the catalysts were analyzed by X-Ray Diffraction (XRD), Scanning Electronic Microscopy (SEM) and Brunauer-Emmett-Teller (BET). The Mn crystalline phases of the Mn/Al2O3 catalysts were identified as α-Mn2O3 and β-MnO2. Mn oxides were covered on γ-Al2O3 supports with an average diameter of around 1 μm. With the increase of Mn loadings, the BET surface areas, pore volumes and average pore diameters of the Mn/Al2O3 catalysts decreased. The catalytic activities of Mn/Al2O3 catalysts increased as the Mn loading was increased from 3.9 wt.% to 18.3 wt.%. The catalyst with 18.3 wt.% Mn loading was able to achieve 100% propionaldehyde conversion at 260 ℃. For the same temperature, a lower Gas Hourly Space Velocity (GHSV) and a lower propionaldehyde concentration promote the complete combustion of propionaldehyde.

Comparative Study of Non-Electrochemical Hysteresis Models for LiFePO₄/Graphite Batteries

Ma, Jiachen,Xie, Jiale,Bai, Kun The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.5

The estimation of $LiFePO_4$/graphite battery states suffers from the prominent hysteresis phenomenon between the respective open-circuit voltage curves towards charging and discharging. A lot of hysteresis models have been documented to investigate the hysteresis mechanism. This paper reviews and deeply interprets four non-electrochemical hysteresis models and some improvements. These models can be conveniently incorporated into commonly used equivalent circuit models to reproduce battery behaviors. Through simulation and experimental comparisons of voltage predictions and state-of-charge estimations, the pros and cons of these models are presented.