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Semi-active friction dampers for seismic control of structures
Kori, Jagadish G.,Jangid, R.S. Techno-Press 2008 Smart Structures and Systems, An International Jou Vol.4 No.4
Semi-active control systems have attracted a great deal of attention in recent years because these systems can operate on battery power alone, proving advantageous during seismic events when the main power source of the structure may likely fail. The behavior of semi-active devices is often highly non-linear and requires suitable and efficient control algorithm. This paper presents the comparative study and performance of variable semi-active friction dampers by using recently proposed predictive control law with direct output feedback. In this control law, the variable slip force of semi-active variable friction damper is kept slightly lower than the critical friction force, which allows the damper to remain in the slip state during an earthquake, resulting in improved energy dissipation capability. This control algorithm is able to produce a continuous and smooth slip forces for a variable friction damper. The numerical examples include a structure controlled with multiple variable semi-active friction dampers and with multiple passive friction dampers. A parameter, gain multiplier defined as the ratio of damper force to critical damper control force, is investigated under four different real earthquake ground motions, which plays an important role in the present control algorithm of the damper. The numerically evaluated optimum parametric value is considered for the analysis of the structure with dampers. The numerical results of the variable friction dampers show better performance over the passive dampers in reducing the seismic response of structures.
How Korean EFL Learners Comprehend Negative Frequency Adverbs
Kory Lauzon,오은정,송상헌 연세대학교 언어정보연구원 2018 언어사실과 관점 Vol.43 No.-
영어의 부정 빈도 부사 집합은 hardly, scarcely, rarely, barely, seldom의 다섯 개 어휘로 구성된다. 이들 부정 빈도 부사는 한국어에서 쉽게 찾을 수 없는 몇 가지 중요한 특성을 지니는데, 이 특성이 영어를 학습하는 한국인에게는 상당한 학습 장애요소가 되곤 한다. 이러한 맥락에서 한국인 영어 학습자의 부정 빈도 부사 사용의 오류 양상을 영어 학습자 말뭉치를 이용하여 분석한 선행 연구가 존재하였다. 본고는 이러한 코퍼스 기반 선행 연구에서 주장한 바를 수용성 판단 실험을 통해 되짚어 보고, 나아가 영어 숙련도가 영어 부정 빈도 부사 사용에 어떠한 영향을 끼치는가 확인해 본다. 기존의 말뭉치 기반 연구에서 분석한 오류 유형은 본 실험 기반 연구에서도 마찬가지로 확인되었다. 부정 빈도 부사의 위치 오류, -ly 형성 규칙의 과잉 적용 및 이중 부정형의 사용 등의 영어 숙련도별 양상을 실험을 통해 확인하였다. 본 연구는 말뭉치와 실험이라는 경험적 연구 방법론을 통해 향후 영어 교수요목에서 더 강조하여야 할 사항을 구체적으로 파악하였다는 점에서 의의를 지닌다.
In silico prediction of epitopes for Chikungunya viral strains
Priyanka Kori,Shrishailnath S. Sajjan,Shivakumar B. Madagi 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.6
Chikungunya is a viral infection transmitted by Aedes mosquitoes in humans. Currently there is no drug available for the treatment of this infection. In absence of a proven therapeutic, vaccines provide an alternative preventive measure for the spread of viral infection in risk prone population. The identification of epitopes is an important step in designing vaccines for viral infections. Traditional methods for vaccine production can be augmented by incorporation of in silico methods at epitopes identification stage. Protein sequences were retrieved for three different viral strains from primary database. Multiple sequence alignment for the retrieved sequences was performed by using MEGA 6.06 to spot the conserved regions. Various immunological databases were utilized to determine the binding affinity with T cells and B cells from structural and non-structural proteins from three different isolates of Chikungunya virus. Five different epitopes were predicted for both structural and non-structural proteins. The epitopes ‘‘KKKPGRRERMCMKIE’’ and ‘‘DAEKEAEEEREAELT’’ and ‘‘AEEEREAEL’’ were predicted as core sequences for class I and class II MHC molecules whereas ‘‘SSKYDLECAQ’’ and ‘‘QVLKAKNIGL’’ were predicted as probable B cell epitopes for structural and non-structural proteins respectively. The identified epitopes can be used for developing a broad spectrum vaccines having effectiveness against different strains of Chikungunya.
Ehsan Dowlati,Kory B. Dylan Pasko,Jiaqi Liu,Charles A. Miller,Daniel R. Felbaum,Samir Sur,Jason J. Chang,Ai-Hsi Liu,Rocco A. Armonda,Jeffrey C. Mai 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.3
In-stent stenosis is a feared complication of flow diversion treatment for cerebral aneurysms. We present 2 cases of patients treated with pipeline flow diversion for unruptured cerebral aneurysms. Initial perioperative dual antiplatelet therapy (DAPT) consisted of standard aspirin plus clopidogrel. At 6-month follow-up cerebral angiography, the patients were noted to have developed significant in-stent stenosis (63% and 53%). The patients were treated with cilostazol and clopidogrel for at least 6 months. Subsequent angiography at 1-year post-treatment showed significant improvement of the in-stent stenosis from 63% to 34% and 53% to 21%. The role of cilostazol as treatment of intracranial in-stent stenosis has not been previously described. Cilostazol’s vasodilatory effect and suppression of vascular smooth muscle proliferation provides ideal benefits in this setting. Cilostazol plus clopidogrel may be a safe and effective alternative to standard DAPT for treatment of in-stent stenosis following flow diversion and warrants further consideration and investigation.
Andrew Yun,Marilena Qutami,Kory B. Dylan Pasko 대한고관절학회 2020 Hip and Pelvis Vol.32 No.4
Purpose: Failed femoral neck fracture (FNF) fixation with in situ pinning presents a surgical challenge. Osteoporotic bone, retained hardware, and a typically elderly population magnify the risks of surgery. Here, outcomes of conversion total hip arthroplasty (THA) using two separate incisions in these high-risk patients were examined. Materials and Methods: Medical records for 42 patients with a prior history of FNF fixation who underwent conversion THA with hardware removal between 2009 and 2019 were retrospectively reviewed. Surgery was performed by a single surgeon at a single institution. All patients underwent hardware removal followed by direct anterior approach (DAA) THA using two separate incisions. Clinical outcomes, radiographic findings, and perioperative morbidity and mortality are reported. Results: Clinically, there were no postoperative dislocations, periprosthetic fractures, or infections at follow-up. After a mean follow-up of 4 years, the mean hip disability and osteoarthritis outcome score, junior (HOOS, Jr) was 91. Radiographically, the mean postoperative cup abduction was 44 degrees and the mean cup anteversion was 21 degrees with an improvement in preoperative leg length discrepancy. Perioperative complications included one case of immediate foot drop and two readmissions for medical issues. One patient died one month after conversion THA. Conclusion: Salvage of failed FNF treatment may be managed with conversion THA and DAA with a separate incision for hardware removal. Preservation of posterior soft tissues using a DAA and intraoperative fluoroscopy may mitigate well-known complications related to fracture and dislocation. While favorable clinical outcomes are possible, salvage surgery is still not without substantial surgical and medical risks.