한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

人口政策에 따른 諸課題

朴聖根(Park Seong Kun),Koh Kap Suk(토론자),Chang Man-Ki(토론자) 한국인구학회 1979 한국인구학 Vol.2 No.1

There are two main problems in formulating population policies. First, is it reasonable to formulate population policy in isolation from other social and economic policies? It is the personal belief of Mr. S. Park that a population policy should be regarded as a part of other social and economic policies. Second, there appears to be no clearly formulated long range objectives in conducting the current population redistribution policy; 1) Community development program should be based on the recognition of the special characteristics of the area. And the re-location program for industries should be strongly supported with special tax and loan consideration. 2) The policy aimed at the dispersion of population should be conducted with the program of providing an equal educational opportunity regardless of geographical location, and family planning. Discussants: Koh, Kap Suk and Chang, Man-Ki. 1. Urbanization may be considered as an inevitable result of industrialization. In order to regulate effectively the population movements into urban centers, there should be a clearly formulated population policy in co-ordination with other social and economic policies. 2. Let us assume that Korea will achieve the zero population growth rate by the year 2,000. The fact that currently there are no long range "visional" proposals to deal with the population composition and distributional problems indicates that there has been no comprehensive research about population planning. 3. The optimal population size for Korea should not be thought of in terms of a static concept but a dynamic concept which is related to manpower supply and housing problems. 4. The problem of aging should not be looked at solely as an economic issue. Instead, it should be examined from a humanistic point of view where high priority is placed on restoring human dignity for the older citizens. Response of Mr. Park: 1. There is a tendency to over-emphasize the economic side of population issues. It should be pointed out that a man not only provides labor which is an input for the production of economic goods, but also he is a consumer for whose welfare economic goods are produced in the first place. It should be remembered that economic growth has beneficial impacts on the population but it also has harmful effects. 2. In order to make the government officials aware of population issues, it has been proposed to the Population Policy Evaluation Committee that the courses in population studies be included in the study program for the re-education of government employees. 3. Issues involved in population dispersion: Urbanization is an inevitable process of economic development. Problems arising from urbanization should be solved not by forcefully preventing the migration of population from rural areas to urban centers but by reducing the rural-urban gap in the living conditions. This policy has already been implemented to some extent as indicated by the government's policy of decentralization of industries and Saemaul Movement. In summary, the basic policy of government is to slow down the rural-urban migration by providing incentives to stay in farms in the rural area rather than by the strong-handed method of preventing the internal migration.

튀김횟수에 따른 튀김식품(돈까스, 감자튀김) 및 식용유지(대두유, 카놀라유, 팜유, 돈지)의 변화

이정훈(Jung-Hoon Lee),박정민(Jung-Min Park),김하정(Ha-Jung Kim),고종호(Jong-Ho Koh),김진만(Jin-Man Kim) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.1

본 연구는 축산물에 사용되는 식용유지의 기준설정을 위하여 모니터링을 실시하였다. 축산물에 사용되는 유지(대두유, 카놀라유, 팜유, 돈지)를 선정하여 식품공전에 고시되고 있는 규격과 비교하여보았다. 상관관계를 구축하여 축산물에 사용되는 식용유지와 일반식품에 사용되는 식용유지의 신선도여부를 파악하였으며, 축산식품과 일반식품의 사용유지 실험값 비교분석을 통한 식품공전에 따른 유지기준(산가 2.5 mg KOH/g 이하, 과산화물가 50meq/kg 이하)을 축산물에도 적용 가능한 지의 여부를 검토하였다. 또한 튀김유지 뿐만 아니라, 유지별 튀김횟수에 따른 튀김식품에 대한 산가, 과산화물가 값을 측정하여 축산물(돈까스)이 일반식품(냉동감자)보다 적은 튀김횟수에서 일반식품의 산가 기준치(5.0 mg KOH/g), 과산화물가 기준치(60 meq/kg)에 도달하는 것을 알 수 있었다. 따라서 본 연구를 통하여 축산물에 사용되는 유지의 기준 규격마련을 위한 기초자료로 사용될 수 있다. The purpose of this study was to investigate the effect of frying number on oxidative changes in edible oils and fried foods. According to the frying number, the extracted edible oils from pork cutlet and fried potato were used as experimental samples. The Ministry of Food and Drug Safety (MFDS) regulations permit edible oils to have <2.5 mg KOH/g of acid value and <50 meq/kg of peroxide value in food. However, there are no regulations for edible oils used to fry livestock. Animal foods contain protein and fat, and should be held to a different standard than ordinary food. Therefore, we present basic information and suggest the establishment of regulations for livestock frying oil and fried livestock.

Ex Vivo Expansion and 3-D Culture of Human Chondrocytes

Ji-Young Han,Seah Park1,Su Yeon An,Kyung Suk Kim,Seung H. Kim,Seung-Ho Koh,Wonjae Roh,Byung-Rok Do,Yong-Dal Yoon,Haekwon Kim 한국동물생명공학회(구 한국동물번식학회) 2004 발생공학 국제심포지엄 및 학술대회 Vol.2004 No.1

Environmental Risk Assessment of Genetically Engineered Herbicide-Tolerant <i>Zoysia japonica</i>

Bae, T. W.,Vanjildorj, E.,Song, S. Y.,Nishiguchi, S.,Yang, S. S.,Song, I. J.,Chandrasekhar, T.,Kang, T. W.,Kim, J. I.,Koh, Y. J.,Park, S. Y.,Lee, J.,Lee, Y.-E.,Ryu, K. H.,Riu, K. Z.,Song, P.-S.,Lee, H Wiley (John WileySons) 2008 Journal of environmental quality Vol.37 No.1

<P>Herbicide-tolerant Zoysia grass (Zoysia japonica Steud.) has been generated previously through Agrobacterium tumefaciens-mediated transformation. The genetically modified (GM) Zoysia grass survived Basta spraying and grew to maturity normally while the wild-type (WT) grass stopped growing and died. GM Zoysia grass will permit more efficient weed control for various turf grass plantings such as home lawns, golf courses, and parks. We examined the environmental/biodiversity risks of herbicide-tolerant GM Zoysia before applying to regulatory agencies for approval for commercial release. The GM and WT Zoysia grass' substantial trait equivalence, ability to cross-pollinate, and gene flow in confined and unconfined test fields were selectively analyzed for environmental/biodiversity effects. No difference between GM and WT Zoysia grass in substantial traits was found. To assess the potential for cross-pollination and gene flow, a non-selective herbicide, Basta, was used. Results showed that unintended cross-pollination with and gene flow from GM Zoysia grass were not detected in neighboring weed species examined, but were observed in WT Zoysia grass (on average, 6% at proximity, 1.2% at a distance of 0.5 m and 0.12% at a radius of 3 m, and 0% at distances over 3 m). On the basis of these initial studies, we conclude that the GM Zoysia grass generated in our laboratory and tested in the Nam Jeju County field does not appear to pose a significant risk when cultivated outside of test fields.</P>

Novel role of platelet reactivity in adverse left ventricular remodelling after ST-segment elevation myocardial infarction: The REMODELING Trial

Park, Yongwhi,Tantry, Udaya,Koh, Jin-Sin,Ahn, Jong-Hwa,Kang, Min,Kim, Kye,Jang, Jeong,Park, Hyun,Park, Jeong-Rang,Hwang, Seok-Jae,Park, Ki-Soo,Kwak, Choong,Hwang, Jin-Yong,Gurbel, Paul,Jeong, Young-Ho Thieme 2017 Thrombosis and Haemostasis Vol.117 No.5

<B>Summary</B><P>The role of platelet-leukocyte interaction in the infarct myocardium still remains unveiled. We aimed to determine the linkage of platelet activation to post-infarct left ventricular remodelling (LVR) process. REMODELING was a prospective, observational, cohort trial including patients (n = 150) with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Patients were given aspirin plus clopidogrel therapy (600 mg loading and 75 mg daily). Platelet reactivity (PRU: P2Y12 Reaction Units) was assessed with VerifyNow P2Y12 assay on admission. Transthoracic echocardiography was performed on admission and at one-month follow-up. The primary endpoint was the incidence of LVR according to PRU-based quartile distribution. LVR was defined as a relative ≥ 20 % increase in LV end-diastolic volume (LVEDV) between measurements. Adverse LVR was observed in 36 patients (24.0 %). According to PRU quartile, LVR rate was 10.8 % in the first, 23.1 % in the second, 27.0 % in the third, and 35.1 % in the fourth (p = 0.015): the optimal cut-off of PRU was ≥ 248 (area under curve: 0.643; 95 % confidence interval: 0.543 to 0.744; p = 0.010). LVR rate also increased proportionally according to the level of high sensitivity-C reactive protein (hs-CRP) (p = 0.012). In multivariate analysis, the combination of PRU (≥ 248) and hs-CRP (≥ 1.4 mg/l) significantly increased the predictive value for LVR occurrence by about 21-fold. In conclusion, enhanced levels of platelet activation and inflammation determined the incidence of adverse LVR after STEMI. Combining the measurements of these risk factors increased risk discrimination of LVR. The role of intensified antiplatelet or anti-inflammatory therapy in post-infarct LVR process deserves further study.</P>

The trend of body donation for education based on Korean social and religious culture.

Park, Jong-Tae,Jang, Yoonsun,Park, Min Sun,Pae, Calvin,Park, Jinyi,Hu, Kyung-Seok,Park, Jin-Seo,Han, Seung-Ho,Koh, Ki-Seok,Kim, Hee-Jin John Wiley Sons 2011 Anatomical sciences education Vol.4 No.1

<P>Until a century ago, Korean medicine was based mainly on Oriental philosophies and ideas. From a religious perspective, Chinese Confucianism was prevalent in Korea at that time. Since Confucianists believe that it is against one's filial duty to harm his or her body, given to them by their parents, most Koreans did not donate their bodies or organs for education in the past. However, by the end of the 20th century, a unique fusion of Western and Oriental medicines were produced on the Korean Peninsula, revolutionizing traditional perspectives on the human body, mortality, and the relationship of medical science to society. Koreans began to think about others' lives as well as their own by realizing the importance of donating one's organs and bodies for scientific purposes. Since then, the number of people donating their bodies to Korean medical and dental schools for the purpose of improving academic learning has increased dramatically. In response, Korean medical schools have begun to hold various types of funeral ceremonies to honor body donors. We have compared such ceremonies performed in Korea with those performed in the United States of America and Taiwan. These ceremonies are viewed as a suitable way to pay proper respect to the dead and to promote knowledge about body donation programs in Korea. Overall, the transition of religions and social ethics in Korea has greatly facilitated body bequeathal programs, benefiting both medical education and the Korean public health administration. Anat Sci Educ. © 2011 American Association of Anatomists.</P>

Difference in Effects of Appended 2-O- and 6-O-Tosyl Groups of $\beta$ -Cyclodextrin on the Binding and Hydration Reaction of 1-Benzyl-1,4-Dihydronicotinamide

Park Koh Kwanghee,Park Hee Sock,Park Joon Woo Korean Chemical Society 1992 Bulletin of the Korean Chemical Society Vol.13 No.4

Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues

Koh, Young Jun,Park, Byung-Hyun,Park, Ji-Hyun,Han, Jinah,Lee, In-Kyu,Park, Jin Woo,Koh, Gou Young Springer Science and Business Media LLC 2009 Experimental and molecular medicine Vol.41 No.12

국내·외 사례비교를 통한 교통안전체험교육센터 프로그램의 개선 방안에 관한 연구

박용우 ( Park Yong Woo ),박신형 ( Park Shin Hyoung ),김준년 ( Kim Jun Nyen ),박현수 ( Park Hyun Su ),고민지 ( Koh Min Ji ),박소은 ( Park So Eun ) 한국도로교통공단 2019 교통안전연구 Vol.38 No.-

Established in 2009, Safe Driving Training Programs Center has been associated with raising awareness regarding the importance of safe driving and has contributed to the reduction of traffic accidents through experience education that is focused on field practice. However, no new experience education courses have been developed since the development of “control the test vehicle training course” in 2013. Therefore, education satisfaction level of the students is continuously decreasing. This study thereby suggested ways to improve experience education program of the Safe Driving Training Programs Center, currently operating in Sangju and Hwaseong. Problems were identified by analyzing the current status of the Safe Driving Training Programs Center program that is currently in operation. This study suggested measures to improve the programs by benchmarking overseas cases. In addition, program improvement was supplemented by referring to the survey results conducted on students of the Safe Driving Training Program Center.