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고착협 내탈립 기계수확 적응 장류⋅두부용 콩 품종 ‘새금’
김현태(Hyun Tae Kim),한원영(Won Young Han),이병원(Byung Won Lee),고종민(Jong Min Ko),이영훈(Yeong Hoon Lee),백인열(In Youl Baek),윤홍태(Hong Tai Yun),하태정(Tae Joung Ha),최만수(Man Soo Choi),강범규(Beom Kyu Kang),김현영(Hyun Yeong K 한국육종학회 2019 한국육종학회지 Vol.51 No.4
The soybean cultivar, ‘Saegeum’, has been developed for preparing soy-paste and tofu. The soybean cultivars ‘Daepung’ and ‘SS98207-3SSD-168’ were crossed in 2003 to obtain ‘Saegeum’. Single seed descent method was used to advance the generation from F3 to F5, and the plant lines with promising traits were selected from F6 to F7 by pedigree method. The preliminary yield (PYT) and advanced yield trials (AYT) were conducted from 2009 to 2010, and the regional yield trial (RYT) was conducted in 12 regions between 2011 and 2013. The morphological characteristics of ‘Saegeum’ were as follows: determinate plant type, white flower, tawny pubescence color, and brown pod color. Flowering and maturity dates were August 2, XXXX and October 17, XXXX, respectively. Plant height, first pod height, number of nodes, number of branches, and number of pods were 79 cm, 18 cm, 16, 2.3, and 44, respectively. The seed characteristics of ‘Saegeum’ were as follows: yellow spherical shape, yellow hilum, and the 100-seed weight was 25.4 g. ‘Saegeum’ was resistant to bacterial pustule and SMV in the field test, and its lodging resistance was mildly strong, whereas its shattering resistance was excellent. The ability of this cultivar to be processed into tofu, soybean malt, and other fermented products was comparable with that of ‘Daewonkong’. The yield of ‘Saegeum’ in the adaptable regions was 3.02 ton ha-1. Thus, ‘Saegeum’ is adaptable to mechanized harvesting because of its high first pod height, as well as lodging and shattering resistance. (Registration number: 5929)
Kallmann syndrome with a Tyr113His <i>PROKR2</i> mutation
Ha, Jeong-Ha,Lee, Sara,Kim, Youngmoon,Moon, Ji In,Seo, Jongkwon,Jang, Ja-Hyun,Cho, Eun-Hae,Kim, Jung Min,Rhee, Byoung Doo,Ko, Kyung Soo,Yoo, Soo Jin,Won, Jong Chul Williams & Wilkins Co 2017 Medicine Vol.96 No.35
<P><B>Abstract</B></P><P><B>Rational:</B></P><P>Kallmann syndrome (KS) is a genetic gonadotropin-releasing hormone deficiency associated with hyposmia or anosmia and characterized by various modes of inheritance.</P><P><B>Patient concerns:</B></P><P>A 16-year-old male did not reach puberty and was associated with hypogonadotropic hypogonadism and anosmia. His magnetic resonance imaging of brain revealed the absence of the olfactory bulb.</P><P><B>Diagnosis:</B></P><P>His karyotype was 46 XY. Sanger sequencing of the <I>KAL1</I> gene revealed no mutations. Diagnostic exome sequencing identified a prokineticin-receptor 2 (<I>PROKR2</I>) gene variant, c.337T > C (p.Tyr113His), previously reported to be a pathogenic mutation; we confirmed the presence of the mutation via Sanger sequencing of the coding exons of <I>PROKR2</I>. His apparently unaffected mother and sister, but not his father, were heterozygous for the <I>PROKR2</I> Tyr113His mutation.</P><P><B>Lessons:</B></P><P>This work advances our understanding of the role played by PROKR signaling and the mode of inheritance of the gene in patients with KS.</P>
Expression of potassium channel genes predicts clinical outcome in lung cancer
Ko, Eun-A,Kim, Young-Won,Lee, Donghee,Choi, Jeongyoon,Kim, Seongtae,Seo, Yelim,Bang, Hyoweon,Kim, Jung-Ha,Ko, Jae-Hong The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Lung cancer is the most common cause of cancer deaths worldwide and several molecular signatures have been developed to predict survival in lung cancer. Increasing evidence suggests that proliferation and migration to promote tumor growth are associated with dysregulated ion channel expression. In this study, by analyzing high-throughput gene expression data, we identify the differentially expressed $K^+$ channel genes in lung cancer. In total, we prioritize ten dysregulated $K^+$ channel genes (5 up-regulated and 5 down-regulated genes, which were designated as K-10) in lung tumor tissue compared with normal tissue. A risk scoring system combined with the K-10 signature accurately predicts clinical outcome in lung cancer, which is independent of standard clinical and pathological prognostic factors including patient age, lymph node involvement, tumor size, and tumor grade. We further indicate that the K-10 potentially predicts clinical outcome in breast and colon cancers. Molecular signature discovered through $K^+$ gene expression profiling may serve as a novel biomarker to assess the risk in lung cancer.
Won Ha Ko,S. J. Yoo,K. -I. You,M. Kwon 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.52
The Hanbit magnetic mirror is being operated in RF sustained modes without any other external power. The ions heated at the ion cyclotron resonance frequency (ICRF) are generally either trapped and re ected near the resonant magnetic eld or are untrapped and eventually disappear into the loss cone. Experiments have been performed to determine the eect of ICRF heating on the ion pitch-angle distribution, the end-loss ion currents, and the ion temperature. A pitch-angle detector array, which can directly obtain the pitch-angle distribution of ions in the peripheral regions of the plasma, is used to measure the ions heated by the RF wave. The ICRF heating process aects the pitch-angle distribution directly and is a main cause of the anisotropy of the ion distribution. Endloss analyzers (ELA) have been used to give the radial temperature distribution of ions escaping along magnetic eld lines.
[P285] A case of disseminated Mycobacterium avium complex infection in an immunocompromised patient
( Won-ku Lee ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Mycobacterium avium intracellulare complex (MAC) includes 2 genetically similar organisms: Mycobacterium avium and Mycobacterium intracellulare. Mycobacterium avium complex (MAC) is a ubiquitous pathogen, widely distributed in the environment including water, soil and animals. Disseminated MAC occurs in cell-mediated immunodeficiency and is mostly described in the setting of advanced HIV disease. To our knowledge, this is a rare case of disseminated MAC in a non-AIDS patient in Korea. A 64-year-old female presented with 2-week history of soft fluctuating mass on scalp. She had past history of MAC infection, pulmonary tuberculosis, Sweet syndrome and undifferentiated connective tissue disease.The bacterium culture from her skin was identified as MAC. This was also isolated from CT guided aspiration of psoas abscess and sputum. A diagnosis of disseminated MAC infection was established based on the laboratory and clinical findings. The patient was initially treated with clarithromycin, ethambutol, and rifabutin as a result of the drug-sensitivity test. Due to poor response, treatment with amikacin and cycloserin was added with successful clinical resolution. Clinicians should be alert for the diagnosis of MAC infection in diverse clinical conditions. Despite the severity of this infection, with timely diagnosis effective treatment is available.
(Won Ha Lee),(Young Hyeh Ko),(Dong Ik Kim),(Byung Boong Lee),(Jeong Euy Park) 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.2
N/A Background : Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the involvement of various immune cells in the pathogenesis of atherosclerosis. Methods : We investigated the presence of foam cells, lymphocytes and killer cells in 11 atherosclerotic plaque specimens removed from Korean patients who underwent carotid endoarterectomy. Atherosclerotic plaques were analyzed by immunohistochemistry using monoclonal antibody specific to foam cells (anti- CD68), pan-T cells (anti-CD3), helper-T cells (anti-CD4), cytotoxic T cells (anti- CD8), granular component of killer cells (anti-TIA-1) and pan-B cells (anti- CD20). Results : Analysis revealed a general infiltration of immune cells not only in atherosclerotic plaques but also in the vascular wall adjacent to the plaque. Heavy infiltration of CD68+ macrophage was observed in all cases. In addition, significant infiltration of CD3+ T-lymphocytes was observed in all cases, while CD20+ B-cells were observed in only a few cases. Majority of the CD3+ cells was found to be CD4+ helper-T cells. CD8+ cytotoxic T cells and TIA-1+ cells were less prominent. Conclusion : Analysis of the human atherosclerotic plaques suggested that helper-T cells and foam cells had a major role in the plaque development.
Generalized pustular psoriasis in a 1-month-old boy
( Won Ku Lee ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Generalized pustular psoriasis (GPP) is a rare type of psoriasis, and it is very rare in children. A safe and consistently effective treatment regimen has not been identified, although many treatment modalities have been suggested so far. To our knowledge, the earliest onset of GPP in childhood that has been reported in the literature is 1.5months. Herein, we report a case of GPP in a child with the earliest onset of age. A healthy 2-month-old boy developed diffuse erythematous scaly patch with tiny pustules on whole body starting at 4 weeks after birth. Pustules were pin head-sized, and the lesions had rapidly progressed to large exuding areas. The clinical findings and histopathological examinations were consistent with the diagnosis of GPP. With topical steroid, the lesions repeated improvement and deterioration resulting lost to follow-up. After 1.5 years, the patient revisited the clinic with severe flare of erythematous lesions and pustules on whole body. The pustular lesions almost disappeared with the treatment of methylprednisolone and cyclosporine. Generalized erythematous eruption in neonate can be the manifestation of various diseases such as atopic dermatitis, seborrheic dermatitis, Leiner disease, and Langerhans cell histiocytosis. We suggest GPP should also be considered in differential diagnosis for neonatal erythroderma.
Periungual osteochondroma: Unusual case involving nail
( Won Ku Lee ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Osteochondroma is the most common skeletal tumor that is rarely seen in periungual area. Though, various types of tumors can occur on periungual area, there has been no case of periungual osteochondroma with various nail abnormalities like this case in English literature yet. Fourteen-year-old girl presented with various finger nail abnormalities such as red longitudinal bands, red and white longitudinal bands (characteristics of Darier disease), longitudinal elevated ridge, and nail splitting and onychoschizia. The cause of these various nail abnormalities were induced by multiple periungual osteochoma, which was confirmed by characteristic radiographic and histopathologic findings. Though periungual osteochondroma is very rare, it should be included in differential diagnoses for above various nail abnormalities.