A Metro WDM Star Network with a Hybrid MAC Protocol Based on an Arrayed Waveguide Grating

Kirmani, Syed Abdul Mannan,Shin, Seo-Yong,Yang, Hyo-Sik Optical Society of Korea 2007 Current Optics and Photonics Vol.11 No.2

In this paper, we introduce a reliable, scalable, and cost-effective switchless wavelength division multiplexing (WDM) network based on a quality-of-service supporting reservation-based medium access control (MAC) protocol. The protocol not only provides both packet and circuit switching but also supports multicasting. The network efficiency is significantly increased by spatially reusing wavelengths and exploiting multiple free spectral ranges (FSRs) of arrayed waveguide grating (AWG) employed in the architecture. We have demonstrated the feasibility of this architecture by simulating in $Optsim^{TM}$.

The Codon 399 Arg/Gln XRCC1 Polymorphism is Associated with Lung Cancer in Indians

Natukula, Kirmani,Jamil, Kaiser,Pingali, Usha Rani,Attili, Venkata Satya Suresh,Madireddy, Umamaheshwar Rao Naidu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Background: The XRCC1 (X-ray repair cross complimenting group-I) gene in BER (base excision repair) pathway is essential for DNA repair process. Polymorphisms in this gene are associated with variations in the repair efficiency which might predispose individuals to development of various cancers. Two variants of XRCC1gene (at codon 399), Gln/Gln and Arg/Gln, have been shown to be related to lowered DNA repair capacity and increased genomic instability in multiple studies. Hence our investigation focused on genotyping these variants to correlate with other multiple risk factors in lung cancer (NSCLC) patients since we hypothesized that these variants of the XRCC1 gene might influence disease susceptibility. Materials and Methods: We examined the frequency of the polymorphism in one hundred cases and an almost equal number of controls after recording their demographics with a structured questionnaire. Genomic DNA from blood samples was extracted for PCR studies, followed by RFLP to determine the variants. The significance of the data was statistically analyzed. Results: The three genotypes in cases and controls were Arg/Arg (40% and 54.45%); Gln/Gln (19% and 9.90%), and Arg/Gln (41.0% and 35.64%) respectively. Among these 3 genotypes, we found Gln/Gln and Arg/Gln to show association with lung cancer. Correlating these genotypes with several parameters, we also found that these two variants were associated with risk in males (p<0.05) and with smoking habits (p<0.05). In females Arg/Gln genotype showed association with stage of the disease (p=0.04). This is the first report in South Indian scenario where Arg399Gln genotypes were found to be associated with stage of the disease in females. Conclusions: It is concluded that XRCC1 genotypes Gln/Gln and Arg/Gln may influence cancer susceptibility in patients with smoking habits and these functional SNPs in XRCC1 gene may act as attractive candidate biomarkers in lung cancer for diagnosis and prognosis.

Survival Analysis in Advanced Non Small Cell Lung Cancer Treated with Platinum Based Chemotherapy in Combination with Paclitaxel, Gemcitabine and Etoposide

Natukula, Kirmani,Jamil, Kaiser,Pingali, Usha Rani,Attili, Venkata Satya Suresh,Madireddy, Umamaheshwar Rao Naidu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Background: The wide spectrum of clinical features in advanced stages of non-small cell lung cancer (NSCLC) probably contributes to disparities in outcomes because of different prognostic variables significant for stage IIIB/IV patients. Hence the aim of this study was to check for favorable response of patients to various chemotherapeutic combinations with respect to patient survival in stage IIIB and stage IV NSCLC disease. We selected those patients for our study who were receiving treatment with paclitaxel, gemcitabine or etoposide in combination with platinum based drugs. Materials and Methods: Seventy-two patients who visited the hospital from June 2009 to November 2012 with confirmed diagnosis of lung cancer were included, and data were collected for follow up and classified according to treatment received with respect to patients' regimen and response, and overall survival. This study analyzed tumor variables that were associated with clinical outcome in advanced NSCLC patients who were undergoing first-line chemotherapy for stage IIIB/IV NSCLC. Results: Comparative data on various parameters like age, gender, stage, histology, site of disease, metastatic site and chemo-regimens was analyzed; these parameters predicted variable significant improvement for overall survival ($p{\geq}0.05$). One and two year survival rates were 20.8% and 15.3%. Conclusions: In this study we found slight improvement in survival rates in NSCLC and clinical outcomes with one combination (carboplatin+paclitaxel). Overall there were only marginal differences in survival rates for other chemo-regimens evaluated in this study.

Performance Analysis of Metro WDM Star Network based on An Arrayed Waveguide Grating

Syed Abdul Mannan Kirmani,Seoyong Shin,양효식,Naeem Zafar Azeemi 한국광학회 2008 Current Optics and Photonics Vol.12 No.4

In this paper, we analyze the performance of a reliable, scalable, and cost-effective switchless wavelength division multiplexing (WDM) network based on an arrayed waveguide grating (AWG). The network efficiency is significantly increased by spatially reusing wavelengths and exploiting multiple free spectral ranges (FSRs) of the AWG employed in the architecture. We have analyzed the performance of this architecture by simulating in OptsimTM with a control channel which exploits the broadband light source, i.e., an LED. The data was successfully transmitted to a distance of 30 km without using any EDFA’s in the network, with a reasonable BER of 4.0530×10-14. We have analyzed the performance of this architecture with a control channel which exploits the broadband light source, i.e., an LED, by simulating in OptsimTM.

Cospectral and hyper-energetic self complementary comparability graphs

Merajuddin,S. A. K. Kirmani,Parvez Ali,S. Pirzada 한국산업응용수학회 2007 Journal of the Korean Society for Industrial and A Vol.11 No.3

A graph G is self-complementary (sc) if it is isomorphic to its complement. G is perfect if for all induced subgraphs H of G, the chromatic number of H (denoted X(H)) equals the number of vertices in the largest clique in H (denoted w(H)). An sc graph which is also perfect is known as sc perfect graph. A comparability graph is an undirected graph if it can be oriented into transitive directed graph. An sc comparability (sec) is clearly a subclass of sc perfect graph. In this paper we show that no two non-isomorphic sec graphs with n vertices each, (n < 13) have same spectrum, and that the smallest positive integer for which there exists hyper-energetic sec graph is 13.

Estimation of co-variance components, genetic parameters, and genetic trends of reproductive traits in community-based breeding program of Bonga sheep in Ethiopia

Areb, Ebadu,Getachew, Tesfaye,Kirmani, MA,G.silase, Tegbaru,Haile, Aynalem Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.9

Objective: The objectives of the study were to evaluate reproductive performance and selection response through genetic trend of community-based breeding programs (CBBPs) of Bonga sheep. Methods: Reproduction traits data were collected between 2012 and 2018 from Bonga sheep CBBPs. Phenotypic performance was analyzed using the general linear model procedures of Statistical Analysis System. Genetic parameters were estimated by univariate animal model for age at first lambing (AFL) and repeatability models for lambing interval (LI), litter size (LS), and annual reproductive rate (ARR) traits using restricted maximum likelihood method of WOMBAT. For correlations bivariate animal model was used. Best model was chosen based on likelihood ratio test. The genetic trends were estimated by the weighted regression of the average breeding value of the animals on the year of birth/lambing. Results: The overall least squares mean±standard error of AFL, LI, LS, and ARR were 375±12.5, 284±9.9, 1.45±0.010, and 2.31±0.050, respectively. Direct heritability estimates for AFL, LI, LS, and ARR were 0.07±0.190, 0.06±0.120, 0.18±0.070, and 0.25±0.203, respectively. The low heritability for both AFL and LI showed that these traits respond little to selection programs but rather highly depend on animal management options. The annual genetic gains were -0.0281 days, -0.016 days, -0.0002 lambs and 0.0003 lambs for AFL, LI, LS, and ARR, respectively. Conclusion: Implications of the result to future improvement programs were improving management of animals, conservation of prolific flocks and out scaling the CBBP to get better results.

Allocation of DG in Distribution Network Using Parameter Independent JAYA Algorithm

Pandey Anand Kumar,Kirmani Sheeraz,Kumar Ankesh,Akhtar Iram 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3

Integration of DGs in the distribution network has led to challenges in making the system reliability, and other parameters improve. This paper gives a detailed discussion on the placement of DG in the distribution system using the new algorithm ‘JAYA’ having no control parameter which makes the algorithm simple than previous used algorithms and also give best solutions according to the study. Three system parameters are considered for DG placement solution: active power loss reduction, voltage deviation reduction and voltage stability index maximization. The methodology is presented to calculate the optimal values for varying load profiles i.e. constant, residential, commercial and industrial. Type-1 DG placement is considered for placement. Simultaneous improvement of all factors using weight based multi-objective function is used. Standard test system IEEE-33 and 69 bus is used to validate the applicability of the methodology and compared to other optimization methods, the results presented proves the JAYA to be better optimization of optimal DG calculation as the method is simple, feasible and have good applicability with other nature inspired and meta-heuristic methods.

Cospectral and hyper-energetic self complementary comparability graphs

( Merajuddin ),( S. A. K. Kirmani ),( Parvez Ali ),( S. Pirzada ) 한국산업응용수학회(구 한국산업정보응용수학회) 2007 한국산업정보응용수학회 Vol.11 No.3

A graph G is self-complementary (sc) if it is isomorphic to its complement. G is perfect if for all induced subgraphs H of G, the chromatic number of H (denoted X(H)) equals the number of vertices in the largest clique in H (denoted w(H)). An sc graph which is also perfect is known as sc perfect graph. A comparability graph is an undirected graph if it can be oriented into transitive directed graph. An sc comparability (scc) is clearly a subclass of sc perfect graph. In this paper we show that no two non-isomorphic scc graphs with n vertices each, (n < 13) have same spectrum, and that the smallest positive integer for which there exists hyper-energetic scc graph is 13.

Estimates of Genetic Parameters and Genetic Trends for Growth Traits of Doyogena Sheep in Southern Ethiopia

Kebede Habtegiorgis,Aynalem Haile,Manzoor Ahmed Kirmani,Tesfaye Getachew 한국동물유전육종학회 2020 한국동물유전육종학회지 Vol.4 No.2

The objective of this study was to estimate the genetic parameters, genetic trends and inbreeding levels for growth traits of Doyogena sheep managed under community-based breeding program. Records used in the study were collected over a period of 6 years (2013-2018).A total of 2990 birth weight (BWT), 2121 three-month weight (WWT), 1303 six month weight (6WT), 2098 average daily gain from birth to weaning (ADG0-3), 1287 average daily gain from weaning to 6-month age (ADG3-6), and 1293 average daily gain from birth to 6-month age (ADG0-6) were used. Variance components and genetic parameters were estimated with univariate analysis by fitting restricted maximum likelihood methods using WOMBAT software. Six different animal models were fitted by including or excluding maternal effects. Multivariate analysis was applied for correlation estimates. The overall least squares means ± standard errors (LSM±SE) of lamb body weight for BWT, WWT and 6WT were 3.05±0.02 kg; 14.8±2.49 kg and 22.0±0.22 kg respectively. The overall LSM±SE of ADG0-3, ADG3-6, and ADG0-6 in gram were 130.4±2.27, 80.6±3.62 and 106.2±1.7 respectively. Based on the best fitted univariate models, direct heritability estimates, for BWT, WWT, 6WT, ADG0-3, ADG3-6 and ADG0-6 were 0.33±0.06, 0.31±0.06, 0.14±0.06, 0.13±0.04, 0.11±0.07, and 0.023±0.05 respectively. The maternal heritability estimates for BWT and WWT were 0.24±0.12 and 0.6±0.07 respectively. BWT has weak genetic correlation with all other traits while genetic correlations between WWT and 6WT was higher (r=0.52±0.09). Genetic changes over the selection period was s0.00085 kg,0.30 kg,0.15 kg, 2.56gm, -0.37gm,0.09 gm, for BWT, WWT, 6WT, ADG0-3, ADG3-6, and ADG0-6, respectively. Genetic parameter estimates and genetic trend over years suggested that the genetic selection can lead to improvement of Doyogena sheep breed under the ongoing community-based breeding programs. Thus, continuation of selection therefore recommended for bringing further improvement.

Compound heterozygosity for a whole gene deletion and p.R124C mutation in CYP21A2 causing nonclassic congenital adrenal hyperplasia

Hamza Nasir,Syed Ibaad Ali,Naeem Haque,Stefan K. Grebe,Salman Kirmani 대한소아내분비학회 2018 Annals of Pediatirc Endocrinology & Metabolism Vol.23 No.3

We present a family with 2 members who received long-term steroid treatment for presumed classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, until molecular testing revealed nonclassic CAH, not necessarily requiring treatment. A 17-year-old male presented to our clinic on glucocorticoid and mineralocorticoid treatment for classic CAH. He was diagnosed at 4 years of age based on mild-moderate elevations of 17-hydroxyprogesterone (17-OHP) and adrenocorticotropic hormone (ACTH), but without evidence of precocious adrenarche/puberty. Due to his diagnosis, his clinically asymptomatic 3-year-old sister was tested and also found to have elevated ACTH and 17-OHP levels and was started on glucocorticoids for classic CAH. Family history revealed a healthy sibling who had no biochemical evidence of CAH and consanguineous healthy parents. We questioned the diagnosis of classic CAH and performed an ACTH1-24 stimulation test, which showed a level of 17-OHP in the borderline range between classic and nonclassic CAH. Molecular testing, using sequencing and multiplex ligation-dependent probe amplification analysis of CYP21A2, revealed that both affected siblings were compound heterozygotes for a whole-gene deletion and a, likely pathogenic (nonclassical), sequence variant, p.R124C. The asymptomatic father had the same genotype, while the mother showed one deleted copy and 2 active copies, making her an asymptomatic carrier. Our report demonstrates the importance of molecular testing in atypical cases of CAH, as well as the importance of both sequencing and deletion analysis. The results of molecular testing should be interpreted in clinical context, and treatment should be prescribed according to guidelines when available.