The level of urinary aflatoxin M1 in Korean adults

Yong-Dae Kim1, Hyojin Kwon, Sun-In Moon, Sang-Yong Eom, Jung-Duk Park, Byung-Sun Choi, Seok-Joon Sohn, Young-Seoub Hong, Ho Kim, Ho-Jang Kwon, Ji-Ae Lim, Hae-Jung Yoon, Gwang-Jin Kim, Heon Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3

Competitive ELISA methods were used to measure the level of aflatoxin M1 (AFM1) from urine in 1008 Korean adults. Subjects were selected by random sampling in all areas of Korea, except Cheju-do. The recovery rate of AFM1 using this method was 105% (73-124%). The geometric mean of urinary AFM1 in all subjects was 3.43 pg/mL (3.67 ng/g creatinine). The level of AFM1 in males was statistically higher, compared with female subjects. However, the levels of AFM1 did not differ according to age. Subjects in Chungbuk-do showed the highest urinary AFM1 concentration, whereas subjects in Kyeongnam-do showed the lowest concentration. Assuming an excretion rate of 5%, this AFM1 excretion corresponds to approximately 0.1 microgram/day in Korean adults.

Nitric oxide and tumor necrosis factor alpha production by Solanum Nigrum in mouse peritoneal macrophages

An HyoJin,Kim HyungMin,Hwang WooJun,Park RaeKil,An NyeonHyoung,Hong SeungHeon 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.1

Activation of inducible nitric oxide synthase by Corydalis Turtschaninovii in mouse peritoneal macrophages

An HyoJin,Kim HyungMin,Hwang WooJun,Park RaeKil,An NeoynHyoung,Hong SeungHeon 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.1

21세기 일본 오타쿠문화의 행방: ‘코미케 스페셜’의 변모를 중심으로

김효진 ( Kim¸ Hyojin ) 현대일본학회 2020 日本硏究論叢 Vol.51 No.-

본 논문은 40년 이상의 역사를 가진 일본 최대 규모의 이벤트인 <코믹마켓>이 5년에 1회, 특별 행사로서 개최하는 <코미케 스페셜>의 변모를 분석하고, 이를 통해 2000년대 이후 일본 오타쿠문화가 주류사회와의 관계를 어떻게 규정해 왔는가를 추적하고 이러한 변화가 내포한 문제점을 비판적으로 고찰하고자 한다. 1년에 2회, 동인지의 배포와 교류를 주 내용으로 하는 동인지 즉매회가 중심인 코미케 본행사와는 달리 코미케 스페셜은 코믹마켓준비회가 특정한 테마를 바탕으로 만화와 관련이 있는 다양한 기획을 실행하는 장으로서 기획되었다. 실제 이벤트 내용과 기획의도를 살펴보면 2005년에 열린 4회까지는 ‘놀이의 장’으로서, 오타쿠문화의 내부자가 즐기기 위한 내용으로 구성되었다면 2010년과 2015년에 열린 5회와 6회에서는 주류사회의 이슈를 반영하여 각각 지역활성화와 쿨재팬 정책과의 관련성이 강화되는 방향으로 나타나고 있다. 특히 6회에서 채택된 <오타쿠 신세기 선언> 및 코미케 관련 단체로서 <국제 오타쿠 엑스포협회>의 발족에서 드러나는 오타쿠문화의 일본적인 특성에 대한 강조는 중앙정부에 의한 오타쿠문화의 전유라는 측면에서 많은 문제를 제기한다. 결론적으로 2000년대 이후 일본 내부에서도 주목하기 시작한 경제적 중요성과 세계적인 위상으로 인해 코미케가 더 이상 주류사회와의 접점을 피할 수 없다면, 주류사회의 ‘어떤’ 행위자와 ‘어떤’ 방식 의 접점을 만들어갈 것인가야말로 앞으로 코미케가 마주한 새로운 도전일 것이다. This study examined how Japanese otaku culture has defined its relationship with mainstream Japanese society since the 2000s by analyzing the changes in Comike Special (CS), the special event of the Comic Market, which is held every five years. Comike Special is designed as an event involving unique performances and events, which cannot be done at regular Comic Market, with a different theme for each event. For example, from CS 1 to CS 4, each CS focused on ‘entertainment for otaku’, by offering a range of performances, symposia, and talk shows. On the other hand, CS 5 with the theme ‘Townmaking by Comiket’ and CS 6 with the theme ‘OTAKU SUMMIT’, closely reflected the interests of mainstream society in otaku culture and appeared to meet its expectations toward otaku and comic market. Moreover, < Declaration of the New Otaku Century > and the inauguration of the International Otaku Expo Association, which are designed as a part of CS 6, are problematic because the emphasis on Japan as the origin of otaku culture came from the appropriation of otaku culture by the Japanese government. In conclusion, the future of Comiket depends on what kind of agency it will co-operate with and what kind of congruence will emerge as a result, as far as mainstream society is interested in Comiket.

Genetic heterogeneity of liver cancer stem cells

Minjeong Kim(Minjeong Kim),Kwang-Woo Jo(Kwang-Woo Jo),Hyojin Kim(Hyojin Kim),Myoung-Eun Han(Myoung-Eun Han),Sae-Ock Oh(Sae-Ock Oh) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1

Cancer cell heterogeneity is a serious problem in the control of tumor progression because it can cause chemoresistance and metastasis. Heterogeneity can be generated by various mechanisms, including genetic evolution of cancer cells, cancer stem cells (CSCs), and niche heterogeneity. Because the genetic heterogeneity of CSCs has been poorly characterized, the genetic mutation status of CSCs was examined using Exome-Seq and RNA-Seq data of liver cancer. Here we show that different surface markers for liver cancer stem cells (LCSCs) showed a unique propensity for genetic mutations. Cluster of differentiation 133 (CD133)-positive cells showed frequent mutations in the IRF2, BAP1, and ERBB3 genes. However, leucine-rich repeat-containing G protein-coupled receptor 5-positive cells showed frequent mutations in the CTNNB1, RELN, and ROBO1 genes. In addition, some genetic mutations were frequently observed irrespective of the surface markers for LCSCs. BAP1 mutations was frequently observed in CD133-, CD24-, CD13-, CD90-, epithelial cell adhesion molecule-, or keratin 19-positive LCSCs. ASXL2, ERBB3, IRF2, TLX3, CPS1, and NFATC2 mutations were observed in more than three types of LCSCs, suggesting that common mechanisms for the development of these LCSCs. The present study provides genetic heterogeneity depending on the surface markers for LCSCs. The genetic heterogeneity of LCSCs should be considered in the development of LCSC-targeting therapeutics.

Measurement of isomeric yield ratios in the photo-production of ^{133m,g;137m,g}Ce from ^natCe using 55-, 60-, and 65-MeV bremsstrahlung

Kim, HyoJin,Noh, Sung Jin,Kang, Yeong-Rok,Lee, Manwoo,Jeong, Dong Hyeok,Kim, Jung Ki,Yang, Kwangmo,Ro, Tae-Ik,Shin, Sung Gyun,Kye, Yong Uk,Cho, Moo-Hyun,Kim, Guinyun Elsevier 2015 Nuclear instruments & methods in physics research. Vol.349 No.-

<P><B>Abstract</B></P> <P>The isomeric yield ratios of <SUP>133m,g</SUP>Ce and <SUP>137m,g</SUP>Ce produced from the <SUP>nat</SUP>Ce(γ,xn) reactions were determined by using the activation and the off-line γ-ray spectrometric technique with the end-point bremsstrahlung energies of 55-, 60-, and 65-MeV at 100-MeV electron linac of the Pohang accelerator laboratory. The induced activities in the irradiated foils were measured by using an energy- and efficiency-calibrated HPGe detector coupled to a PC based multi-channel analyzer. The necessary corrections were made to improve the accuracy of the experimental results. The experimental results at bremsstrahlung energies of 55-, 60-, and 65-MeV were 0.324±0.089, 0.331±0.086, and 0.403±0.089 for the <SUP>133m,g</SUP>Ce, and 0.210±0.062, 0.221±0.061, and 0.262±0.061 for the <SUP>137m,g</SUP>Ce, respectively. The present results for <SUP>nat</SUP>Ce(γ,xn)<SUP>133m,g;137m,g</SUP>Ce in this energy region were obtained for the first time which has no comparable literature data. The obtained isomeric yield ratios are compared with the calculated values based on the statistical model code TALYS 1.6.</P>

A retroperitoneal dedifferentiated liposarcoma mimicking an ovarian tumor

( Hyojin Kim ),( Taewon Jeong ),( Yeongho Lee ),( Gyeonga Kim ),( Sanggi Hong ),( Sukyung Beck ),( Jeongbeom Mun ),( Kyongjin Kim ),( Myeongjin Ju ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.6

A 74-year-old postmenopausal woman visited our gynecology clinic complaining of a palpable abdominal mass. Physical and radiological evaluation indicated that the mass exhibited features of a left ovarian neoplasm showing heterogeneous enhancement. Surgical resection was performed to confirm this suspicion. During surgery, a mass was observed only in the left ovary with no invasive growth, but adhesions to the surrounding peritoneum were seen. Given the patient's age, large mass size, and accompanying uterine myoma and right ovarian cyst, total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The final pathologic diagnosis was dedifferentiated liposarcoma. The liposarcoma was suspected to originate from retroperitoneal adipose tissue rather than the ovary. Radiotherapy was planned if a gross lesion indicating recurrence followed 6 months later. This case required a considerable multi-disciplinary approach for diagnosis and treatment because of its ambiguous clinical and radiological findings.

Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability

Kim, Hyeongmin,Lee, Jong Hyuk,Kim, Jee Eun,Kim, Young Su,Ryu, Choong Ho,Lee, Hong Joo,Kim, Hye Min,Jeon, Hyojin,Won, Hyo-Joong,Lee, Ji-Yun,Lee, Jaehwi The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3

Ginsenosides, dammarane-type triterpene saponins obtained from ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated. The delivery systems improved the bioavailability of ginsenosides by enhancing solubility, permeability, and stability of the natural products. This mini-review aims to provide comprehensive information on the micro-/nano-sized delivery systems for increasing the bioavailability of ginsenosides, which may be helpful for designing better delivery systems to maximize the versatile therapeutic potential of ginsenosides.

Evaluation of Self-assessed Ocular Discomfort among Students in Classrooms According to Indoor Plant Intervention

Kim, Hyojin,Kim, Ho-Hyun,Lee, Jae-Young,Lee, Yong-Won,Shin, Dong-Chun,Kim, Kwang-Jin,Lim, Young-Wook AMERICAN SOCIETY FOR HORTICULTURAL SCIENCE 2016 HortTechnology Vol.26 No.4

Analysis in Research PRODUCTIVITY in the Hospitality Area

Hyojin Kim,Heungsik Park J-INSTITUTE 2021 International Journal of Human & Disaster Vol.6 No.1

Purpose: This study has the following three purposes. First, this study compares the results of research by Kim et al.(2013) with the results of this study and analyzes how much tourism and hospitality professionals have contributed to the academia since 2010. Second, this study analyzes the contribution of researchers according to their positions. Third, the targeted subjects of this study are English-written journals. This study analyzes whether the group of researchers who speak English as their mother language has a high contribution to English-speaking journals or whether the group of non-English-speaking researchers is high. Method: This study carries out the analysis using the research methods of Sheldon(1991) and Kim et al.(2013). The journals for the analysis of research productivity for this study were selected as Journal of Travel Research, Cornell Hospitality Quarterly, and Journal of Hospitality and Tourism Research listed in the Social Science Citation Index(SSCI). Information on all research papers published from 2000 to 2015 was collected from the three journals, and analyses of authorship and research productivity were conducted. Results: The results of the study are as follows. First, there is no big difference between the tourism and hospitality researchers in the contribution of the three journals over the period. However, it is evident that the degree of contribution of non-tourism and non-hospitality professionals to academic journals increased by about 5% over the five years from 2011 to 2015. Second, although there are somewhat differences by journals, it was analyzed that overall, the group of full professors showed higher productivity of research papers than the group of associate and assistant professors. Third, even though they are non-English-speaking researchers, non-English-speaking researchers consistently contribute to English-speaking journals. Conclusion: Based on the results, this study comes to a conclusion that academic interactions between tourism and hospitality fields and other disciplines are increasing, so many topics that are able to be linked to other disciplines and tourism and hospitality fields should be discussed for academic development. Also, this study shows a contradiction that is the expectation that research productivity in the group of assistant professors is higher than other positions for reasons such as tenured position. Lastly, this study turns out that the productivity of non-English-speaking researchers is significant even in English-written journals.