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Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
Seo, Ju-Hee,Leem, Jong-Han,Ha, Eun-Hee,Kim, Ok-Jin,Kim, Byung-Mi,Lee, Ji-Young,Park, Hye-Sook,Kim, Hwan-Cheol,Hong, Yun-Chul,Kim, Young-Ju Blackwell Publishing Ltd 2010 Paediatric and perinatal epidemiology Vol.24 No.2
<P>Summary</P><P>Seo J-H, Leem J-H, Ha E-H, Kim O-J, Kim B-M, Lee J-Y, Park H-S, Kim H-C, Hong Y-C, Kim Y-J. Population-attributable risk of low birthweight related to PM<SUB>10</SUB> pollution in seven Korean cities. <I>Paediatric and Perinatal Epidemiology</I> 2010; <B>24:</B> 140–148.</P><P>To understand the preventable fraction of low birthweight (LBW) deliveries due to maternal exposure to air pollution during pregnancy in Korea, it is important to quantify the population-attributable risk (PAR). Thus, we investigated the association between maternal exposure to air pollution during pregnancy and LBW, and calculated the PAR for air pollution and LBW in seven Korean cities. We used birth records from the Korean National Birth Register for 2004. A geographic information system and kriging methods were used to construct exposure models. Associations between air pollution and LBW were evaluated using univariable and multivariable logistic regression, and the PAR for LBW due to air pollution was calculated.</P><P>Of 177 660 full-term singleton births, 1.4% were LBW. When only spatial variation of air pollution was considered in each city, the adjusted odds ratios unit of particulate matter <10 µm in diameter (PM<SUB>10</SUB>) for LBW were 1.08 [95% confidence interval [CI] 0.99, 1.18] in Seoul, 1.24 [95% CI 1.02, 1.52] in Pusan, 1.19 [95% CI 1.04, 1.37] in Daegu, 1.12 [95% CI 0.98, 1.28] in Incheon, 1.22 [95% CI 0.98, 1.52] in Kwangju, 1.05 [95% CI 1.00, 1.11] in Daejeon and 1.19 [95% CI 1.03, 1.38] in Ulsan.</P><P>The PARs for LBW attributable to maternal PM<SUB>10</SUB> exposure during pregnancy were 7%, 19%, 16%, 11%, 18%, 5% and 16% respectively. Because a large proportion of pregnant women in Korea are exposed to PM<SUB>10</SUB>– which is associated with LBW – a substantial proportion of LBW could be prevented in Korea if air pollution was reduced.</P>
Use of complementary and alternative medicine by lymphoma survivors in South Korea
Kim, Kisook,Kim, Soo Hyun,Ok, Oh Nam,Kim, Im-Ryung,Lee, Suyeon,Kim, So Hee,Kim, Won Seog,Ryu, Min-Hee,Lee, Moon Hee Elsevier 2018 EUROPEAN JOURNAL OF ONCOLOGY NURSING Vol.33 No.-
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>We aimed to examine the experience of complementary and alternative medicine (CAM) use and its association with health-related quality of life (HRQOL) in lymphoma survivors in South Korea.</P> <P><B>Methods</B></P> <P>The participants were 869 lymphoma survivors from three hospitals in South Korea, all diagnosed with lymphoma at least 24 months prior to participation. Self-reported questionnaires were used to assess CAM use. The questionnaire addressed types of CAM used, sources of information about CAM, reason for CAM use, satisfaction with CAM use, discussion of CAM use with doctors, experience of side effects, costs of CAM use, and intentions to continue using CAM. HRQOL was measured with the EORTC QLQ-C30.</P> <P><B>Results</B></P> <P>Of the 869 participants, 42.2% had experience using CAM, and there were statistically significant differences among CAM users and non-users in terms of sex, religion, and time since diagnosis. A special diet (e.g., ginseng, chitosan, mixed cereals) was the most commonly used type of CAM, and most CAM users (82.1%) were satisfied with their CAM use. Most CAM users (77.5%) did not discuss the use of CAM with their doctors, and only 9.2% reported any side effects from CAM. CAM users showed significantly lower HRQOL scores than did non-users.</P> <P><B>Conclusion</B></P> <P>A significant number of lymphoma survivors in Korea have used CAM, and most CAM users are satisfied with their CAM use. Oncology nurses should be aware of the range of CAM use among patients and reflect their responses in their treatment and/or follow-up care.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A significant number of Korean lymphoma survivors (42.2%) have used CAM. </LI> <LI> A special diet was the most commonly used type of CAM. </LI> <LI> A majority of CAM users (77.5%) did not discuss the use of CAM with their doctors. </LI> </UL> </P>
Impact of Visceral Fat on the Postprandial Triglyceride Clearance after Ingestion of Fast Food
( Hee Chul Yu ),( Dal Sik Kim ),( Baik Hwan Cho ),( Seon Hyeong Kim ),( Mi Jin Jeong ),( Haeng Sun Kim ),( Ju Sin Kim ),( Mi Kyung Moon ),( Wan Ki Yoon ),( Ji Hoon Jung ),( Hwa Ok Kim ) 한국정맥경장영양학회 2010 한국정맥경장영양학회 학술대회집 Vol.2010 No.-
Background: The exaggerated postprandial lipemia is an important stimulus for atherogenic disease progression because delayed removal of blood-borne triglyceride (TG)-rich lipoproteins encourages direct deposition of lipoprotein remnants on the arterial wall and increases the likelihood that low-density lipoprotein cholesterol will undergo disease-accelerating oxidative modification. Objective: This study was performed to evaluate the impact of visceral fat on postprandial TG clearance in non-diabetic Korean men. Design: Fifty-one men (mean age: 47 years) referring to the same occupational district, not on hypolipidemic drugs and without any other chronic disease, performed multiple TG profile (at 8 hours-fasting, and every 30min after breakfast for 8 hours) after ingestion of fast food (Big Mac, French fries, and Coca-Cola). The visceral fat (VF) measured by abdominal computed tomography. Results: TG values (mg/dl) were 124.2 (low visceral fat group, VF < 130 cm2) and 179.4 (high visceral fat group, VF > 130 cm2) at fasting (p=0.005), peak TG values were 265.3 vs. 349.6 (p=0.02) and reached at 4-4.5h after breakfast, and area under curve (AUC) were 1514 vs. 2929 8h after meal. Remnant lipoprotein-cholesterol values (mg/dL) were 26.1 vs. 35.6 (p=0.007) at fasting, and 29.3 vs. 39.6 (p=0.006) at 3.5h after meal. Fasting blood glucose (mg/dL), and insulin levels (pmol/L) were 97 vs. 112 (p=0.004), and 36.7 vs. 58.2 (p=0.004). Glucose and insulin AUC 8h after meal were 823 vs. 957.9 (p=0.013) and 118.4 vs. 225.1 (p=0.000). And Log HOMA_insulin resistance were 0.03 vs. 0.27 (p=0.01). Conclusions: We observed persistence of elevated TG level in the blood after ingestion of a high-fat test meal. The increments are directly determined by fasting TG level and the amount of visceral fat. Fasting TG level seems the major nutritional determinant of postprandial TG clearance.
Hee-Jeong Je(제희정),Yeo-Ok Park(박여옥),Sung-Churl Kim(김성철),Ji-Hyun Hwang(황지현),Yong-Jae Lee(이용재),Beung-Gu Son(손병구),Young-Hoon Park(박영훈) 한국원예학회 2009 원예과학기술지 Vol.27 No.3
본 연구에서는 39개 RAPD-PCR primer를 이용하여, 30개 완전단감, 16개 불완전단감, 6개 불완전떫은감, 8개 완전떫은감 등 총 60개의 동양 감(Diospyros kaki Thunb.)에 대한 품종간 유연관계를 분석하였다. 총 250개 RAPD 밴드로부터 확인된 185개 다형성 마커를 이용하여 각 품종을 정확히 분류할 수 있었으며, 유전적 유사도분석(Nei-Li)을 통해 위 60품종이0.70(‘부유’와 ‘서조’)에서 0.99(‘스퍼평핵무’와 ‘대핵무’) 범위의 비교적 근접한 유연관계를 보임을 확인하였다. 비가중산술방식(UPGMA)을 이용한 집괴분석에서는 공시된 모든 완전단감 품종들이 가까운 유연관계(0.85-0.99)로 하나의 대표군(Cluster Ⅰ)을 이루며, 나머지 품종들은 모두 제 2 대표군(Cluster Ⅱ)을 이루는 반면, 주성분 분석(PCA)에서는 ‘핵무’ 계통의 품종들과 ‘도근조생’ ‘삼진조생’ 등 7개의 불완전떫은감이 하나의 독립된 군(Cluster Ⅲ)으로 분리되는 경향이 관찰되었다. 두 분석의 군집양상으로 미루어, 떫은맛이 소실되는 탈삽방법의 차이에 있어서 뿐만 아니라, DNA 수준에서도 불완전단감이 완전단감과는 상이한 차이를 보이며, 떫은감과 가까운 유전적 배경을 지닐 수 있음을 알 수 있었다. 본 연구의 RAPD 마커를 통한 품종간 유연관계분석은 기록된 동양 감 품종의 계보와 형질적 특성, 그리고 AFLP등 타종의 마커를 이용한 보고들과 비교하여 일치되는 결과를 보였으며, 이는 RAPD 가 감 품종간 유전적 관련성 분석과 품종 판별에 효율적인 기술로 사용될 수 있음을 보여준다. The genetic relationships among 60 oriental persimmon (Diospyros kaki Thunb.) accessions including 30 pollination-constant non-astringent (PCNA), 16 pollination-variant non-astringent (PVNA), 6 pollination-variant astringent (PVA), and 8 pollination-constant astringent (PCA) cultivars were evaluated using 39 RAPD (randomly amplified polymorphic DNA)-PCR primers. A total of 185 polymorphic bands out of 250 RAPD bands scored were obtained and unique fingerprints for all 60 cultivars were produced, despite inclusion of closely related bud-sport cultivars. Pair-wise genetic similarity coefficient (Nei-Li) among all pairs of 60 cultivars varied from 0.62 (between ‘Taishu’ and ‘Saijo’) to 0.99 (between ‘Superhiratanenashi’ and ‘O-tanenashi’). Unweighted pair-group method with arithmetic averaging (UPGMA) clustering analysis revealed two main clusters, Ⅰ and Ⅱ; all 30 PCNA cultivars formed cluster Ⅰ and showed a narrow genetic diversity among themselves (0.85-0.99). Cluster Ⅱ contained PVNA cultivars and other astringent type cultivars. Principle component analysis (PCA) showed a third group consisting of seven PVA cultivars, in addition to cluster Ⅰ and Ⅱ that were revealed by UPGMA clustering. RAPD-based phenetic relationships among the persimmon cultivar were comparable to known pedigree records, morphological observations, and reports from previous DNA fingerprinting studies that used different molecular marker types. Our study demonstrated that RAPD markers can be efficiently used for genetic diversity assessment of closely related persimmon varieties and cultivar identification, which are essential for modern breeding program.