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죽황(竹黃)으로부터 분리한 미백활성 성분의 멜라닌생성 억제효과
이기무 ( Ki-moo Lee ),이은창 ( Eun-chang Lee ),조순장 ( Soon-chang Cho ),문석식 ( Surk-sik Moon ) 대한화장품학회 2008 대한화장품학회지 Vol.34 No.4
천연물로부터 미백활성 성분의 개발을 위하여 국내 자생식물 60종으로부터 추출물을 얻어, 이들의 멜라닌 생성과정의 주된 효소인 tyrosinase 활성 억제력을 평가하였다. 평가결과 노랑하늘타리(열매), 죽황, 누리장나무(잎), 우산고로쇠(잎) 추출물이 비교적 높은 tyrosinase 활성억제효과를 보였고, 이들의 IC<sub>50</sub> 값은 50 ∼ 100 μg/mL 이었다. 이들의 멜라닌생성 억제효과를 B16F10 흑색종세포주를 이용하여 실험한 결과, 죽황추출물이 가장 높은 52 %의 멜라닌생성 저해활성을 보였으며, 이는 기존 미백제인 arbutin (42 %)에 비해 10 % 높은 것이다. 죽황추출물로부터 용매추출 및 크로마토그래피 등의 분리과정을 거쳐 10가지 미백활성 성분을 분리하였다. 이들은 모두 페놀유도체 화합물로서, SM701과 SM702, SM703, BPR211은 hydroquinone계 화합물이며, SM707은 gallic acid계, SM704와 SM705, SM706, SM708, SM709는 ferulic acid계로 확인되었다. 이들의 유리기 소거효과를 hydorquinone과 비타민 C와 비교하여 측정하였을 때. SC<sub>50</sub> 값이 SM702와 SM709의 경우 60 ∼ 70 μM로 hydroquinone과 유사하였고, SM701과 SM708은 30 ∼ 40 μM로 비타민 C (45 μM)보다 낮은 값을 보여 죽황추출물은 항산화활성이 높은 성분들을 함유하고 있음을 확인하였다. 이들 중 1,2-O-diferulylglycerol로 확인된 SM709 성분은 tyrosine hydroxylase 및 DOPA oxidase 활성을 각각 18, 60 % 억제하였고, B16F10 흑색종세포주를 이용한 멜라닌생성량 억제시험에서 62 %의 저해효과를 나타내 가장 높은 미백활성을 보였다. 따라서 죽황추출물의 미백활성은 주로 멜라닌 생성과정의 DOPA oxidsae 저해효과와 항산화효과에 의해 나타나는 것으로 생각된다. In order to develop a new depigmenting agent, extracts were obtained from 60 native plants and their antimelanogenic activities were screened by evaluating the inhibitory effect on tyrosinase which is a major enzyme responsibles for the melanin synthesis. The extracts of Trichosanthes kirilowii fruits, Phyllostachys bambusoides inner films (BIF), Clerodendrum trichotomum leaves, and Acer okamotoanum leaves showed relatively high inhibitory effect on tyrosinase and their IC<sub>50</sub> values were 50 ∼ 100 μg/mL. The extract of BIF inhibited melanin synthesis of B16F10 melanoma cells by 52 %, which was the highest among those of various extracts. Furthermore, the effect of BIF extract is 10 % higher than that of arbutin (42 %), a popular depigmenting agent in Korea. Ten compounds having antimelanogenic activity were isolated from the BIF extract by solvent extraction and chromatography. These compounds were identified as phenolic derivatives: SM701, SM702, SM703, and BPR211 were hydroquinone derivatives; SM707 a gallic acid derivative; SM704, SM705, SM706, SM708 and SM709 ferulic acid derivatives. The free radical scavenging activities of these compounds were measured and compared to those of hydroquinone and vitamin C. The SC<sub>50</sub> values scavenging 50 % DPPH of SM702 and SM709 were 60 ∼ 70 μM similar to that of hydroquinone and those of SM701 and SM708 were 30 ∼ 40 μM slightly lower than that of vitamin C. These results suggest the presence of components having high antioxidant activity in the BIF extract. The SM709, identified as 1,2-O-diferulylglycerol, inhibited the activities of tyrosine hydroxylase and dopa oxidase by 18 and 60 %, respectively. The SM709 also inhibited the melanin synthesis of B16F10 melanoma cells by 62 % and this was the highest antimelanogenic activity among those obtained from the various purified compounds. Therefore, antimelanogenic activity of the BIF extract was concluded to be due to both inhibition of DOPA oxidase and antioxidant activity.
水産物의 鹽酸, 黃酸, 酵素에 依한 加水分解에 關한 硏究 (第一報) 鹽酸에 依한 加水分解
이상태,송기무,Lee, Sang-Tai,Song, Ki-Moo 대한화학회 1957 대한화학회지 Vol.4 No.1
We have studied on the effect of hydrochloric acid on the hydrolysis of dried cuttlefish, sardine, shrimp, sea mussel and undaria taking various concentration of acid, heating at various periods at constant temperatures and under atmospheric pressure following results were obtained. 1. The addition of HCl increases hydrolysis ratio of marine products rapidly, having maximum point of its ratio at 30% of dried cuttlefish and shrimp, at 25% of sea mussel and undaria, at 15% of sardine. 2. Hydrolysis ratios of cuttlefish and shirmp, sea mussel and undaria, and sardine reach maximum values at 30% of HCl, 25% of HCl and 15% of HCl, respectively.
외치방인 청기패독산(淸肌敗毒散)의 아토피피부염 동물 병태 모델에서의 면역조절작용에 관한 연구
이윤정 ( Youn Jeong Lee ),김선빈 ( Seon Bin Gim ),최학주 ( Hak Joo Choi ),이기무 ( Ki Moo Lee ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.20 No.2
In order to study the effect of CPS in the treatment of atopic dermatitis (AD), its role on various immune related cytokines were tested. Levels of liver and kidney function markers such as ALT, AST, BUN in NC/Nga mice were all normal indicating no toxicity in CPS treated group. Significant recovery from AD could be observed in CPS treated group through naked eye observation. Dermatitis index was significantly decreased after 11, 12, and 13 weeks of treatment. CD4+, CD8+, CD3+ /CD69+ immune cell ratio in DLN were decreased significantly by 37.2%, 49%, 20.8% in CPS treated group. CD4+ and CD11b+ /Gr-1+ immune cell ratio in dorsal skin were decreased significantly by 50.8% and 59.2% in CPS treated group. Expression of IL-4, IL-5, IL-6, IL-13 and TNF-α in spleen were decreased by 78.8%, 97.8%, 64.7%, 73.6%, and 68.4%, respectively in CPS treated group. The results above strongly indicated the significant immune modulatory effect of CPS and thus clinical application of CPS on AD treatment.
Skin Safety Evaluation of Pectinase Lyase-modified Red Ginseng (GS-E3D) in Human Patch Test
Mi Kyung Pyo(표미경),Gyeong Hee Lee(이경희),Jin Seong Kim(김진성),Yun Ho Jo(조윤호),You Jin Lee(이유진),Dayu Jung(정다유),Dae Seok Yoo(유대석),Won Yong Kim(김원용),Seon Woo Cha(차선우),Ki Young Park(박기용),Ki Moo Lee(이기무) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.2
Evaluation of Acute oral and Dermal Toxicity of Pectinase Lyase-modified Red Ginseng (GS-E3D)
Mi Kyung Pyo(표미경),Gyeong Hee Lee(이경희),Jin Seong Kim(김진성),Yun Ho Jo(조윤호),You Jin Lee(이유진),Dayu Jung(정다유),Dae Seok Yoo(유대석),Won Yong Kim(김원용),Seon Woo Cha(차선우),Ki Young Park(박기용),Ki Moo Lee(이기무) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.2
석자해기탕(石紫解肌湯)이 아토피피부염 유관 인자인 산화적 손상과 염증 인자에 미치는 영향
정대웅 ( Dae Woong Jung ),최학주 ( Hak Joo Choi ),김선빈 ( Seon Bin Gim ),이기무 ( Ki Moo Lee ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.20 No.2
In order to investigate the possibility of SHT as therapeutic for the treatment of atopic dermatitis (AD), cytotoxicity, anti-oxidant activity, modulatory and suppression activities of SHT were tested. 90% or higher cell viability was observed in all tested groups from 25 to 200 ug/ml using Raw 264.7 cells. SHT showed dose-dependent DPPH scavenging activity, with more than 80% scavenging activities at 400 and 800 ug/ml concentrations. SHT showed dose-dependent suppression activity of ROS production, especially at 200 ug/ml of 57.4%. SHT decreased NO production activity dose dependently, expecially at 200 ug/ml of 28.8%. IL-1β, IL-6, MCP-1, TNF-α production rate were decreased by 45.7%, 15.5%, 8.9%, 16.5% respectively when Raw 264.7 cells were treated with LPS and with SHT of 200 ug/ml. However, only IL-6 and TNF-α showed significant changes. The results above indicate that SHT significantly reduces the effect of oxidative and inflammatory cytokines. The use of SHT in dermatitis can be widely suggested.
청기소독탕(淸肌消毒湯)이 아토피피부염 염증 관련 인자에 미치는 영향
김혜림 ( Hye Rim Kim ),김선빈 ( Seon Bin Gim ),윤미영 ( Mi Young Yun ),이기무 ( Ki Moo Lee ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.20 No.2
In vitro tests were performed using CST to investigate its role on oxidative damages and inflammatory cytokines. 90% or higher cell viability was observed in CST treated groups from 25 to 200 ㎍/㎖using Raw 264.7 cells. CST showed dose-dependent DPPH scavenging activity, with 91.3% and 92.2% scavenging activities at 400 and 800 ㎍/㎖concentrations, respectively. CST showed dose-dependent suppression activity of ROS production, especially at 200 ㎍/㎖of 41.3%. CST decreased NO production activity, with significant decrease of 16.2% and 33.5% at 100 and 200 ㎍/㎖concentrations, respectively. IL-1β, IL-6, MCP-1 production rate were significantly decreased by 30.0%, 27.2%, 22.1% when Raw 264.7 cells were treated with LPS and with CST of 200 ㎍/㎖. Also, TNF-α production rate was decreased by 28.6%. The results above indicated therapeutic effect of CST on the AD through anti-oxidative and immune modulatory effect. Various blending of drug substances with CST should be clinically tested.