카드뮴의 중추신경계 독성유발 기전

이종화,장봉기,박종안,박종영,김완종,우기민 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3

Although numerous studies have shown that cadmium disturbs the normal biological processes in central nervous system the mechanism of toxicity is not well understood The present study has investigated the effect of cadmium on oxidative stress, Na+/K- ATPase activity and the aggregation of amyloid beta peptide(β-amylotd) in neuronal cell Ime, HT22 cell LC_(5) and LC_(50) of cadmium for HT22 cell resulted from MTT assay was 4 1 μM and 9 5 μM, respectively Cadmium(2 to 8 μM) dose-dependently increased the lipid peroxidation and decreased the content of glutathione Cadmium 4 μM showed a significant decrease in Na^(-)/K^(+) ATPase activity as compared with control group The aggregation of P-amyloid was accelerated in a dose-dependent manner by the treatment with 2 to 8 μM cadmium These results suggest that the neurotoxicity of cadmium can be mediated by the increase in oxidative stress and decrease in Na^(-)/K^(+) ATPase activity.

아산시 신정호소의 수질오염 현황 및 부영양화 저감 방안

박종안,이종화,장봉기 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.1

This study was conducted to estimate the amount of water pollution load, water quantity and quality of inflow stream, status of water pollution and reduction of eutrophication in the Sinjung lake in Asan city. Inflow of branch to Sinjung lake have two streams, one is Cho-sa stream which are Ki-san bridge and Cho-sa bridge and the other is Hwang-san stream. Number of sampling points for water quality are 23 in the Sinjung lake and it's sediment of bottom from March to July, 1997. Water quality had been tested pH, dissolved oxygen(DO), chemical oxygen demand(COD), suspended solid(SS), total nitrogen(T-N), total phosphorus(T-P), E.coli group, and spring out test for sediment are total nitrogen, total phosphorus and heavy metals(Fe, Pb, Cd). The results were as follows; Amounts of pollution load were highest at Cho-sa stream. The ratio of livestock wastewater was occupied with the above 90% of total water pollution load. Mean daily inflow of Cho-sa stream and Hwang-san stream were 34,092㎥ and 25,524㎥, respectively. In mean level of inflow water quality, COD, SS, T-N, T-P and E. coli group were 16.96㎎/ℓ, 50.3㎎/ℓ, 5.85㎎/ℓ, 0.51㎎/ℓ and 4,096/100㎖, respectively. Water quality of inflow was worst at the point of Ki-san bridge in Cho-sa stream. Mean level of DO, COD, SS, T-N, T-P and E. coli group were 6.43㎎/ℓ, 17.11㎎/ℓ, 194.0㎎/ℓ, 5.96㎎/ℓ, 0.56㎎/ℓ and 2,191/100㎖, respectively at Sinjung lake. These are higher than class V by environmental water quality standards for lake. Spring out level of T-N, T-P, Fe and Pb in sediment of Sinjung lake were 326.6ppm, 17.9ppm, 624.2ppm and 2.65ppm, respectively.

만성 호중구성 백혈병 1례

기장도,박치영,류보열,김태종,모성환,곽재정,문철호,박근홍,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood (PB), hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid. serun viatmin B 12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or underlying infection or disease sufficient to mimic a leukemoid reaction. We have experienced a 34-years-old male patient with atypical chronic neutrophilic leukemia. On admission, the leukocyte count was 56,860/uL. severe neutrophic leukocytosis with 76% neutrophils and rare immature forms on PB smear. Many neutrophils had toxic granules, and vacuoloes. Leukocyte alkaline phosphatase score was decreased. The cytogenetic study showed Philadelphia chromosome negative with normal karyotype.

중합시간과 중합방법에 따른 자가중합형 상교정용 레진의 중합률의 비교에 관한 연구

장기택,김종철,유종욱 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2

가찰성 상교정 장치에 많이 사용되는 자가중합형 상교정용 레진의 미반응 단량체는 레진의 물성과 생물학적인 면에 많은 영향을 끼친다. 다라서 미반은 단량체를 최소화하고 중합률을 최대로 하는 중합방법에 대한 연구는 중요한 의의를 갖는다. 저자는 자가중합형 상교정용 레진의 중합시간과 중합방법에 따른 중합률을 비교해보기 위해 시편을 다음과 같이 5군으로 나누어 연구를 진행하였다. 상교정용 레진의 분말과 용액을 혼합하여 제 1군은 28℃의 공기중에 보관하였고, 제 2군은 28℃의 물에, 제 3군은 28℃의 물과 30psi의 압력에, 제 4군은 43℃의 물에, 제 5군은 43℃의 물과 30psi 의 압력하에 각각 보관하였고, 10분, 1시간, 12시간, 1일, 3일 경과 후에 각 시편을 Fourier 변환적외선분광법을 이용하여 중합률을 측정하여 다음과 같은 결론을 얻었다. 1. 모든 군에서 중합시간이 경과함에 따라 중합률도 지속적으로 증가하는 양상을 보였다. 10분경과 후의 결과와 비교하여 볼 때, 제 1군은 12시간 경과 후부터 중합률의 증가가 유의성이 있었고, 제 2군과 3군, 4군, 5군은 1시간 경과 후부터 유의성이 있었다.(p<0.05) 2. 10분과 1일, 3일 경과 후에는 제 5군, 제 4군, 제 3군, 제 2군, 제 1군의 순서대로 중합률이 높았다. 3. 중합시 온도에 따른 비교에서, 1일 경과 후를 제외하고는 모든 시간에서 43℃에서 중합시킨 군의 중합률이 28℃에서 중합시킨 군의 중합률보다 유의성 있게 높았다.(p<0.05) 4. 압력은 12시간 경과 후를(p<0.05) 제외하고는 중합률에 영향을 주지 못했다. 5. 보관방법은 1시간 경과 후를(p<0.05) 제외하고는 중합률에 영향을 주지 못했다. Autopolymerized resin facilitates a more rapid and easier means for the construction of removable orthodonic appliances than heat cured resin. But many reports reveal that more unreacted monomer is found in autopolymerized resin. It is very important to achieve maximum degree of polymerization because if polymerization is inadequate, high level of unreacted monomer has been shown to adversely affect mechanical and physical properties, and also the question of allergy or toxicity to methylmethacrylate must be considered. The purpose of this study was to compare the degree of polymerization according to curing method and curing time. Five groups were desinged ; Group 1 was polymerizied at room temperature(28℃) ; Group 2 in 28℃ water ; Group 3 in 28℃ water under 30psi pressure ; Group 4 in 43℃ water ; Group 5 in 43℃ water under 30psi pressure for 10 minutes. 1 hour, 12 hour, 1 day and 3 day. The degree of polymerization was meaured by means of Fourier Transform Infrared spectroscopy. The results were as follows : 1. The degree of polymerization increased constantly in accordance with curing time in all groups and after curing for 10 minutes. Group 1 showed significantly higher degree of polymerization after 12 hours and Group 2, Group 3, Group 4, Group 5 after 1 hour (p<0.05). 2. The degree of polymerization decreased in the order of Group 5, Group 4, Group 3, Group 2, Group 1 except when the curing time was 1 hour and 12 hours(p<0.05). 3. The degree of polymerization Group 4, Group 5 cured at 43℃ showed significantly higher degree of polymerization than Group 2, Group 3 at 28℃ except when the curting time was 1 day(p<0.05) 4. Among Group 2, Group 3 and Group 4, Group 5, the pressure had no effect on polymerization except when the curing time was 12 hours(p<0.05) 5. Between Group 1 and Group 2, the method of storage had no effect on polymerization except when the curing time was 1 hour(p<0.05)

아산시 5대 저수지의 오염부하량 산정을 통한 수질오염 요인분석

장봉기;김민중;최재호;이종화 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

Five great reservoirs located in Asan city (Gungpyeong, Gahye, Togo, Masan, Bongjae) for each of the inflow of water pollutants (biochernical oxygen demand (BOD), suspended solids (SS), total nitrogen (T-P), total phosphorus (T- P) in units of pollutant loads were calculated by estimating. The results were as follows; The ratio of livestock wastewater for BOD, SS, T-N and T-P were occupied with the 58.7%, 85.4%, 59.1% and 91.2%, respectively of total water pollution load in the reservoir Gungpyeong. The ratio of livestock wastewater for BOD, SS, T-N and T-P were occupied with the 96.1%, 97.6%, 96.2% and203rmb 99.5%, respectively of total water pollution load in the reservoir Gahye. The ratio of livestock wastewater for BOD, SS, T-N and T-P were occupied with the 93.8%, 96.9%, 91.7% and 98.7%, respectively of tot~l water pollution load in the reservoir Togo. The ratio of livestock wastewater for BOD, SS, T-N and T-P were occupied with the 39.3%, 71.6%, 52.2% and 76.2%, respectively of total water pollution load in the reservoir Masan The ratio of livestock wastewater for BOD, SS, T-N and T-P were occupied with the 96.3%, 98.5%, 96.2% and 99.5%, respectively of total water pollution load in the reservoir Bongjae. Total amounts of each water pollutants was highest in the basin of reservoir Bongjae and the next Gahye, Togo, Masan. Reservoir Gungpyeong was lowest in five reservoirs located in Asan Clty. These results suggest that contamination of the reservoir inflow in Asan city, water pollution management for the reservoirs will be focusing on the livestock wastewater.

백두대간(추풍령-덕유산)구간의 식물상

한종원, 양선규, 최슬기, 장창석, 오병운 忠北大學校部設基礎科學硏究所 2007 自然科學硏究 Vol.21 No.-

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문수산(봉화군) 일대의 식물상

한종원, 양선규, 최슬기, 장창석, 김규식, 오병운 忠北大學校部設基礎科學硏究所 2007 自然科學硏究 Vol.21 No.-

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아산시 호소들의 오염실태조사 및 그 대책

장봉기,이종화,박종범,민준호,박종안 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

The object of this study is to survey water quality of reservoirsin in Asan city. We also suggest some countmeasures for environmental preservation toward sustainable urban development of Asan city. We analyze water qualities (pH, DO, COD, SS, T-P, T-N and Chlorophyll-a) of reservoirs. The level of water quality of small reservoirs is in the range of level Ⅳ-Ⅴ higher than the level Ⅲ established by the Ministry of Environment. Especially, water quality of Sinchang, Youngin and Shinchung reservoirs is worser than that of other reservoirs. Water quality of Asan and Sapkyo lake is the range of level Ⅳ-Ⅴ. As the levels of T-P and T-N are level Ⅳ and level Ⅴ, respectively, eutrophication might be progressed. Reservoirs in Asan city were already serious polluted by inflow of wastewater from residents, animal husbandries and industries. Recently, Metropolitan Area Development Planning(MADP) for Asan bay-area was suggested by the Ministry of Construction. According to this plan, industrialization and urbanization of Asan area will rapidly progress. If sewage and wastewater treatment facilitiesare not provided, water quality of reservoirs in Asan city will be worse. In order to prevent of environment pollution, first, the impact of industrialization and urbanization of Asan area on the environment should be considered at the beginning of MADP. Second, total effluent regulation of water pollution, air pollution and soil wastes, based on the self-purification of the Asan city environment, should be enforced.

레이저에 의한 유리내부의 첨가이온의 전하상태 변화

임기수, 장경식, 신종호, 이수천 忠北大學校部設基礎科學硏究所 2006 自然科學硏究 Vol.20 No.-

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생활 및 건강 행태에 따른 비만도 분석

장봉기,이의선,박종안 순천향대학교 기초과학연구소 2008 순천향자연과학연구 논문집 Vol.14 No.1

This study was to identify the factors affecting the obesity as body mass index by sex, age, lifestyle and health behavior. The subjects for this study were all adult in Choongnam-do and capital region, Korea. The data were collected in November, 2007. The results of this study are as follows. Body mass index (BMI) by sex showed that significantly higher in the male group (23.04±3.5) than in the female group (21.12±2.7) (p<0.01). BMI by age showed that significantly increased according to older group (p<0.01). BMI by exercise showed that significantly higher in does not the exercise group than in the exercise group for male group (p<0.05). BMI by kind of exercise showed that significantly higher in ball game exercise group than in aerobic exercise group for female group (p<0.05). BMI by meal frequency per day showed that significantly higher in 3 times and more group than the 2 times and below group for female group (p<0.05). BMI by speed of eating showed that significantly higher in fast group than the slow group for male group (p<0.05). Generally, a person who drink show that higher BMI. BMI showed that significantly higher in parents is obesity group than the normal parents group (p<0.05).