A novel prediction score for predicting the baseline risk of recurrence of stage I–II endometrial carcinoma

Kenta Takahashi,Mayu Yunokawa,Shinsuke Sasada,Yae Takehara,Naoyuki Miyasaka,Tomoyasu Kato,Kenji Tamura 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.1

Objective: To develop and validate a 3-year recurrence prediction score (RPS) system for predicting the baseline risk of recurrence of stage I–II endometrial carcinoma. Methods: We reviewed 427 patients with International Federation of Gynecology and Obstetrics staging I–II endometrial carcinoma underwent surgery without any adjuvant therapy from 2005 to 2013. The patients were divided into 2 groups: the test cohort (n=251) comprising those who underwent surgery in odd-numbered years, and the validation cohort (n=176) comprising those who underwent surgery in even-numbered years. Multivariate analysis was performed using 7 candidate predictors to identify the risk factors for 3-year recurrence-free interval (RFI) in the test cohort. Each risk factor was scored based on logistic regression analyses of the test data set, and the sum of the risk factor scores was defined as the RPS system. We then applied the system in the validation cohort. Results: Multivariate analysis revealed that the significant risk factors were age ≥60 years, pathological type II, positive cervical stromal invasion, and positive peritoneal cytology. In the test cohort, the 3-year RFI rates were 100%, 95.8%, 79.9%, and 33.3% for RPSs of 0, 1, 2, and 3, respectively. In the validation cohort, the 3-year RFI was significantly higher in the low-RPS group (RPS 0 or 1) than in the high-RPS group (RPS 2 or 3) (95.2% vs. 79.9%, p<0.01). Conclusions: The RPS system shows significant reproducibility for predicting the baseline risk of recurrence. The system could potentially impact the choice of adjuvant therapy for stage I–II endometrial carcinoma.

Histological Architecture of Gastric Epithelial Neoplasias That Showed Absent Microsurface Patterns, Visualized by Magnifying Endoscopy with Narrow-Band Imaging

Kenta Chuman,Kenshi Yao,Takao Kanemitsu,Takashi Nagahama,Masaki Miyaoka,Haruhiko Takahashi,Kentaro Imamura,Rino Hasegawa,Toshiharu Ueki,Hiroshi Tanabe,Seiji Haraoka,Akinori Iwashita 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.2

Background/Aims: The objective of this study was to elucidate the histological structure of the absent microsurface patterns (MSPs)that were visualized by magnifying endoscopy with narrow-band imaging (M-NBI). Methods: The study included consecutive gastric epithelial neoplasias for which M-NBI findings and histological findings couldbe compared on a one-to-one basis. The lesions were classified as absent MSPs and present MSPs based on the findings obtainedusing M-NBI. Of the histopathological findings for each lesion that corresponded to M-NBI findings, crypt opening densities, cryptlengths, crypt opening diameters, intercrypt distances, and crypt angles were measured and compared. Results: Thirty-six lesions were included in the analysis; of these, 17 lesions exhibited absent MSP and 19 lesions exhibited presentMSP. Comparing the histological measurements for absent MSPs vs. present MSPs, median crypt opening density was 0.9 cryptopenings/mm vs. 4.8 crypt openings/mm (p<0.001), respectively. The median crypt length, median crypt opening diameter, medianintercrypt distance, and median crypt angle were 80.0 μm vs. 160 μm (p<0.001), 40.0 μm vs. 44.2 μm (p=0.09), 572.5 μm vs. 166.7μm (p<0.001), and 21.6 degrees vs. 15.5 degrees (p<0.001), respectively. Conclusions: Histological findings showed that lesions exhibiting absent MSPs had lower crypt opening density, shorter crypt length,greater intercrypt distance, and larger crypt angle.

Torque and Rotational Speed Estimation with Parameter Identification of Line-start Induction Motor for Motor Operated Valve

Akiko Takahashi,Ryuichi Oguro,Kenta Sakane 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

This paper presents a torque and rotational speed estimation method for Line-start Induction Motor Operated Valves. Routine inspections are carried out to those valves, because Motor Operated Valves are used in the serious plant such as Power plant. And securing reliability is an extreme important matter for these systems. Movement environments in these plants are high temperature and humidity, so it is difficult to put sensors near motors. In such a case, we must find the trouble of the system without torque sensor or speed sensor. The proposal method can estimate the torque and rotational speed of induction motor by using time-series data of voltages and currents at the switchboard. Furthermore, we propose the parameter identification method of mutual inductance by comparing the inner and outer products between voltages and currents. First, a torque and rotational speed of induction motor are estimated. Next, a mutual inductance parameter is got. Last, the proposed estimation method is verified by results of experiment.

Collapse Behavior of Reduced-Scale Frames by the Inverted Shaking Table Method under Dynamic Seismic Loading

Yuko Shimada,Kenta Takahashi,Satoshi Yamada 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.6

The shaking table test, which is generally conducted using reduced-scale frames to investigate the collapse behavior of structures during underground motion, is an eff ective method in the seismic engineering fi eld. However, unlike the shaking table test with full-scale frames, those with reduced-scale frames possess several problems owing to the scaling eff ect. This paper proposes a novel experimental method for performing the shaking table test with reduced-scale frames to overcome these problems; this method is known as the “inverted shaking table.” Through a series of experiments using this method and two earthquake records as inputs without modifying the time axis, the elastoplastic behaviors of reduced-scale steel frames are obtained up to their collapse owing to the P-Δ eff ect. Additionally, the changes in the collapse process are studied by changing the vertical load on the test specimens. The test results obtained in this study are validated using the response analysis of a single degree-of-freedom system, which reveals that the hysteresis and acceleration multiplier of the input wave obtained using the response analysis and test for each specimen are approximately the same. This indicates that the proposed method is eff ective for reproducing the frame behavior up to collapse for specimens with portable components and using general experimental apparatus.

Effect of acid-reducing agents on clinical relapse in ulcerative colitis with pH-dependent-released 5-aminosalicylic acid: a multicenter retrospective study in Japan

( Yosuke Shimodaira ),( Kengo Onochi ),( Kenta Watanabe ),( So Takahashi ),( Sho Fukuda ),( Noboru Watanabe ),( Shigeto Koizumi ),( Tamotsu Matsuhashi ),( Katsunori Iijima ) 대한장연구학회 2021 Intestinal Research Vol.19 No.2

Background/Aims: 5-Aminosalicylic acid (5-ASA) is a basic drug for inducing and maintaining remission for ulcerative colitis. One of its formulations has a coating with a pH-dependent degradation that ensures the release 5-ASA at the terminal ileum. No evidence has been shown concerning the effects of proton pump inhibitors (PPIs) or H₂ receptor antagonists (H₂RAs) on the clinical course of ulcerative colitis patients in remission. The present study assessed the effect of PPIs or H2RAs on the relapse of ulcerative colitis patients in clinical remission maintained by pH-dependent released 5-ASA. Methods: Ulcerative colitis patients who had been prescribed time- or pH-dependent-released 5-ASA between January 2015 and December 2018 were enrolled in this multicenter retrospective study. The period of remission until relapse occurred was analyzed among the patients taking time-dependent-released 5-ASA or pH-dependent-released 5-ASA with/without PPIs or H2RAs. Results: One hundred and nineteen patients were analyzed in this study. In the primary endpoint, the relapse rate was higher in patients taking pH-dependent-released 5-ASA and PPIs or H2RAs than in those taking the pH-dependent-released 5-ASA without PPIs or H2RAs, while the relapse rate was similar in patients taking the time-dependent-released 5-ASA with or without PPIs or H2RAs concomitantly. Patients with a short duration of disease and middle-aged patients more frequently showed relapse with PPIs or H2RAs than the other patients. Conclusions: The coadministration of PPIs or H2RAs affects the clinical course of ulcerative colitis in remission maintained by pH-dependent-released 5-ASA. (Intest Res 2021;19:225-231)