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Yo Kubota,Satoshi Tanabe,Mizutomo Azuma,Kazue Horio,Yoshiki Fujiyama,Takafumi Soeno,Yasuaki Furue,Takuya Wada,Akinori Watanabe,Kenji Ishido,Chikatoshi Katada,Keishi Yamashita,Wasaburo Koizumi,Chika Ku 대한위암학회 2021 Journal of gastric cancer Vol.21 No.4
Purpose: Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of CDO1 could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD). Materials and Methods: CDO1 methylation values (TaqMeth values) were compared between 33 patients with early gastric cancer (EGC) with no confirmed metachronous lesions at >3 years after ESD (non-MGC: nMGC group) and 11 patients with MGC developing on scars after ESD (MGCSE groups: EGC at the first ESD [MGCSE-1 group], EGC at the second ESD for treating MGC developing on scars after ESD [MGCSE-2 group]). Each EGC specimen was measured at five locations (at tumor [T] and the 4-point tumor-adjacent noncancerous mucosa [TAM]). Results: In the nMGC group, the TaqMeth values for T were significantly higher than that for TAM (P=0.0006). In the MGCSE groups, TAM (MGCSE-1) exhibited significantly higher TaqMeth values than TAM (nMGC) (P<0.0001) and TAM (MGCSE-2) (P=0.0041), suggesting that TAM (MGCSE-1) exhibited CDO1 hypermethylation similar to T (P=0.3638). The area under the curve for discriminating the highest TaqMeth value of TAM (MGCSE-1) from that of TAM (nMGC) was 0.81, and using the cut-off value of 43.4, CDO1 hypermethylation effectively enriched the MGCSE groups (P<0.0001). Conclusions: CDO1 hypermethylation has been implicated in the occurrence of MGC, suggesting its potential as a promising MGC predictor.
Piston Finger Device for Restoring the Motor Function of Chronic Plegic Fingers
Mengsu Wang,Hirofumi Tanabe,Kenji Ooka,Yoshifumi Morita,Yukio Kobayashi,Hiroyuki Daiko,Takafumi Iziri,Naoki Kiriyama 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
A piston finger technique (PFT) was developed for restoring the motor function of chronic plegic fingers with good outcomes, including reduced spasticity and improved muscle shortening. In our previous work, we analyzed finger motions during treatment with the PFT using a motion capture system. Based on the motion analysis results of treatment with the PFT, we determined the required specifications for a piston finger device (PFD). In this study, we developed a PFD utilizing a crank mechanism. We conducted treatment with the PFD on five patients with chronic plegic fingers. The assessment results based on the Modified Ashworth Scale, the Fast Passive Stretch, and the Passive-ROM (Range Of Motion) before and after treatment with the PFD showed that motor function was improved and abnormal muscle tone had decreased. Therefore, the effectiveness of treatment with the PFD was verified.
Verification of Therapeutic Effect of a Piston Device for Foot with Spastic Paralysis
Nguyen Thi Kieu Chinh,Hirofumi Tanabe,Kenji Ooka,Yoshifumi Morita,Yukio Kobayashi,Takafumi Ijiri 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
The second author has developed a piston technique for restoring the motor function of a chronic plegic foot with good outcomes, including reduced spasticity and improved muscle shortening. In this study, we developed a piston device for foot (PDFt) to simulate the piston technique. The PDFt moves the paralyzed foot passively. We considered the therapeutic effects as well as new findings in treatment with the PDFt. We conducted treatment with the PDFt for five minutes on each of six hemiplegic persons. The therapeutic effect was assessed by measuring the passive range of motion, the active range of motion, and the Modified Ashworth Scale score before and after treatment. The use of the PDFt led to improved motor function and decreased abnormal muscle tone. Therefore, the effectiveness of treatment with the PDFt was verified. Moreover, we conducted a 5-Meter Walk Test before and after treatment for one hemiplegic person and performed a gait analysis. It was confirmed that the treatment also had a good effect on the improvement of gait.