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노영일,정은경,박상기,박영봉,박병권,김영숙 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1
Adrenoleukodystrophy(ALD) is a rare genetically determined disorder associated with progressive demyelination of central nervous system and dysfunction of the adrenal cortex. Although it is known to occur in most parts of the world it is seldom reported in Korea. We report a case of ALD in a 3 year old boy. This patient revealed developmental delay & seizure, increased plasma content of very long chain fatty acids (VLCFAs) and had a widespread symmetrical white matter lesion in the peritrigonal areas and brain atropy that was demonstrated with Magnetic Resonance Image.
An, Hyun‐,Jin,Kim, Jung‐,Yeon,Kim, Woon‐,Hae,Gwon, Mi‐,Gyeong,Gu, Hye Min,Jeon, Min Ji,Han, Sang‐,Mi,Pak, Sok Cheon,Lee, Chong‐,Kee,Park, In Sook,Park, Kwan‐ John Wiley and Sons Inc. 2018 British journal of pharmacology Vol.175 No.23
<P><B>Background and Purpose</B></P><P>Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune responses. There are several existing therapies for AD, including topical glucocorticosteroids, emollients, phototherapies, calcineurin inhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inflammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.</P><P><B>Experimental Approach</B></P><P>Effects of bee venom and melittin were studied in a model of AD <I>in vivo</I> induced by 1‐chloro‐2,4‐dinitrobenzene (DNCB) in female Balb/c mice and in cultures of human keratinocytes, stimulated by TNF‐α/IFN‐γ. The potential pharmacological effects of bee venom and melittin on these <I>in vivo</I> and <I>in vitro</I> AD‐like skin disease models were studied.</P><P><B>Key Results</B></P><P>Bee venom and melittin exhibited potent anti‐atopic activities, shown by decreased AD‐like skin lesions, induced by DNCB in mice. <I>In vitro</I> studies using TNF‐α/IFN‐γ‐stimulated human keratinocytes showed that bee venom and melittin inhibited the increased expression of chemokines, such as CCL17 and CCL22, and pro‐inflammatory cytokines, including IL‐1β, IL‐6 and IFN‐γ, through the blockade of the NF‐κB and STAT signalling pathways.</P><P><B>Conclusions and Implications</B></P><P>Our results suggest that bee venom and melittin would be suitable for epicutaneous application, as topical administration is often appropriate for the treatment of AD.</P>