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Genetic and Environmental Influences on Serum Cholesterol Level : A Study of Korean Twins
Kang, Ke Won,Joe, Cheol O,Ahn, Kyung Hee 한국유전학회 1990 Genes & Genomics Vol.12 No.4
The risk of coronary heart disease is linked to cholesterol levels. Previous studies have reported that the level of human plasma cholestery esters is influenced more by genetic factors than the level of free cholesterol. To assess the genetic nature and population differences, a serum cholesterol with free and esterified cholesterol were measured from 22 pairs of twins who ranged from 12 to 26 in age. Thin layer chromatography was used to separate cholestaryl ester and free cholesterol from the rest of serum lipids. No significant contributions of genetic effects were found for any of cholesterol variables. Heterogeneity in variance for the total cholesterol was found in comparison of monozygotic versus dizygotic twins. This might indicated an association of cholesterol variations with twin types as reported previously.
Zinc Transport Mechanism in Animal Intestine
Kang, Ke Won,Joe, Cheol O 한국유전학회 1990 Genes & Genomics Vol.12 No.4
The effects of Prostaglandin E1 [PGE1] , testosterone, 17 β-estradiol and indomethacin on the zinc flux rate across the jejunal segments isolated from rats of each sex were determined using the Ussing chamber technique. Addition of PGE1 (5.0μM to the segment bathing medium significantly stimulated the zinc flux rate from mucosa-to-serosa [J_(ms)] of the jejunal segments isolated from male rats and inhibited it in those from female rats. 17 β-estradiol [10nM] inhibited J_(ms) of jejunal segments isolated from male rats, but testosterone stimulated those from female rats. To confirm that testosterone stimulates and 17 β-estradiol inhibits J_(ms)’ the effects of testasterone on the zinc flux rates of segments isolated from male rats and 17 β-estradiol on those from female rats were determined. In those experiments, both testosterone and 17 β-estradiol inhibited J_(ms) without affecting the zinc flux rate from serosa-to-mucosa [J_(sm)]. However, when rats were ovariectomized, both of these steroid hormones stimulated J_(ms). Interestingly neither PGE1 nor steroid sex hormones produced any effect on the J_(sm), although indomethacin stimulated the J_(sm) of segments from male rats. These results suggest that steroid sex hormones interact with PGs in influencing the intestinal zinc transport and that encogenous PGs and steroid sex hormones augment the effects of exogenous hormones and PGs.
Kang, Ke Won 한국유전학회 1987 Genes & Genomics Vol.9 No.4
Since Galton in 1875 pointed out that the importance of twin studies for comparison of the effects of nature and nurture, twins have a special place in human genetics for evaluation of effects of genes and environment. Many human traits caused wholly or partly by genetic factors have a high concordance rate in monozygotic(MZ) than in dizygotic (DZ) twins. Many of the traits in which twin comparison are used are multifactorial. There have been devised a number of ways for estimating heritabilities and genetic variances from twin methods. The twin methods are further extended to evaluate the children of MZ twins, there are relationships of half-sibs, full-sibs and genetically unrelated spouses in a single MZ family. Twins are also used for co-twin control studies for drug and chemical tests in pharmaceutical companies. Given the simplicity of the twin model it is surprising the number of different methods proposed for twin data analysis and the continuing improvements in methods. Over the years we have attempted to test all testable assumptions of the model while minimizing the assumptions. Our goal has been primarily to test hypotheses and provide a basis for future identification of specific environmental influence and single genes which influence human traits. The presentation will review the twin methods of their usefulness and limitations.
Fatty Acid Analysis from Leech Skin
Kang, Ke Won,Hong, Suk Jin,Kim, Dong Ryeong,Yoon, In Joong 생화학분자생물학회 1977 BMB Reports Vol.28 No.3
The lipids of a Korean nattve blood-sucking leech (Hirudo nipponia) were isolated and analyzed. Cholesterol, fatty acids, triglycerides, glycerylether diester and cholesteryl esters were found from epidermal extracts. The major fatty acids in the leech skin were C_(16:0), C_(18:0), C_(20:1), C_(20:3) components. These components were derived from cholesteryl esters, glycerides, fatty acids and other polar lipids. After 60 days fasting, cholesterol, fatty acids and triglycerides in the skin were reduced in number and the total fatty acid composition was changed slightly. The data of total fatty acids in fasted and fed leech showed that medium-chain fatty acids were more affected than long-chain fatty acids. Other trace fatty acids appeared to be decreased by fasting.
강계원 ( Ke Won Kang ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.3
Embryonic stem cells are known to renew themselves through cell division and can be induced to develop into whole different specialized cell types. These characteristics make stem cells worthy of investigation as a source of cells for tissue engineering and cell therapy, but technical and ethical considerations impede the therapeutic application of this technology. Reprogramming of fibroblasts to a pluripotent state can be induced in vitro through ectopic expression of the four transcription factors Oct4, Sox2, c-Myc and Klf4. Many investigators showed that reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells in DNA methylation, gene expression and chromatin state. Advances in reprogramming cellular mechanisms are transforming biomedical research and offer new expectations on development and potential treatment of various diseases. This review focused on recent researches and developments of iPS and is to stimulate the research in an area of tissue engineering.
Osteogenic Effects on Athymic Rat Calvarial Defects by Human Originated Cortical Bone
( Seog Jin Seo ),( Jae Won Heo ),( Ji Hwa Chae ),( Seong Hyun Jeon ),( Jin Kim ),( Nak Heon Kang ),( Kwang Won Lee ),( Ke Won Kang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
The purpose of this study was to evaluate effects of bone regeneration by the external sources of human bone substitutes which were developed for the transplantation. There are many different forms of bone based substitute materials. This study is focused on transplantable bone products developed by HansBiomed Inc. and some selected products, namely, human cortical bone powder, demineralized bone matrix(DBM), and bovine bone powders. SureOss and SureFuse are freeze-dried form of human cortical bone powder and DBM combined products, available from HansBiomed Corp, Korea, and Bio-Oss is the granule form of bovine bone powder by Geistlich- Pharma, Switzerland. The 4-mm critical size skull defects in athymic rats were prepared, and the defects were filled with the materials to be tested. The animals were sacrificed at 12 weeks. New bone formation was assessed by optical, radiographic and histological analyses. In our results, photographical density showed that SureOss-graft model induced the best bone formation occurring from defect edges. In summary, our findings indicate that human cortical bone powder enhances bone formation in rat model and the new products based human cortical bone powder may be a good bone substitute material for allografts.
박종열,김기웅,Ke Shang,김상원,최유리,Cheng-Dong Yu,Ji-Eun Son,Gyeong-Jun Kim,Won-Bin Jeon,김인환,Bai Wei,Min Kang,장형관,차세연 한국가금학회 2023 韓國家禽學會誌 Vol.50 No.4
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive disease in young chickens, and causes considerable economic losses to the poultry industry. More than 30 years ago, an antigenic variant IBDV (avIBDV) was reported in chicken farms in the United States. Recently, a novel avIBDV exhibited clear differences in molecular characteristics compared with previous variant strains. This study investigated the molecular characteristics of recently isolated avIBDV strains in Korea. Strains of avIBDV were confirmed by reverse transcription PCR (RT-PCR) and were propagated in 10-day-old specific-pathogen-free (SPF) embryonated chicken eggs through chorioallantoic membrane (CAM) inoculation. Multiple sequence alignment and phylogenetic analyses of hypervariable regions VP2 gene revealed that the strains originated from two different avIBDV lineages (G2a and G2d). In our results, we confirmed the co-existence and prevalence of avIBDV genogroup G2a and G2d in chicken farms. It is necessary to study the protective efficacy of current vaccines against avIBDVs.