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Park, Jin Ho,Lee, Sun Yong,Kim, Woe Yeon,Jung, Young Jun,Chae, Ho Byoung,Jung, Hyun Suk,Kang, Chang Ho,Shin, Mi Rim,Kim, Sun Young,Su’udi, Mukhamad,Yun, Dae Jin,Lee, Kyun Oh,Kim, Min Gab,Lee, Sang Yeo Blackwell Publishing Ltd 2011 The New phytologist Vol.191 No.3
<P><B>Summary</B></P><P><P>This study reports that <I>Arabidopsis thaliana</I> protein serine/threonine phosphatase 5 (AtPP5) plays a pivotal role in heat stress resistance. A high‐molecular‐weight (HMW) form of AtPP5 was isolated from heat‐treated <I>A. thaliana</I> suspension cells. AtPP5 performs multiple functions, acting as a protein phosphatase, foldase chaperone, and holdase chaperone. The enzymatic activities of this versatile protein are closely associated with its oligomeric status, ranging from low oligomeric protein species to HMW complexes.</P><P>The phosphatase and foldase chaperone functions of AtPP5 are associated primarily with the low‐molecular‐weight (LMW) form, whereas the HMW form exhibits holdase chaperone activity. Transgenic over‐expression of <I>AtPP5</I> conferred enhanced heat shock resistance to wild‐type <I>A. thaliana</I> and a T‐DNA insertion knock‐out mutant was defective in acquired thermotolerance. A recombinant phosphatase mutant (H290N) showed markedly increased holdase chaperone activity.</P><P>In addition, enhanced thermotolerance was observed in transgenic plants over‐expressing H290N, which suggests that the holdase chaperone activity of AtPP5 is primarily responsible for AtPP5‐mediated thermotolerance.</P><P>Collectively, the results from this study provide the first evidence that AtPP5 performs multiple enzymatic activities that are mediated by conformational changes induced by heat‐shock stress.</P></P>
Kang, Myung Ho,Kwon, Se Gab,Jung, Sung Chul Elsevier 2018 Surface science Vol.669 No.-
<P><B>Abstract</B></P> <P>Density functional theory (DFT) calculations are used to investigate the insulating origin of the Na/Si(111)-(3 × 1) surface with a Na coverage of 2/3 monolayers. In the coverage definition, one monolayer refers to one Na atom per surface Si atom, so this surface contains an odd number of electrons (i.e., three Si dangling-bond electrons plus two Na electrons) per 3 × 1 unit cell. Interestingly, this odd-electron surface has been ascribed to a Mott–Hubbard insulator to account for the measured insulating band structure with a gap of about 0.8 eV. Here, we instead propose a Peierls instability as the origin of the experimental band gap. The concept of Peierls instability is fundamental in one-dimensional metal systems but has not been taken into account in previous studies of this surface. Our DFT calculations demonstrate that the linear chain structure of Si dangling bonds in this surface is energetically unstable with respect to a × 2 buckling modulation, and the buckling-induced band gap of 0.79 eV explains well the measured insulating nature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> DFT calculations predict a Peierls instability of the Na/Si(111)-(3 × 1) surface with a Na coverage of 2/3 monolayers. </LI> <LI> The linear chain of Si dangling-bond atoms undergoes a zigzag buckling modulation. </LI> <LI> The Peierls band-gap opening accounts well for the experimental insulating band structure. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
In Gab Jeong,Kyung Seok Han,Jae Young Joung,Woo Suk Choi,Seung-Sik Hwang,Seung Ok Yang,Ho Kyung Seo,정진수,Kang Hyun Lee 대한의학회 2007 Journal of Korean medical science Vol.22 No.S
The aims of this study were to analyze lymphocyte and eosinophil counts in consecutive peripheral blood samples taken during immunotherapy for metastatic renal cell carcinoma (mRCC) and to correlate the findings with objective response and survival. A total of 40 patients with mRCC who received immunotherapy with interleukin- 2, interferon- , and 5-fluorouracil were analyzed. Objective responses were observed in 14 patients, including 2 (5%) who showed a complete response (CR) and 12 (30%) who showed a partial response (PR). Eleven patients (27%) achieved stable disease (SD), and 15 patients (38%) had progressive disease (PD). Changes from baseline in the total lymphocyte counts were significantly higher in the responding patients (CR+PR+SD) than in the non-responding patients (PD) (p=0.017), but no difference was seen in the total eosinophil counts (p=0.275). Univariate analysis identified the Eastern Cooperative Oncology Group (ECOG) performance status (p=0.017), the presence of a primary renal tumor (p<0.001) and the peripheral lymphocyte counts at week 4 (p=0.034) as prognostic factors, but a low ECOG performance status (p=0.003) and the presence of a primary renal tumor (p=0.001) were identified as independent poor prognostic factors by multivariate analysis. This study provides further evidence that changes in blood lymphocyte counts may serve as an objective indicator of objective responses.