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- 저자 : K.K. Wong (검색결과 173 건)
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Kang, Eun-Young,Jee, Sung Ju,Kim, Cuk-Seong,Suh, Kwang-Sun,Wong, Alex W.K.,Moon, Jae Young Elsevier 2018 Journal of critical care Vol.44 No.-
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>Early cognitive assessment in the intensive care unit (ICU) is essential to monitor cognitive dysfunction after critical illness. We have implemented a Computer Cognitive Senior Assessment System–Screen (CoSAS–S) which is a brief, objective, and tablet-based cognitive screening test as a mobile platform to detect any cognitive problems in ICUs. This study aimed to evaluate the feasibility and initial validation of a tablet-based CoSAS–S in critically ill patients with sepsis.</P> <P><B>Materials and methods</B></P> <P>Thirty-six eligible patients completed CoSAS–S, Mini-Mental State Examination–Korean Version (MMSE–K) and Korean Version of Montreal Cognitive Assessment (K-MoCA) for validity testing at the ICU.</P> <P><B>Results</B></P> <P>Eighty-eight percent of programmed assessments were completed by the sample. Spearman correlations of the CoSAS–S with MMSE–K (rho=0.613–0.874, p<0.00) and K–MoCA scores (rho=0.666–0.897, p<0.001) were moderate to high. Intra-class correlation coefficient (ICC) of total CoSAS–S score between two raters was 0.93 (p<0.001; 95% CI=0.82–0.97), suggesting the inter-rater reliability of CoSAS-S was excellent.</P> <P><B>Conclusions</B></P> <P>Support was found for the feasibility and validity of CoSAS-S. The application of CoSAS-S could identify the cognitive functioning of the patients. Utility of CoSAS-S in other clinical populations should be tested.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cognitive Senior Assessment System–Screen (CoSAS–S) is a mobile flat-form, tablet-based cognitive screening test. </LI> <LI> This study supports the feasibility and validity of tablet-based cognitive screening, ‘CoSAS-S’ in patients with sepsis. </LI> <LI> CoSAS-S could identify the critically ill patients without cognitive dysfunction in the ICUs. </LI> <LI> Utility of CoSAS-S in other clinical settings should be studied in the future study. </LI> </UL> </P>
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K.W. Goh,Y.H. Wong,R.S.K. Singh,Hari Chandran,S.K. Wong,K.Y. Sara Lee 한양대학교 세라믹연구소 2022 Journal of Ceramic Processing Research Vol.23 No.2
The extraction of calcium from natural biowaste material such as chicken eggshells have been shown to be viable to synthesiscalcium phosphate bioceramic. In this work, eggshell-derived hydroxyapatite powder was synthesised by using the wetchemical precipitation technique coupled with microwave irradiation at low power (700 W) at varying exposure time from 5to 30 min. The derived nano-powders were examined to determine the phases present, chemical bonding and microstructuralevolution. It was revealed that the irradiation time has an effect on the degree of crystallinity and both the crystallite andparticle size of the derived powders although the hydroxyapatite phase stability was not disrupted. An exposure time of 15 min. was determined to be sufficient when subjected to low power microwave irradiation to formed a well-defined needle-likehydroxyapatite particles having an average crystallite size of about 22 nm. On the contrary to many literatures, this study hasdemonstrated the viability of synthesizing a useful bioceramic from using biowaste eggshells coupled with microwaveirradiation at low power of 700 W for very short period of time to produce nano-range needle-like hydroxyapatite particlessuitable for biomedical application.
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Edge perturbation on electronic properties of boron nitride nanoribbons
K.L. Wong,K.W. Lai,M.W. Chuan,Y. Wong,A. Hamzah,S. Rusli,N.E. Alias,S. Mohamed Sultan,C.S. Lim,M.L.P. Tan Techno-Press 2023 Advances in nano research Vol.15 No.5
Hexagonal boron nitride (h-BN), commonly referred to as Boron Nitride Nanoribbons (BNNRs), is an electrical insulator characterized by high thermal stability and a wide bandgap semiconductor property. This study delves into the electronic properties of two BNNR configurations: Armchair BNNRs (ABNNRs) and Zigzag BNNRs (ZBNNRs). Utilizing the nearest-neighbour tight-binding approach and numerical methods, the electronic properties of BNNRs were simulated. A simplifying assumption, the Hamiltonian matrix is used to compute the electronic properties by considering the self-interaction energy of a unit cell and the interaction energy between the unit cells. The edge perturbation is applied to the selected atoms of ABNNRs and ZBNNRs to simulate the electronic properties changes. This simulation work is done by generating a custom script using numerical computational methods in MATLAB software. When benchmarked against a reference study, our results aligned closely in terms of band structure and bandgap energy for ABNNRs. However, variations were observed in the peak values of the continuous curves for the local density of states. This discrepancy can be attributed to the use of numerical methods in our study, in contrast to the semi-analytical approach adopted in the reference work.
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IMPACT BEHAVIOR MODELING OF MOTORCYCLE FRONT WHEEL-TIRE ASSEMBLY
K. S. TAN,S. V. WONG,R. S. RADIN UMAR,N. K. GUPTA,A. M. S. HAMOUDA 한국자동차공학회 2009 International journal of automotive technology Vol.10 No.3
Experiments were conducted to investigate the influence of certain parameters that affect the impact response of the motorcycle front wheel-tire assembly under various impact conditions. Impact tests were conducted according to 2V 5–1 fractional factorial design using a pendulum impact test apparatus with impact speed, impact mass, tire inflation pressure level, striker geometry, and impact location as design factors. Significant factors influencing the response of the wheel-tire assembly were identified. Coefficients for each factor were also determined, and empirical models were then developed for each response. An analysis indicates that the developed models fit well within the experimental ranges of the respective factors. However, for several interaction effects, the models become unrealistic, whereby they give certain deformation values when approaching zero impact mass and/or zero impact velocity. This is not consistent with the mechanics of the physical world, as there should not be any significant deformation when delivered impact energy is small enough. Efforts have been made in developing better models to resolve the inconsistency and to include a wider range, especially considering the case of the lower limit of experimental factors, which are an impact mass of 51.18 kg and/or an impact velocity of 3 m s−1 (10.8 km/h) down to zero. The minimum amount of impact energy required to produce the onset of observable deformation on the wheel was incorporated in the development of new models. Finally, the present models have been developed not only to cover the lower regions but also to range up to the upper limits of the factors, which are an impact mass of 101.33 kg and an impact velocity of 6 m s−1 (21.6 km/h). Experiments were conducted to investigate the influence of certain parameters that affect the impact response of the motorcycle front wheel-tire assembly under various impact conditions. Impact tests were conducted according to 2V 5–1 fractional factorial design using a pendulum impact test apparatus with impact speed, impact mass, tire inflation pressure level, striker geometry, and impact location as design factors. Significant factors influencing the response of the wheel-tire assembly were identified. Coefficients for each factor were also determined, and empirical models were then developed for each response. An analysis indicates that the developed models fit well within the experimental ranges of the respective factors. However, for several interaction effects, the models become unrealistic, whereby they give certain deformation values when approaching zero impact mass and/or zero impact velocity. This is not consistent with the mechanics of the physical world, as there should not be any significant deformation when delivered impact energy is small enough. Efforts have been made in developing better models to resolve the inconsistency and to include a wider range, especially considering the case of the lower limit of experimental factors, which are an impact mass of 51.18 kg and/or an impact velocity of 3 m s−1 (10.8 km/h) down to zero. The minimum amount of impact energy required to produce the onset of observable deformation on the wheel was incorporated in the development of new models. Finally, the present models have been developed not only to cover the lower regions but also to range up to the upper limits of the factors, which are an impact mass of 101.33 kg and an impact velocity of 6 m s−1 (21.6 km/h).
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Wong, Vanessa K,Baker, Stephen,Pickard, Derek J,Parkhill, Julian,Page, Andrew J,Feasey, Nicholas A,Kingsley, Robert A,Thomson, Nicholas R,Keane, Jacqueline A,Weill, Franç,ois-Xavier,Edwards, Dav Nature Pub. Co 2015 Nature genetics Vol.47 No.6
The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.
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Antipersistant Effects in the Dynamics of a Competing Population
K. H. Lee,K. Y. Michael Wong 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.1I
We consider a population of agents competing for finite resources by using strategies based on two channels of signals. The model is applicable to financial markets, ecosystems and computer networks. We find that the dynamics of the system is determined by the correlation between the two channels. In particular, occasional mismatches of the signals induce a series of transitions among numerous attractors. Surprisingly, in contrast to the effects of noises on dynamical systems normally resulting in a large number of attractors, the number of attractors due to the mismatched signals remains finite. Both simulations and analyses show that this can be explained by the antipersistent nature of the dynamics. Antipersistence refers to the response of the system to a given signal being opposite to that of the signal’s previous occurrence and is a consequence of the competition of agents to make minority decisions. Thus, it is essential for stabilizing the dynamical systems.
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Wong Joanna K. L.,Ke Yuhe,Ong Yi Jing,Li HuiHua,Wong Ting Hway,Abdullah Hairil Rizal 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.1
Background: Diabetes is a risk factor for postoperative complications. Previous meta-analyses have shown that elevated glycated hemoglobin (HbA1c) levels are associated with postoperative complications in various surgical populations. However, this is the first meta-analysis to investigate the association between preoperative HbA1c levels and postoperative complications in patients undergoing elective major abdominal surgery.Methods: PRISMA guidelines were adhered to for this study. Six databases were searched up to April 1, 2020. Primary studies investigating the effect of HbA1c levels on postoperative complications after elective major abdominal surgery were included. Risk of bias and quality of evidence assessments were performed. Data were pooled using a random effects model. Meta-regression was performed to evaluate different HbA1c cut-off values. Results: Twelve observational studies (25,036 patients) were included. Most studies received a ‘good’ and ‘moderate quality’ score using the NOS and GRADE, respectively. Patients with a high HbA1c had a greater risk of anastomotic leaks (odds ratio [OR]: 2.80, 95% CI [1.63, 4.83], P < 0.001), wound infections (OR: 1.21, 95% CI [1.08, 1.36], P = 0.001), major complications defined as Clavien-Dindo [CD] 3–5 (OR: 2.16, 95% CI [1.54, 3.01], P < 0.001), and overall complications defined as CD 1–5 (OR: 2.12, 95% CI [1.48, 3.04], P < 0.001).Conclusions: An HbA1c between 6% and 7% is associated with higher risks of anastomotic leaks, wound infections, major complications, and overall postoperative complications. Therefore, guidelines with an HbA1c threshold > 7% may be putting pre-optimized patients at risk. Future randomized controlled trials are needed to explore causation before policy changes are made.
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