Electrospun bioactive poly (@?-caprolactone)-cellulose acetate-dextran antibacterial composite mats for wound dressing applications

Liao, N.,Unnithan, A.R.,Joshi, M.K.,Tiwari, A.P.,Hong, S.T.,Park, C.H.,Kim, C.S. Elsevier 2015 Colloids and surfaces. A, Physicochemical and engi Vol.469 No.-

<P>Electrospun nanofibrous mat for wound dressing application was successfully prepared from poly (6caprolactone) (PCL), cellulose acetate (CA) and dextran blend solution. Incorporation of small amount of tetracycline hydrochloride (TCH), an antibacterial drug, improved the cell proliferation, enhanced blood clotting ability and cell attachment as well as antimicrobial activity of the composite mat. The composite mats were characterized by SEM, FTIR and TGA analysis. In order to evaluate the cytocompatibility and cell behavior of the composite scaffolds, fibroblast cells were seeded on the matrix. Results demonstrated that the incorporation of dextran and drug strongly enhanced the adhesion and proliferation of the cells on the composite nanofibers. The antimicrobial activity of the composite was studied by zone inhibition against Gram-positive and Gram-negative bacteria and the result indicates high antibacterial activity. Therefore, as synthesized composite fiber have decent characteristics for wound dressing and skin engineering applications. (C) 2015 Elsevier B.V. All rights reserved.</P>

High-Tc Superconducting Quantum Interference Devices and Biomagnetic Applications

H.C. Yang,C.C. Chen,C.H. Wu,H.E. Horng,K.L. Chen,M.J. Chen,S.H. Liao,S.Y. Yang 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I

The superconducting quantum interference device (SQUID) is the most sensitive detector of the magnetic flux in the range of frequencies from dc to MHz and has widely been used in biomagnetic applications. In this paper, we highlight a few aspects of High-Tc SQUIDs, novel biomagnetic applications, and perspective. We give an overview of the current status and the principle techniques used to fabricate High-Tc SQUIDs. SQUID applications in magnetocardiography, biological immunoassay, and nuclear magnetic resonance are addressed. The results are discussed.=

Probability Density Function for the Critical Current Asymmetry of a HTS dc SQUID

Jen-Tzong Jeng,C. H. Wu,H. C. Yang,H. E. Horng,J. C. Chen,K. H. Huang,K. L. Chen,S. H. Liao,Y. C. Lin 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I

A dc SQUID consisting of grain boundary Josephson junctions may often be asymmetric owing to the large critical-current spread. In this work, the probability density function (PDF) for the critical-current asymmetry of high-transition-temperature-superconductor (HTS) dc SQUID was investigated. To model the critical-current spread in the grain boundaries, we assumed that the barrier thickness of the Josephson junction fluctuated according to a log-Weibull distribution. The resultant PDF for the critical-current spread that fits the histogram data of critical currents reported in literature was the gamma distribution. With the proposed distribution function, the corresponding PDF for the critical-current asymmetry parameter of a HTS dc SQUID was derived and compared with the experimental result. The proposed gamma distribution function is useful in modeling devices, such as the SQUID array and the superconducting quantum interference grating, consisting of many grain-boundary Josephson junctions.

A grid-based dynamic load balancing approach for data-centric storage in wireless sensor networks

Liao, W.H.,Shih, K.P.,Wu, W.C. Pergamon Press ; Elsevier Science Ltd 2010 Computers & electrical engineering Vol.36 No.1

In many data-centric storage techniques, each event corresponds to a hashing location by event type. However, most of them fail to deal with storage memory space due to high percentage of the load is assigned to a relatively small portion of the sensor nodes. Hence, these nodes may fail to deal with the storage of the sensor nodes effectively. To solve the problem, we propose a grid-based dynamic load balancing approach for data-centric storage in sensor networks that relies on two schemes: (1) a cover-up scheme to deal with a problem of a storage node whose memory space is depleted. This scheme can adjust the number of storage nodes dynamically; (2) the multi-threshold levels to achieve load balancing in each grid and all nodes get load balancing. Simulations have shown that our scheme can enhance the quality of data and avoid hotspot of the storage while there are a vast number of the events in a sensor network.

The Oxidation of Methane at HCCI Engine Combustions

C. M. Liao(류춘명),J. M. Jin(진종무),D. H. Ha(하동흔),J. K. Yeom(염정국) 한국동력기계공학회 2007 한국동력기계공학회 학술대회 논문집 Vol.- No.-

압축천연가스(CNG)의 주요성분인 메탄의 산화와 연소를 HCCI엔진조건하에서 컴퓨터 시뮬레이션으로 연구하였다. 먼저, 당량비를 0.2에서 0.45까지 변화시켜 얻은 압력과 온도효과를 CHEMKIN을 사용하여 계산하였다. 그리고, 메탄의 운동학적 특성을 당량비 Ф=0.3, GRI 3.0 방법을 사용하여 계산하였다. 반응물과 생성물의 반응과정과 매개물의 프로파일은 운동학적 모델을 사용하였다. 마지막으로, 메탄의 산화반응의 주요 반응경로를 확인하기 위해 완전반응유동해석을 사용하였다.

Pressure Distribution Assessments for a Beam of a Flat Wiper Blade

( D. -c. Huang ),( M. -z. Zhang ),( Z. -q. Huang ),( K. -c. Liao ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

Recently standard wiper blades have been gradually replaced by flat wiper blades due to several advantages such as simple structures. A schematic approach is developed to appraise the suitability of the geometry of a metallic beam, one of major components of the flat wipe blade, in the present study. The beam is compressed against a level surface via a rocker arm mechanism, and the corresponding pressure distribution under the beam is measured by using piezoelectric sensors. Pressure distributions along the longitudinal direction of the beam based on the numerical simulations are in good agreement with those based on the experiments. A parameterized beam model is proposed here to achieve anticipated characteristics of the pressure distributions of the beam provided. Three geometric parameters built in a computer-aided drawing (CAD) model are investigated to evaluate their influences on the pressure distributions of the beam. An optimization software linked to CAD software and a finite element analysis software is further adopted based on various self-defined optimization indexes to search for an ideal parameter combinations. The suggested geometry of the beam is then sampled to validate the appropriateness of the current pressure assessment procedures.

In-situ deposition of silver-iron oxide nanoparticles on the surface of fly ash for water purification

Joshi, M.K.,Pant, H.R.,Liao, N.,Kim, J.H.,Kim, H.J.,Park, C.H.,Kim, C.S. Academic Press 2015 JOURNAL OF COLLOID AND INTERFACE SCIENCE - Vol.453 No.-

In this study, a fly ash based composite, Ag-iron oxide/fly ash, was synthesized via a facile one-pot hydrothermal process using fly ash, ferrous chloride, and silver nitrate as precursors. Field emission scanning electron microscopy (FE-SEM), EDX, transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FTIR), Photoluminescence (PL) and Brunauer-Emmett-Teller (BET) surface area measurement confirmed the formation of composite particle. FA provided a suitable surface for the in-situ deposition of Fe<SUB>3</SUB>O<SUB>4</SUB> and Ag NPs during hydrothermal treatment. As a result, the particle size of Fe<SUB>3</SUB>O<SUB>4</SUB> and Ag NPs was sufficiently decreased, and the surface area of the NPs as well as, a whole matrix was increased. The antimicrobial activity of the composite was accessed by Escherichia coli inhibition assay. Lead(II) ion adsorption efficiency of the composite was analyzed from a series of batch adsorption experiments (the effects of concentration, contact time, pH and adsorbent dose on the adsorption of Pb(II) ion from aqueous solution). Results indicated that as-synthesized composite has high antibacterial capacity, and the metal ions uptake efficiency compared to fly ash particle. Furthermore, incorporation Fe<SUB>3</SUB>O<SUB>4</SUB> NPs onto the fly ash make it easily separable from a reaction system using an external magnet. The composite synthesis protocol is a simple method that utilizes a readily available industrial byproduct to produce a unique composite for environmental remediation.

Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment

An, E.,Ock, C.-Y.,Kim, T.-Y.,Lee, K.-H.,Han, S.-W.,Im, S.-A.,Kim, T.-Y.,Liao, W.-L.,Cecchi, F.,Blackler, A.,Thyparambil, S.,Kim, W. H.,Burrows, J.,Hembrough, T.,Catenacci, D. V. T.,Oh, D.-Y.,Bang, Y.- KLUWER ACADEMIC PUBLISHERS GROUP 2017 Annals of Oncology Vol. No.

<P><B>Abstract</B></P><P><B>Background</B></P><P>A wide range of response rates have been reported in HER2-positive gastric cancer (GC) patients treated with trastuzumab. Other HER2-targeted therapies for GC have yet to show efficacy in clinical trials. These findings raise question about the ability of standard HER2 diagnostics to accurately distinguish between GC patients who would and would not benefit from anti-HER2 therapies.</P><P><B>Patients and methods</B></P><P>GC patients (<I>n </I>=<I> </I>237), including a subset from the Trastuzumab in GC (ToGA) trial were divided into three groups based on HER2 status and history of treatment with standard chemotherapy or chemotherapy plus trastuzumab. We applied mass spectrometry-based proteomic analysis to quantify HER2 protein expression in formalin-fixed tumor samples. Using HER2 expression as a continuous variable, we defined a predictive protein level cutoff to identify which patients would benefit from trastuzumab. We compared quantitated protein level with clinical outcome and HER2 status as determined by conventional HER2 diagnostics.</P><P><B>Results</B></P><P>Quantitative proteomics detected a 115-fold range of HER2 protein expression among patients diagnosed as HER2 positive by standard methods. A protein level of 1825 amol/µg was predicted to determine benefit from the addition of trastuzumab to chemotherapy. Trastuzumab treated patients with HER2 protein levels above this cutoff had twice the median overall survival (OS) of their counterparts below the cutoff (35.0 versus 17.5 months, <I>P </I>=<I> </I>0.011). Conversely, trastuzumab-treated patients with HER2 levels below the cutoff had outcomes similar to HER2-positive patients treated with chemotherapy. (Progression-free survival = 7.0 versus 6.5 months: <I>P </I>=<I> </I>0.504; OS = 17.5 versus 12.6 months: <I>P </I>=<I> </I>0.520). HER2 levels were not prognostic for response to chemotherapy.</P><P><B>Conclusions</B></P><P>Proteomic analysis of HER2 expression demonstrated a quantitative cutoff that improves selection of GC patients for trastuzumab as compared with current diagnostic methods.</P>

Shakedown analysis of trusses under cyclic thermal load with temperature-dependent yield stress

S.Y. Leu,Y.H. Chen,K.C. Liao 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.78 No.6

The paper aims to revisit shakedown analysis involving temperature-dependent yield stress. Formulations and numerical implementations are focused on truss structures subjected to cyclic thermal and constant mechanical loads. In particular, a systematic approach based on the duality relationship of l∞-norm and l1-norm is established to state the dual formulations for static and kinematic shakedown analysis of truss structures. Illustrative examples are involved statically indeterminate three-bar and five-bar trusses, respectively. Numerical effort is made to acquire shakedown limit temperature by using the linprog function provided by MATLAB. Furthermore, the finite-element analysis using ABAQUS is also performed for rigorous comparisons.

Modeling of temperature distribution in a reinforced concrete supertall structure based on structural health monitoring data

Y.Q. Ni,P. Zhang,X.W. Ye,K.C. Lin,W.Y. Liao 사단법인 한국계산역학회 2011 Computers and Concrete, An International Journal Vol.8 No.3

A long-term structural health monitoring (SHM) system comprising over 700 sensors of sixteen types has been implemented on the Guangzhou Television and Sightseeing Tower (GTST) of 610 m high for real-time monitoring of the structure at both construction and service stages. As part of this sophisticated SHM system, 48 temperature sensors have been deployed at 12 cross-sections of the reinforced concrete inner structure of the GTST to provide on-line monitoring via a wireless data transmission system. In this paper, the differential temperature profiles in the reinforced concrete inner structure of the GTST, which are mainly caused by solar radiation, are recognized from the monitoring data with the purpose of understanding the temperature-induced structural internal forces and deformations. After a careful examination of the pre-classified temperature measurement data obtained under sunny days and non-sunny days, common characteristic of the daily temperature variation is observed from the data acquired in sunny days. Making use of 60-day temperature measurement data obtained in sunny days, statistical patterns of the daily rising temperature and daily descending temperature are synthesized, and temperature distribution models of the reinforced concrete inner structure of the GTST are formulated using linear regression analysis. The developed monitoring-based temperature distribution models will serve as a reliable input for numerical prediction of the temperature-induced deformations and provide a robust basis to facilitate the design and construction of similar structures in consideration of thermal effects.