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병원성 원생동물의 변이와 약물내성: Leishmania major의 클로로퀸 내성
전경희(Kyung Hee Jeune),정시련(See Ryun Chung),바바라 밀러(Barbara Miller),캐롤 시블리(Carol Sibley) 大韓藥學會 1991 약학회지 Vol.35 No.2
A comparative study was performed on two different strains of Leishmania majorchloroquine sensitive strains (ChlS) and its mutant chloroquine resistant strains (ChlR). ChlR strains were obtained at 5X10-4M chloroquine. Remarkable differences were observed at the initial chloroquine uptake in ChlR and ChlS, ie., the rate of uptake was very reduced in ChlR (Km values were 70nM and 125nM, respectively). Influx and accumulation of chloroquine were also compared between wild type and mutant. An increasing tendency in both influx and accumulation of chloroquine was shown in ChlS, but ChlR demonstrated a rapid release after a little uptake (influx) at the early stage. This result is thought to be basis of their resistance for ChlR strains.
해양 천연물에서 분리한 면역기능 조정제 렉틴 MLA의 림프구 자극분열효과 및 면역화학적 특성
전경희(Kyung Hee Jeune),김장환(Jang Hwan Kim),정시련(See Ryun Chung) 대한약학회 1995 약학회지 Vol.39 No.3
Isolation, purification and characterization of biophysicochemical properties of the three new lectins. MLA-I, MLA-II, MLA-III from the hemolymph of Meretrix lusoria have been reported previously. A series of immunochemical studies were investigated in this work. The three lectins were revealed as having partial identity each other by immunodiffusion and immunoelectrophoresis. These results suggest that MLA lectins are isolectins having similar biophysicochemical properties. Particularly, MLA-I proved to be a potent mitogen for murine splenic as well as human peripheral lymphocytes, and the optimum mitogenic dose were 62.5 and 1.95mcg/ml, respectively.
별불가사리(Asterina pectinifera) 렉틴의 사이토카인 생성 양상
전경희(Kyung Hee Jeune),최수정(Soo Jeong Choi),정시련(See Ryun Chung) 대한약학회 1999 약학회지 Vol.43 No.4
The purpose of this study is to define whether Asterina pectinifera Lectin (APL) is effective on the cytokine production. Isolated mRNA from hPBMC (human peripheral blood mononuclear cells) stimulated with APL for various reaction times (1 to 96 hours) was detected by RT-PCR. The intensity of band for IL-1 and IFN gamma mRNA was markedly increased at 1 hour, and IL-2 mRNA was strongly expressed at 4 hours. The mRNA band of APL-induced IL-2 and IFN gamma was weaker than that of IL-1, IL-6 and TNF alpha. The mRNA expression of 4 cytokines (IL-1, IL-2, IFN gamma and TNF alpha) was detected up to 48 hours, and that of IL-6 was detected until 72 hours. ELISA was used to look protein secretion of the cytokine gene with IL-1, IL-2 and TNF alpha expressed strongly in RT-PCR. The highest protein secretion was at 4 hours with IL-1, at 8 hours with IL-2 and at 4 hours with TNF alpha. These results suggest that APL can induce the production of some cytokines and the immune response from PBMC was done within the first few hours of stimulation with APL.
버섯류의 렉틴 성분 개발연구(II) 야생 버섯류의 생리활성 물질, 렉틴 성분 검색
전경희(Kyung Hee Jeune-Chung),김무경(Moo Kyung Kim),정시련(See Ryun Chung) 대한약학회 1987 약학회지 Vol.31 No.4
Twenty species of higher fungi growing in the wild were collected and studied extensively for their lectin activities by using erythrocytes of human, rabbit and mouse blood. In total, 14 species demonstrated hemagglutination with some kinds of erythrocytes. Of twenty species, eight (Boletus edulis, B. splendidus, Clavaria zollingeri, Lactarius subzonarius, L. volemus, Russula cutefracta, Pholiota squarrosa, and P. aspera) were shown lymphoagglutination with murine splenic lymphocytes. Protein contents were estimated from the crude lectin fraction. Above mentioned eight species contained relatively high amounts of proteins than other mushrooms. Since these species had, coincidently, high hemagglutinating activity as well, we could define them as lectin-containing mushrooms. Some species also contained mitogenic lectins toward murine splenic lymphocytes.